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Evidence of dysexecutive syndrome in patients with acromegaly
ConclusionsAcromegalic patients were severely impaired in semantic inhibition, executive processing, working memory and executive inhibition, and they have realized a portion of these deficits. A high level of IGF-1, disease duration may contribute to the impairment of specific aspects of executive function. (Source: Pituitary)
Source: Pituitary - August 19, 2017 Category: Endocrinology Source Type: research

Surgical debulking of pituitary adenomas improves responsiveness to octreotide lar in the treatment of acromegaly
AbstractBackgroundStudies comparing primary medical treatment of acromegaly with surgery are often non-randomized, and not stratified by illness severity. We prospectively compared primary medical therapy with pituitary surgery in patients with acromegaly. All patients had macroadenomas, at least one random human growth hormone (GH) level  ≥12.5 ng/mL, elevated IGF-I levels and failure to suppress GH to
Source: Pituitary - August 19, 2017 Category: Endocrinology Source Type: research

Effect of AP102, a subtype 2 and 5 specific somatostatin analog, on glucose metabolism in rats
ConclusionsAP102 is a new dual SSTR2/SSTR5-specific somatostatin analog that acutely reduces growth hormone but does not cause hyperglycemia during acute or chronic administration in a healthy rat model. Further studies in diabetic animals and in humans are necessary to determine the potential utility of AP102 in the clinical setting. (Source: Endocrine)
Source: Endocrine - August 18, 2017 Category: Endocrinology Source Type: research

Delayed Diagnosis of Acromegaly in the Context of Post-Traumatic Stress Disorder due to Symptoms Mimicking Known Psychotropic Medication Side Effects.
CONCLUSION: This case shows that side effects of medications can easily mimic some medical conditions. The possibility of unrecognized disease should not be overlooked simply because a patient's symptoms that develop after starting a medication correspond well the side effect profile of the prescribed medications. This is especially true if side effects do not stop with alteration of medication dose, cessation of the medication, or changing to another medication. Pituitary adenomas are rare in patients treated for PTSD. However, attribution of PTSD patient's symptoms to the side effects of selective serotonin reuptake inhi...
Source: Military Medicine - August 17, 2017 Category: International Medicine & Public Health Tags: Mil Med Source Type: research

Incidence of myocardial infarction and stroke in acromegaly patients: results from the German Acromegaly Registry
In this study, we examine if the incidence of myocardial infarction (MI) and stroke differ from that of the general population.MethodsData from the German Acromegaly Registry in seven specialized endocrine centres were analysed (n  = 479, 56% female, 46 years old at diagnosis, 5549 person-years from diagnosis). Standardized incidence ratios (SIR) were calculated as compared to the general population.ResultsMI and stroke incidences were very close to those of the general population with an SIR (95% CI) of 0.89 (0.47 –1.52, p = 0.80) for MI and 1.17 (0.66–1.93, p =&thi...
Source: Pituitary - August 14, 2017 Category: Endocrinology Source Type: research

Acromegaly is associated with increased cancer risk: a survey in Italy
It is debated if acromegalic patients have an increased risk to develop malignancies. The aim of the present study was to assess the standardized incidence ratios (SIRs) of different types of cancer in acromegaly on a large series of acromegalic patients managed in the somatostatin analogs era. It was evaluated the incidence of cancer in an Italian nationwide multicenter cohort study of 1512 acromegalic patients, 624 men and 888 women, mean age at diagnosis 45 ± 13 years, followed up for a mean of 10 years (12573 person-years) in respect to the general Italian population. Cancer was diagnosed in 124 patients, 72 wom...
Source: Endocrine-Related Cancer - August 14, 2017 Category: Endocrinology Authors: Terzolo, M., Reimondo, G., Berchialla, P., Ferrante, E., Malchiodi, E., De Marinis, L., Pivonello, R., Grottoli, S., Losa, M., Cannavo, S., Ferone, D., Montini, M., Bondanelli, M., De Menis, E., Martini, C., Puxeddu, E., Velardo, A., Peri, A., Faustini-Fu Tags: Research Source Type: research

