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World ’s tallest 12-year-old towers above at 7ft 5ins
Gabriel Gomes, from Brazil, suffers from gigantism, caused by a tumour of the pituitary gland. A documentary called Body Bizarre, airing on Thursday, follows the boy's journey. (Source: the Mail online | Health)
Source: the Mail online | Health - October 17, 2017 Category: Consumer Health News Source Type: news

Chiasma begins enrolment in Phase III trial for acromegaly
Chiasma has started patient enrolment in Phase III CHIASMA OPTIMAL clinical trial of its product candidate Mycapssa (octreotide capsules) as a maintenance therapy to treat adults with acromegaly. (Source: Drug Development Technology)
Source: Drug Development Technology - September 28, 2017 Category: Pharmaceuticals Source Type: news

Midatech files CTA for MTD201 ’s carcinoid cancer and acromegaly trial
UK-based specialist pharmaceutical firm Midatech Pharma has submitted a clinical trial application (CTA) for its drug candidate MTD201 to treat carcinoid cancer and acromegaly. (Source: Drug Development Technology)
Source: Drug Development Technology - September 4, 2017 Category: Pharmaceuticals Source Type: news

Chiasma and FDA agree on new Phase III trial design for acromegaly drug
The US Food and Drug Administration (FDA) has agreed on biopharmaceutical firm Chiasma ’s new Phase III clinical trial (OPTIMAL) design to evaluate its octreotide capsules product candidate Mycapssa as a maintenance therapy to treat adults with acrome… (Source: Drug Development Technology)
Source: Drug Development Technology - August 13, 2017 Category: Pharmaceuticals Source Type: news

Kent hairdresser with acromegaly could not stop growing
Lauren Bates, 26, from New Romney, Kent, was diagnosed with acromegaly. The rare condition was made famous by Richard Kiel, who played Jaws in The Spy Who Loved Me. (Source: the Mail online | Health)
Source: the Mail online | Health - July 18, 2017 Category: Consumer Health News Source Type: news

Kent hairdresser reveals her feet wouldn't stop growing
Lauren Bates, 26, from New Romney, Kent, was diagnosed with acromegaly. The rare condition was made famous by Richard Kiel, who played Jaws in The Spy Who Loved Me. (Source: the Mail online | Health)
Source: the Mail online | Health - July 18, 2017 Category: Consumer Health News Source Type: news

Celebrating 10 years of success for Infusion
As the business took off, more space was needed, and the company moved in 2009 to “real” office space just up the road in Haddam, CT, across the street from the Connecticut River, eventually employing a staff of 10 that year. A year later, in 2010, Infusion had doubled in size and became part of the UDG/Ashfield family. Infusion continued to grow at a steady pace into new therapeutic areas with more clients and employees, and in October 2016, Infusion left its country setting and moved into larger corporate offices in downtown Middletown, CT. Our staff now comprises 45 people and includes account executives, me...
Source: Ashfield Healthcare News - July 11, 2017 Category: Pharmaceuticals Authors: Sarah Edwards Tags: Ashfield Source Type: news

Ipsen wins approval for gastroenteropancreatic neuroendocrine tumor drug
Ipsen (EPA:IPN) said today that Teijin Pharma Ltd. won approval from the Japanese Ministry of Health, Labor and Welfare for Ipsen’s Somatuline as a therapy for gastroenteropancreatic neuroendocrine tumors. The subcutaneous drug was approved in Japan in 2012 for the treatment of acromegaly and pituitary gigantism. Get the full story at our sister site, Drug Delivery Business News. The post Ipsen wins approval for gastroenteropancreatic neuroendocrine tumor drug appeared first on MassDevice. (Source: Mass Device)
Source: Mass Device - July 3, 2017 Category: Medical Devices Authors: Sarah Faulkner Tags: Pharmaceuticals Regulatory/Compliance Wall Street Beat Ipsen Teijin Pharma Source Type: news

Impaired QoL in Patients With Treated Acromegaly Impaired QoL in Patients With Treated Acromegaly
Find out which factors may negatively impact quality of life among patients with treated and controlled acromegaly.Clinical Endocrinology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 30, 2017 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

