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Obstructive sleep apnea characteristics in patients with well-controlled acromegaly and their compliance with positive airway pressure therapy
Conclusion: Our results confirm OSAS as a common disorder in acromegaly patients as well as PAP therapy being required for a majority of patients. Therefore, all acromegaly patients should be assessed in terms of OSAS and be followed closely for the evaluation of PAP adherence. PMID: 29151303 [PubMed] (Source: Turkish Journal of Medical Sciences)
Source: Turkish Journal of Medical Sciences - November 22, 2017 Category: General Medicine Tags: Turk J Med Sci Source Type: research

Postoperative Gamma Knife radiosurgery for cavernous sinus-invading growth hormone-secreting pituitary adenomas
We aimed to determine the long-term effects of Gamma knife radiosurgery (GKS) on remnants in the cavernous sinus (CS) after transsphenoidal surgery (TSS) for acromegaly and to identify its possible adverse effects. (Source: World Neurosurgery)
Source: World Neurosurgery - November 16, 2017 Category: Neurosurgery Authors: Eui Hyun Kim, Min Chul Oh, Jong Hee Chang, Ju Hyung Moon, Cheol Ryong Ku, Won-Seok Chang, Eun Jig Lee, Sun Ho Kim Tags: Original article Source Type: research

A case of piezogenic pedal papules in a man with acromegaly
Endocrine Practice, Ahead of Print. (Source: Endocrine Practice)
Source: Endocrine Practice - November 16, 2017 Category: Endocrinology Authors: Kenyon C. Bolton Matthew P. Gilbert Source Type: research

Cardiomyopathy in acromegaly and the effect of trans-sphenoidal surgery
Subhash Yadav, Eesh BhatiaNeurology India 2017 65(6):1223-1224 (Source: Neurology India)
Source: Neurology India - November 10, 2017 Category: Neurology Authors: Subhash Yadav Eesh Bhatia Source Type: research

Echocardiographic improvements following transsphenoidal surgery for acromegaly
Antonio Ribeiro-Oliveira, Márta Korbonits, Claudia M V FreireNeurology India 2017 65(6):1225-1226 (Source: Neurology India)
Source: Neurology India - November 10, 2017 Category: Neurology Authors: Antonio Ribeiro-Oliveira M & #225;rta Korbonits Claudia M V Freire Source Type: research

Impact of transsphenoidal surgery on asymptomatic cardiomyopathy in patients with acromegaly. A single-blinded study
Conclusion: Reduction in growth hormone levels and insulin-like growth factor type 1 can decrease the LVM and LVMI, which directly or indirectly contributes to the improvement in diastolic as well as systolic function and probably mortality. (Source: Neurology India)
Source: Neurology India - November 10, 2017 Category: Neurology Authors: Anirudh Srinivasan Ajay Bahl Hemant Bhagat Pinaki Dutta Ashutosh Rai Jagtar S Devgun Rupinder Kaur Kanchan Kumar Mukherjee Source Type: research

Long-term safety of long-acting octreotide in patients with diabetic retinopathy: results of pooled data from 2 randomized, double-blind, placebo-controlled phase 3 studies
ConclusionsThe results from these long-term placebo-controlled studies confirm the established safety profile of long-acting OCT, in particular low risk of cardiac, hepatic and renal toxicity in a high-risk population. (Source: Endocrine)
Source: Endocrine - November 7, 2017 Category: Endocrinology Source Type: research

Has acromegaly been diagnosed earlier?
Conclusion Regarding operated cases of GH-producing pituitary adenoma, acromegaly clinical manifestations tended to be milder at diagnosis in later years of the decade, and acromegaly was diagnosed at lower IGF-1 levels and in smaller lesions. Further study is mandatory for the generalization of this trend. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - November 4, 2017 Category: Neuroscience Source Type: research

Trends in surgery, hospital admissions and imaging for pituitary adenomas in Australia
AbstractPurposeThere is a paucity of epidemiological information on treatment and imaging of pituitary adenomas in Australia.MethodsAustralian data on pituitary surgery, hospital admissions for pituitary adenomas, and pituitary imaging on patients 15 years and over were obtained from administrative databases between 2000/2001 and 2014/2015. Changes over time and by age and sex were assessed.ResultsIn 2014/15 there were 37.7 pituitary procedures/million population, corresponding to a 35.4% (p 
Source: Endocrine - November 4, 2017 Category: Endocrinology Source Type: research

