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Best Post of December 2016: Fibrous Bodies Nicely Demonstrated in a Smear from a Somatotroph Pituitary Adenoma
The next in our " Best of the Month Series " is from December 2, 2016:Christian Davidson, MDDr. Christian Davidson, director of neuropathology at the Robert Wood Johnson University Hospitalin New Jersey, provides today's blog post:A 30-year-old man presented with bitemporal hemianopsia and a 3.0 cm pituitary mass was discovered upon MRI. His IGF-1 was elevated to 900, but he had no signs of acromegaly. A smear of tissue sent for frozen section evaluation (see below) revealed that most cells had round, eosinophilic, perinuclear inclusions suggestive of fibrous bodies (some examples are circled). Dot-like...
Source: neuropathology blog - April 25, 2017 Category: Radiology Tags: Best of the Month series neoplasms pituitary Source Type: blogs

Guest Post: Fibrous Bodies Nicely Demonstrated in a Smear from a Somatotroph Pituitary Adenoma
Christian Davidson, MDDr. Christian Davidson, director of neuropathology at theRobert Wood Johnson University Hospital in New Jersey, provides today's blog post:A 30-year-old man presented with bitemporal hemianopsia and a 3.0 cm pituitary mass was discovered upon MRI. His IGF-1 was elevated to 900, but he had no signs of acromegaly. A smear of tissue sent for frozen section evaluation (see above below) revealed that most cells had round, eosinophilic, perinuclear inclusions suggestive of fibrous bodies (some examples are circled). Dot-like CAM5.2 immunostain (not shown) confirmed my smear-based diagnostic suspicion. ...
Source: neuropathology blog - December 2, 2016 Category: Radiology Tags: neoplasms pituitary Source Type: blogs

Funtabulously Frivolous Friday Five 167
Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 167 Question 1 What is Asturian leprosy? + Reveal the Funtabulous Answer expand(document.getElementById('ddet358938163'));expand(document.getElementById('ddetlink358938163')) Pellagra or vitamin B3 (niacin) deficiency as a result of a corn based diet (Noted in the Asturias community in Spain). In 1915, back when such practices were legal and under the Surgeon General’s sanction in the USA, Dr. Goldbe...
Source: Life in the Fast Lane - November 24, 2016 Category: Emergency Medicine Authors: Neil Long Tags: Frivolous Friday Five acromegaly Andre the giant as you wish Asturian leprosy bicyclists vulva brown sequard Jake leg OPIDN organophosphate induced delayed neuropathy Pellagra placebo vitamin B3 Source Type: blogs

MKSAP: 64-year-old woman with an incidental pituitary adenoma
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 64-year-old woman is seen for follow-up evaluation. Two weeks ago, she was in a car accident, and an incidental pituitary adenoma was found on a cervical spine CT scan. She has no residual injuries from the car accident. She is otherwise healthy and takes no medications. She went through menopause at age 51. She has night sweats two to three times per month and occasional hot flushes. These have improved over the past decade and are not bothersome. She is not sexually active. She has never taken hormon...
Source: Kevin, M.D. - Medical Weblog - September 17, 2016 Category: Journals (General) Authors: < a href="http://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Endocrinology Source Type: blogs

Best Post of July 2016 -- The signature feature of sparsely granulated growth hormone pituitary adenoma: the fibrous body
The next in our " Best of the Month " series is from July 19, 2016:The patient is a middle-aged female with subtle signs of acromegaly.Arrows point to the pale balls in this pituitary adenoma which correspond tofibrous bodies on CAM 5.2 immunohistochemistryThe signature feature of sparsely granulated GH adenomas is the finding of widespread, ball-like, cytoplasmic ‘fibrous bodies’ on CAM5.2 in>70% of cells.CAM 5.2 immunohistochemistry (Source: neuropathology blog)
Source: neuropathology blog - August 29, 2016 Category: Radiology Tags: Best of the Month series pituitary Source Type: blogs

The signature feature of sparsely granulated growth hormone pituitary adenoma: the fibrous body
The patient is a middle-aged female with subtle signs of acromegaly.Arrows point to the pale balls in this pituitary adenoma  which correspond tofibrous bodies on CAM 5.2 immunohistochemistryThe signature feature of sparsely granulated GH adenomas is the finding of widespread, ball-like, cytoplasmic ‘fibrous bodies’ on CAM5.2  in>70% of cells.CAM 5.2 immunohistochemistry (Source: neuropathology blog)
Source: neuropathology blog - July 19, 2016 Category: Radiology Tags: pituitary Source Type: blogs

