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Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation
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Total 298 results found since Jan 2013.
Artificial Grammar Learning with Transcranial Direct Current Stimulation (tDCS): A Pilot Study
The relationship between attention and learning has been well-established [1], with many studies showing that increased attention can improve learning and decreased attention can be detrimental to learning. Although stroke-induced aphasia is defined as a primary language impairment, many persons with aphasia also have attention deficits [2]. Sustained attention, the ability to maintain attention to a stimulus for an extended period of time, is an important prerequisite for participating in speech and language therapy and has been shown to be impaired in persons with aphasia [2].
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - July 1, 2019 Category: Neurology Authors: Ellyn A. Riley, Ying Wu Source Type: research
A single session of bihemispheric transcranial direct current stimulation does not improve quadriceps muscle spasticity in people with chronic stroke
Cerebral lesions following stroke cause an interhemispheric competition in the brain where the excitability of the affected hemisphere decreases and that of the unaffected hemisphere increases. This leads to a reduction of inhibitory control of spinal networks by the corticospinal tract of the affected side which in turn lead to the phenomenon of spasticity [1]. It has been found that i) bihemispheric-transcranial direct current stimulation (bi-tDCS) may reduce the interhemispheric imbalance in chronic stroke people (CSP) [2], and ii) anodal-tDCS applied over the affected leg motor cortex can alter the excitability of some...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - June 27, 2019 Category: Neurology Authors: Thomas Cattagni, Maxime Geiger, Anthony Supiot, Rapha ël Zory, Didier Pradon, Nicolas Roche Source Type: research
Proceedings #57: Recruitment Challenges in Infant Stroke and Non-Invasive Brain Stimulation Research: Demographics and Factors
Background: Recruitment, enrollment, and retention (RER) of participants is a crucial determinant of successful research. Unique challenges exist with RER of pediatric participants due to public perceptions regarding the safety of NIBS, and consent involving family agreement and participation. Pediatric non-invasive brain stimulation (NIBS) research historically struggles with low participant recruitment.[1] Sufficient participant enrollment in pediatric NIBS studies is vital to addressing issues of heterogeneity, validity, and generalizability.[2] Our lab is currently engaged in RER methods for a NIBS study investigating ...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - June 22, 2019 Category: Neurology Authors: Jesse L. Kowalski, Samuel T. Nemanich, Raghavendra Rao, Michael Georgieff, Elizabeth Zorn, Jeremiah Menk, Kyle Rudser, Bernadette T. Gillick Source Type: research
cTBS over contralesional homologue areas deteriorates speech output in isolated Apraxia of Speech after stroke
Apraxia of speech (AOS) is an impairment of motor speech planning/programming, characterized by a combination of phonemic segmental changes and articulatory distortions [1]. AOS is most often accompanied by aphasia, whereas isolated forms may rarely occur after focal damage to the left precentral gyrus [1]. How AOS recovers after brain damage is poorly understood [2]. In particular, it is not known whether recovery of AOS solely depends on the functional reorganisation of perilesional areas [3, 4], or whether it also depends on the compensation through contralesional homologue areas.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - March 17, 2019 Category: Neurology Authors: Brigitte C. Kaufmann, Manuela Pastore-Wapp, Maria L übeck, Monica Koenig, Stephan Bohlhalter, Tim Vanbellingen, Dario Cazzoli, Thomas Nyffeler Source Type: research
Somatosensory and transcranial direct current stimulation effects on manual dexterity and motor cortex function: A metaplasticity study
Non-invasive neuromodulation may provide treatment strategies for neurological deficits affecting movement, such as stroke. For example, weak electrical stimulation applied to the hand by wearing a “mesh glove” (MGS) can transiently increase primary motor cortex (M1) excitability. Conversely, transcranial direct current stimulation with the cathode over M1 (c-tDCS) can decrease corticomotor excitability.Objective/Hypothesis: We applied M1 c-tDCS as a priming adjuvant to MGS and hypothesise d metaplastic effects would be apparent in improved motor performance and modulation of M1 inhibitory and facilitatory circuits.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 26, 2019 Category: Neurology Authors: Anita Trudgen, John Cirillo, Winston D. Byblow Source Type: research
Efficacy and Safety of Multiple Sessions of Quadripulse Stimulation in Patients with Stroke: A Report of Two Cases
This study aimed to investigate how multiple sessions of QPS to the lesioned primary motor cortex (M1) combined with other therapies change motor function and electroencephalograms (EEGs) in stroke patients.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 23, 2019 Category: Neurology Authors: Keiichiro Shindo, Fuminari Kaneko, Megumi Okawada, Masaki Yoneta, Kazuto Akaboshi, Meigen Liu Source Type: research
Transcutaneous auricular vagus nerve stimulation in treating post-stroke insomnia monitored by resting-state fMRI: The first case report
Post-stroke insomnia (PSI) is one of the most frequent complications in the patients with cerebrovascular diseases. About 37 to 59% of the stroke patients report insomnia complaints [1]. Moreover, researches have indicated that insomnia is related to the increased cardiocerebrovascular morbidity and decreased stroke outcome [2]. Cognitive behavioral therapy (CBT) and drug intervention are the common treatments for PSI, however, because of dissatisfacted efficiency and side effects of drugs [1], it is very urgent to find an effective, safe and convenient complementary and alternative therapy.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 21, 2019 Category: Neurology Authors: Bin Zhao, Liang Li, Yue Jiao, Man Luo, Ke Xu, Yang Hong, Jiu-Dong Cao, Yue Zhang, Ji-Liang Fang, Pei-Jing Rong Source Type: research
Light at the End of the Tunnel: Improvement of Post-Stroke Visual Field Defect after Open-Label Navigated Perilesional rTMS
Cortical visual field defects (cVFD) usually show a narrow window of recovery not exceeding a few months. In some studies recovery was mostly in the first 10 days of insult followed by decrease in recovery rate that nearly plateaus 10-12 weeks after insult, and only 5% of patients will show full recovery of their visual field [1 –5].