Colonoscopy examination requires a longer time in patients with acromegaly than in other individuals.
In conclusion, although cecal intubation during colonoscopy was successful in all participants, it required a longer time in patients with acromegaly. Our results underscore the importance of and certain technical difficulties involved in colonoscopy procedures in patients with acromegaly, especially in older patients. PMID: 29081443 [PubMed - as supplied by publisher] (Source: Endocrine Journal)
Source: Endocrine Journal - November 1, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

How to improve effectiveness of pegvisomant treatment in acromegalic patients
ConclusionsPEGV effectiveness improves when up titration is appropriate. Higher PEGV doses at start and a more rapid up-titration are necessary in patients with obesity and/or IGF-1  >  2.7 × ULN. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - October 28, 2017 Category: Endocrinology Source Type: research

Double pituitary adenomas associated with persistent trigeminal artery: a rare case report and the review of literature
We present a quite unique case of double pituitary adenomas associated with persistent trigeminal artery (PTA) treated by endoscopic surgery. To the best of our knowledge, this is the first report in the literature. A 64-year-old woman was referred to our hospital for suspicion of acromegaly. Preoperative magnetic resonance imaging revealed two separate intrasellar masses with intrasellar vascular structure. Right cerebral angiography showed medial-type PTA. The patient underwent endoscopic transsphenoidal surgery and both tumors were resected completely. Postoperative immunohistopathologic examination revealed two histolo...
Source: Neurosurgical Review - October 27, 2017 Category: Neurosurgery Source Type: research

Co-Occurrence of Acromegaly and Hematological Disorders: A Myth or Common Pathogenic Mechanism
Conclusion: In this review, we aim to provide evidence for the correlation between the two disorders.Integr Med Int 2017;4:94-100 (Source: Integrative Medicine International)
Source: Integrative Medicine International - October 25, 2017 Category: Complementary Medicine Source Type: research

Microsurgical therapy of pituitary adenomas
ConclusionsIn experienced hands, transsphenoidal microsurgery for PAs achieves remission in most patients with a low complication rate. Pituitary function is preserved in most cases and can recover in more than one-third of patients with preoperative hypopituitarism. (Source: Endocrine)
Source: Endocrine - October 24, 2017 Category: Endocrinology Source Type: research

The assessment of total antioxidant capacity and superoxide dismutase levels, and the possible role of manganese superoxide dismutase polymorphism in acromegaly.
In this study, we aimed to investigate the effect of acromegaly on superoxide dismutase (SOD) and total antioxidant capacity (TAC) levels, and the possible influence of human manganese superoxide dismutase (MnSOD) polymorphism on these levels. 51 acromegaly patients and 57 age and sex matched healthy subjects were recruited to the study in Bezmialem Vakif University Hospital between 2011 and 2014. The median SOD and TAC levels were 42.7 (33-60) pg/mL and 1,313.7 (155-1,902) μM in acromegaly; and 46.3 (38-95) pg/mL and 1,607.3 (195-1,981) μM in healthy subjects (p
Source: Endocrine Journal - October 20, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Transsphenoidal Surgery for Pituitary Tumors and Other Sellar Masses
Transsphenoidal surgery is an option for dogs and cats with functional and nonfunctional pituitary masses or other sellar and parasellar masses. An adrenocorticotropic hormone –secreting tumor causing Cushing disease is the most common clinically relevant pituitary tumor in dogs, and the most common pituitary tumor seen in cats is a growth hormone–secreting tumor causing acromegaly. Transsphenoidal surgery can lead to rapid resolution of clinical signs and provide a c ure for these patients. Because of the risks associated with this surgery, it should only be attempted by a cohesive pituitary surgery group with...
Source: Veterinary Clinics of North America: Small Animal Practice - October 20, 2017 Category: Veterinary Research Authors: Tina J. Owen, Linda G. Martin, Annie V. Chen Source Type: research

Clinical profile of silent growth hormone pituitary adenomas; higher recurrence rate compared to silent gonadotroph pituitary tumors, a large single center experience
ConclusionThis is the largest single center study characterizing SGHA behavior with SGA and SCA control groups in a cohort of surgically resected pituitary adenomas. SGHA present mostly in young females, and should be closely followed due to their higher likelihood of recurrence and potential of progression to clinical acromegaly. We propose that a complete hormonal staining panel be routinely performed for all pituitary adenomas. (Source: Endocrine)
Source: Endocrine - October 17, 2017 Category: Endocrinology Source Type: research

