Filtered By:
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation
This page shows you your search results in order of relevance.
Order by Relevance | Date
Total 298 results found since Jan 2013.
Intermittent theta burst stimulation over ipsilesional primary motor cortex of subacute ischemic stroke patients: A pilot study
Conclusions: Repetitive sessions of iTBS1200 over ipsilesional M1 of subacute stroke patients are safe and the potential benefits encourage a larger trial to determine the efficacy in stroke patients. (ClinicalTrials.gov: NCT-01323881).
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - May 14, 2012 Category: Neurology Authors: Ya-Fang Hsu, Ying-Zu Huang, Yung-Yang Lin, Chih-Wei Tang, Kwong-Kum Liao, Po-Lei Lee, Yun-An Tsai, Hsien-Lin Cheng, Henrich Cheng, Chang-Ming Chern, I-Hui Lee Tags: Original Articles Source Type: research
Characterizing the Mechanisms of Central and Peripheral Forms of Neurostimulation in Chronic Dysphagic Stroke Patients
Conclusions: In this mechanistic study, an increase in corticobulbar excitability the unaffected projection was correlated with the improvement in swallowing safety (P = .001, rho = −.732), but modality-specific differences were observed. Paradigms providing peripheral input favored change in neurophysiological and behavioral outcome measures in chronic dysphagia patients. Further larger cohort studies of neurostimulation in chronic dysphagic stroke are imperative.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - October 14, 2013 Category: Neurology Authors: Emilia Michou, Satish Mistry, Samantha Jefferson, Pippa Tyrrell, Shaheen Hamdy Tags: Original Research Source Type: research
Transcranial Direct Current Stimulation Post-Stroke Upper Extremity Motor Recovery Studies Exhibit a Dose-Response Relationship
• Transcranial direct current stimulation (tDCS) shows dose-dependent effect in post-stroke motor recovery.• Meta-analysis of 8 studies that administered ≥5 sessions of tDCS therapy and used Fugl-Meyer Upper Extremity scale (FM-UE) as an outcome measure shows that tDCS offers a large post-stroke motor recovery effect size in subjects with chronic stroke when compared with acute stroke.• Bihemispheric montage with anode on ipsilesional side and cathode on contralesional side also seems to offer a large effect size in post-stroke motor recovery.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - September 7, 2015 Category: Neurology Authors: Pratik Y. Chhatbar, Viswanathan Ramakrishnan, Steven Kautz, Mark S. George, Robert J. Adams, Wuwei Feng Source Type: research
Simple Partial Status Epilepticus One-Day Post TMS to the Affected Hemisphere in A Participant with Chronic Stroke
TMS has become a widely used tool to measure motor physiology in stroke patients, and is emerging as an exciting new treatment for a variety of stroke-related deficits. Seizures are exceedingly rare in TMS studies of stroke. Here we report a case of simple partial status epilepticus in a study participant with stroke one day after single- and double-pulse stimulation. The participant was a 51-year-old male eight months post-stroke from a superior sagittal vein thrombosis causing a right-sided hemorrhagic lesion (25.03 cc) involving the precentral gyrus, the superior frontal gyrus, the medial frontal gyrus, the supplemen...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - December 31, 2016 Category: Neurology Authors: R. Harrington, E. Chan, P. Turkeltaub, A.W. Dromerick, M.L. Harris-Love Source Type: research
Can enhancing left lateralization using transcranial direct current stimulation improve recovery from post-stroke aphasia?