Karachi father unable to get a job due to his giant hands
Ashraf-ud-din, 70, from Karachi, has suffered with the rare macrodactyly all of his life - a congenital form of gigantism. It has left him unable to get a job and has stopped him from gaining any skills. (Source: the Mail online | Health)
Source: the Mail online | Health - May 31, 2017 Category: Consumer Health News Source Type: news

Radiation Tx for Persistent Acromegaly Safe, Effective
(MedPage Today) -- Helped normalize IGF-1 levels after surgery failed (Source: MedPage Today Surgery)
Source: MedPage Today Surgery - May 4, 2017 Category: Surgery Source Type: news

Medical management for acromegaly offers hope for patients
In this video, Maria Fleseriu, MD, FACE, professor of medicine and neurological surgery at Oregon Health& Science University in Portland, discusses updates in the management of acromegaly.Healio (Source: Society for Endocrinology)
Source: Society for Endocrinology - April 7, 2017 Category: Endocrinology Source Type: news

Society partner Pfizer introduces 2017 ASPIRE Young Investigator Research Awards in Endocrinology
The mission of the 2017 Global ASPIRE Young Investigator Research Awards in Endocrinology is to advance the medical knowledge of the fundamental mechanisms of disease, mechanisms of action of current and potential future treatments, and to improve the care of patients with endocrine disorders.Pfizer invites junior investigators to apply for the 2017 Global ASPIRE Young Investigator Research Awards in Endocrinology from6 March 2017. Funding will be provided to research proposals that seek to explore translational or clinical research in the area of endocrine disease in children and young adults to address:Morbidity...
Source: Society for Endocrinology - March 20, 2017 Category: Endocrinology Source Type: news

Predictors of Quality of Life in Patients With Acromegaly Predictors of Quality of Life in Patients With Acromegaly
Certain factors may predict the impact of acromegaly on patient quality of life. What are they?Endocrine Practice (Source: Medscape Orthopaedics Headlines)
Source: Medscape Orthopaedics Headlines - March 15, 2017 Category: Orthopaedics Tags: Diabetes & Endocrinology Journal Article Source Type: news

Pachydermoperiostosis Masquerading as Acromegaly Pachydermoperiostosis Masquerading as Acromegaly
This case of pachydermoperiostosis highlights the differential diagnoses that should also be considered when acromegaly is suspected.Journal of the Endocrine Society (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 10, 2017 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

Make the Diagnosis: Unusual Adenoma
(MedPage Today) -- Case Findings: A 42-year-old male presents with a long history of headaches, impaired vision, and fatigue. He mentions that his wedding ring no longer fits, and he reports joint pain. On physical exam, he has swollen hands and feet, coarse facial features, and partial blindness (bitemporal hemianopsia). After diagnosis with acromegaly secondary to a pituitary macroadenoma, the patient is referred for surgery. However, the patient's IGF-1 concentrations remain elevated following a debulking procedure (the tumor location prevented full resection). What is the best next step for this patient? (Source: M...
Source: MedPage Today Cardiovascular - March 6, 2017 Category: Cardiology Source Type: news

Acromegaly tied to worsening heart structure and function
Adults with acromegaly are more likely to have subclinical atherosclerosis with structural and functional damage to the heart, according to findings published inEndocrine Practice.Healio (Source: Society for Endocrinology)
Source: Society for Endocrinology - February 13, 2017 Category: Endocrinology Source Type: news

Writer whose jaw expanded because of rare condition reveals how he could die at any minute
Up to 8,300 people in the UK, including Mike Scalise, have acromegaly - where the body produces too much growth hormone - but it often isn't diagnosed until patients are in their 40s. (Source: the Mail online | Health)
Source: the Mail online | Health - January 9, 2017 Category: Consumer Health News Source Type: news

Writer, 38, whose jaw expanded in size because of a rare condition made famous by a James Bond villain reveals how he could die at any minute from stress
Up to 8,300 people in the UK, including Mike Scalise, have acromegaly - where the body produces too much growth hormone - but it often isn't diagnosed until patients are in their 40s. (Source: the Mail online | Health)
Source: the Mail online | Health - January 9, 2017 Category: Consumer Health News Source Type: news