[Familial isolated pituitary adenomas (FIPA). Case report of four families and review of literature.]
CONCLUSIONS: Familial isolated pituitary adenomas are more common than it was previously thought, therefore, specific questioning regarding family history should be a part of the workup of all patients with pituitary adenomas. Genetically induced pituitary tumors often have aggressive behavior in terms of tumor expansion and resistance to different treatment options and often involve a multidisciplinary approach that combines endocrine, neurosurgical, and radiological specialists. PMID: 29022641 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - October 12, 2017 Category: Endocrinology Authors: Malicka JE, Świrska J, Kurowska M, Dudzińska M, Tarach JS Tags: Endokrynol Pol Source Type: research

Diagnosis and treatment of TSH-secreting adenomas: review of a longtime experience in a reference center
ConclusionIn spite of its relatively straightforward diagnosis, which includes clinical/subclinical hyperthyroidism with or without goiter, increased free thyroxine and nonsuppressed TSH levels, and pituitary mass, the diagnosis of TSH-secreting and cosecreting adenomas was frequently unrecognized and thus much delayed. Serum alpha-subunit levels were high in nearly all patients with TSH-secreting adenomas and useful in excluding other conditions in the differential diagnosis. Proper indication and interpretation of simple laboratory tests should be emphasized in medical education to improve diagnostic accuracy. (Source: J...
Source: Journal of Endocrinological Investigation - October 11, 2017 Category: Endocrinology Source Type: research

Left ventricular twist is impaired in acromegaly: Insights from the three ‐dimensional speckle tracking echocardiographic MAGYAR‐Path Study
Abstract IntroductionAcromegaly is a rare, chronic, disfiguring, and debilitating disease caused, in 90% of cases, by a benign monoclonal growth hormone–secreting pituitary adenoma. The present study aimed to assess left ventricular (LV) rotational and twist mechanics in acromegalic patients and to compare their results to age‐ and gender‐matched healthy controls. MethodsThe present study comprised 24 acromegalic patients, from which 4 were excluded due to insufficient image quality (mean age: 57.8 ± 13.7 years, 7 men). The control group consisted of 18 age‐ and gender‐matched healthy ind...
Source: Journal of Clinical Ultrasound - October 9, 2017 Category: Radiology Authors: Árpád Kormányos, Péter Domsik, Anita Kalapos, Andrea Orosz, Csaba Lengyel, Zsuzsanna Valkusz, Attila Trencsányi, Tamás Forster, Attila Nemes Tags: RESEARCH ARTICLE Source Type: research

Medical Treatments for Acromegaly: Systematic Review and Network Meta-Analysis
To evaluate the safety and efficacy of medical treatments used in acromegaly. (Source: Value in Health)
Source: Value in Health - October 1, 2017 Category: International Medicine & Public Health Authors: LP Leonart, VL Ferreira, FS Tonin, R Pontarolo Source Type: research

Cost-Effectiveness Analysis of Second-Line Pharmacological Treatments of Acromegaly In Spain
To estimate the cost-effectiveness of second line pharmacological treatments in patients with acromegaly resistant to somatostatin analogues (SSA) from the perspective of the Spanish National Health System (NHS). (Source: Value in Health)
Source: Value in Health - October 1, 2017 Category: International Medicine & Public Health Authors: C Peral, F Cordido, V Gimeno, L Sanchez-Cenizo, N Mir, J Parrondo Source Type: research

Burden Of Diabetes Mellitus In Patients With Acromegaly Treated With Second-Line Pharmacotherapy In Spain
To evaluate the burden of diabetes mellitus (DM) in adult patients with acromegaly treated with second-line pharmacotherapy, from the perspective of the Spanish National Health System (NHS). (Source: Value in Health)
Source: Value in Health - October 1, 2017 Category: International Medicine & Public Health Authors: C Peral, L Sanchez-Cenizo, N Mir, J Aller, J Martinez Sesmero, C Rubio-Terres, D Rubio-Rodriguez Source Type: research