Cancers, Vol. 9, Pages 103: Secondary Intracranial Tumors Following Radiotherapy for Pituitary Adenomas: A Systematic Review
Cancers, Vol. 9, Pages 103: Secondary Intracranial Tumors Following Radiotherapy for Pituitary Adenomas: A Systematic Review Cancers doi: 10.3390/cancers9080103 Authors: Ryuya Yamanaka Eisuke Abe Toshiteru Sato Azusa Hayano Yasuo Takashima Pituitary adenomas are often treated with radiotherapy for the management of tumor progression or recurrence. Despite the improvement in cure rates, patients treated by radiotherapy are at risk of development of secondary malignancies. We conducted a comprehensive literature review of the secondary intracranial tumors that occurred following radiotherapy to pituitary aden...
Source: Cancers - August 8, 2017 Category: Cancer & Oncology Authors: Ryuya Yamanaka Eisuke Abe Toshiteru Sato Azusa Hayano Yasuo Takashima Tags: Review Source Type: research

Long-term treatment outcomes of acromegaly patients presenting biochemically-uncontrolled at a tertiary pituitary center
The objective of this study was to examine acromegaly treatment outco... (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - August 4, 2017 Category: Endocrinology Authors: John D. Carmichael, Michael S. Broder, Dasha Cherepanov, Eunice Chang, Adam Mamelak, Qayyim Said, Maureen P. Neary and Vivien Bonert Tags: Research article Source Type: research

Pasireotide is more effective than octreotide, alone or combined with everolimus on human meningioma in vitro.
In this study, we compared the effects of pasireotide to those of octreotide in vitro on meningioma primary cell cultures, both alone and in combination with the mTOR inhibitor everolimus. Significant mRNA expression levels of SST1, SST2, and SST5 were observed in 40.5%, 100%, and 35% of meningioma samples, respectively. Pasireotide had a significantly stronger inhibitory effect on cell proliferation than octreotide. The effect of pasireotide, but not of octreotide, was significantly stronger in the group expressing the highest level of SST1 mRNA. Combined treatment with pasireotide and everolimus induced a higher reductio...
Source: Oncotarget - August 3, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Double pituitary adenomas are most commonly associated with GH- and ACTH-secreting tumors: systematic review of the literature
ConclusionDouble pituitary adenomas are rare but most commonly found with GH- or ACTH-producing tumors. It is critical to remove all identified possible adenomas to achieve biochemical cure and clinicians should have heightened sensitivity in patients with acromegaly or Cushing ’s Disease. (Source: Pituitary)
Source: Pituitary - August 1, 2017 Category: Endocrinology Source Type: research

Craniopharyngioma in a patient with acromegaly due to a pituitary macroadenoma
We present the first reported case of a craniopharyngioma as a second primary tumor in a patient with acromegaly due to a growth hormone (GH)-secreting pituitary adenoma. The patient was lost for follow-up for 18 years after trans-sphenoidal pituitary surgery for a GH-secreting pituitary adenoma. She presented with headaches and decreased visual acuity, and showed unsuppressed GH in an oral glucose load test with high IGF-1 levels. Brain MRI showed a suprasellar cystic mass and the patient underwent surgery for cyst drainage resulting in postoperative improvement in her vision. Biopsy of the mass confirmed the diagnosis of...
Source: Annals of Saudi Medicine - July 27, 2017 Category: General Medicine Tags: ISSUE 6 Source Type: research

