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Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation

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Total 298 results found since Jan 2013.

Female sex hormones modulate the response to low-frequency rTMS in the human motor cortex
Despite evidence supporting sex-inclusive science, awareness of sex-based factors has not translated to neuro-rehabilitation where “the medicine” is often the therapeutic intervention. Optimal neuro-rehabilitation is key to preventing further injury and treating chronic conditions such as stroke; with the goal to help women return to their workplaces, families, and community commitments as quickly as possible. Recent clinic al trials support the therapeutic utility of rTMS for a variety of disorders, including stroke, where a hyperexcitable unlesioned motor cortex can be targeted with slow frequency stimulation (1 Hz r...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 28, 2017 Category: Neurology Authors: Lynn M. Rogers, Yasin Y. Dhaher Source Type: research

Low-intensity (400 mW/cm2, 500 kHz) Pulsed Transcranial Ultrasound Preconditioning May Mitigate Focal Cerebral Ischemia in Rats
Preconditioning methods, which could increase tolerance of brain to subsequent ischemic injuries with a small dose of non-injury stimuli, have gained attention. Capitalizing on noninvasiveness and safety of ultrasound modality, the pulsed transcranial ultrasound stimulation (pTUS) approach may provide a novel treatment for patients with high risk of stroke.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 26, 2017 Category: Neurology Authors: Hangdao Li, Junfeng Sun, Daqu Zhang, Daryl Omire-Mayor, Peter A. Lewin, Shanbao Tong Source Type: research

Low-intensity (400  mW/cm2, 500 kHz) pulsed transcranial ultrasound preconditioning may mitigate focal cerebral ischemia in rats
Preconditioning methods, which could increase tolerance of brain to subsequent ischemic injuries with a small dose of non-injury stimuli, have gained attention. Capitalizing on noninvasiveness and safety of ultrasound modality, the pulsed transcranial ultrasound stimulation (pTUS) approach may provide a novel treatment for patients with high risk of stroke.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 26, 2017 Category: Neurology Authors: Hangdao Li, Junfeng Sun, Daqu Zhang, Daryl Omire-Mayor, Peter A. Lewin, Shanbao Tong Source Type: research

Safety and tolerability of transcranial direct current stimulation to stroke patients – A phase I current escalation study
A prior meta-analysis revealed that higher doses of transcranial direct current stimulation (tDCS) have a better post-stroke upper-extremity motor recovery. While this finding suggests that currents greater than the typically used 2  mA may be more efficacious, the safety and tolerability of higher currents have not been assessed in stroke patients. We aim to assess the safety and tolerability of single session of up to 4 mA in stroke patients.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 26, 2017 Category: Neurology Authors: Pratik Y. Chhatbar, Rong Chen, Rachael Deardorff, Blair Dellenbach, Steven A. Kautz, Mark S. George, Wuwei Feng Source Type: research

Non-invasive brain stimulation to enhance stroke recovery – towards patient-tailored strategies
Stroke is the leading cause of serious long-term disability with growing impact on actual and future health economy. The resulting deficits of a stroke, e.g., of the upper extremity or language, have great impact on activities of daily life, social as well as professional.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 15, 2017 Category: Neurology Authors: F.C. Hummel Source Type: research

Effects of bihemispheric tDCS combined with radial nerve stimulation in acute stroke patients
Introduction: Transcranial direct current stimulation (tDCS) may change the excitability of the central nervous system and contribute to motor recovery of patients with acute stroke. The functional benefit may increase with the combination of tDCS with manoeuvres facilitating motor output. We have evaluated the effects of tDCS coupled with radial nerve stimulation in the acute phase after stroke.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 15, 2017 Category: Neurology Authors: S. Yag üe, M. Veciana, J. Pedro, A. Martínez-Yélamos, H. Kumru, P. Cardona, B. Lara, B. García, J. Montero, J. Valls-Sole Source Type: research

Decoding post-stroke motor function from structural brain images
Introduction: The ability to predict outcome after stroke is clinically important for planning treatment and for stratification in restorative clinical trials. In relation to upper limb function, the proportional recovery rule tells us that initial severity is the best predictor of long-term outcome, with most patients regaining about 70% of their lost motor function by 3 months. This rule works well for those presenting with mild to moderate upper limb impairment but in those with initially severe impairment about 50% fail to experience proportional recovery.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 15, 2017 Category: Neurology Authors: N.S. Ward Source Type: research

