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Ipsilateral corticospinal maps correspond to severe poststroke motor impairment
Motor recovery in the chronic stage, i.e., more than 6 months after stroke is often limited. While there is increasing interest in the development of novel therapies for this patient cohort [1], only very few trials focus on severely impaired chronic stroke patients [2]. Refined therapies are therefore required for this patient population. Furthermore, reliable measures for studying the underlying physiological mechanisms and effectiveness of interventions are crucial. In this context, cortical motor maps appear to be promising, i.e., by assessing the cortical representation of the affected muscles as measured by motor evo...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - May 10, 2022 Category: Neurology Authors: Bettina Hanna Trunk, Lukas Ziegler, Alireza Gharabaghi Source Type: research

On the importance of using both T1-weighted and T2-weighted structural magnetic resonance imaging scans to model electric fields induced by non-invasive brain stimulation in SimNIBS
Computational modeling of the electric fields (E-fields) induced by non-invasive brain stimulation has become increasingly popular and widely implemented in the past decade. E-field modeling is an informative tool that enables researchers to better understand the effects of non-invasive brain stimulation techniques such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) on the cortical and subcortical level. To date, E-field modeling studies have had widespread applications, such as informing how stroke damage alters cortical activation from TMS and tDCS [1], elucidating the impac...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - April 15, 2022 Category: Neurology Authors: Sybren Van Hoornweder, Raf Meesen, Kevin A. Caulfield Source Type: research

Differential effects of anodal and dual tDCS on sensorimotor functions in chronic hemiparetic stroke patients
Previous tDCS studies in chronic stroke patients reported highly inconsistent effects on sensorimotor functions. Underlying reasons could be the selection of different kinematic parameters across studies and for different tDCS setups. We reasoned that tDCS may not simply induce global changes in a beneficial-adverse dichotomy, but rather that different sensorimotor kinematics are differentially affected. Furthermore, the often-postulated higher efficacy of bilateral-dual (bi-tDCS) over unilateral-anodal (ua-tDCS) could not yet be demonstrated consistently either.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - March 3, 2022 Category: Neurology Authors: Toni Muffel, Pei-Cheng Shih, Benjamin Kalloch, Vadim Nikulin, Arno Villringer, Bernhard Sehm Source Type: research

Acute head- and gaze deviation, facial asymmetry and anarthria mimicking stroke, caused by short circuit in deep brain stimulation
We report here the case of a patient with acute onset of head- and gaze deviation, anarthria, and facial asymmetry who received intravenous thrombolysis for suspected cerebral ischemia and was subsequently found to have a causal short circuit of a DBS electrode.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 5, 2022 Category: Neurology Authors: Nils Schr öter, Anna Hager, Alexander Rau, Horst Urbach, Volker A. Coenen, Michel Rijntjes Source Type: research

Transcranial magnetic stimulation to assess motor neurophysiology after acute stroke in the United States: Feasibility, lessons learned, and values for future research
Transcranial magnetic stimulation (TMS) has been widely applied in both basic and clinical neuroscience since its introduction in 1985. In addition to its potential therapeutic value for exciting or inhibiting neural circuits [1], TMS can be used to investigate corticomotor excitability (CME), which is a key aspect of voluntary movement [2]. For example, single-pulse TMS can elicit electrical signals, which propagate along descending motor pathways and are recorded as motor evoked potentials (MEP) in target muscles.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - December 6, 2021 Category: Neurology Authors: Yi-Ling Kuo, David J. Lin, Isha Vora, Julie A. DiCarlo, Dylan J. Edwards, Teresa J. Kimberley Source Type: research

Dual transcranial direct current stimulation for subacute stroke patients with compromised corticospinal integrity: a randomized, double-blind, sham-controlled study
Abstract
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 1, 2021 Category: Neurology Authors: Shih-Pin Hsu, Chia-Feng Lu, Chih-Wei Tang, Bing-Fong Lin, I-Ju Kuo, Yun-An Tsai, Po-Lei Lee, I-Hui Lee Source Type: research

Interhemispheric inhibition (IHI) findings using ipsilateral silent period (iSP) in two stroke patients during acute and subacute phases after stroke
Abstract
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 1, 2021 Category: Neurology Authors: Pratik Chhatbar, Taewon Kim, Parth Malkan, Riki Shimizu, Christine Park, Lindsay Heffron, Alea Penner, Jody Feld, Wuwei Feng Source Type: research

Multimodal assessment of interhemispheric cortical interactions and differential behavioral relevance in upper and lower extremity motor function in chronic stroke
Abstract
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 1, 2021 Category: Neurology Authors: Jacqueline Palmer, Trisha Kesar, Steve Wolf, Lewis Wheaton, Mary Alice Salt ão da Silva, Michael Borich Source Type: research

Disrupted cerebellar-M1 connectivity at the acute and chronic stage after stroke
Abstract
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 1, 2021 Category: Neurology Authors: Ronan Mooney Source Type: research

Evidence for rTMS and TDCS in facilitating rehabilitation of spasticity post stroke
Abstract
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 1, 2021 Category: Neurology Authors: Amanda McIntyre, Takatoshi Hara, Aturan Shanmugalingam, Amer Burhan Source Type: research

Evidence for NIBS in post-stroke and Vascular depression
Abstract
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 1, 2021 Category: Neurology Authors: Amer Burhan, Amanda McIntyre Source Type: research

Evidence for NIBS in facilitating rehabilitation of cognitive function after stroke
Abstract
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 1, 2021 Category: Neurology Authors: Takatoshi Hara, Aturan Shanmugalingam, Amanda McIntyre, Amer M. Burhan Source Type: research

Effects of VNS paired with rehabilitation for chronic upper limb recovery post stroke: cross-over response
Abstract
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 1, 2021 Category: Neurology Authors: Teresa Kimberley, Charles Liu, Gerard Francisco, Steven Wolf, Michael O'Dell, Kathleen Bell, Anand Dixit, Jessica Redgrave, Wuwei Feng, Jesse Dawson Source Type: research

Single session of high amperage transcranial direct current stimulation shows differential montage effect on cortical excitability in ischemic stroke patients
Abstract
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 1, 2021 Category: Neurology Authors: Pratik Chhatbar, Emily Grattan, Scott Hutchison, Viswanathan Ramakrishnan, William DeVries, Mark George, Steven Kautz, Wayne Feng Source Type: research

Novel and non-invasive brain-computer interface-based stimulation device using frequency tuned electromagnetic fields to significantly reduce disability following sub-acute ischemic stroke: A pilot randomized controlled trial
Abstract
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 1, 2021 Category: Neurology Authors: Batsheva Weisinger, Natan M. Bornstein, Esther Shohami, Yaron Segal, Ariela Alter, Assaf Lifshitz, Atul Prasad, Dharam P. Pandey Source Type: research

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