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Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation

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Total 298 results found since Jan 2013.

Transcranial direct current stimulation facilitates reading training in participants with post-stroke central alexia
Introduction: Central alexia is an acquired reading disorder co-occurring with a generalised language deficit (aphasia). We tested the effects of anodal transcranial Direct Current Stimulation targeted at the left inferior frontal gyrus applied in conjunction with a reading training App, called iReadMore, designed to improve word reading accuracy.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 15, 2017 Category: Neurology Authors: S.J. Kerry, Z.V.J. Woodhead, O.M. Aguilar, Y. Ong Hoon, J.S. Hogan, K. Pappa, A.P. Leff, J. Crinion Source Type: research

Non-invasive neuromodulation trials in children: Lessons from perinatal stroke
Introduction: Therapeutic applications of non-invasive brain stimulation are rapidly expanding. Principles are increasingly established, including directional modulation of informed cortical targets, facilitating clinical trial design. The worry is that the high prevalence of burdensome diseases with limited treatment options coupled with unchecked enthusiasm may be allowing trial applications to get ahead of rationale evidence. Concern is even greater in the developing brain where experience is limited and additional issues merit consideration.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 15, 2017 Category: Neurology Authors: A. Kirton Source Type: research

Low-intensity (400  mW/cm2, 500 kHz) pulsed transcranial ultrasound preconditioning may mitigate focal cerebral ischemia in rats
Preconditioning methods, which could increase tolerance of brain to subsequent ischemic injuries with a small dose of non-injury stimuli, have gained attention. Capitalizing on noninvasiveness and safety of ultrasound modality, the pulsed transcranial ultrasound stimulation (pTUS) approach may provide a novel treatment for patients with high risk of stroke.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 26, 2017 Category: Neurology Authors: Hangdao Li, Junfeng Sun, Daqu Zhang, Daryl Omire-Mayor, Peter A. Lewin, Shanbao Tong Source Type: research

Low-intensity (400 mW/cm2, 500 kHz) Pulsed Transcranial Ultrasound Preconditioning May Mitigate Focal Cerebral Ischemia in Rats
Preconditioning methods, which could increase tolerance of brain to subsequent ischemic injuries with a small dose of non-injury stimuli, have gained attention. Capitalizing on noninvasiveness and safety of ultrasound modality, the pulsed transcranial ultrasound stimulation (pTUS) approach may provide a novel treatment for patients with high risk of stroke.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 26, 2017 Category: Neurology Authors: Hangdao Li, Junfeng Sun, Daqu Zhang, Daryl Omire-Mayor, Peter A. Lewin, Shanbao Tong Source Type: research

Seizure induced by repetitive transcranial magnetic stimulation for central pain: adapted guidelines for post-stroke patients
We report the following TMS-related seizure:
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - March 23, 2017 Category: Neurology Authors: M élanie Cogné, Cédric Gil-Jardiné, Pierre-Alain Joseph, Dominique Guehl, Bertrand Glize Source Type: research

Transcranial direct current stimulation in primary progressive aphasia: Whom does it help?
Transcranial direct current stimulation (tDCS) has been shown to be a valuable adjunct to speech and language therapy, mainly in stroke rehabilitation and recently in primary progressive aphasia. An intriguing question that has not been addressed is whether different brain pathologies, atrophy patterns and symptoms associated with each variant of PPA have a differential impact on the effectiveness of electrical stimulation. We conducted a randomized sham-controlled, double-blind clinical trial using a within-subjects crossover design and we compared effects of tDCS coupled with oral and written naming therapy vs.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - June 18, 2017 Category: Neurology Authors: Kyrana Tsapkini, Kim Webster, Bronte N. Ficek, John Desmond, Chiadi Onyike, Brenda Rapp, Constantine E. Frangakis, Argye E. Hillis Source Type: research

Concurrent tDCS and Mirror Feedback has additive effects on M1 excitability
Mirror visual feedback (MVF) has been shown to aid recovery of movement after stroke, potentially by facilitating sensorimotor areas contralateral to the mirror-reflected hand. Similarly, non-invasive brain stimulation, such as transcranial direct stimulation (tDCS), can boost excitability of the motor cortex (M1) and aid recovery. Here we test if combining the two approaches concurrently will yield synergistic effects on M1 excitability compared to either approach alone. Four healthy subjects each performed 4 sessions of goal-oriented right finger movements in a virtual environment while receiving either MVF or veridical ...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - June 18, 2017 Category: Neurology Authors: Ge “Paul” Chen, Mathew Yarossi, Seth Gordon, Kayla Gomes, Anna Rubakhina, Sergei Adamovich, Eugene Tunik Source Type: research