What are Potential Health Problems Associated with Polycystic Ovary Syndrome?
DiscussionPolycystic ovary syndrome (PCOS) affects 6-8% of reproductive-age women making it the most common endocrinopathy in this age group. There is no consensus on the specific diagnostic criteria for PCOS in adolescents as many of the characteristics overlap with normal adolescent physiology. However, patients should have evidence of hyperandrogenism, oligo- or amenorrhea, and potentially polycystic ovaries. PCOS has a genetic component although a specific gene has not been identified. Incidence of PCOS is 20-40% for a woman with a family history. Hyperandrogenism Androgen levels change during puberty therefore actual ...
Source: PediatricEducation.org - December 5, 2016 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

This Teen Is Almost 8 Feet Tall -- And Still Growing
At 7 feet 8 inches, Broc Brown definitely sticks out in a crowd, and he’s only going to get bigger. Brown’s family knew something was up at a young age: He was 5-foot-2 in kindergarten, according to his mother, Darci Elliot. “When he got into middle school he was around 6 feet tall, and by high school he was 7 feet tall,” Elliot told Barcroft TV. “It’s a genetic disorder and there’s nothing that can stop him from growing – I don’t know if he will ever stop.” Brown, 19, grows an astounding six inches a year because of a rare genetic disorder called S...
Source: Healthy Living - The Huffington Post - September 22, 2016 Category: Consumer Health News Source Type: news

What Causes Hyperphosphatemia?
Discussion Constipation is a common problem in general pediatrics and its causes are numerous. It can cause acute and recurrent abdominal pain and is a cause of abdominal distention. Patients who are young, whose presentations are other than routine or who had complications should be invested for underlying causes of their constipation. This patient had undergone some evaluations in the past for constipation but because of the presentation of sepsis a more rigorous evaluation was undertaken. The differential diagnoses of the following can be found here: constipation, acute abdominal pain, recurrent abdominal pain, and abdo...
Source: PediatricEducation.org - September 12, 2016 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Acromegaly FAQs
(Source: eMedicineHealth.com)
Source: eMedicineHealth.com - July 15, 2016 Category: Journals (General) Source Type: news

Understanding Acromegaly Medications
Acromegaly Medications (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - July 15, 2016 Category: Journals (General) Source Type: news

Camurus concludes Phase II trial of CAM2029 to treat NETs
Swedish-based pharmaceutical company Camurus has concluded the Phase II study of CAM2029 to treat acromegaly or neuroendocrine tumours (NETs). (Source: Drug Development Technology)
Source: Drug Development Technology - July 13, 2016 Category: Pharmaceuticals Source Type: news

Indian man with enormous 20kg arm is forced to leave his home
Bablu, who was forced to flee to Mumbai, suffers from local gigantism, which is the result of an over-productive growth hormone. His condition means he even struggles to hold a cup of water. (Source: the Mail online | Health)
Source: the Mail online | Health - May 25, 2016 Category: Consumer Health News Source Type: news

Radiosurgery in Patients With Acromegaly or Cushing DiseaseRadiosurgery in Patients With Acromegaly or Cushing Disease
A new study reports on the incidence of hypopituitarism after gamma knife radiosurgery in patients with acromegaly or Cushing's disease. Clinical Endocrinology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 10, 2016 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

FDA rejects Chiasma's drug to treat growth disorder
The U.S. Food and Drug Administration has rejected Chiasma Inc's experimental drug to treat adults with acromegaly, the company said on Friday. Reuters (Source: Society for Endocrinology)
Source: Society for Endocrinology - April 21, 2016 Category: Endocrinology Source Type: news

ACROSCORE: A New and Simple Tool for Diagnosing AcromegalyACROSCORE: A New and Simple Tool for Diagnosing Acromegaly
A novel scoring tool has been developed that may play an important role in the diagnosis of this rare disease. Clinical Endocrinology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 19, 2016 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

