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Source: Hypertension

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Total 263 results found since Jan 2013.

Association Between Prepregnancy Cardiovascular Function and Subsequent Preeclampsia or Fetal Growth RestrictionNovelty and Significance Preeclampsia, Pregnancy, and Hypertension
Preeclampsia and fetal growth restriction during pregnancy are associated with increased risk of maternal cardiovascular disease later in life. It is unclear whether this association is causal or driven by similar antecedent risk factors. Clarification requires recruitment before conception which is methodologically difficult with high attrition rates and loss of outcome numbers to nonconception/miscarriage. Few prospective studies have, therefore, been adequately powered to address these questions. We recruited 530 healthy women (mean age: 35.0 years) intending to conceive and assessed cardiac output, cardiac index, strok...
Source: Hypertension - July 11, 2018 Category: Cardiology Authors: Fung L. Foo, Amita A. Mahendru, Giulia Masini, Abigail Fraser, Stefano Cacciatore, David A. MacIntyre, Carmel M. McEniery, Ian B. Wilkinson, Phillip R. Bennett, Christoph C. Lees Tags: Clinical Studies, Hemodynamics, Preeclampsia Original Articles Source Type: research

Benefits of Intensive Blood Pressure Treatment in Patients With Type 2 Diabetes Mellitus Receiving Standard but Not Intensive Glycemic ControlNovelty and Significance Type 2 Diabetes Mellitus and Hypertension
This study aimed to assess whether intensive blood pressure (BP) treatment has benefits in preventing cardiovascular events, including heart failure in patients with type 2 diabetes mellitus. Using the ACCORD BP trial (Action to Control Cardiovascular Risk in Diabetes Blood Pressure) data, hazard ratios for cardiovascular events with 95% confidence intervals were calculated using the Cox proportional hazard models to compare the time to the first cardiovascular event in patients receiving standard (n=2362) or intensive glycemic control (n=2371). The overall mean follow-up period was 4.5 years, and cardiovascular events wer...
Source: Hypertension - July 11, 2018 Category: Cardiology Authors: Tetsuro Tsujimoto, Hiroshi Kajio Tags: Hypertension Original Articles Source Type: research

Effect of Adherence to Antihypertensive Medication on the Long-Term Outcome After Hemorrhagic Stroke in KoreaNovelty and Significance Hemorrhagic Stroke
Hypertension is the single most important risk factor for hemorrhagic stroke, a leading cause of mortality and disability worldwide. Adherence to antihypertensive medication is essential to achieving strict blood pressure control, but poor adherence is common in clinical practice. We evaluated adherence to antihypertensive medication in patients with acute hemorrhagic stroke and its effects on long-term outcome. This was a retrospective cohort study based on a nationwide health insurance claims database in South Korea. We included 1872 hypertensive patients who were admitted with acute hemorrhagic stroke during 2002 to 201...
Source: Hypertension - July 11, 2018 Category: Cardiology Authors: Jinkwon Kim, Cheryl D. Bushnell, Hye Sun Lee, Sang Won Han Tags: Secondary Prevention, Hypertension, Compliance/Adherence, Intracranial Hemorrhage Original Articles Source Type: research

20-HETE Excellence Award for Hypertension Research
Source: Hypertension - June 13, 2018 Category: Cardiology Authors: Richard J. Roman, Fan Fan Tags: Gene Expression & Regulation, Genetically Altered and Transgenic Models, Hypertension, Cerebrovascular Disease/Stroke Excellence Award for Hypertension Research Source Type: research

Common Carotid Artery Diameter and Risk of Cardiovascular Events and MortalityNovelty and Significance Epidemiology/Population
Carotid arterial diameter enlargement is a manifestation of arterial remodeling and may be a risk factor for cardiovascular disease (CVD). We evaluated the association between carotid artery diameter and risk of stroke, coronary heart disease, CVD, and all-cause mortality and explored whether the associations could be explained by processes involved in arterial remodeling, that is, blood pressure–related media thickening, arterial stiffness, arterial wall stress, and atherosclerosis. We included 4887 participants (mean age 67±9 years; 54% women) from 4 cohort studies: Rotterdam Study, NEPHROTEST, Hoorn Study, and a stud...
Source: Hypertension - June 13, 2018 Category: Cardiology Authors: Sanaz Sedaghat, Thomas T. van Sloten, Stephane Laurent, Gerard M. London, Bruno Pannier, Maryam Kavousi, Francesco Mattace–Raso, Oscar H. Franco, Pierre Boutouyrie, M. Arfan Ikram, Coen D.A. Stehouwer Tags: Cardiovascular Disease, Epidemiology, Risk Factors, Ultrasound, Cerebrovascular Disease/Stroke Original Articles Source Type: research