One third of stroke victims suffer from aphasia, an acquired language disorder for which there are few effective medical treatments. Aphasia often does not resolve completely, resulting in substantial long-term disability. After a stroke that causes aphasia, the reorganization of language networks in the brain involves compensatory recruitment of brain tissue in the left hemisphere as well as potentially maladaptive recruitment of symmetric areas in the right hemisphere. One avenue for intervention might be to externally “left lateralize” the brain, enhancing activity of the left frontal lobe while inhibiting the right...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - March 1, 2014 Category: Neurology Authors: Mackenzie Fama, Elizabeth Lacey, Alexa Desko, Lauren Taylor, Laura Hussey, Peter Turkeltaub Tags: Abstracts Presented at NYC Neuromodulation 2013 Source Type: research
The effectiveness of 1Hz rTMS over the primary motor area of the unaffected hemisphere to improve hand function after stroke depends on hemispheric dominance
Motor recovery of the affected upper limb after stroke is determined by dominance of the affected hemisphere. Stroke of the dominant hemisphere is associated with per se poorer improvement of the affected hand. 1Hz rTMS over the contralesional M1 significantly improves dexterity of the affected hand in patients with stroke of the dominant hemisphere, but not in those with stroke of the non-dominant hemisphere.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - March 17, 2015 Category: Neurology Authors: Jitka Lüdemann-Podubecká, Kathrin Bösl, Steven Theilig, Ralf Wiederer, Dennis Alexander Nowak Source Type: research
Promoting motor recovery in patients with stroke enhancing cerebellar cortical plasticity: a randomized double blinded controlled repetitive TMS trial
Introduction: The cerebellum is known to be strongly implicated in the functional reorganization of motor networks in stroke patients. In animal models of stroke it has been shown that stimulation of cerebellar-cortical networks plays a major role for motor recovery. Repetitive transcranial magnetic stimulation (rTMS) can be used to enhance adaptive processes and prevent those potentially maladaptive in stroke recovery. In this randomized, double blind, sham-controlled trial we investigated the efficacy of cerebellar intermittent theta burst stimulation (iTBS) coupled with intensive physical therapy (PT) in promoting funct...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 15, 2017 Category: Neurology Authors: Francesco Di Lorenzo, Sonia Bonn ì, Elias P. Casula, Alex Martino Cinnera, Silvia Picazio, Viviana Ponzo, Carlo Caltagirone, Marco Iosa, Stefano Paolucci, Fabrizio Sallustio, Marco Bozzali, Giacomo Koch Source Type: research
Mapping Early Changes of Cortical Motor Output after Subcortical Stroke: A Transcranial Magnetic Stimulation Study
Abstract: After acute stroke several changes in cortical excitability occur involving affected (AH) and unaffected hemisphere (UH) but whether they contribute to motor recovery is still controversial. We performed transcranial magnetic stimulation mapping of several upper limb muscles over the two hemispheres in thirteen patients at 4–12 days from subcortical stroke and after 1 month. The occurrence of mirror movements (MMs) on the healthy side during contraction of paretic muscles was measured. At baseline, cortical excitability parameters over the AH decreased in comparison with controls, while excitability over the UH...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - July 2, 2012 Category: Neurology Authors: Raffaella Chieffo, Alberto Inuggi, Laura Straffi, Elisabetta Coppi, Javier Gonzalez-Rosa, Francesca Spagnolo, Antonella Poggi, Giancarlo Comi, Mauro Comola, Letizia Leocani Tags: Original Articles Source Type: research
Does cathodal transcranial direct current stimulation (ctDCS) plus standard upper limb rehabilitation augment motor recovery post acute stroke? – A pilot study
Interhemispheric balance (IHB) is disrupted after stroke. The contralesional hemisphere can exert an excessive inhibitory influence on the lesioned side, reducing activity in the damaged motor cortex and interfering with motor recovery. Non-invasive brain stimulation (NIBS) may ameliorate this imbalance. One form of NIBS is transcranial direct current stimulation (tDCS). tDCS can modulate cortical excitability in three ways: (1) excitatory (anodal) tDCS to the aff5cted hemisphere; (2) inhibitory (cathodal) tDCS (ctDCS) can dampen overactivity in the contralesional hemisphere; and (3) bihemispheric tDCS which produces a com...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - March 1, 2014 Category: Neurology Authors: Jimena Garcia-Vega, Gillian Bowater, Belinda Rapperport, Christopher Lind, David Blacker, Souyma Ghosh, Gary Thickbroom, Ian Cooper, Barbara Singer Tags: Abstracts Presented at NYC Neuromodulation 2013 Source Type: research
BDNF Polymorphism and Differential rTMS Effects on Motor Recovery of Stroke Patients
Conclusions: The findings suggest that the BDNF gene polymorphism negatively influences the effect of rTMS on the motor recovery of upper extremities in stroke patients.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - March 28, 2014 Category: Neurology Authors: Won Hyuk Chang, Oh Young Bang, Yong-Il Shin, Ahee Lee, Alvaro Pascual-Leone, Yun-Hee Kim Tags: Original Articles Source Type: research
Is the contralesional hemisphere a suitable target for noninvasive brain stimulation after stroke?
