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Condition: Osteoporosis

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Total 356 results found since Jan 2013.

Osteoporosis drug may benefit heart health
(Wiley) The osteoporosis drug alendronate was linked with a reduced risk of cardiovascular death, heart attack, and stroke in a Journal of Bone and Mineral Research study of patients with hip fractures.
Source: EurekAlert! - Medicine and Health - May 11, 2018 Category: International Medicine & Public Health Source Type: news

Depression Has Spiked By 33% In the Last Five Years, a New Report Says
Diagnoses of clinical depression — also known as major depression — have risen by 33% since 2013, according to a new report from health insurer Blue Cross Blue Shield. The report, which was based on insurance claims filed by 41 million privately insured Blue Cross Blue Shield members, calls depression the “second most impactful condition on overall health for commercially insured Americans,” behind only high blood pressure. That’s because people with depression also tend to have other health issues, such as chronic illnesses and substance abuse, and as a result may have more significant health...
Source: TIME: Health - May 10, 2018 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized healthytime Mental Health/Psychology onetime Source Type: news

The Relationship Between Bone Mineral Density and Cardiovascular Function in Duchenne Muscular Dystrophy: A Retrospective Cohort Study
In this study, we explored the relationship between BMD and cardiovascular health, and observed no association between BMD and LVEF. The primary results were in the opposite direction than the hypothesized direction, with the model beta coefficient for BMD indicating a negative relationship with LVEF; however, the size of the effect BMD had on LVEF was very small and not statistically significant. The secondary linear regression analyses provided consistent results with the primary linear regression, indicating that the primary results are sensitive to a variety of slightly modified conditions. It is possible that the nul...
Source: PLOS Currents Muscular Dystrophy - March 22, 2018 Category: Neurology Authors: Tara Anne Kervin Source Type: research

Progression of diabetes, heart disease, and stroke multimorbidity in middle-aged women: A 20-year cohort study
ConclusionsStroke was associated with increased risk of progression to diabetes or heart disease. Social inequality, obesity, hypertension, physical inactivity, smoking, or having other chronic conditions were also significantly associated with increased odds of accumulating multimorbidity. Our findings highlight the importance of awareness of the role of diabetes, heart disease, and stroke multimorbidity among middle-aged women for clinicians and health-promotion agencies.
Source: PLoS Medicine - March 13, 2018 Category: Internal Medicine Authors: Xiaolin Xu Source Type: research

S-adenosylhomocysteine hydrolase over-expression does not alter S-adenosylmethionine or S-adenosylhomocysteine levels in CBS deficient mice
Publication date: June 2018 Source:Molecular Genetics and Metabolism Reports, Volume 15 Author(s): Hyung-Ok Lee, Liqun Wang, Yin-Ming Kuo, Andrew J. Andrews, Sapna Gupta, Warren D. Kruger Elevated plasma total homocysteine (tHcy) is associated with a number of human diseases including coronary artery disease, stroke, osteoporosis and dementia. It is highly correlated with intracellular S-adenosylhomocysteine (SAH). Since SAH is a strong inhibitor of methyl-transfer reactions involving the methyl-donor S-adenosylmethionine (SAM), elevation in SAH could be an explanation for the wide association of tHcy and human disease. H...
Source: Molecular Genetics and Metabolism Reports - February 27, 2018 Category: Genetics & Stem Cells Source Type: research

Association Between Glucocorticoid Exposure and Healthcare Expenditures for Potential Glucocorticoid-related Adverse Events in Patients with Rheumatoid Arthritis.
CONCLUSION: Chronic exposure to low to medium doses of OGC was associated with significantly increased risk of potential OGC-related AE in patients with RA, and greater cumulative OGC dose was associated with substantially higher AE-related healthcare expenditures among patients with AE. PMID: 29335343 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - January 18, 2018 Category: Rheumatology Tags: J Rheumatol Source Type: research

Anti ‐inflammaging effects of human alpha‐1 antitrypsin
Summary Inflammaging plays an important role in most age‐related diseases. However, the mechanism of inflammaging is largely unknown, and therapeutic control of inflammaging is challenging. Human alpha‐1 antitrypsin (hAAT) has immune‐regulatory, anti‐inflammatory, and cytoprotective properties as demonstrated in several disease models including type 1 diabetes, arthritis, lupus, osteoporosis, and stroke. To test the potential anti‐inflammaging effect of hAAT, we generated transgenic Drosophila lines expressing hAAT. Surprisingly, the lifespan of hAAT‐expressing lines was significantly longer than that of geneti...
Source: Aging Cell - October 1, 2017 Category: Cytology Authors: Ye Yuan, Benedetto DiCiaccio, Ying Li, Ahmed S. Elshikha, Denis Titov, Brian Brenner, Lee Seifer, Hope Pan, Nurdina Karic, Mohammad A. Akbar, Yuanqing Lu, Sihong Song, Lei Zhou Tags: Original Article Source Type: research