Mapping Acroqol Scores to EQ-5D to Obtain Utility Values for Patients with Acromegaly
Estimate a preference-based single index for disease specific instrument (AcroQOL) by mapping it onto the EQ-5D for future economic evaluations. (Source: Value in Health)
Source: Value in Health - October 1, 2017 Category: International Medicine & Public Health Authors: X Badia, N Biermasz, J Tiemensma, A Carreno, M Roset, A Forsythe Source Type: research

One-Center Analysis of Cost Associated With Acromegaly Management In Poland
Acromegaly is a rare disease caused by growth hormone (GH) hypersecretion from pituitary adenoma. Peripheral action of GH is mediated by insulin-like growth factor-1 (IGF-1), and results in acral overgrowth and metabolic complications. Acromegaly and its treatment is associated with high direct and indirect costs, caused by the necessity of life-long treatment of hormonal normalisation and systemic disturbances management. The aim of our study was to assess the costs of medical care of patients with acromegaly in real life setting in one academic centre in Wroclaw. (Source: Value in Health)
Source: Value in Health - October 1, 2017 Category: International Medicine & Public Health Authors: M Elbaum Source Type: research

The efficacy of medical treatment in patients with acromegaly in clinical practice.
Authors: Young Lee S, Hee Kim J, Hyun Lee J, Hwy Kim Y, Jin Cha H, Wan Kim S, Ha Paek S, Soo Shin C Abstract Although somatostatin analogues (SSAs) are recommended as the first-line medical therapy for acromegaly, dopamine agonists (DAs) are also a therapeutic option for treatment. We aimed to assess and compare the efficacies of DAs and SSAs in treating acromegaly in clinical practice. We included 89 patients with acromegaly who took DAs (bromocriptine [BCT], n = 63; cabergoline [CAB], n = 11) or SSAs (n = 15) as a primary medical therapy for more than 3 months in the Seoul National University Hospital. The CAB (4...
Source: Endocrine Journal - September 23, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

AIP and the somatostatin system in pituitary tumours
Classic somatostatin analogues aimed at somatostatin receptor type 2, such as octreotide and lanreotide, represent the mainstay of medical treatment for acromegaly. These agents have the potential to decrease hormone secretion and reduce tumour size. Patients with a germline mutation in the aryl hydrocarbon receptor-interacting protein gene, AIP, develop young-onset acromegaly, poorly responsive to pharmacological therapy. In this review, we summarise the most recent studies on AIP-related pituitary adenomas, paying special attention to the causes of somatostatin resistance; the somatostatin receptor profile including type...
Source: Journal of Endocrinology - September 22, 2017 Category: Endocrinology Authors: Ibanez-Costa, A., Korbonits, M. Tags: Review Source Type: research

Guidelines versus real life practice: the case of colonoscopy in acromegaly
AbstractPurposeThe aim of this study is to investigate guideline application and colonoscopy findings in real-life practice in acromegaly.MethodsWe conducted a retrospective observational non-interventional and cross-sectional analysis on 146 patients with acromegaly (ACRO) referred to our clinic. We evaluated colonoscopy data, focusing on the correlation between colonoscopy findings and hormonal/metabolic values.ResultsThe total number of colonoscopies performed in ACRO patients increased from 6 in the period 1990 –1994 to 57 in the period 2010–2014. Colonoscopy procedures were performed according to guideline...
Source: Pituitary - September 21, 2017 Category: Endocrinology Source Type: research

[The mouth of patients with acromegaly].
Abstract Orofacial changes are frequent in acromegaly. Their evolution is slowly progressive. The lips (everted and thickened), the mandibular morphology (prognathism), the tongue (macroglossia), the soft palate and the uvula (increased and thickened), the parodontis (gingival hyperplasia, paradontitis), the teeth (increased interdental spaces, hypercementosis, increased dental mobility, multiple tooth loss) are concerned. Functional consequences are significant (obstructive sleep apnea syndrome, malocclusion, pain of the oral maxillofacial area, decrease of the quality of life). They are rarely noticed as the fir...
Source: Presse Medicale - September 21, 2017 Category: General Medicine Authors: Cortet-Rudelli C Tags: Presse Med Source Type: research

Fibroblast Growth Factor 21 in Patients with Acromegaly
Conclusions FGF-21 levels were similar in patients with acromegaly compared to controls. However, our results indicate that FGF-21 may have a potential role in the development of acromegaly complications. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - September 20, 2017 Category: Endocrinology Authors: Halupczok- Żyła, Jowita Jawiarczyk-Przyby łowska, Aleksandra Skrzypski, Marek Strowski, Mathias Z. Bolanowski, Marek Tags: Article Source Type: research

