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Source: Hypertension

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Total 263 results found since Jan 2013.

High Blood Pressure After Acute Ischemic Stroke Is Associated With Poor Clinical Outcomes: Fukuoka Stroke Registry Stroke and Blood Pressure
The relationship between the poststroke blood pressure (BP) and functional outcomes in patients with acute ischemic stroke is still controversial. The aim of the present study was to elucidate the impact of the poststroke BP on the clinical outcomes of acute ischemic stroke. Among the patients in the Fukuoka Stroke Registry, 1874 patients with first-ever acute ischemic stroke (within 24 hours of onset) who had been functionally independent before onset were prospectively enrolled in the present study. The poststroke BP levels were defined as the average values during the 48 hours after onset. The study outcomes were a good...
Source: Hypertension - December 11, 2013 Category: Cardiology Authors: Ishitsuka, K., Kamouchi, M., Hata, J., Fukuda, K., Matsuo, R., Kuroda, J., Ago, T., Kuwashiro, T., Sugimori, H., Nakane, H., Kitazono, T., on behalf of the FSR Investigators Tags: Stroke and Blood Pressure Source Type: research

Association Between Ambulatory Systolic Blood Pressure During the Day and Asymptomatic Intracranial Arterial Stenosis Cerebrovascular Atherosclerosis
In conclusion, the present study showed a significant association between early morning SBP and asymptomatic ICAS in patients with hypertension after accounting for conventional cardiovascular risk factors. Our findings highlight the importance of morning SBP as a cardiovascular risk factor and should be validated in prospective studies.
Source: Hypertension - December 11, 2013 Category: Cardiology Authors: Chen, C.-T., Li, Y., Zhang, J., Wang, Y., Ling, H.-W., Chen, K.-M., Gao, P.-J., Zhu, D.-L. Tags: Cerebrovascular disease/stroke, Angiography, Risk Factors for Stroke Cerebrovascular Atherosclerosis Source Type: research

Williams Syndrome Predisposes to Vascular Stiffness Modified by Antihypertensive Use and Copy Number Changes in NCF1 Vascular Stiffness
Williams syndrome is caused by the deletion of 26 to 28 genes, including elastin, on human chromosome 7. Elastin insufficiency leads to the cardiovascular hallmarks of this condition, namely focal stenosis and hypertension. Extrapolation from the Eln+/– mouse suggests that affected people may also have stiff vasculature, a risk factor for stroke, myocardial infarction, and cardiac death. NCF1, one of the variably deleted Williams genes, is a component of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex and is involved in the generation of oxidative stress, making it an interesting candidate mod...
Source: Hypertension - December 11, 2013 Category: Cardiology Authors: Kozel, B. A., Danback, J. R., Waxler, J. L., Knutsen, R. H., de las Fuentes, L., Reusz, G. S., Kis, E., Bhatt, A. B., Pober, B. R. Tags: Clinical genetics, Other Vascular biology Vascular Stiffness Source Type: research

Abstract 208: Augmented Cerebrovascular Responses to Diazoxide, an Opener of MitokAtp Channels, Following Middle Cerebral Artery (MCA) Occlusion in Rats Poster Session I
Previous research has not examined the effects of ischemia on cerebral vascular responses to mitochondrial activation in experimental strokes caused by occlusion of the MCA (MCAO). We investigated the role and mechanisms of mitochondrial derived vasoreactivity in the MCA of male SD rats following 90 min ischemia/48 h reperfusion injury. Ischemia was induced ipsilaterally (I) and the contralateral (C) side was non-ischemic. Electron microscopy showed disrupted mitochondrial morphology on the I side. Western blots for expression of mitochondrial proteins (Mean±SEM of immunoband intensity normalized to β-actin and...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Rutkai, I., Dutta, S., Liu, D., Katakam, P. V., Busija, D. W. Tags: Poster Session I Source Type: research

Abstract 522: HEALS Program Implementation in African American Churches for Hypertension Control and Prevention Poster Session II
Conclusion: If successful, the findings from this study will provide much-needed information on the translation and sustainability of evidence-based lifestyle modification in HTN members in community-based settings, particularly within churches, which represent the most influential institution in the community lives of AA
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Dodani, S., Arora, S., Mahin, C., Butterfield, R. Tags: Poster Session II Source Type: research

Abstract 241: Splenic T Regulatory Lymphocytes Are Reduced in Genetically Hypertensive Rats Associated with Central Sympathoexcitation Poster Session I
Conclusion: Our findings indicate that splenic Tregs are reduced in SHRSP at both prehypertensive and established hypertensive stages. These alterations may contribute to the development and maintenance of hypertension. Central sympathoinhibition increases the reduced splenic Tregs in SHRSP suggesting interaction between sympathetic hyperactivity and Tregs.
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Katsuki, M., Hirooka, Y., Kishi, T., Sunagawa, K. Tags: Poster Session I Source Type: research

Abstract 567: Combined Treatment With Irbesartan and Vitamin D Retards Renal Injury in Salt-loaded Uni-nephrectomized Stroke-prone Spontaneously Hypertensive Rats Poster Session II
Vitamin D diminishes renin expression. In addition, we previously reported that vitamin D increased renal expression of klotho in rats with normal kidney function. In the present study, effects of vitamin D on renal injury was assessed in four groups of rats (n=6-8 for each group); uni-nephrectomized stroke-prone spontaneously hypertensive rats fed high salt (6%) diet as a control (C), those treated with irbesartan (100 mg/kg/day) (I), rats treated with calcitriol (30 ng/kg/day) (V), and rats treated with both irbesartan and calcitriol (I+V). Six weeks later, rats were killed with over-anesthesia, and harvested right kidne...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Takenaka, T., Inoue, T., Ohno, Y., Miyazaki, T., Nishiyama, A., Ishii, N., Suzuki, H. Tags: Poster Session II Source Type: research

