Abstract #94: BDNF polymorphism predicts plasticity in motor cortex following continuous theta burst stimulation

Introduction: Continuous theta burst stimulation (cTBS) is under investigation as a method to induce inhibitory cortical plasticity after stroke, but assessment of its therapeutic value is hampered by variability in individual responses. Previous studies have investigated sources of variability, including biological factors that influence brain plasticity, such as a common polymorphism in the brain-derived neurotropic factor (BDNF) gene (i.e., Val66Val vs. Val66Met carriers). However, the evidence to date is mixed, with some studies reporting no effect or paradoxical effects of BDNF on TBS-induced cortical plasticity.

Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: Denise Y. Harvey, Laura DeLoretta, Rachel Wurzman, Daniela Sacchetti, Ahmed Ahmed, Abdou Thiam, Falk Lohoff, Olufunsho Faseyitan, Roy H. Hamilton Source Type: research