Diabetic ketoacidosis in acromegaly; a rare complication precipitated by corticosteroid use
Insulin resistance and the development of diabetes mellitus is a common complication of acromegaly. Prevalence of type 2 diabetes in acromegaly varies from 19 to 56% depending on the case series [1]. In acromegaly, high levels of growth hormone and subsequent stimulation of insulin-like growth factor 1 synthesis contribute to peripheral insulin resistance and the development of diabetes [2]. Although absolute insulin levels may be normal or high, the presence of severe insulin resistance may predispose to diabetic ketoacidosis. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 18, 2017 Category: Endocrinology Authors: Jeremy Weiss, Anna J. Wood, Jeffrey D. Zajac, Mathis Grossmann, Sofianos Andrikopoulos, Elif I Ekinci Source Type: research

Body composition and ectopic lipid changes with biochemical control of acromegaly.
Conclusions: Acromegaly is characterized by insulin resistance and hyperinsulinemia but lower IHL, compared to age-, BMI- and sex-matched healthy controls. Biochemical control of acromegaly improves insulin resistance but leads to a less favorable anthropometric phenotype with increased IHL, abdominal adiposity and decreased muscle mass. PMID: 28945897 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - September 18, 2017 Category: Endocrinology Authors: Bredella MA, Schorr M, Dichtel LE, Gerweck AV, Young BJ, Woodmansee WW, Swearingen B, Miller KK Tags: J Clin Endocrinol Metab Source Type: research

Association between FTO gene polymorphisms and HDL cholesterol concentration may cause higher risk of cardiovascular disease in patients with acromegaly
ConclusionThe risk-allele frequencies of studied polymorphisms in acromegaly were higher than in general European population. There is an association betweenFTO gene polymorphisms and HDL cholesterol concentration, suggestingFTO gene polymorphisms may be associated with higher CVD risk in patients with acromegaly. (Source: Pituitary)
Source: Pituitary - September 14, 2017 Category: Endocrinology Source Type: research

Acromegaly, genetic variants of the aryl hydrocarbon receptor pathway and environmental burden
Publication date: 5 December 2017 Source:Molecular and Cellular Endocrinology, Volume 457 Author(s): S. Cannavo, F. Trimarchi, F. Ferraù Increasing evidence suggests that environmental contaminants can exert endocrine disruptors activities and that pollution exposition can have a role in tumorigenic processes. Several environmental pollutants have been shown to affect pituitary cells biology and function. The aryl hydrocarbon receptor (AHR) pathway is involved in xenobiotics' metabolism and in tumorigenesis. A deregulation of the AHR pathway could have a role in pituitary tumours' pathophysiology, especially in the...
Source: Molecular and Cellular Endocrinology - September 14, 2017 Category: Endocrinology Source Type: research

Acromegaly and Cushing's syndrome caused by a neuroendocrine tumor arising within a sacrococcygeal teratoma
Key Clinical Message A 60‐year‐old man with a pre‐existing stable sacrococcygeal teratoma developed acromegaly, ectopic Cushing's syndrome, and 5HIAA secretion. To our knowledge, this represents the first reported case of ACTH and serotonin secretion, and likely GHRH or GH cosecretion, from a sacrococcygeal teratoma in an adult. A 60‐year‐old man with a pre‐existing stable sacrococcygeal teratoma developed acromegaly, ectopic Cushing's syndrome, and 5HIAA secretion. To our knowledge, this represents the first reported case of ACTH and serotonin secretion, and likely GHRH or GH cosecretion, from a sacrococcygea...
Source: Clinical Case Reports - September 14, 2017 Category: General Medicine Authors: Tarig Babiker, Efstathia Kyrodimou, Daniel M. Berney, Mark Gurnell, William M. Drake, Antonia Brooke Tags: Case Report Source Type: research

An unusual airway challenge in a patient with acromegaly
Shivacharan Patel, Jigeeshu V Divatia, Sheila Nainan MyatraJournal of Anaesthesiology Clinical Pharmacology 2017 33(3):410-411 (Source: Journal of Anaesthesiology Clinical Pharmacology)
Source: Journal of Anaesthesiology Clinical Pharmacology - September 11, 2017 Category: Anesthesiology Authors: Shivacharan Patel Jigeeshu V Divatia Sheila Nainan Myatra Source Type: research

