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Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation

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Total 298 results found since Jan 2013.

Predictive models for response to non-invasive brain stimulation in stroke: A critical review of opportunities and pitfalls
Noninvasive brain stimulation has been successfully applied to improve stroke-related impairments in different behavioral domains. Yet, clinical translation is limited by heterogenous outcomes within and across studies. It has been proposed to develop and apply noninvasive brain stimulation in a patient-tailored, precision medicine-guided fashion to maximize response rates and effect magnitude. An important prerequisite for this task is the ability to accurately predict the expected response of the individual patient.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - September 21, 2021 Category: Neurology Authors: Maximilian J. Wessel, Philip Egger, Friedhelm C. Hummel Source Type: research

Generating artificial sensations with spinal cord stimulation in primates and rodents
For patients who have lost sensory function due to a neurological injury such as spinal cord injury (SCI), stroke, or amputation, spinal cord stimulation (SCS) may provide a mechanism for restoring somatic sensations via an intuitive, non-visual pathway. Inspired by this vision, here we trained rhesus monkeys and rats to detect and discriminate patterns of epidural SCS. Thereafter, we constructed psychometric curves describing the relationship between different SCS parameters and the animal's ability to detect SCS and/or changes in its characteristics.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - May 17, 2021 Category: Neurology Authors: Amol P. Yadav, Shuangyan Li, Max O. Krucoff, Mikhail A. Lebedev, Muhammad M. Abd-El-Barr, Miguel A.L. Nicolelis Source Type: research

Navigated repetitive transcranial magnetic stimulation improves the outcome of postsurgical paresis in glioma patients – A randomized, double-blinded trial
Navigated repetitive transcranial magnetic stimulation (nrTMS) is effective therapy for stroke patients. Neurorehabilitation could be supported by low-frequency stimulation of the non-damaged hemisphere to reduce transcallosal inhibition.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - May 10, 2021 Category: Neurology Authors: Sebastian Ille, Anna Kelm, Axel Schroeder, Lucia E. Albers, Chiara Negwer, Vicki M. Butenschoen, Nico Sollmann, Thomas Picht, Peter Vajkoczy, Bernhard Meyer, Sandro M. Krieg Source Type: research

Deep brain stimulation of midbrain locomotor circuits in the freely moving pig
Deep brain stimulation (DBS) of the mesencephalic locomotor region (MLR) has been studied as a therapeutic target in rodent models of stroke, parkinsonism, and spinal cord injury. Clinical DBS trials have targeted the closely related pedunculopontine nucleus in patients with Parkinson ’s disease as a therapy for gait dysfunction, with mixed reported outcomes. Recent studies suggest that optimizing the MLR target could improve its effectiveness.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 27, 2021 Category: Neurology Authors: Stephano J. Chang, Andrea J. Santamaria, Francisco J. Sanchez, Luz M. Villamil, Pedro Pinheiro Saraiva, Francisco Benavides, Yohjans Nunez-Gomez, Juan P. Solano, Ioan Opris, James D. Guest, Brian R. Noga Source Type: research

Feasibility of remote transcranial direct current stimulation for pediatric cerebral palsy during the COVID-19 pandemic
Brain injury and stroke early in life occur during a time of heightened neuroplastic potential1. Non-invasive brain stimulation (NIBS) technology including transcranial direct current stimulation (tDCS) are a promising way to enhance standard therapies and pediatric rehabilitation interventions by harnessing neuroplasticity2. Our experience in pioneering applications of NIBS during pediatric development has demonstrated its safety and efficacy when combined with rehabilitation strategies e.g. constraint induced movement therapy (CIMT)3,4.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - October 22, 2020 Category: Neurology Authors: Daniel H. Lench, Emma Simpson, Ellen N. Sutter, Bernadette T. Gillick Source Type: research

Phase-dependent transcranial magnetic stimulation of the lesioned hemisphere is accurate after stroke
Transcranial magnetic stimulation (TMS) can produce plastic changes within descending motor pathways and distributed brain networks [1-2]. It has been proposed that TMS could enhance post-stroke motor recovery by normalizing imbalanced sensorimotor network function and/or upregulating corticospinal output [3-4] but studies using TMS to boost motor recovery have shown heterogeneous results [5]. However, TMS has traditionally been delivered uncoupled from endogenous brain oscillatory activity, leading to indiscriminate application of individual TMS pulses across different, physiologically distinct brain states.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - July 16, 2020 Category: Neurology Authors: Sara J. Hussain, William Hayward, Farah Fourcand, Christoph Zrenner, Ulf Ziemann, Ethan R. Buch, Margaret K. Hayward, Leonardo G. Cohen Source Type: research

Localizing Central Swallowing Functions by Combining Non-invasive Brain Stimulation with Neuroimaging
Swallowing is a complex sensorimotor process, which involves precise temporal coordination of the upper and lower lips, tongue, and pharyngeal and esophageal musculatures. This integrated process is controlled by neural interplay across cortical and subcortical networks. Although numerous functional brain imaging studies have suggested means to measure post-stroke pathological changes in the cortical control region of swallowing [1], identifying the precise functional localization of the motor area for swallowing has been challenging.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - June 1, 2020 Category: Neurology Authors: Shasha Li, Marziye Eshghi, Sheraz Khan, Qiyuan Tian, Juho Joutsa, Yangming Ou, Qing Mei Wang, Jian Kong, Bruce Robert Rosen, Jyrki Ahveninen, Aapo Nummenmaa Source Type: research

