Acromegaly at diagnosis in 3173 patients from the Liege Acromegaly Survey (LAS) Database
Acromegaly is a rare disorder caused by chronic growth hormone (GH) hypersecretion. While diagnostic and therapeutic methods have advanced, little information exists on trends in acromegaly characteristics over time. The Liège Acromegaly Survey (LAS) Database, a relational database, is designed to assess the profile of acromegaly patients at diagnosis and during long-term follow-up at multiple treatment centers. The following results were obtained at diagnosis. The study population consisted of 3173 acromegaly patients from ten countries; 54.5% were female. Males were significantly younger at diagnosis than females (43.5 vs 46.4 years; P
Effect of polyvalent immunoglobulins on the cytokine cascade in monocytes from colorectal cancer patients: Basis for a new adjuvant therapy . Int J Clin Pharmacol Ther. 2017 Dec 12;: Authors: Gasser M, Lissner R, Waaga-Gasser AM PMID: 29231166 [PubMed - as supplied by publisher]
CONCLUSION: The results suggest that the combination of lapatinib plus capecitabine can improve PFS and OS in patients with HER2-positive breast cancer that has progressed on trastuzumab. However, it appears that trastuzumab emtansine provides better treatment outcomes in this context. . PMID: 29231164 [PubMed - as supplied by publisher]
Linda van Eikenhorst, Katja Taxis, Liset van Dijk, Han de Gier
Conclusion: The overall melanoma detection rate in our free Skin Cancer Screening Program is comparable to those in European public activities. The costs of free screening programs compare favorably with the prevented potential therapeutic costs of late-stage melanoma. The low response rate of screenees agreeing to be followed up limits conclusions of this study.Dermatology
This study aimed to assess the effects of ZST93 on cell proliferation and its role in the chemosensitivity to gemcitabine in human pancreatic cancer cells. The effects of ZST93 on cancer cell proliferation, cell cycle distribution, apoptosis and autophagy were evaluated in various human pancreatic cancer cell lines, and the anti‐tumor effects of ZST93 alone and in combination with gemcitabine were identified in a xenograft mouse model. The results showed that ZST93 could inhibit the proliferation of pancreatic cancer cells and arrest cell cycle at G0/G1 phase by regulating the expression of Cyclin D1 and Cyclin A2. Moreo...
Date: Tuesday, 04 03, 2018; Speaker: Paul Bieniasz, Rockefeller University; Gordon Carmichael, University of Connecticut; Mariano Garcia-Blanco, University of Texas; Eva Gottwein, Northwestern University; Wei-Shau Hu, National Cancer Institute; Jianming Hu, Pennsylvania State University; Rozanne Sandri-Goldin, University of California, Irvine; Building: Building 45 (Natcher Building); E1/E2
Date: Monday, 04 09, 2018; Speaker: Bruno Amati, European Institute of Oncology; Jay Bradner, Novartis; Michael Cole, Dartmouth College; Chi Van Dang, Ludwig Institute for Cancer Research; Martin Eilers, University of Wurzburg; Robert Eisenman, Fred Hutch Cancer Research Center; Gerard Evan, Cambridge University; Dean Felsher, Stanford University; Carla Grandori, Cure First; Ross Hannon, John Curtin School of Medical Research; Marie Arsenian Henriksson, Karolinska Institutet; Laurence Hurley, University of Arizona; Raghu Kalluri, MD Anderson Cancer Center; Angela Koehler, Massachusetts Institute of Technology; Linda Penn, ...
HEART attack symptoms include chest pain, shortness of breath and lightheadedness. But, the life-threatening condition could be spotted early by this surprising sign.
Conclusion: Troxerutin preconditioning protected against myocardial I/R injury via the PI3K/Akt pathway.Cell Physiol Biochem 2017;44:1939 –1948
VASCULAR dementia symptoms include memory loss and mood changes. It is the second most common form of dementia after Alzheimer ’s disease. Signs, causes and whether stroke can bring on the condition.
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