Modeling Superimposed Preeclampsia Using Ang II (Angiotensin II) Infusion in Pregnant Stroke-Prone Spontaneously Hypertensive RatsNovelty and Significance Preeclampsia
Hypertensive disorders of pregnancy are the second leading cause of maternal deaths worldwide. Superimposed preeclampsia is an increasingly common problem and often associated with impaired placental perfusion. Understanding the underlying mechanisms and developing treatment options are crucial. The pregnant stroke-prone spontaneously hypertensive rat has impaired uteroplacental blood flow and abnormal uterine artery remodeling. We used Ang II (angiotensin II) infusion in pregnant stroke-prone spontaneously hypertensive rats to mimic the increased cardiovascular stress associated with superimposed preeclampsia and examine ...
Source: Hypertension - June 13, 2018 Category: Cardiology Authors: Hannah L. Morgan, Elaine Butler, Shona Ritchie, Florian Herse, Ralf Dechend, Elisabeth Beattie, Martin W. McBride, Delyth Graham Tags: ACE/Angiotensin Receptors/Renin Angiotensin System, Animal Models of Human Disease, Hypertension, Preeclampsia Original Articles Source Type: research

Vascular Nox (NADPH Oxidase) Compartmentalization, Protein Hyperoxidation, and Endoplasmic Reticulum Stress Response in HypertensionNovelty and Significance Oxidative Stress
Vascular Nox (NADPH oxidase)-derived reactive oxygen species and endoplasmic reticulum (ER) stress have been implicated in hypertension. However, relationships between these processes are unclear. We hypothesized that Nox isoforms localize in a subcellular compartment-specific manner, contributing to oxidative and ER stress, which influence the oxidative proteome and vascular function in hypertension. Nox compartmentalization (cell fractionation), O2− (lucigenin), H2O2 (amplex red), reversible protein oxidation (sulfenylation), irreversible protein oxidation (protein tyrosine phosphatase, peroxiredoxin oxidation), and ER...
Source: Hypertension - June 13, 2018 Category: Cardiology Authors: Livia L. Camargo, Adam P. Harvey, Francisco J. Rios, Sofia Tsiropoulou, Renee de Nazare Oliveira Da Silva, Zhenbo Cao, Delyth Graham, Claire McMaster, Richard J. Burchmore, Richard C. Hartley, Neil Bulleid, Augusto C. Montezano, Rhian M. Touyz Tags: Hypertension Original Articles Source Type: research

Absolute Risk-Based Treatment Using Adaptive Blood Pressure Thresholds and Targets Is Crucial to Older Multimorbid Patients With High Fall Risk Guidelines Conversation
Source: Hypertension - May 9, 2018 Category: Cardiology Authors: Vernon Min Sen Oh Tags: High Blood Pressure, Hypertension, Treatment, Ethics and Policy, Quality and Outcomes, Cerebrovascular Disease/Stroke Guidelines Conversation Source Type: research

Blood Pressure-Related Risk Among Users Versus Nonusers of AntihypertensivesNovelty and Significance Epidemiology/Population
In conclusion, this population-based study demonstrated that the associations between BP and adverse outcomes were J-shaped among active antihypertensive users, but linear or flat and then increasing among nonusers or irregular users.
Source: Hypertension - May 9, 2018 Category: Cardiology Authors: Hae Hyuk Jung, Ji In Park, Jin Seon Jeong Tags: Nephrology and Kidney, Cardiovascular Disease, Epidemiology, Hypertension, Mortality/Survival Original Articles Source Type: research

Effect of Lowering Diastolic Pressure in Patients With and Without Cardiovascular DiseaseNovelty and Significance SPRINT Trial
Systolic and diastolic blood pressure thresholds, below which cardiovascular events increase, are widely debated. Using data from the SPRINT (Systolic Blood Pressure Intervention Trial), we evaluated the relation between systolic and diastolic pressure and cardiovascular events among 1519 participants with or 7574 without prior cardiovascular disease. Using Cox regression, we examined the composite risk of myocardial infarction, other acute coronary syndrome, stroke, heart failure, or cardiovascular death, and follow-up systolic and diastolic pressure were analyzed as time-dependent covariates for a median of 3.1 years. Mo...
Source: Hypertension - April 11, 2018 Category: Cardiology Authors: Nadia A. Khan, Simon W. Rabkin, Yinshan Zhao, Finlay A. McAlister, Julie E. Park, Meijiao Guan, Sammy Chan, Karin H. Humphries Tags: Hypertension Original Articles Source Type: research

