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Source: Hypertension
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Total 263 results found since Jan 2013.
Abstract P454: Does Intensive Pulse Pressure control results in lower rates of cardiovascular events? An Analysis of Systolic BP Intervention Trial (SPRINT) database Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Conclusion: In the SPRINT database of 9347 participants, we found that higher PP conferred an increased risk for multiple adverse cardiovascular event. Our study is among the largest US studies of PP and adds further support to the prognostic utility of PP. In addition, the SPRINT database offers a contemporary analysis of the relationship between PP and DBP, which is important given that nature pathophysiology of blood pressure. Current study also strengthen the possibility that DBP
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Quan Tran Tags: Poster Abstract Presentations Source Type: research
Abstract P465: Arterial Hypertension and Orthostatic Hypotension in Diabetic Patients Session Title: Obesity, Metabolic Syndrome, and Diabetes
Conclusion: Presence of orthostatic hypotension in diabetics is associated with higher prevalence of macrovascular and microvascular complications of diabetes mellitus and also with higher 10-year mortality.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Ludovit Gaspar, Slavomira Filipova, Matej Bendzala, Iveta Gasparova Tags: Poster Abstract Presentations Source Type: research
Abstract P478: Barriers to Health Care Access and Hypertension Treatment Among Us Adults With Self-reported Hypertension Session Title: Antihypertensive Drugs and Pharmacology, Patient-Provider-Healthcare System Issues, and Pediatric and Adolescent Hypertension
Conclusion: Although antihypertensive medication use is common among those with hypertension, this study found lower levels of reported antihypertensive medication use among those with perceived barriers to health care access.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Jing Fang, Guijing Wang, Carma Ayala, Sal Lucido, Fleetwood Loustatol Tags: Poster Abstract Presentations Source Type: research
Abstract P480: Effects Of Long And Intermediate Acting Dihydropyridine Calcium Channel Blockers In Hypertension: A Systematic Review And Aeta-analysis Of 18 Prospective, Actively Controlled, Randomized Clinical Trials Session Title: Antihypertensive Drugs and Pharmacology, Patient-Provider-Healthcare System Issues, and Pediatric and Adolescent Hypertension
Conclusions: This study suggests that Amlodipine offers greater protection against major complications of hypertension compared to intermediate acting dihydropyridine calcium channel blockers.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Sandip Chaugai, Hisatomi Arima, Lhamo Yangchen Sherpa, Amir Sepehry Tags: Poster Abstract Presentations Source Type: research
Abstract P482: Different Hemodynamic Phenotypes Of Isolated Systolic Hypertension In Adolescents Session Title: Antihypertensive Drugs and Pharmacology, Patient-Provider-Healthcare System Issues, and Pediatric and Adolescent Hypertension
Objective: Isolated systolic hypertension (ISH) is a dominant form of primary hypertension (PH) in adolescents. Some of them present with normal central systolic blood pressure (cSBP), a phenomenon called spurious hypertension (sHT). The study was aimed to describe hemodynamics of PH in relation to cSBP, central pulse pressure (cPP) and target organ damage (TOD) in adolescents referred because of PH.Patients and Methods: In 267 children (59 girls; 14.9 ±2.6 years) referred with arterial hypertension, in whom secondary hypertension was excluded, 24 hour ABPM, left ventricular mass index (LVMi), carotid intima-media thickne...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Lukasz Obrycki, Anna Niemirska, Jedrzej Sarnecki, Zbigniew Kulaga, Mieczyslaw Litwin Tags: Poster Abstract Presentations Source Type: research
Abstract P486: Effects of Isometric Leg Training on Ambulatory Blood Pressure and Morning Blood Pressure Surge in Young Normotensive Men and Women Session Title: Non-Pharmacological Therapy and Nutrition and Hypertension
Conclusion: These results support previous research showing that IRT is effective in lowering ambulatory BP. Furthermore, the significant reductions in the MBPS offer the potential for clinically meaningful CVD and stroke risk reduction, provided these effects can be demonstrated in those who are at risk.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Anthony W Baross, Kevin J Milne, Cheri L McGowan, Ian L Swaine Tags: Poster Abstract Presentations Source Type: research