A multicenter, observational study of lanreotide depot/autogel (LAN) in patients with acromegaly in the United States: 2-year experience from the SODA registry
AbstractPurposeThis analysis evaluates the 2-year effectiveness and safety of lanreotide depot/autogel (LAN), as well as treatment convenience and acromegaly symptom relief, from the Somatuline® Depot for Acromegaly (SODA) registry, a post-marketing, open-label, observational, multicenter, United States registry study.MethodsPatients with acromegaly treated with LAN were eligible for enrollment. Demographics, LAN dose, extended dosing interval (EDI) (interval of injections ≥42 days), insulin-like growth factor 1 (IGF-1), growth hormone (GH), glycated hemoglobin, adverse events (AEs), injection convenience, and sympt...
Source: Pituitary - July 24, 2017 Category: Endocrinology Source Type: research

Co-Occurrence of Acromegaly and Hematological Disorders: A Myth or Common Pathogenic Mechanism
Conclusion: In this review, we aim to provide evidence for the correlation between the two disorders.Integr Med Int 2017;4:94-100 (Source: Integrative Medicine International)
Source: Integrative Medicine International - July 21, 2017 Category: Complementary Medicine Source Type: research

Co-Occurrence of Acromegaly and Hematological Disorders: A Myth or Common Pathogenic Mechanism?
Conclusion: In this review, we aim to provide evidence for the correlation between the two disorders.Integr Med Int 2017;4:94-100 (Source: Integrative Medicine International)
Source: Integrative Medicine International - July 20, 2017 Category: Complementary Medicine Source Type: research

Oldest case of gigantism? Assessment of the alleged remains of Sa-Nakht, king of ancient Egypt
Publication date: August 2017 Source:The Lancet Diabetes & Endocrinology, Volume 5, Issue 8 Author(s): Francesco M Galassi, Maciej Henneberg, Wouter de Herder, Frank Rühli, Michael E Habicht (Source: The Lancet Diabetes and Endocrinology)
Source: The Lancet Diabetes and Endocrinology - July 19, 2017 Category: Endocrinology Source Type: research

Effects of environmental pollutants on signaling pathways in rat pituitary GH3 adenoma cells.
Abstract An increased rate of acromegaly was reported in industrialized areas, suggesting an involvement of environmental pollutants in the pathogenesis and behavior of GH-secreting pituitary adenomas. Based on these premises, the aim of the study was to evaluate the effects of some widely diffused pollutants (i.e. benzene, BZ; bis(2-ethylhexyl) phthalate, DEHP and polychlorinated biphenyls, PCB) on growth hormone secretion, the somatostatin and estrogenic pathways, viability and proliferation of rat GH-producing pituitary adenoma (GH3) cells. All the pollutants induced a statistically significant increase in GH s...
Source: Environmental Research - July 18, 2017 Category: Environmental Health Authors: Fortunati N, Guaraldi F, Zunino V, Penner F, D'Angelo V, Zenga F, Pecori Giraldi F, Catalano MG, Arvat E Tags: Environ Res Source Type: research

Association between ACE and AGT polymorphism and cardiovascular risk in acromegalic patients
AbstractPurposeWhether the renin –angiotensin–aldosterone system plays a role or not in the development of cardiovascular morbidity in acromegaly patients is unknown. The aim of the study was to investigate the association between ACE (I/D) and AGT (M235T) gene polymorphisms and cardiovascular and metabolic disorders in the acr omegaly.MethodsThe study included one hundred and seventeen acromegalic patients (62  F/55 M, age: 50.2 ± 12.3 years) and 106 healthy controls (92 F/14 M, age: 41.4 ± 11.3 years). PCR method was used to evaluate the prevalence...
Source: Pituitary - July 15, 2017 Category: Endocrinology Source Type: research

Etiology of Hypopituitarism in Adult Patients: The Experience of a Single Center Database in the Serbian Population.
Conclusion. The most common causes of hypopituitarism in our database are pituitary adenomas. Increased awareness of the other causes of pituitary dysfunction, such as congenital, head trauma, extrapituitary cranial irradiation, and infections, is the reason for a higher frequency of these etiologies of hypopituitarism in the presented database. PMID: 28702053 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - July 14, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Erratum to: Acromegaly: surgical results in 548 patients
(Source: Pituitary)
Source: Pituitary - July 5, 2017 Category: Endocrinology Source Type: research