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 31, 2019 Category: Neurology Authors: Nevine M. El Nahas, Ahmed M. Elbokl, Randa M. Amin, Tamer M. Roushdy, Aya Ahmed Ashour, Ahmed Zaki Akl, Eman Hamid Abd Eldayem, Shahinaz M. Helmy, Mohamed Nowara, Tamer H. Emara Source Type: research
Proceedings #18: Paradoxal Heightened Ipsilesional Corticospinal Excitability in Mild to Moderate Hemiplegia
Stroke is responsible for one out of every twenty deaths in the world and is a leading cause of serious long-term disabilities. Transcranial magnetic stimulation (TMS) is used clinically to measure and evaluate the integrity of the corticospinal pathway via the electromyographic response termed, the Motor Evoked Potential (MEP). The aim is to investigate corticospinal excitability from the affected and unaffected motor cortex in chronic post-stroke hemiparesis. The data used in this project form the baseline collection of a broader interventional study, in first time ischemic stroke patients with residual right hemiparesis...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: Celeste R.S. De Camargo, Mar Cortes, Avrielle Rykman Peltz, Dylan Edwards Source Type: research
Proceedings #15: Concurrent HD-tDCS/fMRI Study Exploring Changes in Motor Network Physiology and Complexity
Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) can be an efficient way to modulate cortical excitability and promote motor recovery following stroke. However, the effects of M1 tDCS on behavior have been highly variable across individuals. Here we explored whether another motor region that is less often affected by stroke (dorsal premotor cortex, PMd) could also modulate cortical excitability. We also examined motor network neural complexity changes following stimulation of either M1 or PMd using simultaneous fMRI.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: Stephanie Lefebvre, Kay Jann, Allie Schmiesing, Kaori Ito, Mayank Jog, Nicolas Schweighofer, Danny JJ. Wang, Sook-Lei Liew Source Type: research
Proceedings #4: Repetitive Transcranial Magnetic Stimulation (rTMS) Improves Depressive Symptoms and Quality of Life of Post-Stroke Patients
Introduction: Post-Stroke Depression (PSD) reaches nearly a third of stroke survivors, early or late, affecting their functional recovery and quality of life. Repetitive Transcranial Magnetic Stimulation (rTMS) has been explored as a safe supporting tool in the treatment of PSD.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: Herc ílio Barbosa da Silva Júnior, Marcos Rassi Fernandes, Ângela Maria Costa Souza Source Type: research
Abstract #161: When stimulating the unaffected (healthy) hemisphere in stroke patients makes sense
Research investigating the use of noninvasive electrical stimulation (e.g., transcranial direct current stimulation (tDCS)) has provided compelling evidence that such stimulation can modulate sensorimotor function, behavior and cognition, and even facilitate recovery of function after a focal brain injury. Our understanding of the mechanisms that lead to such changes is limited, and the influence of variables such as current strength, electrode montage and which regions of the brain to target is the focus of ongoing investigations.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: Gottfried Schlaug Source Type: research
Intermittent theta burst stimulation plus external counterpulsation for upper limb motor recovery after ischemic stroke
Background and Purpose: Upper limb dysfunction is common after ischemic stroke. The single application of intermittent theta burst stimulation (iTBS) or external counterpulsation (ECP) has been proved effectively to enhance the cortical motor excitability in previous researches. However, it still needs to verify the augment effect and its duration when these two treatments are applied orderly. We hypothesized that there was a synergistic effect of ECP followed by iTBS to upper limb function through the improvement in both the cerebral perfusion and neuron excitability.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: W. He, T. Leung, H. Leung, L. Wong Source Type: research
Proceedings #39: Effects of tDCS alone and combined with virtual reality in clinical practice
The brain can be modulated by electricity and emotions. We performed an open-label study in 134 patients with many clinical conditions, specially stroke, chronic pain and depression. The set up for transcranial direct current stimulation (tDCS) was dependent of the disease using always an intensity of 2 mA/30 min/day for 20 days. Virtual reality (VR) was applied concomitantly using an Oculus Rift. The outcomes were based on the subjective perception of the patients as follows: 1=no response at all, 2=mild response during the stimulation and 3=consistent response after 3 months of follow-up.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: Milena Artifon, Lauren Adachi, Pedro Schestatsky Source Type: research
Proceedings #23: Inaccurate segmentation of lesioned brains can significantly affect targeted transcranial electrical stimulation on stroke patients
Transcranial electrical stimulation (TES) has been shown to improve stroke recovery. Computational models of electrical current flow are often used to guide electrode placement on the scalp for targeted stimulation. This process relies on accurate segmentation of the brain, cerebrospinal fluid (CSF), skull and scalp, especially the lesion areas for stroke patients. Current software for brain segmentation usually cannot capture the lesions with high accuracy and manual labor is thus needed to correct segmentation errors from automated tools.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: Yu Huang, Chris Thomas, Abhishek Datta, Lucas C. Parra Source Type: research