Abstract P504: Resistin Mediates Sex-dependent Effects of Perivascular Adipose Tissue on Vascular Function in the SHRSP Session Title: Vascular
Conclusion: We identified a novel role for resistin in sex-dependent PVAT mediated vascular function in hypertension through a KATP channel mediated mechanism.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Sarah McNeilly, Heather Y Small, Adam Sheikh, Sheon Mary, Karine Pinel, Christian Delles Tags: Poster Abstract Presentations Source Type: research
Abstract P521: Relationship Between Carotid Arterial Elastic Properties and Central Aortic Hemodynamics in Patients with Stroke Session Title: Vascular
This study aims to investigate the association between carotid artery parameters and central aortic hemodynamics in patients with ischemic stroke.Methods: A total of 101 consecutive patients with ischemic stroke who underwent clinically indicated transesophageal echocardiography (TEE) were performed carotid ultrasonography to assess vascular elastic properties. Using velocity-vector imaging (VVI), instantaneous vessel area (cm2) and deformation as fractional area change (FAC, %) and circumferential strain (%) were obtained in both cross-sectional image of common carotid artery (CA) and descending thoracic aorta (DTA) durin...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Sung-ai Kim, Sang-Ho Jo, Kyung-Ha Park, Hyun-Sook Kim Tags: Poster Abstract Presentations Source Type: research
Abstract P532: Hypertension and Gender Differences in Acute Ischemic Stroke Patients Treated With Rtpa Session Title: Genetics and Epigenetics
Conclusion: The important factor for the poorer outcome and gender differences in hypertensive patients with acute ischemic stroke is mainly due to stroke severity and thrombolysis may play a major role in neutralizing this effect.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Thomas I Nathaniel, Jordan Gainey, Leah Wormack, Chibueze Ubah, Leanne Brechtel, Amber Frazier Tags: Poster Abstract Presentations Source Type: research
Transcriptome-Wide Analysis Identifies Novel Associations With Blood PressureNovelty and Significance Genomics
Hypertension represents a major cardiovascular risk factor. The pathophysiology of increased blood pressure (BP) is not yet completely understood. Transcriptome profiling offers possibilities to uncover genetics effects on BP. Based on 2 populations including 2549 individuals, a meta-analyses of monocytic transcriptome-wide profiles were performed to identify transcripts associated with BP. Replication was performed in 2 independent studies of whole-blood transcriptome data including 1990 individuals. For identified candidate genes, a direct link between long-term changes in BP and gene expression over time and by treatmen...
Source: Hypertension - September 13, 2017 Category: Cardiology Authors: Tanȷa Zeller, Claudia Schurmann, Katharina Schramm, Christian Muller, Soonil Kwon, Philipp S. Wild, Alexander Teumer, David Herrington, Arne Schillert, Licia Iacoviello, Adelheid Kratzer, Annika Jagodzinski, Mahir Karakas, Jingzhong Ding, Johannes Tags: Cardiovascular Disease, Gene Expression & Regulation, Genetic, Association Studies, Hypertension Original Articles Source Type: research
Vitamin D, Hypertension, and Ischemic Stroke Editorial Commentary
Source: Hypertension - August 9, 2017 Category: Cardiology Authors: Ronen Levi-Vardi, Yoram Yagil Tags: Epidemiology, Genetic, Association Studies, High Blood Pressure, Ischemic Stroke Editorial Commentaries Source Type: research
Vitamin D, Hypertension, and Ischemic Stroke in 116 655 Individuals From the General PopulationNovelty and Significance Epidemiology/Population
Observational studies indicate that low concentrations of plasma 25-hydroxyvitamin D (25(OH)D) are associated with high blood pressure, hypertension, and ischemic stroke. However, whether these associations are causal remain unknown. A total of 116 655 white individuals of Danish descent from the general population were genotyped for genetic variants in DHCR7 and CYP2R1 affecting plasma 25(OH)D concentrations; 35 517 had plasma 25(OH)D measurements. Primary outcomes were blood pressure, hypertension, and ischemic stroke. Median follow-up for incident ischemic stroke was 9.3 years (range, 1 day–33.6 years). DHCR7/CYP2R1 a...