Impact of obstructive sleep apnea in transsphenoidal pituitary surgery: An analysis of inpatient data
Objectives/HypothesisAlthough previous studies have reported increased perioperative complications among obstructive sleep apnea (OSA) patients undergoing any surgery requiring general anesthesia, there is a paucity of literature addressing the impact of OSA on postoperative transsphenoidal surgery (TSS) complications. The aim of this study was to analyze postoperative outcomes in transsphenoidal pituitary surgery patients with OSA. Secondarily, we examined patient characteristics and comorbidities. Study DesignRetrospective analysis. MethodsThe 2002 to 2013 National Inpatient Sample was queried for patients undergoing TSS...
Source: The Laryngoscope - July 3, 2017 Category: ENT & OMF Authors: Sei Y. Chung, Michael J. Sylvester, Varesh R. Patel, Michael Zaki, Soly Baredes, James K. Liu, Jean Anderson Eloy Tags: Allergy/Rhinology Source Type: research

Endocrine hypertension
Up to 10% of patients have a secondary cause for hypertension. Endocrine conditions associated with hypertension include diseases associated with mineralocorticoid excess, phaeochromocytomas/paragangliomas, acromegaly and primary hyperparathyroidism. Primary hyperaldosteronism (PH) is the most common endocrine cause of hypertension. If not appropriately managed, PH has an unfavourable cardiovascular morbidity and mortality profile. It is treatable by medical or surgical approaches. Phaeochromocytomas and paragangliomas are rare neuro-endocrine tumours frequently associated with genetic abnormalities. (Source: Medicine)
Source: Medicine - July 3, 2017 Category: Internal Medicine Authors: Mark Sherlock, Isolda Frizelle Tags: Adrenal disorders Source Type: research

Acromegaly
is a rare, chronic, debilitating condition. Untreated, it causes significant morbidity and reduces life expectancy by about 10 years. The disease process is insidious, and early presenting features can be non-specific (e.g. sweating, fatigue). Physicians, dentists and surgeons should consider this diagnosis if any of the more classically recognized features is present (e.g. dental malocclusion, symptoms of median nerve entrapment, sleep apnoea, type 2 diabetes mellitus without a family history). (Source: Medicine)
Source: Medicine - July 3, 2017 Category: Internal Medicine Authors: Belayet Hossain, Willliam M. Drake Tags: Pituitary disorders Source Type: research

Insulin resistance in endocrine disorders - treatment options.
icz D Abstract Changes in sensitivity to insulin occur in the course of a number of endocrine disorders. Most of the hormones through their antagonistic action to insulin lead to increased hepatic glucose output and its decreased utilisation in peripheral tissues. Carbohydrate disorders observed in endocrine diseases result from the phenomenon of insulin resistance, and in some cases also a reduction in insulin secretion is present. Abnormalities of glucose metabolism are observed in acromegaly, but also in growth hormone deficiency, hypercortisolism in the course of Cushing's syndrome, hyper- or hypothyroidism, p...
Source: Endokrynologia Polska - July 1, 2017 Category: Endocrinology Authors: Rogowicz-Frontczak A, Majchrzak A, Zozulińska-Ziółkiewicz D Tags: Endokrynol Pol Source Type: research

The impact of growth hormone on proteomic profiles: a review of mouse and adult human studies
AbstractGrowth hormone (GH) is a protein that is known to stimulate postnatal growth, counter regulate insulin ’s action and induce expression of insulin-like growth factor-1. GH exerts anabolic or catabolic effects depending upon on the targeted tissue. For instance, GH increases skeletal muscle and decreases adipose tissue mass. Our laboratory has spent the past two decades studying these effects, includ ing the effects of GH excess and depletion, on the proteome of several mouse and human tissues. This review first discusses proteomic techniques that are commonly used for these types of studies. We then examine th...
Source: Clinical Proteomics - June 29, 2017 Category: Biochemistry Source Type: research