Magnetic focusing by magnetic shielding for Non-Invasive Brain Stimulation
Instruction: Transcranial magnetic stimulation (TMS) is one of the most widely used methods for brain stimulation. It is utilized in diagnosis and treatment for many neural diseases, such as neuropathic pain and loss of function caused by stroke. Current commercial TMS stimulators cannot provide well targeted stimulation. Due to fast field divergence, the effective distance in TMS is limited to around 1.5 cm. A breakthrough is needed to achieve non-invasive, focused brain stimulation.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 15, 2017 Category: Neurology Authors: Q. Meng, M. Cherry, X. Du, H. Lu, E. Hong, Y. Yang, F.-S. Choa Source Type: research

Variability in response to non-invasive brain stimulation in stroke patients
Introduction: It may be possible to simplify determinants of variability into two groups: intrinsic and extrinsic. Intrinsic variability may relate to factors that are impossible to modify, such as age, gender, and genetics. Extrinsic variability is potentially controllable and includes factors such as detection of the motor hotspot, stability of holding coil, the attention level of subjects in a long experiment, etc. In case of stroke patients, two factors may be added to this extrinsic variability, such as anatomical regions and the time from stroke onset.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 15, 2017 Category: Neurology Authors: N.S. Ward Source Type: research

Brain stimulation in aphasia rehabilitation: Current state and future projects
Stroke remains the leading cause for severe long-term disability despite all successes in treating or even preventing acute stroke. Persistent language deficits lead not only to impairment in activities of daily living, failure to return to work, and profound personal and family suffering including limited social participation.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 15, 2017 Category: Neurology Authors: A. Fl öel, R. Darkow, M. Meinzer Source Type: research

5Hz repetitive transcranial magnetic stimulation (rTMS)-effects on cortical excitability and speech and swallowing functions in stroke patients
This study aimed to further study the effects of 5Hz rTMS on cortical excitability and speech and swallowing functions.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 15, 2017 Category: Neurology Authors: I.K.Y. Cheng, E.M.L. Yiu, L.S.W. Li, K.M.Y. Chiu, C.S. Wong, K.M.K. Chan Source Type: research

Brain-stimulation for arm recovery after stroke - protocol for a randomised clinical trial
Background: Many surviving stroke patients are left with moderate to severe sensorimotor impairments, including no or limited ability to execute muscle movements with the affected arm or hand. Limited stroke recovery is often associated with an imbalanced interaction between the two cerebral hemispheres, with reduced excitability of the ipsilesional primary motor cortex (M1) and increased excitability of the contralesional M1. One of many forms of rTMS, Theta Burst Stimulation (TBS), can elicit significant behavioral improvement in recovering stroke patients.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 15, 2017 Category: Neurology Authors: E.C.C. van Lieshout, J.M.A. Visser-Meily, H.B. van der Worp, S.F.W. Neggers, R.M. Dijkhuizen Source Type: research

Transcranial direct current stimulation facilitates reading training in participants with post-stroke central alexia
Introduction: Central alexia is an acquired reading disorder co-occurring with a generalised language deficit (aphasia). We tested the effects of anodal transcranial Direct Current Stimulation targeted at the left inferior frontal gyrus applied in conjunction with a reading training App, called iReadMore, designed to improve word reading accuracy.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 15, 2017 Category: Neurology Authors: S.J. Kerry, Z.V.J. Woodhead, O.M. Aguilar, Y. Ong Hoon, J.S. Hogan, K. Pappa, A.P. Leff, J. Crinion Source Type: research

The efficacy of selective transcranial magnetic stimulation with functional near-infrared spectroscopy and intensive speech therapy on individuals with post-stroke aphasia
Introduction: To examine the efficacy of selective repetitive transcranial magnetic stimulation (rTMS) therapy guided by functional near-infrared spectroscopy (fNIRS) combined with intensive speech therapy(ST) on post-stroke patients with aphasia, and right hemisphere high-frequency rTMS combined with intensive ST on patients who were right hemisphere-activated in a language task.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 15, 2017 Category: Neurology Authors: T. Hara, M. Abo, K. Kakita Source Type: research

Sequential Theta burst stimulation changes language function after stroke - Preliminary analysis in Chinese survivors
Introduction: Theta burst stimulation (TBS) is a patterned repetitive transcranial magnetic stimulation (rTMS) protocol with relatively short stimulation period and strong power. Controlled trial of sequential TBS in post-stroke aphasia has been scarce. We aimed to investigate the potential therapeutic effect of consecutive suppressive-facilitatory TBS on language outcome after stroke.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 15, 2017 Category: Neurology Authors: W. He, K. Lee, T. Leung, H. Leung, Q. Zhang, L. Wong Source Type: research