Cranial nerve non-invasive neuromodulation improves gait and balance in stroke survivors: A pilot randomised controlled trial
Cranial nerve non-invasive neuromodulation (CN-NINM) is delivered using a Portable Neuromodulation Stimulation (PoNS ™) device that stimulates two cranial nerve nuclei (trigeminal and facial nerve nuclei) using electrodes embedded in a mouthpiece that rests on the tongue. Danilov and colleagues reported that prolonged and repetitive (20 minutes or more) tongue stimulation coupled with specific training of balanc e and gait can initiate long-lasting neuronal reorganization that can be measured in participants' behaviour [1].
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - September 1, 2017 Category: Neurology Authors: Mary P. Galea, L. Eduardo Cofr é Lizama, Andisheh Bastani, Maya G. Panisset, Fary Khan Source Type: research

Non-invasive vagus nerve stimulation reduces blood-brain barrier disruption in a rat model of ischemic stroke
Vagus nerve stimulation (VNS) significantly reduces infarct volume in rat models of cerebral ischemia, but the mechanism of this protective effect remains open.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 15, 2018 Category: Neurology Authors: Yirong Yang, Lisa Y. Yang, Lilla Orban, Darnell Cuylear, Jeffrey Thompson, Bruce Simon, Yi Yang Source Type: research

Low Frequency repetitive Transcranial Magnetic Stimulation: Potential role in treatment of patients with hemispheric cerebellar strokes
Five years prior to TMS study, a 64 years old left-handed man with mild tremor-predominant Parkinson's disease that predominantly affected his right side experienced a large embolic left cerebellar infarct and subsequently required cerebellar hemispherectomy due to complications of cerebellar edema. He had no other evidence of brain lesions or stroke (Supplementary Figure). Patient was on Parkinson's medication Carbidopa/Levodopa 25 –100mg 3 times per day and denied having ON of OFF periods. Residual difficulties with coordination, speech, fine motor movements, spasticity and most prominently his balance led to the perma...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 22, 2018 Category: Neurology Authors: Isabelle Buard, Jean M. Berliner, Benzi M. Kluger Source Type: research

Non-invasive vagus nerve stimulation reduces blood-brain barrier disruption in a rat model of ischemic stroke
Vagus nerve stimulation (VNS) significantly reduces infarct volume in rat models of cerebral ischemia, but the mechanism of this protective effect remains open.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 15, 2018 Category: Neurology Authors: Yirong Yang, Lisa Y. Yang, Lilla Orban, Darnell Cuylear, Jeffrey Thompson, Bruce Simon, Yi Yang Source Type: research

Low frequency rTMS combined with visual scanning training in patients with post-stroke visuospatial neglect. A randomized, double-blind, placebo-controlled study
Background: Visuospatial neglect (VSN) is defined as a failure to detect, orient or respond to stimuli located in space contralateral to the side of the brain lesion and occurs most frequently after right hemisphere damage. VSN may arise as a consequence of the inter-hemispheric imbalance of neural activity. Repetitive transcranial magnetic stimulation (rTMS) allows the balance between two hemispheres to be re-established.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - October 25, 2018 Category: Neurology Authors: Szczepan Iwa ński, Marcin Leśniak, Katarzyna Polanowska, Jan Bembenek, Wojciech Czepiel, Joanna Seniów Source Type: research

Delayed, distant skin lesions after transcranial direct current stimulation
Transcranial direct current stimulation (tDCS) has attracted considerable interest in recent years, especially as a potential intervention in stroke rehabilitation and the treatment of depression. Common safety guidelines exist to ensure the safety of the procedure [1]. However, mild adverse effects (AEs) are common and more severe AEs are occasionally encountered. Here, we report two cases of skin lesions following tDCS.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 3, 2018 Category: Neurology Authors: Aaron Kortteenniemi, Soili M. Lehto, Amir-Homayoun Javadi Source Type: research

rTMS can improve post-stroke apraxia of speech. A case study
Apraxia of Speech (AoS) is a rare disorder of motor speech planning distinct from both aphasia and dysarthria. It is characterized by inconsistent articulatory errors imposing a trial-and-error approximation to a target word, slow speech rate, segmentation of syllables, sound distortions and substitutions [1]. At difference with aphasia, in fact, in AoS errors are non-linguistic in nature (i.e. they are neither lexical nor morphological) and other language-related abilities (i.e. reading and auditory comprehension and writing) are usually preserved.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - December 10, 2018 Category: Neurology Authors: Calogero Malfitano, Elisabetta Banco, Angela Rossetti, Carlotta Casati, Chiara Malloggi, Stefano Scarano, Luigi Tesio Source Type: research