Evaluation of depressive mood and cognitive functions in patients with acromegaly under somatostatin analogue therapy
ConclusionThe present findings show that acromegaly negatively affects learning, attention, and planning. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 28, 2017 Category: Endocrinology Source Type: research

Acromegaly discovered during a routine out-patient surgical procedure: a case report
ConclusionsThis case underscores the notable absence of recognizing the clinical presentation of acromegaly in this patient by his primary care physician, and the value of thorough history taking, vigilance, and observation in making a new diagnosis that has the potential to alter a patient ’s health care and mitigate impending morbidity and/or mortality. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - June 24, 2017 Category: General Medicine Source Type: research

Acromegaly —the importance of early diagnosis
(Source: QJM)
Source: QJM - June 24, 2017 Category: Internal Medicine Source Type: research

How does pregnancy affect the patients with pituitary adenomas: a study on 113 pregnancies from Turkey
ConclusionMedical treatment can be safely done stopped in patients with prolactinoma and acromegaly when pregnancy is confirmed and reinstituted when necessary. Prospective studies may help to determine the effects of medical treatment during gestation on the mother and fetus. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 20, 2017 Category: Endocrinology Source Type: research

Hearing Loss in Acromegaly - A Review
Conclusion The results are not consistent, but led to different conclusions. Therefore, more studies with greater numbers of patients with acromegaly are needed. [...] Thieme Revinter Publicações Ltda Rio de Janeiro, BrazilArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: International Archives of Otorhinolaryngology)
Source: International Archives of Otorhinolaryngology - June 16, 2017 Category: ENT & OMF Authors: Teixeira, Liane Sousa Silva, Isabelle Braz de Oliveira Sampaio, Andre Luiz Lopes Oliveira, Carlos Augusto Pires de Bahamad J únior, Fayez Tags: Systematic Review Source Type: research

High levels of IGF-1 predict difficult intubation of patients with acromegaly
ConclusionsIn patients with acromegaly, neck movement is confined, the time of tracheal intubation is prolonged, and the neck circumference is enlarged, and these patients suffer from an increased incidence of difficult intubation (62.5%) during anesthesia induction. The apnea/hypoxia index and insulin-like growth factor 1 levels are both increased in acromegalic patients with difficult intubation, and elevated insulin-like growth factor 1 levels are an independent risk factor of difficult intubation in acromegalic patients. (Source: Endocrine)
Source: Endocrine - June 15, 2017 Category: Endocrinology Source Type: research

Efficacy and safety of long-acting pasireotide in Japanese patients with acromegaly or pituitary gigantism: results from a multicenter, open-label, randomized, phase 2 study.
Authors: Tahara S, Murakami M, Kaneko T, Shimatsu A Abstract A multicenter, open-label, phase 2 study was conducted to investigate the efficacy and safety of long-acting pasireotide formulation in Japanese patients with acromegaly or pituitary gigantism. Medically naïve or inadequately controlled patients (on somatostatin analogues or dopamine agonists) were included. Primary end point was the proportion of all patients who achieved biochemical control (mean growth hormone [GH] levels
Source: Endocrine Journal - June 9, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Cytopathologic evaluation of patients submitted to radiotherapy for uterine cervix cancer
Summary Cervical cancer is an important public health problem. Pap smear is the leading strategy of screening programs for cervical cancer worldwide. However, delayed diagnosis leads to more aggressive and less effective treatments. Patients with uterine cervix malignancies who are referred for radiotherapy have advanced-stage disease, which results in high rates of locoregional recurrence. The use of radiotherapy as a treatment for cervical cancer causes morphological changes in neoplastic and non-neoplastic epithelial cells, as well as in stromal cells, which make it difficult to diagnose the residual lesion, resulting i...
Source: Revista da Associacao Medica Brasileira - June 9, 2017 Category: General Medicine Source Type: research