Funtabulously Frivolous Friday Five 120
Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia…introducing Funtabulously Frivolous Friday Five 120 Question 1 What rheumatological condition does Rembrandt’s Scholar have? + Reveal the Funtabulous Answer expand(document.getElementById('ddet1210722826'));expand(document.getElementById('ddetlink1210722826')) Scleroderma He has a pinched nose, tight mouth, pale face with a malar flush, his hands are puffy and the joints on his right thumbs are swollen. Could this be Scleroderma? [Reference] Question 2 When Ra...
Source: Life in the Fast Lane - October 9, 2015 Category: Emergency Medicine Authors: Neil Long Tags: Frivolous Friday Five collapse dentist FFFF hands Kluver-bucy syndrome melanoma pleural collapse rachmaninoff rachmaninov Rembrandt scleroderma TB teeth temporal lobe Source Type: blogs

Symptoms of Unknown Origin – The Prevalence of False Diagnosis of Disease
This study only raises the question, “How common is the error of assigning a false diagnosis of a disease?” The literature is surprisingly silent on the prevalence of false diagnoses. I can find only one dated study of the prevalence of false diagnoses in a population. In 1967, Berman and Stamm studied over 100 children in the Seattle school system that carried a diagnosis of heart disease. (2.) Rounding off the figures, only 20 percent were found to have heart disease on careful study. Eighty percent did not have heart disease. The most telling finding was the presence of severe psychological and physical disa...
Source: The Health Care Blog - September 16, 2015 Category: Consumer Health News Authors: John Irvine Tags: THCB Source Type: blogs

The Story of the Dying Doctor Who Saved a Patient’s Life
By TERRY BENNETT, MD I have mentioned that in the past, often at times of great duress in my life, often in the midst of cacophony, some window in time and space opens, if only for a moment, but the moment becomes a moment of grace, and, in that moment,  an extraordinary medical feat has been granted to me.  I have no explanation for any of this, I admit freely that I “hear voices”, voices that others do not hear. I cannot complain about a gift, this gift, weird as it may sound to others This year,  while sick as a dog from the cancer chemotherapy I was receiving for the metastatic cancer that I ...
Source: The Health Care Blog - September 8, 2015 Category: Consumer Health News Authors: John Irvine Tags: THCB Source Type: blogs

An Introduction to IGF-1 in Aging
Of the many proteins and signaling pathways shown to influence the pace of aging, insulin-like growth factor 1 (IGF-1) is perhaps the most studied: The really fun thing about discussing signaling networks (the inputs that let cells make decisions based on their environment) in aging is the wide range of ways that these pathways exert their influence. They take inputs (nutrition, hormones, toxic molecules) and use their existing programming (epigenetic state) to make decisions. Components that control one process, such as regulating body size, can play roles in completely different processes. Today, I'll discuss an example...
Source: Fight Aging! - April 8, 2015 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Top stories in health and medicine, December 5, 2014
From MedPage Today: Duplication Error May Make Giants. A duplication in a short stretch of the X chromosome may be responsible for a specific type of gigantism seen in children. Lab Work Moves More Quickly to Clinical Setting. A second investigational drug in the isocitrate dehydrogenase (IDH) inhibitor class has demonstrated activity in acute myeloid leukemia (AML). ICH Outcome Better with Early Rehab. Starting rehabilitation within 48 hours of an intracerebral hemorrhage was associated with improved survival and functional outcomes at 6 months. Unnecessary Chest X-Rays on Kids Common. Too many pediatric chest X-ray...
Source: Kevin, M.D. - Medical Weblog - December 5, 2014 Category: Journals (General) Authors: Tags: News Endocrinology Neurology Pediatrics Radiology Source Type: blogs

Carcinoid Tumor
Carcinoid tumor is a type of neuroendocrine tumor Pathophysiology 1) contains and may secrete physiologically active substances 2) occurs in GI tract (appendix, rectum, small bowel, stomach), thymus, lung, ovary, and testes 3) produces “local” symptoms, systemic but non-carcinoid syndrome symptoms, and systemic carcinoid syndrome symptoms Signs and Symptoms of Carcinoid Tumor Local Symptoms 1) appendix – usually asymptomatic and found incidentally on appendectomy 2) small intestine – obstruction, episodic abdominal pain, bleeding 3) rectum – bleeding, constipation, and diarrhea 4) stomach/thym...
Source: Inside Surgery - November 18, 2013 Category: Surgeons Authors: Editor Tags: Oncology 5-HIAA appendix flushing GI metastases motilin serotonin Source Type: blogs

Top stories in health and medicine, October 14, 2013
From MedPage Today: Fluid Strategies for Hypovolemic Shock Equal. For fluid resuscitation in the intensive care unit (ICU), colloid solutions didn’t definitively boost survival compared with crystalloids. Peanut Butter Alzheimer’s Test Not Passing the Sniff Test. Could a scoop of peanut butter and a ruler become that elusive test? Pot a Common Remedy to Ease Back Pain. Use of marijuana to ease back pain was common among patients at a university spine clinic in Colorado where pot has been legal for medical purposes since 2000, but most of the users did not have a prescription. Growth Disorder Tx Has Room f...
Source: Kevin, M.D. - Medical Weblog - October 14, 2013 Category: Family Physicians Tags: News Endocrinology Neurology orthopedics Source Type: blogs