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Correction to: Effects of pegvisomant and somatostatin receptor ligands on incidence of vertebral fractures in patients with acromegaly
AbstractThe original version of the article contained an error in the results section of the Abstract. The vertebral fractures (VFs) odds ratio is incorrectly published as 61.0 and the correct value is 6.10. (Source: Pituitary)
Source: Pituitary - February 23, 2018 Category: Endocrinology Source Type: research

Endocrine remission after pituitary stereotactic radiosurgery: Differences in rates of response for matched cohorts of Cushing ’s disease and acromegaly patients
To compare and describe the time to endocrine remission and new hypopituitarism among patients with growth hormone (GH) and adrenocorticotropic hormone (ACTH) secreting pituitary adenomas after radiosurgery after controlling for several known prognostic factors. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - February 20, 2018 Category: Radiology Authors: Daniel M. Trifiletti, Zhiyuan Xu, Sunil W. Dutta, Alfredo Qui ñones-Hinojosa, Jennifer Peterson, Mary Lee Vance, Jason P. Sheehan Tags: Clinical Investigation Source Type: research

Clinicopathological significance of baseline T2-weighted signal intensity in functional pituitary adenomas
AbstractPurposeTo assess baseline T2-weighted signal intensity (T2-WSI) of functional pituitary adenomas (FPA), and to investigate the relationship of baseline T2-WSI with clinical features, histopathological granulation patterns, and response to treatment in patients with acromegaly, prolactinoma and Cushing ’s disease (CD).MethodsSomatotroph adenomas (n  = 87), prolactinomas (n = 78) and corticotroph adenomas (n = 29) were included in the study. Baseline T2-WSI findings (grouped as hypo-, iso- and hyperintense) were compared with hormone levels, tumor diameter, granulation ...
Source: Pituitary - February 19, 2018 Category: Endocrinology Source Type: research

Germline mutations of aryl hydrocarbon receptor-interacting protein ( AIP ) gene and somatostatin receptor 1 –5 and AIP immunostaining in patients with sporadic acromegaly with poor versus good response to somatostatin analogues
AbstractObjectiveTo determine aryl hydrocarbon interacting protein (AIP) gene variations andAIP and somatostatin receptor (SSTR) 1 –5 immunostaining in patients with apparently sporadic acromegaly with poor versus good response to somatostatin analogues (SRLs).MethodsA total of 94 patients (66 with poor and 28 with good response to SRLs) were screened for theAIP gene variations using Sanger sequencing. Immunostaining was performed in 60 tumors.ResultsSeveral variations, albeit some with undetermined significance, were detected, especially in poor responder patients. The prevalence ofAIP mutation was 2.1% in the whole...
Source: Pituitary - February 17, 2018 Category: Endocrinology Source Type: research

Prognostic implications of telomerase expression in pituitary adenomas
Conclusions A telomerase expression rate greater than 10% in the pituitary tumor tissue was associated with recurrence or progression of the PA, especially in the nonfunctioning cases. (Source: Revista Clinica Espanola)
Source: Revista Clinica Espanola - February 15, 2018 Category: Internal Medicine Source Type: research

CyberKnife robotic radiosurgery in the multimodal management of acromegaly patients with invasive macroadenoma: a single center ’s experience
AbstractSurgery is the primary treatment for acromegaly. However, surgery may not be curative of some tumors, particularly invasive macroadenomas. Adjuvant radiation, specifically robotic stereotactic radiosurgery (rSRS), may improve the endocrine outcome. We retrospectively reviewed hormonal and radiological data of 22 acromegalic patients with invasive macroadenomas treated with rSRS at Stanford University Medical Center between 2000 and 2016. Prior to treatment, the tumor ’s median maximal diameter was 19 mm (2.5–50 mm). Cavernous sinus invasion occurred in 19 patients (86.3%) and compression of th...
Source: Journal of Neuro-Oncology - February 10, 2018 Category: Cancer & Oncology Source Type: research

Factors affecting early versus late remission in acromegaly following stereotactic radiosurgery
This study aims to identify factors affecting the timing of remission and also to quantify the rate of late remission. This is a retrospective analysis of acromegaly patients who underwent SRS between 1988 and 2016. Early and late remissions were defined based on our prior median remission time of 29 months. The median imaging and endocrine follow-ups are 66 and 104.8 months, respectively. Multivariate analysis was conducted to analyze factors leading to late remission. A total number of 157 patients, of those 102 (64.9%) patients achieved remission. of those 102 patients, 62 patie nts (60.7%) had remission in le...
Source: Journal of Neuro-Oncology - February 7, 2018 Category: Cancer & Oncology Source Type: research