Pachydermoperiostosis of the complete type: A novel missense mutation c.101T   >  C in the SLCO2A1 gene.
We report on a rare case of pachydermoperiostosis (PDP) in a 25-year-old male who was admitted to our hospital because of enlargement of fingers and toes. Through examination, we found some typical features on the patient including finger clubbing, periostosis, pachydermia, and cutis verticis gyrata (CVG). But laboratory tests were almost within normal ranges, which ruled out rheumatic arthritis, osteopulmonary arthropathy, thyroid acropathy, and acromegaly. Then, we diagnosed this case as PDP, which was confirmed by gene sequencing. The pathogenesis is concerned with abnormal rise of the level of PGE2 that results from th...
Source: European Journal of Medical Genetics - June 8, 2017 Category: Genetics & Stem Cells Authors: Ma W, Guo S, Li Y, Li Z Tags: Eur J Med Genet Source Type: research

Acromegaly: surgical results in 548 patients
ConclusionsSurgery remains the first line of therapy for a majority of acromegalic patients. This series proves to be very valuable in circumscribed adenomas but also in invasive tumours. Levels of GH and IGF-I were decreased in almost all the patients without remission. (Source: Pituitary)
Source: Pituitary - June 6, 2017 Category: Endocrinology Source Type: research

Recurrent Kidney Stone Episodes Leading to a Diagnosis of Occult Acromegaly
We present a case of occult acromegaly secondary to a pituitary tumor discovered 20 years after the patient's first stone episode. (Source: Urology Case Reports)
Source: Urology Case Reports - June 3, 2017 Category: Urology & Nephrology Source Type: research

Effects of anti-somatostatin agents on glucose metabolism.
e;s B Abstract The anti-somatostatin agents used to treat acromegaly, Cushing's disease and neuroendocrine tumours also have hyperglycaemic effects. This is particularly true for pasireotide. Hyperglycaemic events are seen in 57-73% of patients with Cushing's treated with pasireotide, with a need to initiate antidiabetic treatment in about 50% of these patients. In acromegaly, treatment with pasireotide induces hyperglycaemia in 29-61% of patients. Pasireotide-induced hyperglycemia occurs early, within the first 3 months of treatment, due to a decrease in insulin secretion secondary to a fall in secretion of GLP-1...
Source: Diabetes and Metabolism - June 1, 2017 Category: Endocrinology Authors: Vergès B Tags: Diabetes Metab Source Type: research

Tyrannosauroid integument reveals conflicting patterns of gigantism and feather evolution.
We describe fossil integument from Tyrannosaurus and other tyrannosaurids (Albertosaurus, Daspletosaurus, Gorgosaurus and Tarbosaurus), confirming that these large-bodied forms possessed scaly, reptilian-like skin. Body size evolution in tyrannosauroids reveals two independent occurrences of gigantism; specifically, the large sizes in Yutyrannus and tyrannosaurids were independently derived. These new findings demonstrate that extensive feather coverings observed in some early tyrannosauroids were lost by the Albian, basal to Tyrannosauridae. This loss is unrelated to palaeoclimate but possibly tied to the evolution of gig...
Source: Biology Letters - June 1, 2017 Category: Biology Authors: Bell PR, Campione NE, Persons WS, Currie PJ, Larson PL, Tanke DH, Bakker RT Tags: Biol Lett Source Type: research

[Correspondence] Acromegaly in Lorenzo the Magnificent, father of the Renaissance
Lorenzo de' Medici (1449 –92), also known as the Magnificent, was a statesman, patron of arts, and a key supporter of the Renaissance, a cultural movement in Italy that spread throughout Europe, marking the beginning of the Early Modern Age (from the 14th to the 17th century). (Source: LANCET)
Source: LANCET - May 26, 2017 Category: General Medicine Authors: Donatella Lippi, Philippe Charlier, Paola Romagnani Tags: Correspondence Source Type: research

