Polymerization-Incompetent Uromodulin in the Pregnant Stroke-Prone Spontaneously Hypertensive RatNovelty and Significance [Uromodulin in Hypertensive Pregnancy]

The kidney is centrally involved in blood pressure regulation and undergoes extensive changes during pregnancy. Hypertension during pregnancy may result in an altered urinary peptidome that could be used to indicate new targets of therapeutic or diagnostic interest. The stroke-prone spontaneously hypertensive rat (SHRSP) is a model of maternal chronic hypertension. Capillary electrophoresis-mass spectrometry was conducted to interrogate the urinary peptidome in SHRSP and the control Wistar–Kyoto strain at three time points: prepregnancy and gestational days 12 and 18. The comparison within and between the Wistar–Kyoto and SHRSP peptidome at all time points detected 123 differentially expressed peptides (fold change>1.5; P
Source: Hypertension - Category: Cardiology Authors: Tags: Animal Models of Human Disease, Proteomics, Hypertension Original Articles Source Type: research