Filtered By:
Source: Hypertension
This page shows you your search results in order of date. This is page number 10.
Order by Relevance | Date
Total 263 results found since Jan 2013.
Abstract P229: Is a Multidisciplinary Approach to Hypertension Better Than Traditional Care in Female Hypertensive Patients? Session Title: Clinical/Blood Pressure/Therapeutic/Other 2
Conclusion: The multidisciplinary approach had better BP control in female hypertensive pts. Prospective studies comparing MDA to standard practice may help to assess improved quality of life, compliance and outcomes.
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Weber, J. A., Shah, S. C., Turley, S., Braun, L. T., Kent, E. R., Volgman, A. S. Tags: Session Title: Clinical/Blood Pressure/Therapeutic/Other 2 Source Type: research
Abstract P157: Tractography of White Matter Connections Predicts for Vascular Cognitive Impairment in Hypertensive Patients Session Title: Cerebrovascular Disease and Stroke
In this study, we used DTI and cognitive assessment (CA), in order to identify a regional pattern of fractional anisotropy (FA) changes that could predict for VCI in hypertensive patients (HT).We have examined 15 HT (moderate to severe, with antihypertensive medications) vs 15 normotensive (NT), subjecting them to DTI and CA. HT had significant higher SBP (138±4 vs 118±3 in NT) and DBP (87±2 vs 75±2 in NT) (p<0.001), displayed a significant LV hypertrophic remodeling (LVM/BSA 112±5 vs 83±3 for NT) (p<0.0001), with a significant moderate increase in albuminuria (15.7±2....
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Carnevale, L., Selvetella, G., Cugino, D., Grillea, G., Lembo, G., Carnevale, D. Tags: Session Title: Cerebrovascular Disease and Stroke Source Type: research
Abstract P158: Increased Circulating Cathepsin K in Patients with Chronic Heart Failure Session Title: Cerebrovascular Disease and Stroke
Conclusions: These data indicate that elevated levels of CatK are closely associated with the presence of CHF and that the measurement of circulating CatK provides a noninvasive method of documenting and monitoring the extent of cardiac remodeling and dysfunction in patients with CHF.
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Cheng, X. W., Zhao, G., Han, X., Fang, E., Li, X., Zhou, D., Jiang, H., Li, Y., Cui, L. Tags: Session Title: Cerebrovascular Disease and Stroke Source Type: research
Abstract P159: Effect of Pharmacological Kinin Receptor Activation on Brain Damage and Mortality in Experimental Cerebral Ischemia in Non-diabetic and Diabetic Mice Session Title: Cerebrovascular Disease and Stroke
Brain ischemia is a major complication of arterial diseases and has a poorer prognosis in diabetic patients. As activation of the kallikrein-kinin system has been shown to enhance cardiac and renal tolerance to ischemia we tested effect of kinin receptor activation by pharmacological agonists, selective B1R or B2R, in a mouse model of transient middle cerebral artery occlusion [C57bl6 male, 10 week-old, anaesthesia, occlusion 60 min (MCAO)]. Treatment with the B1R agonist NG29 (B1Rago) or the B2R agonist NG291 (B2Rago) was started at reperfusion using osmotic micropumps. Neurological deficit (ND) was evaluated at 1 and 2 d...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Desposito, D., Taveau, C., Zadigue, G., Adam, C., Bouby, N., Alhenc-Gelas, F., Roussel, R. Tags: Session Title: Cerebrovascular Disease and Stroke Source Type: research
Abstract P160: Role of Uncoupling Protein 2 in Stroke Susceptibility of Stroke-prone Spontaneously Hypertensive Rat Session Title: Cerebrovascular Disease and Stroke