Acromegaly and bone.
CONCLUSIONS: In this article, we summarize the pathophysiology, clinical aspects and the new diagnostic tools to better understand bone impairment in acromegaly. PMID: 28880058 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 8, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Macrodystrophia Lipomatosa
We present a 25‐year‐old man who presented with overgrowth of the right hand associated with occasional pain, numbness, and limited function who was found to have macrodystrophia lipomatosa with fibrolipomatous hamartoma of the median nerve. Reports of this condition are limited in the dermatology literature, and early recognition can lead to better outcomes. (Source: Pediatric Dermatology)
Source: Pediatric Dermatology - September 8, 2017 Category: Dermatology Authors: Tyler Willenbrink, Lindsay Thelin, Gregory Connor, Lucia Diaz Tags: Brief Report Source Type: research

Development of ACRODAT ® , a new software medical device to assess disease activity in patients with acromegaly
ConclusionThe validation study underlined IGF-I and tumor status for routine clinical decision-making, whereas patient-oriented outcome measures received less medical attention. An Acromegaly Disease Activity Tool (ACRODAT) is in development that might assist clinicians towards a more holistic approach to patient management in acromegaly. (Source: Pituitary)
Source: Pituitary - September 8, 2017 Category: Endocrinology Source Type: research

Acromegaly determination using discriminant analysis of the three-dimensional facial classification in Taiwanese.
CONCLUSION: The discriminant functions of detection developed in this study could help patients, their families, medical practitioners and others to identify and track progressive facial change patterns before the possible patients go to the hospital, especially the lateral "angles" which can be calculated by relative point-to-point changes derived from 2D lateral imagery without the 3D anthropometric measurements. This study tries to provide a novel and easy method to detect acromegaly when the patients start to have awareness of abnormal appearance because of facial measurement changes, and it also suggests tha...
Source: Neuroendocrinology Letters - September 7, 2017 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Endoscopic Endo-Nasal Trans-Sphenoidal Excision of Pituitary Tumors: An Institutional Experience
AbstractTo analyze the clinical presentation, management and outcomes of patients with pituitary adenoma treated by Endoscopic Endo-nasal Trans-sphenoidal (EETS) excision. Study was conducted on the basis of medical records of 14 patients who had undergone EETS excision of pituitary adenomas. The data obtained was assessed for demographic and clinical characteristics, radiographic features and post-operative outcomes. Study included 10 males and 4 females. Mean age of patients was 46.43  years (range 16–70 Years). Most common presentation was diminished vision reported in 79% patients. Features of acromegaly enc...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - September 7, 2017 Category: ENT & OMF Source Type: research

Is there any difference in acromegaly and other chronic disease in quality of life and psychiatric morbidity?
CONCLUSIONS: The psychiatric morbidity, mainly anxiety and insomnia, occurs in 50% of patients with acromegaly. However, the psychological wellbeing and mood seem to be related to other factor such as the acceptance of the illness. Thus, concerning the diagnosis, treatment and monitoring of acromegaly, an interdisciplinary approach, taking into account psychological and psychiatric consultation, is needed. PMID: 28879648 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - September 7, 2017 Category: Endocrinology Authors: Szcześniak DM, Jawiarczyk-Przybyłowska A, Matusiak Ł, Bolanowska A, Maciaszek J, Siemińska M, Rymaszewska J, Bolanowski M Tags: Endokrynol Pol Source Type: research

Acromegaly treatment in Romania. How close are we to disease control?
Abstract INTRODUCTION: In Romania no nationwide data for acromegaly treatment and control rate are available. Our objective was to assess the acromegaly control rate in a tertiary referral center which covers an important part of Romanian territory and population of patients with acromegaly. MATERIAL AND METHODS: We reviewed the records of all 164 patients (49 males and 115 female; median age 55 (47, 63.5) years) with newly or previously diagnosed acromegaly who have been assessed at least once in our tertiary referral center between January 1st, 2012 and March 31st, 2016. This sample represents 13.6% of the ...
Source: Endokrynologia Polska - September 7, 2017 Category: Endocrinology Authors: Niculescu DA, Baciu IF, Capatina C, Galoiu SA, Gheorghiu ML, Radian S, Trifanescu RA, Caragheorgheopol A, Coculescu M, Poiana C Tags: Endokrynol Pol Source Type: research

