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Source: Hypertension
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Total 263 results found since Jan 2013.
Downregulation of Endothelial Transient Receptor Potential Vanilloid Type 4 Channel and Small-Conductance of Ca2+-Activated K+ Channels Underpins Impaired Endothelium-Dependent Hyperpolarization in HypertensionNovelty and Significance Endothelium
Endothelium-dependent hyperpolarization (EDH)–mediated responses are impaired in hypertension, but the underlying mechanisms have not yet been determined. The activation of small- and intermediate-conductance of Ca2+-activated K+ channels (SKCa and IKCa) underpins EDH-mediated responses. It was recently reported that Ca2+ influx through endothelial transient receptor potential vanilloid type 4 channel (TRPV4) is a prerequisite for the activation of SKCa/IKCa in endothelial cells in specific beds. Here, we attempted to determine whether the impairment of EDH in hypertension is attributable to the dysfunction of TRPV4 and ...
Source: Hypertension - December 6, 2016 Category: Cardiology Authors: Takunori Seki, Kenichi Goto, Kanako Kiyohara, Yasuo Kansui, Noboru Murakami, Yoshie Haga, Toshio Ohtsubo, Kiyoshi Matsumura, Takanari Kitazono Tags: Endothelium/Vascular Type/Nitric Oxide, Hypertension Original Articles Source Type: research
Relationship of Albuminuria and Renal Artery Stent Outcomes: Results From the CORAL Randomized Clinical Trial (Cardiovascular Outcomes With Renal Artery Lesions) Clinical Trial: CORAL
Randomized clinical trials have not shown an additional clinical benefit of renal artery stent placement over optimal medical therapy alone. However, studies of renal artery stent placement have not examined the relationship of albuminuria and treatment group outcomes. The CORAL study (Cardiovascular Outcomes in Renal Atherosclerotic Lesions) is a prospective clinical trial of 947 participants with atherosclerotic renal artery stenosis randomized to optimal medical therapy with or without renal artery stent which showed no treatment differences (3(5.8% and 35.1% event rate at mean 43-month follow-up). In a post hoc analysi...
Source: Hypertension - October 11, 2016 Category: Cardiology Authors: Murphy, T. P., Cooper, C. J., Pencina, K. M., DAgostino, R., Massaro, J., Cutlip, D. E., Jamerson, K., Matsumoto, A. H., Henrich, W., Shapiro, J. I., Tuttle, K. R., Cohen, D. J., Steffes, M., Gao, Q., Metzger, D. C., Abernethy, W. B., Textor, S. C., Brigu Tags: High Blood Pressure, Hypertension, Revascularization, Stent, Atherosclerosis Clinical Trial: CORAL Source Type: research
Activation of SIRT1 Attenuates Klotho Deficiency-Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity Heart
In conclusion, this study provides the first evidence that Klotho deficiency downregulates SIRT1 activity in arterial endothelial and smooth muscle cells. Pharmacological activation of SIRT1 may be an effective therapeutic strategy for arterial stiffness and hypertension.
Source: Hypertension - October 11, 2016 Category: Cardiology Authors: Gao, D., Zuo, Z., Tian, J., Ali, Q., Lin, Y., Lei, H., Sun, Z. Tags: Animal Models of Human Disease, Physiology, Hypertension Heart Source Type: research
Role of Tumor Necrosis Factor-{alpha} and Natural Killer Cells in Uterine Artery Function and Pregnancy Outcome in the Stroke-Prone Spontaneously Hypertensive Rat Pregnancy and Hypertension
Women with chronic hypertension are at increased risk of maternal and fetal morbidity and mortality. We have previously characterized the stroke-prone spontaneously hypertensive rat (SHRSP) as a model of deficient uterine artery function and adverse pregnancy outcome compared with the control Wistar–Kyoto. The activation of the immune system plays a role in hypertension and adverse pregnancy outcome. Therefore, we investigated the role of tumor necrosis factor-α in the SHRSP phenotype in an intervention study using etanercept (0.8 mg/kg SC) at gestational days 0, 6, 12, and 18 in pregnant SHRSP compared with ve...