Integrating tDCS into Routine Inpatient Rehabilitation Practice to Boost Post-stroke Recovery
Transcranial direct current stimulation (tDCS), a non-invasive brain modulation tool, has gained popularity due to the portability, ease-of-use, and low cost. A majority of stroke recovery studies using tDCS have been focused on the chronic stage of recovery, as this time frame is relatively easy to conduct clinical trials and measure efficacy. However, studies during the chronic stage likely miss a window of opportunity where dynamic brain plasticity is occurring, the acute and subacute stages after stroke.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - April 5, 2020 Category: Neurology Authors: Shreyansh Shah, Pratik Y. Chhatbar, Jody Feld, Wuwei Feng Source Type: research

Effects of high-frequency repetitive transcranial magnetic stimulation over the contralesional motor cortex on motor recovery in severe hemiplegic stroke: a randomized clinical trial
The contralesional hemisphere compensation may play a critical role in the recovery of stroke when there is extensive damage to one hemisphere. There is little research on the treatment of hemiplegia by high-frequency repetitive transcranial magnetic stimulation (rTMS) delivered to the contralesional cortex.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - April 1, 2020 Category: Neurology Authors: Qi Wang, Dai Zhang, Ying-Yu Zhao, Hong Hai, Yue-Wen Ma Source Type: research

The differential roles of contralesional frontoparietal areas in cortical reorganization after stroke
Studies examining the contribution of contralesional brain regions to motor recovery after stroke have revealed conflicting results comprising both supporting and disturbing influences. Especially the relevance of contralesional brain regions beyond primary motor cortex (M1) has rarely been studied, particularly concerning the temporal dynamics post-stroke.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 31, 2020 Category: Neurology Authors: Caroline Tscherpel, Lukas Hensel, Katharina Lemberg, Mattias Vollmer, Lukas J. Volz, Gereon R. Fink, Christian Grefkes Source Type: research

The unusual case of dental pain with sham repetitive transcranial magnetic stimulation: a benign idiosyncrasy or diagnostic opportunity?
Repetitive transcranial magnetic stimulation (rTMS) is a promising treatment for major depressive disorder [1]. Recently, we investigated 10 sessions of high-frequency rTMS applied to the left dorsolateral prefrontal cortex (DLPFC) in chronic stroke survivors with depression (randomised controlled trial; ACTRN12619001303134; institutional ethics approval 200697). Stimulation was delivered at 110% resting motor threshold at 10 Hz for a total of 3000 pulses. Here we report the experience of a 51-year-old male with mild upper-limb impairment (Fugl-Meyer 49/66; structural imaging Figure 1), who experienced anatomically confine...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - December 9, 2019 Category: Neurology Authors: Brenton Hordacre, Kristina Comacchio, G. Lorimer Moseley Source Type: research

Barriers and Opportunities of Cortical Stimulation via Cerebral Venous Approach
Brain stimulation technologies, both invasive and non-invasive, have been successful in acquiring FDA approval for several indications within neuropsychiatry to include depression, Parkinson ’s disease, and others. Unfortunately, despite extensive testing, brain stimulation has failed to be part of the clinical toolbox for treatment of stroke or brain injury. Epidural stimulation showed promise in early stages of validation but failed in phase III studies with a major limitation of de layed timing of intervention(1).
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 22, 2019 Category: Neurology Authors: Ali Alawieh, L.Fernando Gonzalez, Wuwei Feng Source Type: research

Transcranial Direct Current Stimulation for a Patient with Locked-in Syndrome
Locked-in syndrome (LIS) was first introduced by Plum and Posner. It refers to the combination of quadriplegia and anarthria brought about by disruption of the corticospinal and corticobulbar pathways of the brain stem, respectively [1]. Patients with LIS are alert and aware of their environment but cannot speak or move their limbs. They retain the capacity to use vertical eye movements and blinking to communicate. LIS occurs following disruption of the motor tracts in the ventral brain stem and at least 60% of the cases are caused by stroke [2].Early and intensive rehabilitation reportedly improves the functional outcome ...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 15, 2019 Category: Neurology Authors: Takeshi Satow, Taro Komuro, Takuya Yamaguchi, Nobuhiko Tanabe, Tatsuya Mima Source Type: research

Transcranial Direct Current Stimulation ASsociated With Physical-therapy In Acute Stroke Patients - the tDCS ASAP - a Randomized, Triple Blind, Sham-controlled Study
Transcranial Direct Current Stimulation has been increasing in popularity in the last few years. Despite vast amounts of articles on the use of tDCS on stroke patients, very little has been done during the acute phase.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - October 30, 2019 Category: Neurology Authors: Stephen Bornheim, Jean-Louis Croisier, Pierre Maquet, Jean-Fran çois Kaux Source Type: research

Feasibility of home-based, self-applied transcranial direct current stimulation to enhance motor learning in middle-aged and older adults
We read with great interest the recent letter sent to you by McConnell and colleagues [1], in which they discuss one of the first applications of truly independent home-based electrical brain stimulation, applied following safety recommendations. Transcranial direct-current stimulation (tDCS) is a non-invasive brain stimulation technique capable of modulating cortical excitability beyond the stimulation period [2,3]. tDCS presents interesting options as a therapeutic intervention in multiple neurological disorders, such as stroke, depression, chronic pain, schizophrenia, and Alzheimer ’s and Parkinson’s disease [4,5].
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - September 23, 2019 Category: Neurology Authors: Pablo Maceira-Elvira, Traian Popa, Anne-Christine Schmid, Friedhelm C. Hummel Source Type: research