Acromegaly at diagnosis in 3173 patients from the Liege Acromegaly Survey (LAS) Database

Acromegaly is a rare disorder caused by chronic growth hormone (GH) hypersecretion. While diagnostic and therapeutic methods have advanced, little information exists on trends in acromegaly characteristics over time. The Liège Acromegaly Survey (LAS) Database, a relational database, is designed to assess the profile of acromegaly patients at diagnosis and during long-term follow-up at multiple treatment centers. The following results were obtained at diagnosis. The study population consisted of 3173 acromegaly patients from ten countries; 54.5% were female. Males were significantly younger at diagnosis than females (43.5 vs 46.4 years; P
Source: Endocrine-Related Cancer - Category: Endocrinology Authors: Tags: Research Source Type: research

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Authors: Pellino G, Gallo G, Pallante P, Capasso R, De Stefano A, Maretto I, Malapelle U, Qiu S, Nikolaou S, Barina A, Clerico G, Reginelli A, Giuliani A, Sciaudone G, Kontovounisios C, Brunese L, Trompetto M, Selvaggi F Abstract Colorectal cancer (CRC) is the third leading cause of cancer-related deaths worldwide. It has been estimated that more than one-third of patients are diagnosed when CRC has already spread to the lymph nodes. One out of five patients is diagnosed with metastatic CRC. The stage of diagnosis influences treatment outcome and survival. Notwithstanding the recent advances in multidisciplinary ma...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Publication date: Available online 28 June 2018Source: Journal of Molecular LiquidsAuthor(s): Shokoh Najafi, Saeid Amani, Mohsen ShahlaeiAbstractGemcitabine hydrochloride is an established chemotherapeutic agent in several solid tumors. Along with its outstanding effects, Gemcitabine has some side effects, which may cause suffering to patients. Herein we developed, a novel but simple method for the selective and sensitive quantitative determination of Gemcitabine drug based upon measuring the fluorescence quenching of functionalized Au doped quantum dots (QDs) in biological samples. The TGA capped Au doped CdTe quantum dot...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Publication date: Available online 17 July 2018Source: Redox BiologyAuthor(s): Xiaoliang Jiang, Yunpeng Liu, Xing Liu, Wenjie Wang, Zihao Wang, Yongyan Hu, Yuanyuan Zhang, Yanrong Zhang, Pedro A. Jose, Qiang Wei, Zhiwei YangAbstractDilated cardiomyopathy (DCM) is a severe disorder caused by medications or genetic mutations. D5 dopamine receptor (D5R) gene knockout (D5-/-) mice have cardiac hypertrophy and high blood pressure. To investigate the role and mechanism by which the D5R regulates cardiac function, we generated cardiac-specific human D5R F173L(hD5F173L-TG) and cardiac-specific human D5R wild-type (hD5WT-TG) transg...
Source: Redox Biology - Category: Biology Source Type: research
Publication date: 1 September 2018Source: Life Sciences, Volume 208Author(s): Maria Florencia Albertoni Borghese, Sandra Hope, Maria del Carmen Ortiz, Magalí Barchuk, Camila Kessler, Carlos Davio, Marcelo Vatta, Mónica MajowiczAbstractAimsThe aim of the present study was to evaluate the regulation of Aquaporin-2 (AQP2) water channel in the kidney of one-kidney, one-clip rats (Goldblatt-1 model). In addition, some mechanisms that underlie the role of AQP2 in the Goldblatt-1 model were evaluated.Main methodsSprague-Dawley rats were divided in three groups: control two-kidney, no clip (C, 2 K-NC); nephrectomiz...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: 1 September 2018Source: Life Sciences, Volume 208Author(s): Cui Zhai, Wenhua Shi, Wei Feng, Yanting Zhu, Jian Wang, Shaojun Li, Xin Yan, Qingting Wang, Qianqian Zhang, Limin Chai, Cong Li, Pengtao Liu, Manxiang LiAbstractAimsIt has been shown that activation of autophagy is involved in the development of pulmonary arterial hypertension (PAH). Meanwhile, activation of nuclear factor-kappaB (NF-κB) has been found to induce autophagy in several types of human diseases including cancer and cardiac diseases. However, it is still unknown whether NF-κB mediates autophagy activation in PAH, and whethe...
Source: Life Sciences - Category: Biology Source Type: research
New York health officials are investigating after significant rates of leukemia, bladder, lung and thyroid cancers were found in three Long Island counties - 16 percent of all cases in New York state.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
SKIN cancer symptoms can be difficult to identify - even specialists can struggle to tell if a skin blemish is cancerous. So what signs should you be looking out for and when should you see your doctor?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
People who eat dinner before 9 p.m. -- or at least two hours before going to sleep -- have a 20% lower risk of breast and prostate cancer than those who eat after 10 p.m. or go to bed shortly after supper, researchers found.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 17 July 2018Source: Medicina Intensiva (English Edition)Author(s): M. Serrano-Dueñas, M.J. Rodriguez-Muñoz, M. Portilla-Botelho
Source: Medicina Intensiva - Category: Intensive Care Source Type: research
A longtime leader of the National Cancer Institute, he was known for his willingness to help anyone with a cancer diagnosis seeking advice or a referral.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Rabson, Dr. Alan Deaths (Obituaries) Cancer Research National Cancer Institute National Institutes of Health Kirschstein, Ruth Source Type: news
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