Source: Hypertension - August 9, 2017 Category: Cardiology Authors: Shoaib Afzal, Borge G. Nordestgaard Tags: Risk Factors, Genetic, Association Studies, High Blood Pressure, Hypertension Original Articles Source Type: research
Blood Pressure Trajectories and the Risk of Intracerebral Hemorrhage and Cerebral InfarctionNovelty and Significance Epidemiology/Population
The association between long-term blood pressure (BP) patterns in community-dwelling adults and risk of intracerebral hemorrhage and cerebral infarction is not well characterized. This prospective study included 79 385 participants, free of stroke, myocardial infarction, and cancer in or before 2010 (baseline). Systolic BP trajectories were identified using latent mixture modeling with data from 2006, 2008, and 2010. Incident cases of intracerebral hemorrhage and cerebral infarction occurred during 2010 to 2014, confirmed by review of medical records, by 3 physicians. We identified 5 distinct systolic BP trajectories durin...
Source: Hypertension - August 9, 2017 Category: Cardiology Authors: Weijuan Li, Cheng Jin, Anand Vaidya, Yuntao Wu, Kathryn Rexrode, Xiaoming Zheng, Mahmut E. Gurol, Chaoran Ma, Shouling Wu, Xiang Gao Tags: Cardiovascular Disease, Epidemiology, High Blood Pressure Original Articles Source Type: research
Aortic Arch Pulse Wave Velocity Assessed by Magnetic Resonance Imaging as a Predictor of Incident Cardiovascular EventsNovelty and Significance Arterial Stiffness
The predictive value of aortic arch pulse wave velocity (PWV) assessed by magnetic resonance imaging for cardiovascular disease (CVD) events has not been fully established. The aim of the present study was to evaluate the association of arch PWV with incident CVD events in MESA (Multi-Ethnic Study of Atherosclerosis). Aortic arch PWV was measured using magnetic resonance imaging at baseline in 3527 MESA participants (mean age, 62±10 years at baseline; 47% men) free of overt CVD. Cox regression was used to evaluate the risk of incident CVD (coronary heart disease, stroke, transient ischemic attack, or heart failure) in rel...
Source: Hypertension - August 9, 2017 Category: Cardiology Authors: Yoshiaki Ohyama, Bharath Ambale-Venkatesh, Chikara Noda, Jang-Young Kim, Yutaka Tanami, Gisela Teixido-Tura, Atul R. Chugh, Alban Redheuil, Chia-Ying Liu, Colin O. Wu, W. Gregory Hundley, David A. Bluemke, Eliseo Guallar, Joao A.C. Lima Tags: Epidemiology, Magnetic Resonance Imaging (MRI) Original Articles Source Type: research
Genetic Interference With Endothelial PPAR–{gamma} (Peroxisome Proliferator–Activated Receptor–{gamma}) Augments Effects of Angiotensin II While Impairing Responses to Angiotensin 1–7Novelty and Significance Renin-Angiotensin System
Pharmacological activation of PPAR-γ (peroxisome proliferator–activated receptor-γ) protects the vasculature. Much less is known on the cell-specific impact of PPAR-γ when driven by endogenous ligands. Recently, we found that endothelial PPAR-γ protects against angiotensin II–induced endothelial dysfunction. Here, we explored that concept further examining whether effects were sex dependent along with underlying mechanisms. We studied mice expressing a human dominant–negative mutation in PPAR-γ driven by the endothelial-specific vascular cadherin promoter (E-V290M), using nontransgenic littermates as controls. A...
Source: Hypertension - August 9, 2017 Category: Cardiology Authors: T. Michael De Silva, Chunyan Hu, Dale A. Kinzenbaw, Mary L. Modrick, Curt D. Sigmund, Frank M. Faraci Tags: Cerebrovascular Disease/Stroke, Vascular Disease Original Articles Source Type: research