Abstract 614: Premenopausal Women May Not Be Protected Against Early Vascular Disease In The Presence Of Diabetes. Poster Session II
CONCLUSION: In our population, diabetic women after age 40 should be considered at possibly high risk of cardiovascular events compared with a non-diabetic group. Direct assessment of atherosclerotic burden, such as TPA, should be used early in this population, even in the presence of menstrual cycles, instead of relying on traditional risk scores.
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Garcia, N. H., Perez, H. A., Spence, J. D., Armando, L. J. Tags: Poster Session II Source Type: research

Abstract 615: Progression Of Atherosclerosis Plaque Area In Postmenopausal Women During Controlled Traditional Risk Factors Poster Session II
Conclusion, these results indicate that in the presence of controlled traditional risk factors, atherosclerosis may progress in some patients, including in menopausal women. Additional promoters of atherosclerosis should be evaluated in these progressive patients or possibly more intensive treatment should be used in such patients.
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Perez, H. A., Garcia, N. H., Spence, J. D., Armando, L. J. Tags: Poster Session II Source Type: research

Abstract 616: The Population Impact and Cost-Effectiveness of Blood Pressure Treatment in U.S. Adults Age 75 and Older Poster Session II
Conclusions: Treatment of systolic blood pressure to a target of 140 mmHg would prevent the most cardiovascular events and result in the greatest QALYs gained. The presence of side effects, polypharmacy-related cognitive impairment, fractures, or frailty could substantially offset this benefit. Treatment strategies that are tailored to the health status of older adults are warranted.
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Odden, M. C., Coxson, P., Moran, A., Guzman, D., Goldman, L., Bibbins-Domingo, K. Tags: Poster Session II Source Type: research

Abstract 620: Angiotensin AT2 Receptor Exerts an Anti-inflammatory Response in Lipopolysaccharide-activated THP-1 Macrophages Poster Session II
In conclusion, AT2R stimulation may potentially suppress the inflammatory response of macrophages to LPS by shifting the balance from pro- to anti-inflammatory cytokine production and may prove to be beneficial in the control of the inflammatory component of stroke and hypertension.
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Dhande, I. S., Hussain, T. Tags: Poster Session II Source Type: research

Abstract 5: Intrarenal Responses to Angiotensin I and Angiotensin (1-7) in the Stroke-Prone Spontaneously Hypertensive Rat Are Y Chromosome Dependent Oral Session I: Concurrent A Angiotensin Action and Signaling
This study provides novel evidence that the Y chromosome influences the vasodilatory arm of the RAS and intrarenal vascular function.
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Sampson, A. K., Andrews, K. L., Graham, D., McBride, M. W., Chin-Dusting, J. P., Dominiczak, A., Jennings, G. L. Tags: Oral Session I: Concurrent A Angiotensin Action and Signaling Source Type: research

Abstract 351: Mineralocorticoid Receptor Antagonism During the Development of Hypertension Improves Cerebral Artery Endothelium Dependent Dilation Even After Treatment Withdrawal Poster Session II
Hypertension causes cerebral artery remodeling and increases the risk of stroke. Renin angiotensin system blockade during the development of hypertension has therapeutic effects even after treatment withdrawal. Mineralocorticoid receptor (MR) activation has been implicated in artery remodeling and impaired endothelial function. The possibility that there is a critical therapeutic window for MR antagonism has not been investigated. We hypothesized that temporary MR antagonism while hypertension develops would improve endothelium dependent dilation even after treatment withdrawal. Six-week-old male stroke prone spontaneously...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: McClain, J. L., Dorrance, A. M. Tags: Poster Session II Source Type: research

Abstract 364: Maternal History of Hypertension and Incident Atrial Fibrillation According to Blood Pressure Category in a General Urban Population: The Suita Study Poster Session II
Conclusions: A maternal history of hypertension is a predictor of incident AF. For persons with a maternal history of hypertension, BP control would be under normal BP for AF prevention.
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Kokubo, Y., Watanbe, M., Kobayashi, T., Kamakura, S., Kawanishi, K., Miyamoto, Y. Tags: Poster Session II Source Type: research

Abstract 70: Eplerenone Increases Dilation and the Diameter of Cerebral Penetrating Arterioles in Rats with Sustained Hypertension Oral Session IX: Concurrent A Aldosterone, Its Receptors and Other Hormones
Hypertension is linked to dementia in humans, as well as remodeling and dysfunction in large cerebral arteries. The effects of hypertension on cerebral microvessels, such as penetrating arterioles (PenA), are still unknown. These arterioles are the bottlenecks bridging the pial circulation to the deep parenchymal microcirculation, and they are vital for neurovascular coupling and functional hyperemia. Mineralocorticoid receptor (MR) antagonism reverses hypertension-induced changes in large cerebral arteries. Thus, we hypothesized that MR antagonism will improve PenA dilation and structure in adult rats with sustained hyper...
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Pires, P. W., Jackson, W. F., Dorrance, A. M. Tags: Oral Session IX: Concurrent A Aldosterone, Its Receptors and Other Hormones Source Type: research