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Source: Hypertension
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Total 263 results found since Jan 2013.
High Salt Intake: Independent Risk Factor for Obesity? Salt Intake
High salt intake is the major cause of raised blood pressure and accordingly leads to cardiovascular diseases. Recently, it has been shown that high salt intake is associated with an increased risk of obesity through sugar-sweetened beverage consumption. Increasing evidence also suggests a direct link. Our study aimed to determine whether there was a direct association between salt intake and obesity independent of energy intake. We analyzed the data from the rolling cross-sectional study–the UK National Diet and Nutrition Survey 2008/2009 to 2011/2012. We included 458 children (52% boys; age, 10±4 years) and ...
Source: Hypertension - September 9, 2015 Category: Cardiology Authors: Ma, Y., He, F. J., MacGregor, G. A. Tags: Cerebrovascular disease/stroke, Other hypertension Salt Intake Source Type: research
Rho-Associated Kinase Activity Is an Independent Predictor of Cardiovascular Events in Acute Coronary Syndrome Acute Coronary Syndrome
Rho-associated kinases play an important role in a variety of cellular functions. Although Rho-associated kinase activity has been shown to be an independent predictor for future cardiovascular events in a general population, there is no information on Rho-associated kinase activity in patients with acute coronary syndrome. We evaluated leukocyte Rho-associated kinase activity by Western blot analysis in 73 patients with acute coronary syndrome and 73 age- and gender-matched control subjects. Rho-associated kinase activity within 2 hours of acute coronary syndrome onset was higher in patients with acute coronary syndrome t...
Source: Hypertension - September 9, 2015 Category: Cardiology Authors: Kajikawa, M., Noma, K., Nakashima, A., Maruhashi, T., Iwamoto, Y., Matsumoto, T., Iwamoto, A., Oda, N., Hidaka, T., Kihara, Y., Aibara, Y., Chayama, K., Sasaki, S., Kato, M., Dote, K., Goto, C., Liao, J. K., Higashi, Y. Tags: Risk Factors, Other arteriosclerosis Acute Coronary Syndrome Source Type: research
Pathological Effects of Obstructive Apneas During the Sleep Cycle in an Animal Model of Cerebral Small Vessel Disease Obstructive Sleep Apnea
We tested the hypothesis that apneas during the sleep cycle exacerbate hypertension and accelerate changes that occur with cerebral small vessel disease. Obstructive sleep apnea was modeled by intermittent inflations of a chronically implanted tracheal balloon to occlude the airway during the sleep cycle (termed OSA) in spontaneously hypertensive stroke-prone (SHRSP) rats, a model of cerebral small vessel disease. SHRSP rats and their parent strain, Wistar Kyoto (WKY) rats, were exposed to OSA for 2 weeks (from 9 to 11 or from 18 to 20 weeks). At 9 weeks, hypertension was developing in the SHRSP rats and was firmly establi...
Source: Hypertension - September 9, 2015 Category: Cardiology Authors: Lloyd, E. E., Durgan, D. J., Martini, S. R., Bryan, R. M. Tags: Animal models of human disease, Hypertension - basic studies Obstructive Sleep Apnea Source Type: research
Ethnicity: New Challenge for Cardiovascular Prevention in Europe Editorial Commentaries
Source: Hypertension - August 12, 2015 Category: Cardiology Authors: Modesti, P. A. Tags: Other hypertension, Other Stroke Treatment - Medical Editorial Commentaries Source Type: research
Neuron-Specific Tumor Necrosis Factor Receptor-Associated Factor 3 and Acute Ischemic Stroke Editorial Commentaries
Source: Hypertension - August 12, 2015 Category: Cardiology Authors: Ojeda, N. B. Tags: Other hypertension, Neuroprotectors Editorial Commentaries Source Type: research
Ethnic Differences in Associations Between Blood Pressure and Stroke in South Asian and European Men Epidemiology/Population
We report findings from a UK cohort study of 1375 European and 1074 South Asian men, not receiving antihypertensive medication, aged 40 to 69 years at baseline (1988–1991). Assessment included BP, blood tests, anthropometry, and questionnaires. Incident stroke was established at 20 years from death certification, hospital and primary care records, and participant report. South Asians had higher systolic BP, diastolic BP, and mean arterial pressure than Europeans, and similar pulse pressure. Associations between systolic BP or diastolic BP and stroke were stronger in South Asians than Europeans, after adjustment for a...