Your Dentist Is More Important to Your General Health Than You May Realize
Most people view their twice-yearly visits to the dentist as little more than a cleaning and a check-up. But in reality, those visits are much more important than you probably realize. That's because your dentist is looking inside your mouth for a lot more than cavities. Plenty of medical conditions -- including some alarming ones! -- manifest in the mouth, which is the part of your body your dentist knows the most about. In fact, it's possible that your dentist is able to alert you of a potentially serious condition long before you even think about going to a primary care doctor. Here's a list of some of the medical cond...
Source: Healthy Living - The Huffington Post - March 29, 2016 Category: Consumer Health News Source Type: news

Greeks Gone West: The Geneticist Helping To Treat 'Gigantism'
Constantine A. Stratakis - Greeks Gone West by HuffPost_Greece In the third episode of HuffPost Greece's video series 'Greeks Gone West,' we introduce Constantine A. Stratakis, M.D. D.Sc., a tenured investigator in the NICHD, who has been the head of the Section on Genetics and Endocrinology (SEGEN) since its inception in 1999. His work is focused on treating the rare condition of 'gigantism.' The research began with a family who came to the the U.S. National Institutes of Health for treatment for gigantism in the mid-1990s. In that family, the mother and two of her sons all had the condi...
Source: Science - The Huffington Post - October 16, 2015 Category: Science Source Type: news

How Big Could a World Record Pumpkin Get?
This article originally appeared on Inverse. By Ben Guarino Thanks to the efforts of Illinois farmer Gene McMullen, the North American record for the heaviest pumpkin now sits at 2,145 pounds. McMullen's Cucurbita Maxima Brobdingnag is the second greatest pumpkin the world has ever known, trailing only Beni Meier of Switzerland's monster fruit, which tipped the scales at 2,378 pounds in 2014. The most remarkable thing about these overachieving gourds is that their size is not singular: The weight of the massive pumpkin growth has been linear over the past few decades according to an analysis by University of Wisconsin-Mad...
Source: Science - The Huffington Post - October 2, 2015 Category: Science Source Type: news

Indian boy with giant hands from local gigantism gets life changing operation
Mohammad Kaleem, eight, from Jharkhand State, eastern India, was born with a form of giantism which has seen his hands and arms grow until they weighed a colossal two stone between them. (Source: the Mail online | Health)
Source: the Mail online | Health - August 10, 2015 Category: Consumer Health News Source Type: news

Why Were Dinosaurs So Big?
Why were dinosaurs so big?: originally appeared on Quora: The best answer to any question. Ask a question, get a great answer. Learn from experts and access insider knowledge. You can follow Quora on Twitter, Facebook, and Google+. Answer by Marc Srour, Invertebrate Paleontologist Image by MathKnight There is actually no uncontroversial explanation for the as-of-yet unparalleled size of dinosaurs. If you look at the distribution of large sizes in dinosaurs, one distinction becomes clear: the only dinos that were small (less than 1m) were carnivorous theropods. Except for the 70 cm Fruitadens Haagarorum, no herbivorous or...
Source: Science - The Huffington Post - July 7, 2015 Category: Science Source Type: news

Research Goal: 'No More Giants'Research Goal: 'No More Giants'
A gene linked to 'gigantism' may hold the key to identifying and treating babies who otherwise would grow extremely tall and have shortened life spans. Medscape Diabetes & Endocrinology (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - April 25, 2015 Category: Endocrinology Tags: Diabetes & Endocrinology Commentary Source Type: news

Funding for nurses wishing to attend ECE 2015
An educational programme for endocrine nurses has been arranged at ECE 2015 in Dublin. It includes a half-day pre-congress course on Acromegaly on Saturday 16 May and 3 dedicated nurse sessions as part of the ECE Programme on 17 and 18 May. There will also be opportunities for networking during catering breaks and poster presentations. An unrestricted educational grant which can fund up to 55 nurses with a €500 travel grant to attend the Acromegaly course and ECE meeting has been provided by pharmaceutical sponsors; these will be awarded on a first-come-first-serve basis. Please visit the&n...
Source: Society for Endocrinology - March 26, 2015 Category: Endocrinology Source Type: news