Stroke is the leading cause of adult disability and there are no treatments that can repair neural damage that results from stroke. Functional recovery for many patients is modest and therefore adjuvants to traditional therapies are urgently required. This talk will revisit the use of non-invasive brain stimulation (NIBS) as a potential adjuvant for stroke rehabilitation, which is well documented in clinical neurophysiological research, but not routinely used in clinical practice. One tenet is that functional restoration may be enhanced using techniques that increase excitability in the hemisphere in which the lesion has o...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: Winston D. Byblow, Cathy M. Stinear Source Type: research
Motor cortical reorganization and clinical outcomes after stroke: a longitudinal TMS/EEG evaluation
Introduction: Since early days after stroke, the brain undergoes a complex reorganization to allow compensatory mechanisms that promote functional recovery. Characterizing specific neurophysiological markers of motor recovery after stroke could improve clinical decision making. Our study aimed to track the time-course of motor cortical reorganization in a stroke patients group, and to individuate the neurophysiological markers associated to clinical outcome.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 15, 2017 Category: Neurology Authors: M.C. Pellicciari, S. Bonn ì, A. Martino Cinnera, V. Ponzo, E. Casula, G. Koch Source Type: research
Can TMS of forearm muscles improve prediction of dexterity after stroke?
In the acute phase after stroke, active finger extension is a strong predictor of long-term dexterity. Transcranial magnetic stimulation (TMS) with surface electromyography of proximal arm and intrinsic hand muscles has proven to be of additional prognostic value to clinical assessment, especially in patients unable to follow instructions. The current study aimed to determine whether TMS of the extensor digitorum communis (EDC) further improves the prognostic accuracy. Motor evoked potentials (MEPs) of the EDC at rest and Fugl-Meyer Assessment (FMA) of the upper extremity were measured in 18 participants within 4 weeks aft...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 15, 2017 Category: Neurology Authors: C.D. Bakker, M. Massa, T. Feuth, J. Pasman, A.A. van Kuijk, G. Kwakkel, A.C.H. Geurts, D. Stegeman Source Type: research
Brain-stimulation for arm recovery after stroke - protocol for a randomised clinical trial
Background: Many surviving stroke patients are left with moderate to severe sensorimotor impairments, including no or limited ability to execute muscle movements with the affected arm or hand. Limited stroke recovery is often associated with an imbalanced interaction between the two cerebral hemispheres, with reduced excitability of the ipsilesional primary motor cortex (M1) and increased excitability of the contralesional M1. One of many forms of rTMS, Theta Burst Stimulation (TBS), can elicit significant behavioral improvement in recovering stroke patients.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 15, 2017 Category: Neurology Authors: E.C.C. van Lieshout, J.M.A. Visser-Meily, H.B. van der Worp, S.F.W. Neggers, R.M. Dijkhuizen Source Type: research
Safety and tolerability of transcranial direct current stimulation to stroke patients – A phase I current escalation study
A prior meta-analysis revealed that higher doses of transcranial direct current stimulation (tDCS) have a better post-stroke upper-extremity motor recovery. While this finding suggests that currents greater than the typically used 2 mA may be more efficacious, the safety and tolerability of higher currents have not been assessed in stroke patients. We aim to assess the safety and tolerability of single session of up to 4 mA in stroke patients.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 26, 2017 Category: Neurology Authors: Pratik Y. Chhatbar, Rong Chen, Rachael Deardorff, Blair Dellenbach, Steven A. Kautz, Mark S. George, Wuwei Feng Source Type: research