The impact of long-term systemic glucocorticoid use in severe asthma: A UK retrospective cohort analysis.
CONCLUSIONS: Most patients with severe asthma are exposed to SGC, which increases SGC-related AE risk. This suggests that SGC exposure should be minimized as recommended by asthma treatment guidelines. PMID: 28925768 [PubMed - as supplied by publisher]
Source: Journal of Asthma - September 20, 2017 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Acromegaly at diagnosis in 3173 patients from the Liege Acromegaly Survey (LAS) Database
In conclusion, this study of >3100 patients is the largest international acromegaly database and shows clinically relevant trends in the characteristics of acromegaly at diagnosis.
Source: Endocrine-Related Cancer - August 22, 2017 Category: Endocrinology Authors: Petrossians, P., Daly, A. F., Natchev, E., Maione, L., Blijdorp, K., Sahnoun-Fathallah, M., Auriemma, R., Diallo, A. M., Hulting, A.-L., Ferone, D., Hana, V., Filipponi, S., Sievers, C., Nogueira, C., Fajardo-Montanana, C., Carvalho, D., Hana, V., Stalla, Tags: Research Source Type: research

The 2017 hormone therapy position statement of The North American Menopause Society
Abstract: The 2017 Hormone Therapy Position Statement of The North American Menopause Society (NAMS) updates the 2012 Hormone Therapy Position Statement of The North American Menopause Society and identifies future research needs. An Advisory Panel of clinicians and researchers expert in the field of women's health and menopause was recruited by NAMS to review the 2012 Position Statement, evaluate new literature, assess the evidence, and reach consensus on recommendations, using the level of evidence to identify the strength of recommendations and the quality of the evidence. The Panel's recommendations were reviewed and a...
Source: Menopause - June 27, 2017 Category: OBGYN Tags: Position Statement Source Type: research

Predictors of near-term fracture in osteoporotic women aged ≥65 years, based on data from the study of osteoporotic fractures
ConclusionsSeveral clinical characteristics predictive of hip and non-vertebral fracture within a 1-year follow-up period among elderly women with osteoporosis were identified, and a subset of those for hip fracture was incorporated into a risk assessment tool. Assessment of these risk factors may help guide osteoporosis treatment choices by identifying patients in whom there is urgency to treat. Additional research is needed to validate the findings of this study and the accuracy of the risk assessment tool.
Source: Osteoporosis International - June 7, 2017 Category: Orthopaedics Source Type: research

Review finds no link between dairy and heart attack or stroke risk
Conclusion This large meta-analysis of cohort studies demonstrated no increased risk to cardiovascular disease, coronary heart disease or all-cause death from eating dairy products. The review has strengths in its large size and the fact it was able to analyse different types of dairy product, such as high and low-fat and everyday products such as cheese and yoghurt. However, there are a number of factors to consider: The results of a systematic review are only as good as the quality of the underlying studies. These are all observational studies and it's possible that unadjusted health and lifestyle factors are having an...
Source: NHS News Feed - May 9, 2017 Category: Consumer Health News Tags: Food/diet Heart/lungs Neurology Source Type: news

Effects of weight training time on bone mineral density of patients with secondary osteoporosis after hemiplegia.
In conclusion, in order to stimulate BMD and reverse osteoporosis in patients with secondary osteoporosis after hemiplegia, daily weight training for minimum 60 and 90 min was needed for males and females, respectively. PMID: 28450926 [PubMed - in process]
Source: Experimental and Therapeutic Medicine - May 1, 2017 Category: Journals (General) Tags: Exp Ther Med Source Type: research

Exploring the Link Between Posttraumatic Stress Disorder and inflammation-Related Medical Conditions: An Epidemiological Examination
This study examined the relation between posttraumatic stress disorder (PTSD) and inflammation-related medical conditions using data from the 2013 –2014 New York City Health and Nutrition Examination Survey. Using a representative sample of 1,527 residents in New York City, the association between PTSD and 17 inflammation-related medical conditions were examined. Bivariate and multivariable analyses were conducted, adjusting for demographic characteristics and lifetime depression. PTSD was strongly associated with increased odds for hypercholesterolemia, insulin resistance, angina, heart attack, and emphysema with the gr...
Source: Psychiatric Quarterly - March 25, 2017 Category: Psychiatry Source Type: research

Postmenopausal hormone therapy and Alzheimer disease: A prospective cohort study
Conclusions: Our results do not provide strong evidence for a protective association between postmenopausal HT use and AD or dementia, although we observed a reduced AD risk among those with long-term self-reported HT use.
Source: Neurology - March 12, 2017 Category: Neurology Authors: Imtiaz, B., Tuppurainen, M., Rikkonen, T., Kivipelto, M., Soininen, H., Kröger, H., Tolppanen, A.-M. Tags: Alzheimer's disease, Cohort studies ARTICLE Source Type: research