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Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation

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Total 298 results found since Jan 2013.

Abstract #140: BDNF Genotype and tDCS Interaction in Aphasia Therapy
Introduction: Using a double blinded randomized controlled trial, we evaluated the extent to which brain stimulation (anodal transcranial direct current stimulation [A-tDCS]) applied during speech therapy, was a futile adjunctive intervention to improve speech production (naming) in individuals with chronic post-stroke aphasia. This futility design evaluated a null hypothesis of 'A-tDCS results in better treatment outcome than sham tDCS.'
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: Julius Fridriksson, Jordan Elm, Brielle C. Stark, Alexandra Basilakos, Chris Rorden, Souvik Sen, Mark George, Leonardo Bonilha Source Type: research

Abstract #130: EEG Beta-band Coherence for Prognosis of Motor Recovery in Stroke Patients with tDCS-BCI Intervention
Introduction: Substantial evidence in the literature suggests how the transcranial Direct Current Stimulation (tDCS) can be used as a tool to modulate the motor activity and its applications in neurorehabilitation research. However, it is little explored whether the tDCS can be used in conjunction with Brain-Computer Interface (BCI) therapy for prognosticating the motor recovery in chronic stroke population.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: Vikram Shenoy Handiru, Cuntai Guan, Kai Keng Ang, Effie Chew Source Type: research

Abstract #128: Chronic Vagus Nerve Stimulation Enables Long-term Plasticity in Mouse Auditory Cortex
Introduction: Vagus nerve stimulation is currently used as a medical treatment for those suffering from severe epilepsy or depression, but the mechanisms underlying vagus nerve stimulation are poorly understood. The vagus nerve helps connect essentially all peripheral organs to the central nervous system, sending afferents to the nucleus tractus solitarius. Recent studies indicate that vagus nerve stimulation can produce long-lasting plasticity in the cerebral cortex, leading to improved sensory processing and recovery of motor behavior after stroke (Boreland et al, Brain Stimul (2016).
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: Eleni S. Papadoyannis, Kathleen A. Martin, Jennifer K. Schiavo, Nesibe Z. Temiz, Robert C. Froemke Source Type: research

Abstract #113: Individualized Modeling for Subjects with Primary Progressive Aphasia
Introduction: Transcranial Direct Current Stimulation (tDCS) is a non-invasive neuromodulation technique that has shown promise in a multitude of rehabilitation protocols, e.g. motor and speech, as well as cognitive enhancement. However, anatomical variability is known to influence both the intensity and spatial focality of tDCS in healthy subjects and especially in stroke lesioned subjects. Subjects with progressive brain atrophy are potential candidates for many tDCS applications, but few studies have quantified this subject population's anatomical influence on induced cortical electric fields.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: Gozde Unal, Bronte N. Ficek, Kimberly T. Webster, Syed Shahabuddin, Dennis Q. Truong, Marom Bikson, Kyrana Tsapkini Source Type: research

Abstract #112: Recruitment Challenges in Infant Stroke and Non-Invasive Brain Stimulation Research: Demographics and Factors
Introduction: Recruitment, enrollment, and retention (RER) of participants is a crucial determinant of successful research. Unique challenges exist with RER of pediatric participants due to public perceptions regarding the safety of non-invasive brain stimulation (NIBS), and consent involving family agreement and participation. Pediatric NIBS research historically struggles with low enrollment, resulting in issues of heterogeneity, validity, and generalizability. Our lab is currently engaged in RER methods for a NIBS study investigating cortical excitability, corticospinal tract organization, and motor function of infants ...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: Jesse L. Kowalski, Samuel T. Nemanich, Raghavendra Rao, MIchael Georgieff, Jeremiah Menk, Kyle Rudser, Bernadette Gillick Source Type: research

Abstract #94: BDNF polymorphism predicts plasticity in motor cortex following continuous theta burst stimulation
Introduction: Continuous theta burst stimulation (cTBS) is under investigation as a method to induce inhibitory cortical plasticity after stroke, but assessment of its therapeutic value is hampered by variability in individual responses. Previous studies have investigated sources of variability, including biological factors that influence brain plasticity, such as a common polymorphism in the brain-derived neurotropic factor (BDNF) gene (i.e., Val66Val vs. Val66Met carriers). However, the evidence to date is mixed, with some studies reporting no effect or paradoxical effects of BDNF on TBS-induced cortical plasticity.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: Denise Y. Harvey, Laura DeLoretta, Rachel Wurzman, Daniela Sacchetti, Ahmed Ahmed, Abdou Thiam, Falk Lohoff, Olufunsho Faseyitan, Roy H. Hamilton Source Type: research

Abstract #71: Effects of Repetitive Transcranial magnetic Stimulation on Cognition and Neuroplasticity in Subacute Stroke Patients
Introduction: The purpose of this study is to determine the cognitive improvement and neurophysiological effects of repetitive transcranial magnetic stimulation (rTMS) over the left dorsolateral prefrontal cortex(L-DLPFC) in subacute stroke patients.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: Yeong Wook Kim Source Type: research