Medical Treatments for Acromegaly: A Systematic Review and Network Meta-Analysis
Acromegaly results from the hypersecretion of growth hormone. Because of the low incidence rates of this disease worldwide, few clinical trials evaluating drug treatments have been conducted. (Source: Value in Health)
Source: Value in Health - February 7, 2018 Category: International Medicine & Public Health Authors: Let ícia P. Leonart, Vinicius L. Ferreira, Fernanda S. Tonin, Fernando Fernandez-Llimos, Roberto Pontarolo Tags: Systematic Review Source Type: research

Female gonadal functions and ovarian reserve in patients with acromegaly: experience from a single tertiary center
ConclusionThe most important factors affecting gonadal functions, excluding central hypogonadism, are hyperprolactinemia and the duration of the indolent period before diagnosis of acromegaly. AMH levels in the majority of patients were found to be lower than the expected age. Despite the decreased ovarian reserve, fertilization and normal birth can be achieved with careful surveillance. (Source: Endocrine)
Source: Endocrine - February 5, 2018 Category: Endocrinology Source Type: research

Effects of pegvisomant and somatostatin receptor ligands on incidence of vertebral fractures in patients with acromegaly
ConclusionsPegV and SRLs had comparable effects on VF risk in acromegaly. The activity of disease was the main determinant of VFs independently of the drug used to control acromegaly. (Source: Pituitary)
Source: Pituitary - February 3, 2018 Category: Endocrinology Source Type: research

The comprehensive impact on human body induced by resolution of growth hormone excess.
CONCLUSIONS: The rapid resolution of excessive GH led to the reversible changes of systemic comorbidities in a time-dependent and organ-specific manner. PMID: 29386229 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - January 31, 2018 Category: Endocrinology Authors: Zhang Z, Li Q, He W, Qiu H, Ye H, Wang Y, Shen M, He M, Yu Y, Shou X, Huang C, Yu H, Huang G, Tang W, Geng D, Fu C, Liu C, Ma Z, Ye Z, Zhang Q, Zhang Y, Shen Y, Yang Y, Wang M, Liu X, Lu Y, Ming HR, Mao Y, Zhou L, Li YM, Li S, Tritos NA, Zhao Y Tags: Eur J Endocrinol Source Type: research

Molecular evidence and clinical importance of β‐arrestins expression in patients with acromegaly
Abstract β‐arrestins seem to have a role in endocytosis and desensitization of somatostatin receptor subtype 2 (sst2) and could be associated with the responsiveness to somatostatin receptor ligands (SRL) in patients with acromegaly. To investigate the in vivo correlation between β‐arrestins 1 and 2 with sst2, sst5 and dopamine receptor subtype 2 (D2) expressions, and the association of β‐arrestins with response to first‐generation SRL and invasiveness in somatotropinomas. β‐arrestins 1 and 2, sst2, sst5 and D2 mRNA expressions were evaluated by quantitative real‐time RT‐PCR on tumora...
Source: Journal of Cellular and Molecular Medicine - January 27, 2018 Category: Molecular Biology Authors: Maria Caroline Alves Coelho, Marina Lipkin Vasquez, Luiz Eduardo Wildemberg, Mari C. V ázquez‐Borrego, Luciana Bitana, Aline Helen da Silva Camacho, Débora Silva, Liana Lumi Ogino, Nina Ventura, Leila Chimelli, Raul M. Luque, Leandro Kasuki, Mônica R Tags: Original Article Source Type: research

Effects of active acromegaly on bone mRNA and microRNA expression patterns.
Abstract OBJECTIVE: To evaluate the response of bone to chronic long-term growth hormone (GH) and insulin-like growth factor-1 (IGF1) excess by measuring the expression of selected mRNA and microRNA (miR) in bone samples of patients with active acromegaly. DESIGN: case-control study Methods: bone samples were obtained during transsphenoidal adenomectomy from the sphenoid bone (sella turcica) from 14 patients with clinically and biochemically-confirmed acromegaly and 10 patients with clinically non-functioning pituitary adenoma (NFPA) matched by sex and age. Expression of genes involved in the regulation of bo...
Source: European Journal of Endocrinology - January 26, 2018 Category: Endocrinology Authors: Belaya Z, Grebennikova T, Melnichenko GA, Nikitin A, Solodovnikov A, Brovkina O, Grigoriev A, Rozhinskaya L, Lutsenko A, Dedov II Tags: Eur J Endocrinol Source Type: research