Source: Hypertension - August 12, 2015 Category: Cardiology Authors: Eastwood, S. V., Tillin, T., Chaturvedi, N., Hughes, A. D. Tags: Cerebrovascular disease/stroke, Risk Factors, Epidemiology Epidemiology/Population Source Type: research
Use of Nonsteroidal Anti-Inflammatory Drugs and Risk of Chronic Kidney Disease in Subjects With Hypertension: Nationwide Longitudinal Cohort Study Kidney
Limited studies have examined the effects of nonsteroidal anti-inflammatory drug (NSAID) use on the risk of chronic kidney disease (CKD), especially in subjects with hypertension. Using National Health Insurance claims data in Taiwan, we conducted a propensity score–matched cohort study to investigate the relationship between NSAID use and CKD in subjects with hypertension. A total of 31976 subjects were included in this study: subjects not taking any NSAIDs in 2007 (n=10782); subjects taking NSAIDs for 1 to 89 days in 2007 (n=10605); and subjects taking NSAIDs for ≥90 days in 2007 (n=10589). We performed multivar...
Source: Hypertension - August 12, 2015 Category: Cardiology Authors: Hsu, C.-C., Wang, H., Hsu, Y.-H., Chuang, S.-Y., Huang, Y.-W., Chang, Y.-K., Liu, J.-S., Hsiung, C. A., Tsai, H.-J. Tags: Clinical Studies Kidney Source Type: research
Neuron-Specific Tumor Necrosis Factor Receptor-Associated Factor 3 Is a Central Regulator of Neuronal Death in Acute Ischemic Stroke Nervous System
Neuronal death after ischemic stroke involves multiple pathophysiological events, as well as a complex molecular mechanism. Inhibiting a single therapeutic target that is involved in several ischemic signaling cascades may be a promising strategy for stroke management. Here, we report the versatile biological roles of tumor necrosis factor receptor–associated factor 3 (TRAF3) in ischemic stroke. Using several genetically manipulated mouse strains, we also demonstrated that TRAF3 inhibition can be neuroprotective. TRAF3 expression, which is robustly induced in response to ischemia/reperfusion (I/R) injury, was detecte...
Source: Hypertension - August 12, 2015 Category: Cardiology Authors: Gong, J., Li, Z.-Z., Guo, S., Zhang, X.-J., Zhang, P., Zhao, G.-N., Gao, L., Zhang, Y., Zheng, A., Zhang, X.-F., Xiang, M., Li, H. Tags: Apoptosis, Ischemic biology - basic studies, Acute Cerebral Infarction, Oxidant stress Nervous System Source Type: research
Short-Term Blood Pressure Variability Relates to the Presence of Subclinical Brain Small Vessel Disease in Primary Hypertension Cerebral Small Vessel Disease
Blood pressure (BP) variability is associated with stroke risk, but less is known about subclinical cerebral small vessel disease (CSVD). We aimed to determine whether CSVD relates to short-term BP variability independently of BP levels and also, whether they improve CSVD discrimination beyond clinical variables and office BP levels. This was a cohort study on asymptomatic hypertensives who underwent brain magnetic resonance imaging and 24-hour ambulatory BP monitoring. Office and average 24-hour, daytime and nighttime BP levels, and several metrics of BP variability (SD, weighted SD, coefficient of variation, and average ...
Source: Hypertension - August 12, 2015 Category: Cardiology Authors: Filomena, J., Riba-Llena, I., Vinyoles, E., Tovar, J. L., Mundet, X., Castane, X., Vilar, A., Lopez-Rueda, A., Jimenez-Balado, J., Cartanya, A., Montaner, J., Delgado, P., on behalf of ISSYS Investigators Tags: Clinical Studies, Cerebral Lacunes Cerebral Small Vessel Disease Source Type: research
Amino-Terminal Pro-B-Type Natriuretic Peptide Improves Discrimination for Incident Atherosclerotic Cardiovascular Disease Beyond Ambulatory Blood Pressure in Elderly Men NT-proBNP and Cardiovascular Risk
Improvement of risk prediction for atherosclerotic cardiovascular disease (ASCVD) is needed. Both ambulatory blood pressure (ABP) and biomarkers amino-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein and cystatin C improve risk prediction but they have not been evaluated in relation to each other. We analyzed whether NT-proBNP, high-sensitivity C-reactive protein, or cystatin C improved risk prediction beyond traditional ASCVD risk factors combined with 24-hour systolic BP (SBP). Secondary aim was to evaluate whether ABP improved risk prediction when compared with models with the bio...
