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Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation
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Total 298 results found since Jan 2013.
Transcranial direct current stimulation of areas above the motor cortex (C3) in waking resting state and REM sleep induces motor imagery
Motor imagery and corresponding motor cortical activation have been shown to benefit later motor performance. We assume that motor imagery and motor cortical activation form a functional unit which, if activated in resting state, serves the purpose of rehearsing for later motor performance. While athletes, musicians, surgeons and some stroke-patients can actively visualize specific movements to prepare and enhance later motor performance, many clinical populations cannot use such cognitive task paradigms for the rehabilitation of their motor system.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: J. Speth, C. Frenzel, T. Harley Source Type: research
Effects of transcutaneous lumbar spinal cord alternating current stimulation on tonic stretch reflex threshold in stroke - a case series
*Research is supported by Franco-Indian INRIA-DST Associate Team support 2014-2017.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: A. Dutta, A. Das Source Type: research
Single electrode DBS through motor thalamus and caudal zona incerta for the treatment of tremor syndromes
Both nucleus ventralis lateralis (VL) and subthalamic nucleus (STN) DBS are effective in the treatment of essential tremor and Parkinson's disease tremor. Complex tremor syndromes may present the overlapping of different clinical aspects (at rest, postural and kinetic) and can be associated to syndromic forms (dystonic, cerebellar, spastic), but also to different etiologies (following brain injury or stroke). In these cases DBS does not always guarantees an effective outcome. A recent study proposed single electrode DBS of both ventralis oralis posterior (vop) thalamic nucleus and caudal Zona Incerta (cZI) for the treatmen...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: M. Rizzi, G. Messina, R. Cordella, F. Penner, A. Franzini Source Type: research
Chronic post stroke central pain: Increased success rate of chronic epidural motor cortex stimulation using somatotopic, navigated repetitive TMS for patient selection and implant placement
Neuromodulation for severe central pain using repetitive stimulation of motor cortices has been used for more than two decades, first via direct cortical stimulation (DCS) by implanted electrodes, later non-invasively mainly by repetitive transcranial magnetic stimulation (rTMS). The outcome at group level has been limited, though for some, the effects have been of large value. There is a need for selection of patients that are likely to benefit from this procedure. Based on a preliminary report indicating that rTMS could contribute to this, we aimed to address this problem.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: M. Thordstein, G. Pegenius, K. Gatzinsky Source Type: research
DBS in critical care conditions
The efficacy of Deep Brain Stimulation (DBS) is well established in the treatment of chronic neurological diseases such as Parkinson's disease and primary dystonia. Emerging indications include, refractory epilepsy, chronic cluster headache, major depression, obsessive compulsive disorder, disruptive behaviour and Gilles de la Tourette syndrome. Nevertheless in selected cases DBS may be a treatment option in acute neurological disease or sudden dramatic worsening of pre-existing diseases in emergency conditions such as status dystonicus (SD) and post-stroke conditions.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: M. Rizzi, R. Cordella, G. Messina, C.E. Marras, G. Zorzi, D. Caldiroli, A. Franzini Source Type: research
The mechanism of functional recovery of upper extremity motor function among patients with chronic stroke: Modulation of cortical and spinal interneuron
We hypothesized that functional recovery of upper extremity motor function is based on cortical and spinal plasticity.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: Toshiyuki Fujiwara, Kaoru Honaga, Michiyuki Kawakami, Atsuko Nishimoto, Kaoru Abe, Katsuhiro Mizuno, Mitsuhiko Kodama, Yoshihisa MasakadoMD, Tetsuya Tsuji, Meigen Liu Source Type: research
Does Vascular Endothelial Growth factor(VEGF) expression in combination with Physiotherapy with/without repetitive Transcranial Magnetic Stimulation (rTMS) play the role in acute stroke recovery?
This project has been supported by Indian Council of Medical Research, New Delhi, India
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: Hina Sharma, M.V. Padma Srivastava, Rohit Bhatia, Nand Kumar, Rajeshwari Moganty Source Type: research
Electroencephalography - Near-infrared spectroscopy based assessment of neurovascular effects under transcranial direct current stimulation - a stroke case series
*Research is supported by Franco-Indian INRIA-DST Associate Team support 2014-2017.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: A. Dutta, S. Roy Chowdhury, A. Das Source Type: research
Simple Partial Status Epilepticus One-Day Post Single-Pulse TMS to the Affected Hemisphere in a Participant with Chronic Stroke
We report a TMS-related seizure. A 51-year-old man 8 months post superior sagittal vein thrombosis reported “twitching” in his affected arm, leg, and face one day after participating in a TMS trial. The day prior to the seizure event, the patient received 70 trials of single pulse TMS over the unaffected hemisphere primary motor cortex and double-pulse stimulation applied first over dorsal premotor cortex of the affected hemisphere (80 trials) and then over primary motor cortex of the affected hemisphere (70 trials).