Source: Hypertension - October 11, 2016 Category: Cardiology Authors: Small, H. Y., Nosalski, R., Morgan, H., Beattie, E., Guzik, T. J., Graham, D., Delles, C. Tags: Animal Models of Human Disease, Basic Science Research, Inflammation, Hypertension, Preeclampsia Pregnancy and Hypertension Source Type: research
Activation of SIRT1 Attenuates Klotho Deficiency-Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase ActivityNovelty and Significance Heart
In conclusion, this study provides the first evidence that Klotho deficiency downregulates SIRT1 activity in arterial endothelial and smooth muscle cells. Pharmacological activation of SIRT1 may be an effective therapeutic strategy for arterial stiffness and hypertension.
Source: Hypertension - October 11, 2016 Category: Cardiology Authors: Gao, D., Zuo, Z., Tian, J., Ali, Q., Lin, Y., Lei, H., Sun, Z. Tags: Animal Models of Human Disease, Physiology, Hypertension Original Articles Source Type: research
Role of Tumor Necrosis Factor-{alpha} and Natural Killer Cells in Uterine Artery Function and Pregnancy Outcome in the Stroke-Prone Spontaneously Hypertensive RatNovelty and Significance Pregnancy and Hypertension
Women with chronic hypertension are at increased risk of maternal and fetal morbidity and mortality. We have previously characterized the stroke-prone spontaneously hypertensive rat (SHRSP) as a model of deficient uterine artery function and adverse pregnancy outcome compared with the control Wistar–Kyoto. The activation of the immune system plays a role in hypertension and adverse pregnancy outcome. Therefore, we investigated the role of tumor necrosis factor-α in the SHRSP phenotype in an intervention study using etanercept (0.8 mg/kg SC) at gestational days 0, 6, 12, and 18 in pregnant SHRSP compared with vehicle-tre...
Source: Hypertension - October 11, 2016 Category: Cardiology Authors: Small, H. Y., Nosalski, R., Morgan, H., Beattie, E., Guzik, T. J., Graham, D., Delles, C. Tags: Animal Models of Human Disease, Basic Science Research, Inflammation, Hypertension, Preeclampsia Original Articles Source Type: research
Orthostatic Hypotension in the ACCORD (Action to Control Cardiovascular Risk in Diabetes) Blood Pressure Trial: Prevalence, Incidence, and Prognostic Significance Clinical Trial
Orthostatic hypotension (OH) is associated with hypertension and diabetes mellitus. However, in populations with both hypertension and diabetes mellitus, its prevalence, the effect of intensive versus standard systolic blood pressure (BP) targets on incident OH, and its prognostic significance are unclear. In 4266 participants in the ACCORD (Action to Control Cardiovascular Risk in Diabetes) BP trial, seated BP was measured 3x, followed by readings every minute for 3 minutes after standing. Orthostatic BP change, calculated as the minimum standing minus the mean seated systolic BP and diastolic BP, was assessed at baseline...
Source: Hypertension - September 6, 2016 Category: Cardiology Authors: Fleg, J. L., Evans, G. W., Margolis, K. L., Barzilay, J., Basile, J. N., Bigger, J. T., Cutler, J. A., Grimm, R., Pedley, C., Peterson, K., Pop-Busui, R., Sperl-Hillen, J., Cushman, W. C. Tags: Hypertension Clinical Trial Source Type: research
Orthostatic Hypotension in the ACCORD (Action to Control Cardiovascular Risk in Diabetes) Blood Pressure TrialNovelty and Significance Clinical Trial
Orthostatic hypotension (OH) is associated with hypertension and diabetes mellitus. However, in populations with both hypertension and diabetes mellitus, its prevalence, the effect of intensive versus standard systolic blood pressure (BP) targets on incident OH, and its prognostic significance are unclear. In 4266 participants in the ACCORD (Action to Control Cardiovascular Risk in Diabetes) BP trial, seated BP was measured 3×, followed by readings every minute for 3 minutes after standing. Orthostatic BP change, calculated as the minimum standing minus the mean seated systolic BP and diastolic BP, was assessed at baselin...