Mitochondrial dysfunction causes severe cellular derangements potentially underlying tissue injury and consequent diseases. Evidence of a direct involvement of mitochondrial dysfunction in hypertensive target organ damage is still poor.The gene encoding Uncoupling Protein 2 (UCP2), a inner mitochondrial membrane protein, maps inside stroke QTL/STR1 in stroke prone spontaneously hypertensive rat (SHRSP). We explored the role of UCP2 in stroke pathogenesis of SHRSP. Male SHRSP, stroke resistant SHR (SHRSR) and reciprocal STR1/congenic rats were fed with stroke permissive Japanese style diet (JD). A group of SHRSP received JD...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Rubattu, S., Cotugno, M., Bianchi, F., Di Castro, S., Stanzione, R., Busceti, C., Marchitti, S., Nicoletti, F., Volpe, M. Tags: Session Title: Cerebrovascular Disease and Stroke Source Type: research
Abstract P161: Angiotensin Receptor Blockade Decreases Glutamate-induced Brain Inflammation Session Title: Cerebrovascular Disease and Stroke
Chronic Kidney Disease (CKD) is very frequently associated with brain inflammation and cell injury leading to cognitive loss. At present a combined treatment of related kidney and brain injury has never been proposed. We focused on glutamate-induced excitotoxicity and neuronal inflammation, and on the effects of candesartan, a renoprotective Angiotensin Receptor Blocker (ARB) ameliorating hypertension and diabetes-induced kidney damage, and with accompanying neuroprotective efficacy. Primary cerebellar granule cells (CGC) were exposed to 100 μM glutamate and pre-treated for one hour with candesartan at neuroprotective c...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Saavedra, J., Elkahloun, A. G., Hafko, R. Tags: Session Title: Cerebrovascular Disease and Stroke Source Type: research
Abstract P254: Hypertension: A proposed Mechanistic Pathway for Arterial System Remodeling Session Title: Vascular Remodeling and Dysfunction/Endothelin Factors
Conclusion: Reliable and accessible markers that indicate changes in arterial pressure, flow & volume, are: PP and AC (SV/PP), and AC (Tau /TPR). These variables detected increases in the heart-load and alterations in pressure-flow patterns that impair cardiovascular-function resulting in HTN-CVD; input and characteristic impedance, also provides remodeling information about the arterial system but are not readily available to clinicians.
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Randall, O. S., Lee, D., Retta, T., Haddad, G., Ketete, M., Kwagyan, J., Xu, S. Tags: Session Title: Vascular Remodeling and Dysfunction/Endothelin Factors Source Type: research
Abstract P636: Sex Differences in Cardioprotective AT2R Expression in Diabetic Rats and Its Correlation with Myocardial Damage Session Title: Diabetes, Nutrition and Obesity/Insulin and Metabolic Syndrome
Diabetes mellitus (DM) is an independent risk factor for cardiovascular disease (CVD). Healthy, young women are protected from CVD, while diabetic women are more susceptible to CVD compared to age-matched diabetic men and non-diabetic women. Underlying mechanisms for this sex difference in CVD are not fully elucidated. The angiotensin II type 2 receptor (AT2R) is a member of the protective, vasodilative arm of the renin angiotensin system. The Agtr2 gene that codes for AT2R is X-linked, and increased Agtr2 expression is reported in female vasculature of rodent models. We hypothesized that a sex difference might exist in DM...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Lum-Naihe, K., Mahmood, A., Bajwa, J., Emter, C. A., Pulakat, L. Tags: Session Title: Diabetes, Nutrition and Obesity/Insulin and Metabolic Syndrome Source Type: research
Abstract P256: Structural Alterations of Subcutaneous Small Resistance Arteries in Resistant Hypertension Session Title: Vascular Remodeling and Dysfunction/Endothelin Factors
Conclusion: Hypertensive patients with true resistant hypertension have greater microvascular structural alterations compared with non-resistant hypertensive patients. This could partly explain the resistance to treatment and the high cardiovascular risk observed in these patients.
