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Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation

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Total 298 results found since Jan 2013.

The mechanism of functional recovery of upper extremity motor function among patients with chronic stroke: Modulation of cortical and spinal interneuron
We hypothesized that functional recovery of upper extremity motor function is based on cortical and spinal plasticity.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: Toshiyuki Fujiwara, Kaoru Honaga, Michiyuki Kawakami, Atsuko Nishimoto, Kaoru Abe, Katsuhiro Mizuno, Mitsuhiko Kodama, Yoshihisa MasakadoMD, Tetsuya Tsuji, Meigen Liu Source Type: research

DBS in critical care conditions
The efficacy of Deep Brain Stimulation (DBS) is well established in the treatment of chronic neurological diseases such as Parkinson's disease and primary dystonia. Emerging indications include, refractory epilepsy, chronic cluster headache, major depression, obsessive compulsive disorder, disruptive behaviour and Gilles de la Tourette syndrome. Nevertheless in selected cases DBS may be a treatment option in acute neurological disease or sudden dramatic worsening of pre-existing diseases in emergency conditions such as status dystonicus (SD) and post-stroke conditions.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: M. Rizzi, R. Cordella, G. Messina, C.E. Marras, G. Zorzi, D. Caldiroli, A. Franzini Source Type: research

Single electrode DBS through motor thalamus and caudal zona incerta for the treatment of tremor syndromes
Both nucleus ventralis lateralis (VL) and subthalamic nucleus (STN) DBS are effective in the treatment of essential tremor and Parkinson's disease tremor. Complex tremor syndromes may present the overlapping of different clinical aspects (at rest, postural and kinetic) and can be associated to syndromic forms (dystonic, cerebellar, spastic), but also to different etiologies (following brain injury or stroke). In these cases DBS does not always guarantees an effective outcome. A recent study proposed single electrode DBS of both ventralis oralis posterior (vop) thalamic nucleus and caudal Zona Incerta (cZI) for the treatmen...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: M. Rizzi, G. Messina, R. Cordella, F. Penner, A. Franzini Source Type: research

Chronic post stroke central pain: Increased success rate of chronic epidural motor cortex stimulation using somatotopic, navigated repetitive TMS for patient selection and implant placement
Neuromodulation for severe central pain using repetitive stimulation of motor cortices has been used for more than two decades, first via direct cortical stimulation (DCS) by implanted electrodes, later non-invasively mainly by repetitive transcranial magnetic stimulation (rTMS). The outcome at group level has been limited, though for some, the effects have been of large value. There is a need for selection of patients that are likely to benefit from this procedure. Based on a preliminary report indicating that rTMS could contribute to this, we aimed to address this problem.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: M. Thordstein, G. Pegenius, K. Gatzinsky Source Type: research

Dual-mode Noninvasive Brain Stimulation over Prefrontal Cortices on Working Memory in Stroke Patients
This study investigated the effects of dual-mode noninvasive brain stimulation (NBS) using the transcranial direct current stimulation (tDCS) and high frequency repetitive transcranial magnetic stimulation (rTMS) over bilateral dorsolateral prefrontal cortices (DLPFC) on verbal working memory (VWM) function in chronic stroke patients.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: Ahee Lee, Won Hyuk Chang, Min Ji Lee, Min-Su Kim, Yun-Hee Kim Source Type: research

Primed physiotherapy enhances recovery of upper limb function in chronic stroke patients
This study tested the effects of priming upper limb therapy with intermittent Theta Burst Stimulation (iTBS), a form of non-invasive brain stimulation.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: Suzanne J. Ackerley, Winston D. Byblow, P. Alan Barber, Hayley MacDonald, Andrew McIntyre-Robinson, Cathy M. Stinear Source Type: research

Effects of transcutaneous lumbar spinal cord alternating current stimulation on tonic stretch reflex threshold in stroke - a case series
*Research is supported by Franco-Indian INRIA-DST Associate Team support 2014-2017.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: A. Dutta, A. Das Source Type: research

Beneficial effect of transcranic magnetic stimulation combined with mirror therapy in stroke patients: a pilot study in neurorehabilitative setting
Both mirror therapy (MT) and repetitive transcranial magnetic stimulation (TMS) have been proved to promote cortical reorganization and functional recovery of post- stroke patients.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: D. Dalla Libera, S. Regazzi, C. Fasoletti, D. Dinacci Ruggieri, P. Rossi Source Type: research