Abstract #24: Transcranial direct current stimulation (tDCS) electric field modeling in children after perinatal stroke
Background: Perinatal stroke (PS), the leading cause of hemiparetic cerebral palsy (HCP), typically results from occlusion of the middle cerebral artery (arterial ischemic stroke, AIS). Subsequent motor impairments last a lifetime and improving function is difficult. Transcranial direct-current stimulation (tDCS) is a form of non-invasive brain stimulation that may facilitate neuroplasticity and improve function. How current moves through the developing brain is different from adults. Modeling tDCS-induced electric fields (EF) is feasible but individual idiosyncrasies in lesion topology, white (WM) and grey matter (GM) arc...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: H.L. Carlson, A. Giuffre, P. Ciechanski, A. Kirton Source Type: research

Abstract #7: HD-tDCS to contralesional hemisphere to enhance treatment outcomes in persons with stroke-induced aphasia
Background: Chronic aphasia, or language difficulty persisting beyond one year post-stroke, affects over 2.5 million individuals in the United States. Treatment response varies and language abilities are rarely restored. Intact, connected ipsilesional language areas and improved interhemispheric balance following stroke are consistent predictors of recovery. A promising approach to target these brain dynamics is using high-definition transcranial direct current stimulation (HD-tDCS) to deliver focal cathodal current to right frontal areas in the contralesional hemisphere, combined with efficacious behavioral treatment that...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: J.D. Richardson, S.G.H. Dalton, J.F. Cavanagh, C. Shultz, J. Adams Source Type: research

Abstract #4: Pipeline Verification for the Identification of Noninvasive Neuromodulation Targets for Pediatric Stroke Rehabilitation
Introduction: Ischemic perinatal stroke affects as many as 1 in 2,300 live births and may result in lifelong burden of care. Thus, better rehabilitation techniques are indicated to improve quality of life for individuals and families. Implementing interventions early in life can harness neuroplastic potential to promote recovery. Transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) have shown promise as noninvasive cortical assessment and neuromodulation techniques for stroke rehabilitation; regaining motor control and function can be facilitated through the induction of plasticity.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: Kathleen E. Mantell, Samuel T. Nemanich, Ellen Sutter, Bernadette T. Gillick, Alexander Opitz Source Type: research

Use of TMS to evaluate cortical excitability of lower limb muscles: effects of post-stroke gait retraining
Gait rehabilitation treatments intended to alter gait patterns are more likely to be effective if they induce a change in the relevant brain circuitry. However, neuroplasticity principles typically applied during gait rehabilitation are derived largely from experiments involving hand muscles. Here, we discuss and address the paucity of research investigating neural correlates underlying rehabilitation of lower extremity movements and gait rehabilitation. Without in-depth understanding of how corticospinal circuitry is modulated following gait retraining, developing evidence-based gait rehabilitation treatments that induce ...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: T. Kesar, J. Xu Source Type: research

Long-term, non-invasive brain stimulation for locked-in syndrome
Background& significance: Locked-in syndrome is a very serious condition with desperate quality of life due to profound paralysis, and there is no effective treatment other than rehabilitation. Repetitive transcranial magnetic stimulation (rTMS) seems to be benefit in motor recovery of stroke patients. We explored the benefit and feasibility of rTMS in locked-in syndrome.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: S. Choi, M. Son, Y. Hong, S. Kang Source Type: research

Primary motor cortex plasticity is enhanced by transcranial direct current stimulation in mice: underlying molecular mechanisms and impact on motor performance
There is a consistent body of evidence showing that transcranial direct current stimulation (tDCS) over the motor cortex facilitates motor learning and promotes motor recovery after stroke.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: M. Podda, V. Longo, S. Barbati, S. Cocco, K. Gironi, A. Mattera, M. Spinelli, C. Grassi Source Type: research

Effect of different frequencies in repetitive transcranial magnetic stimulation for the patients with post-stroke motor aphasia
In this study, we applied low and high frequency rTMS targeting the bilateral hemispheres. The purpose of this study is to evaluate the efficacy of two types of rTMS for post-stroke motor aphasia.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: R. Awa, H. Tokimura, H. Yamanaka, Y. Tokimura, S. Etoh, K. Todoroki, K. Takasaki, M. Atsuchi, M. Atsuchi Source Type: research

The use of rTMS to augment walking recovery after stroke
The goal of non-invasive brain stimulation to directly target brain circuitry to increase neural plasticity and improve coordinated activation of muscles after walking rehabilitation. Neuromodulation using rTMS has been incredibly successful in treating depression and has had some success with improving upper extremity (UE) motor control after stroke through either exciting (E-rTMS) ipsilesional or inhibiting (I-rTMS) contralesional activity. However, similar successes with rTMS for walking have not been achieved in the very few attempts made to date.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: M. Bowden Source Type: research