Prolonged preoperative treatment of acromegaly with Somatostatin analogs may improve surgical outcome in patients with invasive pituitary macroadenoma (Knosp grades 1 –3): a retrospective cohort study conducted at a single center
This study aimed to investigate preoperative somatostatin analogs (SSAs) treatment on the surgical outcome in patients with acromegaly. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - September 6, 2017 Category: Endocrinology Authors: Lian Duan, Huijuan Zhu, Bing Xing and Feng Gu Tags: Research article Source Type: research

Endoscopic Transsphenoidal Approach for Acromegaly: Remission Rates in 401 Patients: 2010 Consensus Criteria
Transsphenoidal surgery is the first choice treatment for acromegaly. Postoperative remission is an important predictor of outcome. Various factors have been described as markers of remission preoperative mean growth hormone (GH) and insulin-like growth factor-1 levels, cavernous sinus invasion, tumor size, extra pseudocapsule resection, and experience of the surgeon. (Source: World Neurosurgery)
Source: World Neurosurgery - September 5, 2017 Category: Neurosurgery Authors: Ihsan ANIK, Burak CABUK, Aykut GOKBEL, Alev SELEK, Berrin CETINARSLAN, Yonca ANIK, Savas CEYLAN Tags: Original article Source Type: research

Endoscopic Transsphenoidal Approach for Acromegaly with Remission Rates in 401 Patients: 2010 Consensus Criteria
Transsphenoidal surgery is the first-choice treatment for acromegaly. Postoperative remission is an important predictor of outcome. Various factors have been described as markers of remission: preoperative mean growth hormone (GH) and insulin-like growth factor-1 levels, cavernous sinus invasion, tumor size, extrapseudocapsular resection, and experience of the surgeon. (Source: World Neurosurgery)
Source: World Neurosurgery - September 5, 2017 Category: Neurosurgery Authors: Ihsan Anik, Burak Cabuk, Aykut Gokbel, Alev Selek, Berrin Cetinarslan, Yonca Anik, Savas Ceylan Tags: Original Article Source Type: research

Multihormonal pituitary adenoma concomitant with Pit-1 and Tpit lineage cells causing acromegaly associated with subclinical Cushing ’s disease: a case report
A functional pituitary adenoma can produce multiple anterior-pituitary hormones, such as growth hormone (GH) -producing adenomas (GHoma) with prolactin or thyrotropin stimulating hormone production in the same... (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - September 2, 2017 Category: Endocrinology Authors: Tomoko Takiguchi, Hisashi Koide, Hidekazu Nagano, Akitoshi Nakayama, Masanori Fujimoto, Ai Tamura, Eri Komai, Akina Shiga, Takashi Kono, Seiichiro Higuchi, Ikki Sakuma, Naoko Hashimoto, Sawako Suzuki, Yui Miyabayashi, Norio Ishiwatari, Kentaro Horiguchi & Tags: Case report Source Type: research

Reoperation for growth hormone-secreting pituitary adenomas: report on an endonasal endoscopic series with a systematic review and meta-analysis of the literature.
CONCLUSIONS Reoperative EEA for acromegaly had results similar to those for first-time surgery and rates of control for macroadenomas that were better than historical rates. Cavernous sinus invasion continues to be a negative prognostic indicator for disease control; however, results with EEA show improvement compared with results reported in the prior literature. PMID: 28862548 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - September 1, 2017 Category: Neurosurgery Authors: Almeida JP, Ruiz-Treviño AS, Liang B, Omay SB, Shetty SR, Chen YN, Anand VK, Grover K, Christos P, Schwartz TH Tags: J Neurosurg Source Type: research

Response to Letter: "Calcium and Bone Turnover Markers in Acromegaly: A Prospective, Controlled Study".
Response to Letter: "Calcium and Bone Turnover Markers in Acromegaly: A Prospective, Controlled Study". J Clin Endocrinol Metab. 2017 Sep 01;102(9):3561-3562 Authors: Constantin T, Tangpricha V, Shah R, Oyesiku NM, Ioachimescu O, Ritchie J, Ioachimescu AG PMID: 28911163 [PubMed - in process] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - September 1, 2017 Category: Endocrinology Authors: Constantin T, Tangpricha V, Shah R, Oyesiku NM, Ioachimescu O, Ritchie J, Ioachimescu AG Tags: J Clin Endocrinol Metab Source Type: research