Anti-tumoral effects of somatostatin analogs: a lesson from the CLARINET study
AbstractOctreotide and lanreotide, the first-generation somatostatin analogs, successfully control hormone hyperproduction, and related syndromes, in patients with acromegaly and neuroendocrine tumors. However, their anti-tumor effect, rather evident in large number of pituitary adenomas in acromegalic patients, has been hypothesized for a long time in patients with neuroendocrine tumors as well, although a significant tumor shrinkage has rarely been observed. However, the recent publication of the CLARINET study has strengthened the evidence, already emerged with the PROMID trial, that the long-term treatment with the fir...
Source: Journal of Endocrinological Investigation - May 26, 2017 Category: Endocrinology Source Type: research

Acromegaly in Lorenzo the Magnificent, father of the Renaissance
Publication date: 27 May–2 June 2017 Source:The Lancet, Volume 389, Issue 10084 Author(s): Donatella Lippi, Philippe Charlier, Paola Romagnani (Source: The Lancet)
Source: The Lancet - May 26, 2017 Category: General Medicine Source Type: research

Independent evolution of baleen whale gigantism linked to Plio-Pleistocene ocean dynamics
Vertebrates have evolved to gigantic sizes repeatedly over the past 250 Myr, reaching their extreme in today's baleen whales (Mysticeti). Hypotheses for the evolution of exceptionally large size in mysticetes range from niche partitioning to predator avoidance, but there has been no quantitative examination of body size evolutionary dynamics in this clade and it remains unclear when, why or how gigantism evolved. By fitting phylogenetic macroevolutionary models to a dataset consisting of living and extinct species, we show that mysticetes underwent a clade-wide shift in their mode of body size evolution during the Plio-Ple...
Source: Proceedings of the Royal Society B: Biological Sciences - May 24, 2017 Category: Biology Authors: Slater, G. J., Goldbogen, J. A., Pyenson, N. D. Tags: palaeontology, evolution Palaeobiology Source Type: research

Cross-sectional prevalence of pancreatic cystic lesions in patients with acromegaly, a single-center experience
AbstractPurposeAcromegaly is a disease associated with an increased risk for several kinds of neoplasms including colon and thyroid cancer. Although the association between acromegaly and pancreatic neoplasms has not been elucidated, it has recently been reported thatGNAS gene mutations were found in 58% of intraductal papillary mucinous neoplasms (IPMNs), which are representative pancreatic cystic lesions, suggesting a link between IPMNs and acromegaly. To assess the prevalence of pancreatic cystic lesions in patients with acromegaly, we performed a retrospective cross-sectional single institute study.MethodsThirty consec...
Source: Pituitary - May 24, 2017 Category: Endocrinology Source Type: research

Standardization of Growth Hormone and Insulin-like Growth Factor-I Measurements.
Authors: Katsumata N Abstract Measurement of the levels of growth hormone (GH) and its related factor insulin-like growth factor I (IGF-I) is essential for the diagnosis and treatment of GH deficiency (GHD) and conditions related to excess GH such as acromegaly and pituitary gigantism. Measurement of GH levels is also used as an indicator of hypothalamic-pituitary function. Because of the marked variability in GH measurements among kits, the Study Committee for GH and Its Related Factors of The Foundation for Growth Science, Japan standardized GH values measured with various commercially available GH assay kits in ...
Source: Pediatric Endocrinology Reviews - May 19, 2017 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research