Chiasma Announces Completion of $70 Million Series E Financing
NEWTON, Mass. and JERUSALEM, Feb. 27, 2015 -- (Healthcare Sales & Marketing Network) -- Chiasma, Inc., a U.S. privately-held biopharma company developing octreotide capsules, its lead product for the orphan condition acromegaly, today announced the closin... Biopharmaceuticals, Venture CapitalChiasma, octreotide capsules, acromegaly (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - February 27, 2015 Category: Pharmaceuticals Source Type: news

Acromegaly Responds to Oral Drug in Trial (CME/CE)
(MedPage Today) -- Tradeoff between convenience and lower response rate versus injectable treatments. (Source: MedPage Today Endocrinology)
Source: MedPage Today Endocrinology - February 10, 2015 Category: Endocrinology Source Type: news

New Indications for Somatostatin Analogs
(MedPage Today) -- FDA okayed pasireotide for acromegaly and lanreotide for gastroenteropancreatic neuroendocrine tumors. (Source: MedPage Today Endocrinology)
Source: MedPage Today Endocrinology - December 19, 2014 Category: Endocrinology Source Type: news

FDA Okays Pasireotide (Signifor LAR) for AcromegalyFDA Okays Pasireotide (Signifor LAR) for Acromegaly
The long-acting somatostatin analog pasireotide has been approved for the additional indication of treatment of acromegaly in the US, for patients who don't respond well to surgery or first-line agents. FDA Approvals (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - December 17, 2014 Category: Endocrinology Tags: Diabetes & Endocrinology News Alert Source Type: news

Novartis receives FDA approval for Signifor LAR to treat acromegaly
Swiss drugmaker Novartis has received approval from US Food and Drug Administration (FDA) for its Signifor long-acting release LAR (pasireotide) for injectable suspension and intramuscular use to treat patients with acromegaly. (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - December 17, 2014 Category: Pharmaceuticals Source Type: news

Gene Discovery in Giants Could Shed Light on Human GrowthGene Discovery in Giants Could Shed Light on Human Growth
A duplication in a gene on the X chromosome is associated with an early-onset form of gigantism; the discovery is likely to shed light on how growth hormone is regulated, the researchers say. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 9, 2014 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

Genetic basis for gigantism identified
Researchers at the National Institutes of Health have found a duplication of a short stretch of the X chromosome in some people with a rare disorder that causes excessive childhood growth; their study was published this week in The New England Journal of Medicine. Medical Xpress (Source: Society for Endocrinology)
Source: Society for Endocrinology - December 9, 2014 Category: Endocrinology Source Type: news

This Week: CDC Says Severe Flu Season Possible
(MedPage Today) -- The CDC warns about the coming flu season, and researchers report on a possible cause of gigantism in children. (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - December 5, 2014 Category: American Health Source Type: news

Duplication of gene on X chromosome causes gigantism
Brooks HaysBETHESDA, Md., Dec. 4 (UPI) -- Researchers now believe gene duplication in a specific chromosome region, key in growth regulation, is responsible for the rare disorder known as gigantism. (Source: Health News - UPI.com)
Source: Health News - UPI.com - December 4, 2014 Category: Consumer Health News Source Type: news

Duplication Error May Make Giants
(MedPage Today) -- Novel mutation may underlie some cases of gigantism. (Source: MedPage Today Pediatrics)
Source: MedPage Today Pediatrics - December 4, 2014 Category: Pediatrics Source Type: news

NIH researchers link chromosome region to gigantism
Duplication of gene on X chromosome appears to cause excessive growth (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - December 4, 2014 Category: American Health Source Type: news

Scientists May Have Spotted Genetic Cause of 'Gigantism'
Title: Scientists May Have Spotted Genetic Cause of 'Gigantism'Category: Health NewsCreated: 12/3/2014 12:00:00 AMLast Editorial Review: 12/4/2014 12:00:00 AM (Source: MedicineNet Kids Health General)
Source: MedicineNet Kids Health General - December 4, 2014 Category: Pediatrics Source Type: news

Novartis received EU approval for drug that treats rare hormonal disorder
Novartis International has announced that it has received approval from the European Commission for its drug called Signifor to treat the rare hormonal disorder acromegaly. HNGN (Source: Society for Endocrinology)
Source: Society for Endocrinology - November 25, 2014 Category: Endocrinology Source Type: news