Increasing Frequency of Combination Medical Therapy in the Treatment of Acromegaly with the GH Receptor Antagonist Pegvisomant.
Abstract Pegvisomant monotherapy is effective and safe in treatment of acromegaly.1,2 However, some clinicians combine pegvisomant with somatostatin analogues(SSA) or dopamine agonist(DA).2,3 In this analysis of ACROSTUDY, a long-term non-interventional study, the use of combination regimens was evaluated. Based on their baseline treatment, 2043 patients were retrospectively categorized as: long-acting SSA combined with pegvisomant, "Combo SSA" 768 patients(38%); DA combined with pegvisomant, "Combo DA" 123(6%); Pegvisomant monotherapy, "Peg mono" 1128(55%).Treatment patterns changed ...
Source: European Journal of Endocrinology - January 25, 2018 Category: Endocrinology Authors: Strasburger CJ, Mattsson AF, Wilton P, Aydin F, Hey-Hadavi J, Biller BMK Tags: Eur J Endocrinol Source Type: research

Efficacy of combined treatment with pasireotide, pegvisomant and cabergoline in an acromegalic patient resistant to other treatments: a case report
The approach to acromegalic patients with persistent acromegaly after surgery and inadequate response to first-generation somatostatin receptor ligands (SRLs) should be strictly tailored. Current options inclu... (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - January 24, 2018 Category: Endocrinology Authors: A. Ciresi, S. Radellini, V. Guarnotta and C. Giordano Tags: Case report Source Type: research

Cardiovascular Risk Factors in Acromegaly: What's the Impact of Disease Control?
Conclusion There is some reduction in cardiovascular risk factors with control of the disease, but possibly without the return to basal levels. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - January 24, 2018 Category: Endocrinology Authors: Amado, Ana Ara újo, Fernando Carvalho, Davide Tags: Article Source Type: research

Biochemical efficacy of long-acting lanreotide depot/Autogel in patients with acromegaly na ïve to somatostatin-receptor ligands: analysis of three multicenter clinical trials
AbstractPurposeIn clinical research involving acromegalic patients na ïve to somatostatin-receptor ligands (SRLs), 19 and 31% of those receiving the SRLs octreotide LAR and pasireotide LAR, respectively, achieved GH 
Source: Pituitary - January 22, 2018 Category: Endocrinology Source Type: research

MANAGEMENT OF ENDOCRINE DISEASE: Personalized medicine in the treatment of acromegaly.
Abstract Acromegaly is associated with high morbidity and elevated mortality when not adequately treated. Surgery is the first-line treatment for most patients as it is the only one that can lead to immediate cure. In patients who are not cured by surgery, treatment is currently based on a trial-and-error approach. First-generation somatostatin receptor ligands (fg-SRL) are initiated for most patients, although approximately 25% of patients present resistance to this drug class. Some biomarkers of treatment outcome are described in the literature, with the aim of categorizing patients into different groups to indi...
Source: European Journal of Endocrinology - January 16, 2018 Category: Endocrinology Authors: Kasuki L, Wildemberg LE, Gadelha MR Tags: Eur J Endocrinol Source Type: research

Markers of proliferation and invasiveness in somatotropinomas.
ConclusionsKi-67, TOPO 2A, AIP and VEGF were expressed in over 70% of all somatotropinomas. Only Ki-67 and TOPO 2A expression correlated with tumour size and tumour invasiveness. PMID: 29334118 [PubMed - as supplied by publisher] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - January 15, 2018 Category: Endocrinology Authors: Baldys-Waligorska A, Wierzbicka I, Sokolowski G, Adamek D, Golkowski F Tags: Endokrynol Pol Source Type: research

Cant ú syndrome with coexisting familial pituitary adenoma
ConclusionsActivating mutations in theABCC9 and, less commonly,KCNJ8 genes —representing the two subunits of the ATP-sensitive potassium channel—have been linked with Cantú syndrome. Interestingly, minoxidil, a well-known ATP-sensitive potassium channel agonist, can cause a similar phenotype. There is no clear explanation why activating this channel would lead to acro megaloid features or hypertrichosis. This report raises awareness for this complex condition, especially for adult or pediatric endocrinologists who might see these patients referred for evaluation of acromegaloid features or hirsutism. The...
Source: Endocrine - January 11, 2018 Category: Endocrinology Source Type: research

