Deep brain stimulation of midbrain locomotor circuits in the freely moving pig
Deep brain stimulation (DBS) of the mesencephalic locomotor region (MLR) has been studied as a therapeutic target in rodent models of stroke, parkinsonism, and spinal cord injury. Clinical DBS trials have targeted the closely related pedunculopontine nucleus in patients with Parkinson ’s disease as a therapy for gait dysfunction, with mixed reported outcomes. Recent studies suggest that optimizing the MLR target could improve its effectiveness.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - Category: Neurology Authors: Stephano J. Chang, Andrea J. Santamaria, Francisco J. Sanchez, Luz M. Villamil, Pedro Pinheiro Saraiva, Francisco Benavides, Yohjans Nunez-Gomez, Juan P. Solano, Ioan Opris, James D. Guest, Brian R. Noga Source Type: research
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