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Source: Hypertension
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Total 263 results found since Jan 2013.
Estrogen Protects Against Intracranial Aneurysm Rupture in Ovariectomized Mice Estrogen and Intracranial Aneurysm Rupture
Clinical observations suggest that postmenopausal women have a higher incidence of aneurysmal rupture than premenopausal women. We hypothesize that a relative deficiency in estrogen may increase the risks of aneurysmal growth and subarachnoid hemorrhage in postmenopausal women. We assessed the effects of estrogen and selective estrogen receptor subtype agonists on the development of aneurysmal rupture in ovariectomized female mice. We used an intracranial aneurysm mouse model that recapitulates the key features of human intracranial aneurysms, including spontaneous rupture. Ten- to 12-week-old ovariectomized female mice re...
Source: Hypertension - May 7, 2014 Category: Cardiology Authors: Tada, Y., Wada, K., Shimada, K., Makino, H., Liang, E. I., Murakami, S., Kudo, M., Shikata, F., Pena Silva, R. A., Kitazato, K. T., Hasan, D. M., Kanematsu, Y., Nagahiro, S., Hashimoto, T. Tags: Animal models of human disease, Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Other Stroke Treatment - Medical Estrogen and Intracranial Aneurysm Rupture Source Type: research
Is Hypertension Associated With an Accelerated Aging of the Brain? Brief Reviews
Source: Hypertension - April 9, 2014 Category: Cardiology Authors: Tzourio, C., Laurent, S., Debette, S. Tags: Cerebrovascular disease/stroke, Cerebral Lacunes, Epidemiology Brief Reviews Source Type: research
End of the Joint National Committee Heritage? Editorial
Source: Hypertension - April 9, 2014 Category: Cardiology Authors: O'Brien, E. Tags: Health policy and outcome research, Cerebrovascular disease/stroke Editorial Source Type: research
Optimum Blood Pressure Target After Lacunar Stroke: Pro Side of the Argument Controversies in Hypertension
Source: Hypertension - April 9, 2014 Category: Cardiology Authors: Hankey, G. J., Lacey, B. Tags: Other hypertension, Other Stroke Treatment - Medical Controversies in Hypertension Source Type: research
Optimum Blood Pressure Target After Lacunar Stroke: Con Side of the Argument Controversies in Hypertension
Source: Hypertension - April 9, 2014 Category: Cardiology Authors: Schiffrin, E. L. Tags: Other hypertension Controversies in Hypertension Source Type: research
Synergistic Effects of High Blood Cholesterol and Hypertension on Leukocyte and Platelet Recruitment in the Cerebral Microcirculation Vessels
In this study, we examined whether larger increments in blood cholesterol (4-fold) exerts a similar modulating influence on the vasculature in the presence of hypertension. Apolipoprotein E–knockout mice with deoxycorticosterone acetate salt–induced hypertension were placed on a high-cholesterol diet and exhibited exaggerated leukocyte and platelet adhesion responses in cerebral microvessels. Intermittent feeding (every fourth day) with high-cholesterol diet yielded similar phenotypic changes in the vasculature. Once the mice were placed on high-cholesterol diet, 4 days on normal diet (ND) were needed to revert...
Source: Hypertension - March 12, 2014 Category: Cardiology Authors: Rodrigues, S. F., Almeida-Paula, L. D., Granger, D. N. Tags: Cerebrovascular disease/stroke Vessels Source Type: research
Rho-Associated Kinase Activity Is a Predictor of Cardiovascular Outcomes Cardiovascular Outcomes
Cardiovascular diseases are associated with chronic activation of Rho-associated kinase. Rho-associated kinase activity is significantly correlated with endothelial function and Framingham risk score. However, there is no information on the prognostic value of Rho-associated kinase activity. We evaluated Rho-associated kinase activity in peripheral leukocytes by Western blot analysis in 633 subjects who underwent health-screening examination at Hiroshima University Hospital. We assessed the associations between Rho-associated kinase activity and first major cardiovascular events (death from cardiovascular causes, myocardia...
Source: Hypertension - March 12, 2014 Category: Cardiology Authors: Kajikawa, M., Noma, K., Maruhashi, T., Mikami, S., Iwamoto, Y., Iwamoto, A., Matsumoto, T., Hidaka, T., Kihara, Y., Chayama, K., Nakashima, A., Goto, C., Liao, J. K., Higashi, Y. Tags: Risk Factors Cardiovascular Outcomes Source Type: research
Natriuretic Peptide: A Probable Culprit in Prevention of Primary Cardiovascular Diseases Using {beta}-Blockers Letters to the Editor
Source: Hypertension - March 12, 2014 Category: Cardiology Authors: Peng, H., Liu, Y. Tags: Biochemistry and metabolism, Cerebrovascular disease/stroke, Myocardial cardiomyopathy disease Letters to the Editor Source Type: research
Prevention of Hypertension and Cardiovascular Diseases: A Comparison of Lifestyle Factors in Westerners and East Asians Brief Reviews
Source: Hypertension - March 12, 2014 Category: Cardiology Authors: Kokubo, Y. Tags: Obesity, Primary prevention, Cerebrovascular disease/stroke, Risk Factors Brief Reviews Source Type: research
Effect of Serum Chloride on Mortality in Hypertensive Patients Letters to the Editor
Source: Hypertension - February 12, 2014 Category: Cardiology Authors: Kawada, T. Tags: Cerebrovascular disease/stroke Letters to the Editor Source Type: research
Refractory Hypertension: Determination of Prevalence, Risk Factors, and Comorbidities in a Large, Population-Based Cohort Epidemiology/Population
Refractory hypertension is an extreme phenotype of antihypertensive treatment failure. Participants in the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study, a large (n=30 239), population-based cohort were evaluated to determine the prevalence of refractory hypertension and associated cardiovascular risk factors and comorbidities. Refractory hypertension was defined as uncontrolled blood pressure (systolic/diastolic, ≥140/90 mm Hg) on ≥5 antihypertensive drug classes. Participants with resistant hypertension (systolic/diastolic, ≥140/90 mm Hg on ≥3 or <140/90 mm Hg on ≥4 antihyperte...
Source: Hypertension - February 12, 2014 Category: Cardiology Authors: Calhoun, D. A., Booth, J. N., Oparil, S., Irvin, M. R., Shimbo, D., Lackland, D. T., Howard, G., Safford, M. M., Muntner, P. Tags: Cardiovascular Pharmacology, Other hypertension Epidemiology/Population Source Type: research
Tight Versus Standard Blood Pressure Control in Patients With Hypertension With and Without Cardiovascular Disease Heart
In conclusion, an intensive treatment aimed to lower systolic BP<130 mm Hg reduced left ventricular hypertrophy and improved clinical outcomes to a similar extent in patients with hypertension and without established cardiovascular disease.
Source: Hypertension - February 12, 2014 Category: Cardiology Authors: Reboldi, G., Angeli, F., de Simone, G., Staessen, J. A., Verdecchia, P., on behalf of the Cardio-Sis Investigators Tags: Primary prevention, Secondary prevention, Cerebrovascular disease/stroke, Hypertrophy Heart Source Type: research
The Value of N-Terminal Pro-B-Type Natriuretic Peptide in Determining Antihypertensive Benefit: Observations From the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) Natriuretic Peptides
We investigated 3 hypotheses: (1) N-terminal pro–B-type natriuretic peptide (NT-proBNP) predicts cardiovascular disease events in patients with hypertension, (2) NT-proBNP is associated with blood pressure variability, and (3) NT-proBNP predicts benefit from antihypertensive regimens. The Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) randomized a subset of 6549 patients at risk with no history of coronary heart disease to either atenolol-based or amlodipine-based blood pressure–lowering treatment. During 5.5 years of follow-up, 485 cardiovascular disease cases accrued and were matched with 1367 controls. Ba...
Source: Hypertension - February 12, 2014 Category: Cardiology Authors: Welsh, P., Poulter, N. R., Chang, C. L., Sever, P. S., Sattar, N., on behalf of the ASCOT Investigators Tags: Cerebrovascular disease/stroke Natriuretic Peptides Source Type: research
Evidence-Based Triple Antihypertensive Therapy Yields Lower Mortality in Older Patients With Diabetes Mellitus Editorial Commentary
Source: Hypertension - January 8, 2014 Category: Cardiology Authors: Yamout, H., Bakris, G. L. Tags: Cerebrovascular disease/stroke, Other hypertension, Clinical Studies Editorial Commentary Source Type: research
Aggressive Blood Pressure Lowering Is Dangerous: The J-Curve: Con Side of the Argument Controversies in Hypertension
Source: Hypertension - December 11, 2013 Category: Cardiology Authors: Verdecchia, P., Angeli, F., Mazzotta, G., Garofoli, M., Reboldi, G. Tags: Cerebrovascular disease/stroke, Other hypertension Controversies in Hypertension Source Type: research
