Abstract P451: Cerebrovasuclular Events in Patients With Primary Aldosteronism: Results of the PA Sendai Study Registry [Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke]

Background: Hyperaldosteronism is associated with the risk of cardio-and cerebrovascular events (CVE) that is independent of blood pressure levels and Primary aldosteronism (PA) display a higher risk of CVE compared with essential hypertension (EH).Objective: Our objective was to elucidate the prevalence of symptomatic stroke in PA patients and to characterize their clinical features.Design and Setting: This was a retrospective cross-sectional single center study (PA Sendai Study registry) between 2007 and 2016 in Japan.Patient: 807 patients with PA were registered and analyzed. The all patients were performed adrenal venous sampling(AVS) to make the diagnosis of PA subtypes.Results: Of 807 patients (male/female:395/412, age:53.3±11.8), 357 patients (44.2%) with alsosterone producing adenoma underwent adrenalectomy. The other patients were treated by medical therapy mostly administrating MR antagonists. Around the same time performed AVS, 698 patients were also performed MRI brain scans. Unruptured cerebral aneurysms were detected in about 4%, and Silent Brain Infarction were detected mainly around subcortical and basal ganglia region in about 30%. 27 patients (3.35%) suffered symptomatic stroke before the confirmed diagnosis of PA. The ratio of elderly and male was significantly high in stroke patients with PA. These patients had a higher rate of cerebral hemorrhage (thalamus or putaminal hemorrhage) rather than cerebellar infarction (63% vs 37%, p
Source: Hypertension - Category: Cardiology Authors: Tags: Poster Abstract Presentations Source Type: research