Alveoli, teeth, and tooth loss: Understanding the homology of internal mandibular structures in mysticete cetaceans
by Carlos Mauricio Peredo, Nicholas D. Pyenson, Mark D. Uhen, Christopher D. Marshall The evolution of filter feeding in baleen whales (Mysticeti) facilitated a wide range of ecological diversity and extreme gigantism. The innovation of filter feeding evolved in a shift from a mineralized upper and lower dentition in stem mysticetes to keratinous baleen plates that hang only from t he roof of the mouth in extant species, which are all edentulous as adults. While all extant mysticetes are born with a mandible lacking a specialized feeding structure (i.e., baleen), the bony surface retains small foramina with elongated sulc...
Source: PLoS One - May 19, 2017 Category: Biomedical Science Authors: Carlos Mauricio Peredo Source Type: research

Somatotropinomas inadequately controlled with octreotide may over-respond to pasireotide: the importance of dose adjustment to achieve long-term biochemical control.
CONCLUSION: These patients achieved long-term biochemical control, tumour volume reduction and improvement of clinical signs/symptoms after switching from octreotide to pasireotide. IGF-1 over-suppression is observed in a few patients and requires dose adjustment of pasireotide. PMID: 28500831 [PubMed - in process] (Source: Hormones)
Source: Hormones - May 15, 2017 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Evaluation of macular and peripapillary choroidal thickness, macular volume and retinal nerve fiber layer in acromegaly patients
AbstractPurposeTo evaluate macular volume, retinal nerve fiber layer, and macular and peripapillary choroidal thickness in acromegaly patients.MethodIn this prospective, case –control study, 31 patients with acromegaly and 32 healthy subjects were recruited. Only right eyes were evaluated. Macular choroidal thickness (CT) was measured at three points, peripapillary CT was measured at eight points, and macular volume was measured at nine areas in the central 6 mm circl e zone by spectraldomain optical coherence tomography (OCT). Retinal nerve fiber layer (RNFL) was measured automatically at six segments by OCT.Re...
Source: International Ophthalmology - May 15, 2017 Category: Opthalmology Source Type: research

Classification of patients with GH disorders may vary according to the IGF-I assay.
Conclusion: Even when using normative data obtained in the same large population of healthy subjects and when using calculated IGF-I SD scores, agreement among IGF-I assay methods is only moderate to good. Differences in assay performance must be taken into account when evaluating and monitoring patients with GH disorders. This argues for the use of the same IGF-I assay for a given patient throughout follow-up. PMID: 28505364 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - May 12, 2017 Category: Endocrinology Authors: Mavromati M, Kuhn E, Agostini H, Brailly-Tabard S, Massart C, Piketty ML, Arnoux A, Young J, Souberbielle JC, Chanson P Tags: J Clin Endocrinol Metab Source Type: research

Octreotide ‐Associated Neutropenia
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 10, 2017 Category: Drugs & Pharmacology Authors: Stacy S. Tse, Troy Kish Tags: Case Report Source Type: research

GH-secreting pituitary macroadenoma (acromegaly) associated with progressive dental malocclusion and refractory CPAP treatment
A link between progressive dental malocclusion, the use of a continuous positive airway pressure mask and GH-secreting pituitary macroadenoma (acromegaly) has not been previously reported. The present clinicop... (Source: Head and Face Medicine)
Source: Head and Face Medicine - May 10, 2017 Category: ENT & OMF Authors: Jaume Miranda-Rius, Llu ís Brunet-LLobet, Eduard Lahor-Soler, David de Dios-Miranda and Josep Anton Giménez-Rubio Source Type: research

Melvin M. Grumbach 1925-2016 [Retrospectives]
Generations of clinicians have been faced with often striking developmental and acquired hormonal syndromes associated with reproductive, growth, and metabolic phenotypes. These syndromes have included ambiguous genitalia, anomalies of sexual development, intersex forms, accelerated or delayed puberty, gigantism, and short stature. Although clinical phenotypes of these disorders have been well-established,... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - May 9, 2017 Category: Science Authors: Shlomo Melmed Tags: Retrospectives Source Type: research