Source: Hypertension - August 12, 2015 Category: Cardiology Authors: Skoglund, P. H., Hoijer, J., Arnlov, J., Zethelius, B., Svensson, P. Tags: Risk Factors NT-proBNP and Cardiovascular Risk Source Type: research
Metabolomic Identification of a Novel Pathway of Blood Pressure Regulation Involving Hexadecanedioate Metabolomics
High blood pressure is a major contributor to the global burden of disease and discovering novel causal pathways of blood pressure regulation has been challenging. We tested blood pressure associations with 280 fasting blood metabolites in 3980 TwinsUK females. Survival analysis for all-cause mortality was performed on significant independent metabolites (P<8.9x10–5). Replication was conducted in 2 independent cohorts KORA (n=1494) and Hertfordshire (n=1515). Three independent animal experiments were performed to establish causality: (1) blood pressure change after increasing circulating metabolite levels in Wista...
Source: Hypertension - July 8, 2015 Category: Cardiology Authors: Menni, C., Graham, D., Kastenmuller, G., Alharbi, N. H. J., Alsanosi, S. M., McBride, M., Mangino, M., Titcombe, P., Shin, S.-Y., Psatha, M., Geisendorfer, T., Huber, A., Peters, A., Wang-Sattler, R., Xu, T., Brosnan, M. J., Trimmer, J., Reichel, C., Mohn Tags: Clinical Studies Metabolomics Source Type: research
Higher Blood Pressure as a Risk Factor for Diseases Other Than Stroke and Ischemic Heart Disease Brief Reviews
Source: Hypertension - July 8, 2015 Category: Cardiology Authors: Kokubo, Y., Iwashima, Y. Tags: Other hypertension Brief Reviews Source Type: research
Pressure Changes Within the Sac of Human Cerebral Aneurysms in Response to Artificially Induced Transient Increases in Systemic Blood Pressure Brain
We examined the effects of controlled increases in blood pressure on different pressure parameters inside the sac of human cerebral aneurysms and corresponding parent arteries using invasive technology. Twelve patients (10 female, 2 male, age 54±15 years) with unruptured cerebral aneurysms undergoing endovascular coiling were recruited. Dual-sensor microwires with the capacity to simultaneously measure flow velocity and pressure were used to measure systolic, diastolic, and mean pressure inside the aneurysm sac and to measure both pressures and flow velocities in the feeder vessel just outside the aneurysm. These pr...
Source: Hypertension - July 8, 2015 Category: Cardiology Authors: Hasan, D. M., Hindman, B. J., Todd, M. M. Tags: Cerebrovascular disease/stroke, Clinical Studies Brain Source Type: research
Circulating Vascular Cell Adhesion Molecule-1 Is Associated With Cerebral Blood Flow Dysregulation, Mobility Impairment, and Falls in Older Adults Endothelium
Soluble vascular cell adhesion molecule-1 (sVCAM-1) is associated with hypertension, vascular inflammation, and systemic endothelial dysfunction. We evaluated whether elevated plasma sVCAM-1 is associated with impaired cerebrovascular function and mobility impairments in elderly people. We studied the cross-sectional relationships between plasma sVCAM-1 level, gait speed, and cerebrovascular hemodynamics, and its longitudinal relationship with falls in 680 community-dwelling participants aged ≥65 years in the Maintenance of Balance, Independent Living, Intellect, and Zest in the Elderly (MOBILIZE) Boston Study. Falls we...
Source: Hypertension - July 8, 2015 Category: Cardiology Authors: Tchalla, A. E., Wellenius, G. A., Travison, T. G., Gagnon, M., Iloputaife, I., Dantoine, T., Sorond, F. A., Lipsitz, L. A. Tags: Cerebrovascular disease/stroke, Pathophysiology Endothelium Source Type: research
Stages in Discovery: Angiotensin-Converting Enzyme Type 2 and Stroke Editorial Commentaries
Source: Hypertension - June 10, 2015 Category: Cardiology Authors: Pena-Silva, R. A., Heistad, D. D. Tags: ACE/Angiotension receptors, Cerebrovascular disease/stroke, Other hypertension, Acute Cerebral Infarction, Neuroprotectors Editorial Commentaries Source Type: research