Changes in Cerebral Arteries and Parenchymal Arterioles With AgingNovelty and Significance Cerebrovascular Dysfunction With Aging
Vascular aging fundamentally contributes to large and small vessel disease. Despite the importance of such changes for brain function, mechanisms that mediate such changes are poorly defined. We explored mechanisms that underlie changes with age, testing the hypothesis that ROCK (Rho kinase) plays an important role. In C57BL/6 mice, baseline diameters of isolated pressurized parenchymal arterioles were similar in adult (4–5 month) and old mice (22±1 month; ≈15±1 µm). Endothelium-dependent dilation was impaired in old mice compared with adults in a pathway-specific manner. Vasodilation to NS-309 (which activates smal...
Source: Hypertension - April 11, 2018 Category: Cardiology Authors: T. Michael De Silva, Mary L. Modrick, Fabrice Dabertrand, Frank M. Faraci Tags: Basic Science Research, Vascular Biology, Cerebrovascular Disease/Stroke, Vascular Disease Original Articles Source Type: research

Primary Aldosteronism and Cardiovascular Events Editorial Commentary
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Martin Reincke Tags: High Blood Pressure, Cerebrovascular Disease/Stroke Editorial Commentaries Source Type: research

Prevalence of Cardiovascular Disease and Its Risk Factors in Primary AldosteronismNovelty and Significance Primary Aldosteronism
There have been several clinical studies examining the factors associated with cardiovascular disease (CVD) in patients with primary aldosteronism (PA); however, their results have left it unclear whether CVD is affected by the plasma aldosterone concentration or hypokalemia. We assessed the PA database established by the multicenter JPAS (Japan Primary Aldosteronism Study) and compared the prevalence of CVD among patients with PA with that among age-, sex-, and blood pressure-matched essential hypertension patients and participants with hypertension in a general population cohort. We also performed binary logistic regress...
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Youichi Ohno, Masakatsu Sone, Nobuya Inagaki, Toshinari Yamasaki, Osamu Ogawa, Yoshiyu Takeda, Isao Kurihara, Hiroshi Itoh, Hironobu Umakoshi, Mika Tsuiki, Takamasa Ichiȷo, Takuyuki Katabami, Yasushi Tanaka, Norio Wada, Yui Shibayama, Takanobu Yosh Tags: Cardiovascular Disease, Risk Factors, Hypertension, Vascular Disease Original Articles Source Type: research

Uric Acid Is a Strong Risk Marker for Developing Hypertension From PrehypertensionNovelty and Significance Hyperuricemia and Prehypertension
Prehypertension frequently progresses to hypertension, a condition associated with high morbidity and mortality from cardiovascular diseases and stroke. However, the risk factors for developing hypertension from prehypertension remain poorly understood. We conducted a retrospective cohort study using the data from 3584 prehypertensive Japanese adults (52.1±11.0 years, 2081 men) found to be prehypertensive in 2004 and reexamined in 2009. We calculated the cumulative incidences of hypertension over 5 years, examined risk factors, and calculated odds ratios (ORs) for developing hypertension after adjustments for age, sex, bo...
Source: Hypertension - December 13, 2017 Category: Cardiology Authors: Masanari Kuwabara, Ichiro Hisatome, Koichiro Niwa, Shigeko Hara, Carlos A. Roncal-Jimenez, Petter Bjornstad, Takahiko Nakagawa, Ana Andres-Hernando, Yuka Sato, Thomas Jensen, Gabriela Garcia, Bernardo Rodriguez-Iturbe, Minoru Ohno, Miguel A. Lanaspa, Rich Tags: Cardiovascular Disease, Epidemiology, Risk Factors, High Blood Pressure, Hypertension Original Articles Source Type: research

Cerebrovascular Reactivity and Vascular Activation in Postmenopausal Women With Histories of PreeclampsiaNovelty and Significance Preeclampsia
This study examined an association between pregnancy history and CVR using a subgroup of 40 age- and parity-matched pairs of women having histories of preeclampsia (n=27) or normotensive pregnancy (n=29) and the association of activated blood elements with CVR. Middle cerebral artery velocity was measured by Doppler ultrasound before and during hypercapnia to assess CVR. Thirty-eight parameters of blood cellular elements, microvesicles, and cell–cell interactions measured in venous blood were assessed for association with CVR using principal component analysis. Middle cerebral artery velocity was lower in the preeclampsi...
Source: Hypertension - December 13, 2017 Category: Cardiology Authors: Jill N. Barnes, Ronee E. Harvey, Kathleen B. Miller, Muthuvel Jayachandran, Katherine R. Malterer, Brian D. Lahr, Kent R. Bailey, Michael J. Joyner, Virginia M. Miller Tags: Physiology, Preeclampsia, Cerebrovascular Disease/Stroke Original Articles Source Type: research