Abstract P257: Investigating Angiotensin II Infusion as a Model of Superimposed Preeclampsia in Pregnant Stroke Prone Spontaneously Hypertensive Rats [Session Title: Onsite Poster Competition II]

Background: Hypertensive disorders of pregnancy are a leading cause of maternal mortality worldwide. Chronic hypertension with superimposed preeclampsia is becoming more prevalent in modern society. Animal models are vital for understanding this condition. Our aim was to induce a preeclamptic phenotype in pregnant stroke prone spontaneously hypertensive (SHRSP) rats by angiotensin II (AngII) infusion.Methods: AngII, at a dose of 500ng/kg/min or 1000ng/kg/min, was administered by minipump in pregnant SHRSP rats from gestational day (GD)10. Cardiovascular and renal changes were monitored using radiotelemetry, echocardiography and weekly urine collections. GD18 ex vivo uterine artery function and structure were assessed using myography.Results: Both AngII doses resulted in an immediate and sustained increase in systolic blood pressure compared to vehicle control (172.5±5.0mmHg; 500ng/kg/min and 204.1±5.6mmHg; 1000ng/kg/min vs 159.0±0.4mmHg; p
Source: Hypertension - Category: Cardiology Authors: Tags: Poster Abstract Presentations Source Type: research