Source: Hypertension - September 6, 2016 Category: Cardiology Authors: Fleg, J. L., Evans, G. W., Margolis, K. L., Barzilay, J., Basile, J. N., Bigger, J. T., Cutler, J. A., Grimm, R., Pedley, C., Peterson, K., Pop-Busui, R., Sperl-Hillen, J., Cushman, W. C. Tags: Hypertension Original Articles Source Type: research
Angiotensin-Converting Enzyme Inhibitor Use and Major Cardiovascular Outcomes in Type 2 Diabetes Mellitus Treated With the Dipeptidyl Peptidase 4 Inhibitor AlogliptinNovelty and Significance Cardiovascular Outcomes in the EXAMINE Trial
Activation of the sympathetic nervous system when there is dipeptidyl peptidase 4 inhibition in the presence of high-dose angiotensin-converting enzyme (ACE) inhibition has led to concerns of potential increases in cardiovascular events when the 2 classes of drugs are coadministered. We evaluated cardiovascular outcomes from the EXAMINE (Examination of Cardiovascular Outcomes With Alogliptin versus Standard of Care) trial according to ACE inhibitor use. Patients with type 2 diabetes mellitus and a recent acute coronary syndrome were randomly assigned to receive the dipeptidyl peptidase 4 inhibitor alogliptin or placebo add...
Source: Hypertension - August 9, 2016 Category: Cardiology Authors: White, W. B., Wilson, C. A., Bakris, G. L., Bergenstal, R. M., Cannon, C. P., Cushman, W. C., Heller, S. K., Mehta, C. R., Nissen, S. E., Zannad, F., Kupfer, S. Tags: Heart Failure, Myocardial Infarction, Complications, Mortality/Survival Original Articles Source Type: research
More Versus Less Intensive Blood Pressure-Lowering StrategyNovelty and Significance Intensive Blood Pressure Reduction and Outcome
Several randomized trials compared a more versus less intensive blood pressure–lowering strategy on the risk of major cardiovascular events and death. Cumulative meta-analyses and trial sequential analyses can establish whether and when firm evidence favoring a specific intervention has been reached from accrued literature. Therefore, we conducted a cumulative trial sequential analysis of 18 trials that randomly allocated 53 405 patients to a more or less intensive blood pressure–lowering strategy. We sought to ascertain the extent to which trial evidence added to previously accrued data. Outcome measures were stroke...
Source: Hypertension - August 9, 2016 Category: Cardiology Authors: Verdecchia, P., Angeli, F., Gentile, G., Reboldi, G. Tags: Cardiovascular Disease, Hypertension, Meta Analysis, Mortality/Survival, Quality and Outcomes Original Articles Source Type: research
Invasively Measured Aortic Systolic Blood Pressure and Office Systolic Blood Pressure in Cardiovascular Risk AssessmentNovelty and Significance Aortic Blood Pressure and Cardiovascular Risk
In conclusion, invasively measured aortic systolic BP does not add prognostic information about cardiovascular outcomes and all-cause mortality compared with office BP in patients with stable angina pectoris, either with or without diabetes mellitus.
Source: Hypertension - August 9, 2016 Category: Cardiology Authors: Laugesen, E., Knudsen, S. T., Hansen, K. W., Rossen, N. B., Jensen, L. O., Hansen, M. G., Munkholm, H., Thomsen, K. K., Sondergaard, H., Bottcher, M., Raungaard, B., Madsen, M., Hulman, A., Witte, D., Botker, H. E., Poulsen, P. L. Tags: Myocardial Infarction, Hypertension, Mortality/Survival Original Articles Source Type: research
Trends in Antihypertensive Medication Discontinuation and Low Adherence Among Medicare Beneficiaries Initiating Treatment From 2007 to 2012 Epidemiology/Population
In conclusion, low adherence to antihypertensive medication has decreased among Medicare beneficiaries; however, rates of discontinuation and low adherence remain high.