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: De Ciuceis, C., Rossini, C., Muiesan, M. L., Salvetti, M., Porteri, E., Gavazzi, A., Paini, A., Pileri, P., Agabiti Rosei, E., Rizzoni, D. Tags: Session Title: Vascular Remodeling and Dysfunction/Endothelin Factors Source Type: research
Abstract P638: Investigating Gene Pleiotropy in the Metabolic Syndrome in Lyon Hypertensive Rats Session Title: Diabetes, Nutrition and Obesity/Insulin and Metabolic Syndrome
The metabolic syndrome (MetS) - hypertension, obesity, dyslipidemia, and insulin resistance - is a major risk factor for cardiovascular disease and stroke. Our overall goal is to identify novel genes and pathways causing MetS. Our previous work determined that rat chromosome 17 (RNO17) contributes to several MetS-defining traits (including high blood pressure, obesity, and dyslipidemia) in the Lyon Hypertensive (LH) rat, a genetically determined MetS rat model. We hypothesized that at least some of the traits on RNO17 are controlled by a single gene with pleiotropic effects. To address this hypothesis, we generated congeni...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Kwitek, A. E., Pettus, J., Jakoubek, J., Ma, J. Tags: Session Title: Diabetes, Nutrition and Obesity/Insulin and Metabolic Syndrome Source Type: research
Angiotensin-II, the Brain, and Hypertension: An Update Recent Advances in Hypertension
Source: Hypertension - October 7, 2015 Category: Cardiology Authors: Young, C. N., Davisson, R. L. Tags: Cerebrovascular disease/stroke, Other hypertension, Hypertension - basic studies, Autonomic, reflex, and neurohumoral control of circulation, Oxidant stress Recent Advances in Hypertension Source Type: research
High B-Type Natriuretic Peptide Hypertensives at Target Blood Pressure: Potential Role of {beta}-Blockers to Reduce Their Elevated Risk Brief Review
Source: Hypertension - October 7, 2015 Category: Cardiology Authors: Struthers, A. D., George, J. Tags: Cardiovascular Pharmacology, Primary prevention, Cerebrovascular disease/stroke, Other hypertension, Clinical Studies Brief Review Source Type: research
Left Ventricular Wall Stress-Mass-Heart Rate Product and Cardiovascular Events in Treated Hypertensive Patients: LIFE Study Clinical Trial
In the Losartan Intervention for End Point Reduction in Hypertension (LIFE) study, 4.8 years’ losartan- versus atenolol-based antihypertensive treatment reduced left ventricular hypertrophy and cardiovascular end points, including cardiovascular death and stroke. However, there was no difference in myocardial infarction (MI), possibly related to greater reduction in myocardial oxygen demand by atenolol-based treatment. Myocardial oxygen demand was assessed indirectly by the left ventricular massxwall stressxheart rate (triple product) in 905 LIFE participants. The triple product was included as time-varying covariate...
Source: Hypertension - October 7, 2015 Category: Cardiology Authors: Devereux, R. B., Bang, C. N., Roman, M. J., Palmieri, V., Boman, K., Gerdts, E., Nieminen, M. S., Papademetriou, V., Wachtell, K., Hille, D. A., Dahlof, B. Tags: Hypertrophy, Other etiology Clinical Trial Source Type: research
Prevalence of Apparent Therapy-Resistant Hypertension and Its Effect on Outcome in Patients With Chronic Kidney Disease Kidney
New options recently became available for treatment of uncontrolled blood pressure. Information on the prevalence of therapy-resistant hypertension (TRH) in patients with chronic kidney disease and its consequences is relevant to balance risks and benefits of potential new therapies. Data of 788 patients with chronic kidney disease came from a multicenter study investigating the effect on outcome of an integrated multifactorial approach delivered by nurse practitioners added to usual care versus usual care alone. Blood pressure was measured at the office and during 30 minutes using an automated oscillometric device. Appare...
Source: Hypertension - October 7, 2015 Category: Cardiology Authors: de Beus, E., Bots, M. L., van Zuilen, A. D., Wetzels, J. F. M., Blankestijn, P. J., on behalf of the MASTERPLAN Study Group* Tags: Other hypertension Kidney Source Type: research
Clinical Effects of Phosphodiesterase 3A Mutations in Inherited Hypertension With Brachydactyly Genetics
Autosomal-dominant hypertension with brachydactyly is a salt-independent Mendelian syndrome caused by activating mutations in the gene encoding phosphodiesterase 3A. These mutations increase the protein kinase A–mediated phosphorylation of phosphodiesterase 3A resulting in enhanced cAMP-hydrolytic affinity and accelerated cell proliferation. The phosphorylated vasodilator-stimulated phosphoprotein is diminished, and parathyroid hormone-related peptide is dysregulated, potentially accounting for all phenotypic features. Untreated patients die prematurely of stroke; however, hypertension-induced target-organ damage is ...
Source: Hypertension - September 9, 2015 Category: Cardiology Authors: Toka, O., Tank, J., Schachterle, C., Aydin, A., Maass, P. G., Elitok, S., Bartels-Klein, E., Hollfinger, I., Lindschau, C., Mai, K., Boschmann, M., Rahn, G., Movsesian, M. A., Muller, T., Doescher, A., Gnoth, S., Muhl, A., Toka, H. R., Wefeld-Neuenfeld, Y Tags: Cerebrovascular disease/stroke, Clinical Studies Genetics Source Type: research