Boosting recovery of vision loss in post-acute stroke with tDCS – A pilot Study
Posterior cerebral artery (PCA) stroke usually results in visual field defects varying in size and extent of the blind field. Vision restoration training (VRT) may reduce the visual field impairment. Combined application of anodal transcranial direct current stimulation (tDCS) over visual cortex together with VRT indicates that tDCS may accelerate VRT-effects in the post-acute stage. We investigated safety, applicability and efficacy in 7 post-acute PCA stroke patients and compared their visual field changes to 7 control subject who were matched with respect to lesion-age and defect-size and underwent standard rehabilitation.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: R. Alber, H. Moser, B.A. Sabel, Gall C Source Type: research

Transcranial direct current stimulation of areas above the motor cortex (C3) in waking resting state and REM sleep induces motor imagery
Motor imagery and corresponding motor cortical activation have been shown to benefit later motor performance. We assume that motor imagery and motor cortical activation form a functional unit which, if activated in resting state, serves the purpose of rehearsing for later motor performance. While athletes, musicians, surgeons and some stroke-patients can actively visualize specific movements to prepare and enhance later motor performance, many clinical populations cannot use such cognitive task paradigms for the rehabilitation of their motor system.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: J. Speth, C. Frenzel, T. Harley Source Type: research

Treatment of Post-stroke Motor Dsyfunction by Interleaved Trancranial Magnetic Stimulation Combined with Functional MRI (TMS-fMRI)
Transcranial magnetic stimulation (TMS) was first used by Anthony Baker and his co-investigators in 1985. They used TMS to induce weak electric currents of 1.0 Hz or less to stimulate and promote a neural metabolic response within the cerebral nervous system. This resulted not only in a physical response but a functional response as well. Further investigations and experimentation though the manipulation of repetitive TMS pulses has shown either increases or decreases in the promotion of neural transmissions depending upon the coil orientation of the TMS device, intensity of the magnetic pulse as well as its frequency.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: Qiwen Mu, Huaping Chen, Bin He, Zhiwei Guo, Jun Ou, Morgan A. McClure Source Type: research

Cerebral blood flow augmentation by external counterpulsation enhances corticomotor excitability in subacute stroke patients: a randomized controlled trial
External counterpulsation (ECP) enhances cerebral blood flow in patients with subacute ischemic stroke but whether it changes corticomotor excitability, which is a powerful prognostic predictor for motor recovery, remains unknown.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: J.Y. Liu, C. Stinear, H. Leung, H.L. Ip, S.Y. Fan, Y.L. Lau, W.H. Leung, X.Y. Chen, K.S. Wong Source Type: research

Proportional upper limb recovery after stroke is predicated upon corticospinal tract integrity
For most patients after stroke, upper limb impairment resolves by approximately 70% of the maximum amount possible i.e., the proportional recovery rule (PRR; Prabhakaran et al., Neurorehabil Neural Repair 2008 22: 64-71). This presentation will demonstrate how the PRR relies on corticospinal system integrity as determined with transcranial magnetic stimulation and diffusion-weighted MRI. Data were obtained from 48 patients previously enrolled in an upper limb rehabilitation interventional trial.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: Winston D. Byblow, Cathy M. Stinear Source Type: research

Effects of epidural cortical stimulation on motor recovery after a primary motor cortex ischemic stroke: preliminary results in a non-human primate model
Nearly 15 million people suffer from stroke every year worldwide. Spontaneous recovery is usually considered to be limited to 6 months. Rehabilitative therapies performed during the first weeks can enhance recovery; however 1/3 of the patients are left with some chronic deficit for which current rehabilitative treatments are limited. Cortical stimulation techniques have been proposed to enhance motor rehabilitation with promising results, but until now these techniques were only considered for research.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 29, 2015 Category: Neurology Authors: A. Balossier, C. Orset, O. Etard, C. Gakuba, E. Emery, D. Vivien Source Type: research

Repetitive Transcranial Magnetic Stimulation for the recovery of stroke patients with disturbance of consciousness
Consciousness is human’s greatest treasure, and disturbance of consciousness after stroke constitutes a grave medical concern, while recovery technique for stroke patients greatly challenges our medical practice and scientific research.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 21, 2015 Category: Neurology Authors: Ying Xie, Tong Zhang, Andrew CN. Chen Source Type: research