Source: Hypertension - August 9, 2016 Category: Cardiology Authors: Tajeu, G. S., Kent, S. T., Kronish, I. M., Huang, L., Krousel-Wood, M., Bress, A. P., Shimbo, D., Muntner, P. Tags: Cardiovascular Disease, Epidemiology, Risk Factors, Hypertension Epidemiology/Population Source Type: research
Angiotensin-Converting Enzyme Inhibitor Use and Major Cardiovascular Outcomes in Type 2 Diabetes Mellitus Treated With the Dipeptidyl Peptidase 4 Inhibitor Alogliptin Cardiovascular Outcomes in the EXAMINE Trial
Activation of the sympathetic nervous system when there is dipeptidyl peptidase 4 inhibition in the presence of high-dose angiotensin-converting enzyme (ACE) inhibition has led to concerns of potential increases in cardiovascular events when the 2 classes of drugs are coadministered. We evaluated cardiovascular outcomes from the EXAMINE (Examination of Cardiovascular Outcomes With Alogliptin versus Standard of Care) trial according to ACE inhibitor use. Patients with type 2 diabetes mellitus and a recent acute coronary syndrome were randomly assigned to receive the dipeptidyl peptidase 4 inhibitor alogliptin or placebo add...
Source: Hypertension - August 9, 2016 Category: Cardiology Authors: White, W. B., Wilson, C. A., Bakris, G. L., Bergenstal, R. M., Cannon, C. P., Cushman, W. C., Heller, S. K., Mehta, C. R., Nissen, S. E., Zannad, F., Kupfer, S., for the EXAMINE Investigators Tags: Heart Failure, Myocardial Infarction, Complications, Mortality/Survival Cardiovascular Outcomes in the EXAMINE Trial Source Type: research
More Versus Less Intensive Blood Pressure-Lowering Strategy: Cumulative Evidence and Trial Sequential Analysis Intensive Blood Pressure Reduction and Outcome
Several randomized trials compared a more versus less intensive blood pressure–lowering strategy on the risk of major cardiovascular events and death. Cumulative meta-analyses and trial sequential analyses can establish whether and when firm evidence favoring a specific intervention has been reached from accrued literature. Therefore, we conducted a cumulative trial sequential analysis of 18 trials that randomly allocated 53 405 patients to a more or less intensive blood pressure–lowering strategy. We sought to ascertain the extent to which trial evidence added to previously accrued data. Outcome measures were ...
Source: Hypertension - August 9, 2016 Category: Cardiology Authors: Verdecchia, P., Angeli, F., Gentile, G., Reboldi, G. Tags: Cardiovascular Disease, Hypertension, Meta Analysis, Mortality/Survival, Quality and Outcomes Intensive Blood Pressure Reduction and Outcome Source Type: research
Invasively Measured Aortic Systolic Blood Pressure and Office Systolic Blood Pressure in Cardiovascular Risk Assessment: A Prospective Cohort Study Aortic Blood Pressure and Cardiovascular Risk
In conclusion, invasively measured aortic systolic BP does not add prognostic information about cardiovascular outcomes and all-cause mortality compared with office BP in patients with stable angina pectoris, either with or without diabetes mellitus.
Source: Hypertension - August 9, 2016 Category: Cardiology Authors: Laugesen, E., Knudsen, S. T., Hansen, K. W., Rossen, N. B., Jensen, L. O., Hansen, M. G., Munkholm, H., Thomsen, K. K., Sondergaard, H., Bottcher, M., Raungaard, B., Madsen, M., Hulman, A., Witte, D., Botker, H. E., Poulsen, P. L. Tags: Myocardial Infarction, Hypertension, Mortality/Survival Aortic Blood Pressure and Cardiovascular Risk Source Type: research