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - March 14, 2015 Category: Neurology Authors: Rachael M. Harrington, Evan Chan, Peter E. Turkeltaub, Alexander W. Dromerick, Michelle L. Harris-Love Source Type: research
Use of computational modeling to inform tDCS electrode montages for the promotion of language recovery in post-stroke aphasia
Although pilot trials of transcranial direct current stimulation (tDCS) in aphasia are encouraging, protocol optimization is needed. Notably, it has not yet been clarified which of the varied electrode montages investigated is the most effective in enhancing language recovery.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - July 2, 2015 Category: Neurology Authors: Elizabeth E. Galletta, Andrea Cancelli, Carlo Cottone, Ilaria Simonelli, Franca Tecchio, Marom Bikson, Paola Marangolo Source Type: research
Modulation of cortical motor evoked potential after stroke during electrical stimulation of the lateral cerebellar nucleus
Deep brain stimulation (DBS) targeting the dentato-thalamo-cortical (DTC) pathway at its origin in the lateral cerebellar nucleus (LCN) has been shown to enhance motor recovery in a rodent model of cortical ischemia. LCN DBS also yielded frequency specific changes in motor cortex excitability in the normal brain, indexed by motor evoked potential (MEP) amplitude.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - July 8, 2015 Category: Neurology Authors: Hyun-Joo Park, Havan Furmaga, Jessica Cooperrider, John T. Gale, Kenneth B. Baker, Andre G. Machado Source Type: research
Transcranial Direct Current stimulation of the Leg Motor Cortex Enhances Coordinated Motor Output during Walking with a Large Inter-Individual Variability.
• tDCS can enhance the coordinated motor output during walking in healthy subjects, but there is large inter-individual variability in response• Dual-hemispheric tDCS tends to have a larger effect on the coordinated motor output than uni-hemisperic tDCS.• tDCS did not result in improved coordinated motor output in the paretic leg of chronic stroke survivors.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - October 7, 2015 Category: Neurology Authors: Edwin H.F. van Asseldonk, Tjitske A. Boonstra Source Type: research
The Proof is in the Pudding: Does tDCS Actually Deliver DC Stimulation?
Transcranial direct current stimulation (tDCS) is an increasingly used investigational modality for a variety of disease conditions worldwide, including stroke.1 It is relatively easy-use, low-cost, and has a reasonable safety profile with currents up to 2 mA. The effect of tDCS on membrane potentials has been demonstrated in vitro2 as well as in vivo through simulation of tDCS-generated electric fields.3 Real-time monitoring of applied voltage and injected current in tDCS application is offered as an inbuilt feature of many tDCS devices and can be achieved with a simple data acquisition setup.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - May 10, 2016 Category: Neurology Authors: Pratik Y. Chhatbar, James R. Sawers, Wuwei Feng Source Type: research
A Systematic Review on the Acceptability and Tolerability of Transcranial Direct Current Stimulation Treatment in Neuropsychiatry Trials
• We investigated the tolerability and acceptability of tDCS in clinical trials.• Sixty-four studies (n=2262 subjects) were included in our systematic review and meta-analysis.• Drop-out rate was similar in active (6%) and sham (7.2%) groups.• The quality of AEs reporting was limited, particularly in smaller trials and stroke studies.• An updated questionnaire and guidelines for assessment of AEs in tDCS trials are proposed.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - May 15, 2016 Category: Neurology Authors: Luana VM Aparício, Fabiana Guarienti, Lais Boralli Razza, André F Carvalho, Felipe Fregni, André Russowsky Brunoni Source Type: research
Does Transcranial Direct Current Stimulation Actually Deliver DC Stimulation: Response to Letter to the Editor
Transcranial direct current stimulation (tDCS) is a common form of transcranial electric stimulation (tES). It delivers constant, low intensity currents to the brain through spongy type electrodes on the scalp [1]. tDCS has been explored for producing behavioral changes and cognitive enhancement in healthy individuals [2]. Furthermore, tDCS may be helpful in attenuating symptoms of neurological disorders such as Parkinson's disease, Alzheimer's disease, schizophrenia, and stroke [3,4]. There are currently no FDA approved indications for its clinical use.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - June 2, 2016 Category: Neurology Authors: Yousef Salimpour, Kelly A. Mills, Zhikui Wei, Phan Q. Duy, William S. Anderson Source Type: research