Elevated serum IGF-1 level enhances retinal and choroidal thickness in untreated acromegaly patients
AbstractPurpose1) To compare the retinal, choroidal, Haller ’s layer, and Sattler’s/choriocapillaris thicknesses of untreated acromegaly patients without chiasm compression or diabetes mellitus and healthy controls. 2) To evaluate the correlations of retinal and choroidal thicknesses with serum growth hormone (GH) and insulin-like growth factor 1 (IGF) b urden.MethodsThis prospective, case-control study included 27 untreated acromegaly patients and 27 sex-matched and age-matched controls. Subfoveal choroidal, Haller ’s layer and Sattler’s/choriocapillaris thicknesses were determined by enhanced-dept...
Source: Endocrine - January 10, 2018 Category: Endocrinology Source Type: research

Risk of left ventricular hypertrophy and diastolic and systolic dysfunction in Acromegaly: A meta-analysis
Conclusions Patients with treatment-naïve acromegaly are at an increased risk of developing left ventricular hypertrophy, diastolic dysfunction and systolic dysfunction than the general population. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - January 6, 2018 Category: Neuroscience Source Type: research

Silent somatotroph pituitary adenomas: an update
AbstractSilent growth hormone adenomas (SGHA) are a rare entity of non-functioning pituitary neuroendocrine tumors. Diagnosis is invariably made post-operatively of a tumor immunopositive for GH (and Pit-1 in selected cases) but without clinical acromegaly. Mainly young females are affected, and tumors are often uncovered by investigation for headaches or oligoamenorrhea. Integration of clinical, pathological and biochemical data is required for proper diagnosis. Beside normal IGF-1 levels, a third of SGHAs displays elevated GH levels and some will eventually progress to acromegaly. Almost two-thirds will be mixed GH-prola...
Source: Pituitary - January 5, 2018 Category: Endocrinology Source Type: research

Bone histological correlates for air sacs and their implications for understanding the origin of the dinosaurian respiratory system.
Abstract Air sacs are an important component of the avian respiratory system, and corresponding structures also were crucial for the evolution of sauropod dinosaur gigantism. Inferring the presence of air sacs in fossils so far is restricted to bones preserving internal pneumatic cavities and foramina as osteological correlates. We here present bone histological correlates for air sacs as a new potential identification tool for these elements of the respiratory system. The analysis of several avian and non-avian dinosaur samples revealed delicate fibres in secondary trabecular and secondary endosteal bone that in ...
Source: Biology Letters - January 1, 2018 Category: Biology Authors: Lambertz M, Bertozzo F, Sander PM Tags: Biol Lett Source Type: research

Severe prostate enlargement with severe lower urinary tract symptoms in poorly controlled acromegaly successfully treated with 5 α‐reductase inhibitors: A 15‐year longitudinal case report
Acromegaly is a rare disease associated with an increased risk of prostate enlargement. Severe prostate enlargement with severe lower urinary tract symptoms (LUTS) in an acromegalic patient is even more uncommon. Herein we report on a 55‐year‐old man who was diagnosed with acromegaly and prostate enlargement at 40 years of age. Transsphenoidal surgery, postoperative radiotherapy, and octreotide medical therapy failed to control the acromegaly, and growth hormone (GH) and insulin‐like growth factor 1 (IGF‐1) levels remained elevated. When the patient was 53 years of age, severe LUTS and prostate enlarg...
Source: LUTS: Lower Urinary Tract Symptoms - January 1, 2018 Category: Urology & Nephrology Authors: Yu ‐Chen Chen, Hao‐Wei Chen, Ming‐Tan Chen, Chun‐Hsiung Huang, Ching‐Chia Li, Yung‐Shun Juan, Hung‐Lung Ke Tags: CASE REPORT Source Type: research

Correction to: Pegvisomant in acromegaly: an update
AbstractUnfortunately, in page 584, second column, the first sentence under the heading “Type of switch” has been published incorrectly. The complete correct sentence is given below. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - December 28, 2017 Category: Endocrinology Source Type: research

Coronary microvascular dysfunction may be related to IGF-1 in acromegalic patients and can be restored by therapy
Acromegaly increases the risk of cardiovascular mortality. Data on the cardiovascular risk in asymptomatic acromegaly are limited. In particular, data on coronary microvascular abnormalities are lacking. We assessed coronary flow reserve (CFR) as a marker of coronary microvascular function in asymptomatic acromegaly. (Source: Atherosclerosis)
Source: Atherosclerosis - December 23, 2017 Category: Cardiology Authors: Sara Tellatin, Pietro Maffei, