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Source: Hypertension
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Total 263 results found since Jan 2013.
A Blood Pressure Genetic Risk Score Is a Significant Predictor of Incident Cardiovascular Events in 32 669 Individuals Genetics
In conclusion, BP findings from genome-wide association studies are strongly replicated. GRSs comprising bona fide BP-single nucleotide polymorphisms predicted CVD risk, consistent with a lifelong effect on BP of these variants collectively.
Source: Hypertension - April 17, 2013 Category: Cardiology Authors: Havulinna, A. S., Kettunen, J., Ukkola, O., Osmond, C., Eriksson, J. G., Kesaniemi, Y. A., Jula, A., Peltonen, L., Kontula, K., Salomaa, V., Newton-Cheh, C. Tags: Other hypertension, Epidemiology Genetics Source Type: research
Skeletal Muscle Signaling and the Heart Rate and Blood Pressure Response to Exercise: Insight From Heart Rate Pacing During Exercise With a Trained and a Deconditioned Muscle Group Exercise and Blood Pressure
Endurance training lowers heart rate and blood pressure responses to exercise, but the mechanisms and consequences remain unclear. To determine the role of skeletal muscle for the cardioventilatory response to exercise, 8 healthy young men were studied before and after 5 weeks of 1-legged knee-extensor training and 2 weeks of deconditioning of the other leg (leg cast). Hemodynamics and muscle interstitial nucleotides were determined during exercise with the (1) deconditioned leg, (2) trained leg, and (3) trained leg with atrial pacing to the heart rate obtained with the deconditioned leg. Heart rate was 15 bpm lower during...
Source: Hypertension - April 17, 2013 Category: Cardiology Authors: Mortensen, S. P., Svendsen, J. H., Ersboll, M., Hellsten, Y., Secher, N. H., Saltin, B. Tags: Exercise/exercise testing/rehabilitation, Other Vascular biology Exercise and Blood Pressure Source Type: research
Left Ventricular Global Function Index by Magnetic Resonance Imaging--A Novel Marker for Assessment of Cardiac Performance for the Prediction of Cardiovascular Events: The Multi-Ethnic Study of Atherosclerosis Epidemiology/Population Science
Left ventricular (LV) function is generally assessed independent of structural remodeling and vice versa. The purpose of this study was to evaluate a novel LV global function index (LVGFI) that integrates LV structure with global function and to assess its predictive value for cardiovascular (CV) events throughout adult life in a multiethnic population of men and women without history of CV diseases at baseline. A total of 5004 participants in the Multi-Ethnic Study of Atherosclerosis underwent a cardiac magnetic resonance study and were followed up for a median of 7.2 years. The LVGFI by cardiac magnetic resonance was def...
Source: Hypertension - March 13, 2013 Category: Cardiology Authors: Mewton, N., Opdahl, A., Choi, E.-Y., Almeida, A. L. C., Kawel, N., Wu, C. O., Burke, G. L., Liu, S., Liu, K., Bluemke, D. A., Lima, J. A. C. Tags: Congestive, Risk Factors, Hypertrophy, CT and MRI Epidemiology/Population Science Source Type: research
Angiotensin-Converting Enzyme 2 Priming Enhances the Function of Endothelial Progenitor Cells and Their Therapeutic Efficacy Original Articles Part 2
Angiotensin-converting enzyme 2 (ACE2) is a lately discovered enzyme catalyzing Angiotensin II into Angiotensin 1-7. Angiotensin II has been reported to impair endothelial progenitor cell (EPC) function and is detrimental to stroke. Here, we studied the role of ACE2 in regulating EPC function in vitro and in vivo. EPCs were cultured from human renin and angiotensinogen transgenic (R+A+) mice and their controls (R–A–). In in vitro experiments, EPCs were transduced with lentivirus-ACE2 or lentivirus-green fluorescence protein. The effects of ACE2 overexpression on EPC function and endothelial NO synthase (eNOS)/n...
Source: Hypertension - February 13, 2013 Category: Cardiology Authors: Chen, J., Xiao, X., Chen, S., Zhang, C., Chen, J., Yi, D., Shenoy, V., Raizada, M. K., Zhao, B., Chen, Y. Tags: ACE/Angiotension receptors, Angiogenesis, Animal models of human disease Original Articles Part 2 Source Type: research
Relationship Between Stroke Subtypes and Morning Surge or Dipping Pattern Letters to the Editors
Source: Hypertension - January 16, 2013 Category: Cardiology Authors: Hosaka, M., Asayama, K., Imai, Y., Ohkubo, T. Tags: Letters to the Editors Source Type: research
Initial Combination Therapy Reduces the Risk of Cardiovascular Events in Hypertensive Patients: A Matched Cohort Study Original Articles
This study evaluated the effects of initial versus delayed treatment with a drug combination on blood pressure (BP) control and the risk of cardiovascular (CV) events in hypertensive patients. Clinical trials suggest that the time to BP control is an important determinant of long-term outcomes, but real-world evidence is scarce. Using electronic medical charts (2005–2009), we retrospectively analyzed 1762 adult patients with BP elevation initiating combination therapy matched 1:1 with similar patients initiating monotherapy and later switched to combination therapy. Incidence rate ratios of CV events (myocardial infa...
Source: Hypertension - January 16, 2013 Category: Cardiology Authors: Gradman, A. H., Parise, H., Lefebvre, P., Falvey, H., Lafeuille, M.-H., Duh, M. S. Tags: Original Articles Source Type: research
Loss of Epidermal Growth Factor Receptor in Vascular Smooth Muscle Cells and Cardiomyocytes Causes Arterial Hypotension and Cardiac Hypertrophy Original Articles
The epidermal growth factor receptor (EGFR), a receptor tyrosine kinase, contributes to parainflammatory dysregulation, possibly causing cardiovascular dysfunction and remodeling. The physiological role of cardiovascular EGFR is not completely understood. To investigate the physiological importance of EGFR in vascular smooth muscle cells and cardiomyocytes, we generated a mouse model with targeted deletion of the EGFR using the SM22 (smooth muscle-specific protein 22) promoter. While the reproduction of knockout animals was not impaired, life span was significantly reduced. Systolic blood pressure was not different between...
Source: Hypertension - January 16, 2013 Category: Cardiology Authors: Schreier, B., Rabe, S., Schneider, B., Bretschneider, M., Rupp, S., Ruhs, S., Neumann, J., Rueckschloss, U., Sibilia, M., Gotthardt, M., Grossmann, C., Gekle, M. Tags: Original Articles Source Type: research
Differential Modulation of Uncoupling Protein 2 in Kidneys of Stroke-Prone Spontaneously Hypertensive Rats Under High-Salt/Low-Potassium Diet Original Articles
In conclusion, high-salt diet downregulates the antioxidant UCP2-dependent mechanism in kidneys of SHRsp, but not of stroke-resistant SHR. A parallel differential kidney miR regulation under high-salt diet in the 2 strains may contribute to the differential UCP2 modulation. UCP2 is a critical protein to prevent oxidative stress damage in renal mesangial cells in vitro.
Source: Hypertension - January 16, 2013 Category: Cardiology Authors: Di Castro, S., Scarpino, S., Marchitti, S., Bianchi, F., Stanzione, R., Cotugno, M., Sironi, L., Gelosa, P., Duranti, E., Ruco, L., Volpe, M., Rubattu, S. Tags: Original Articles Source Type: research
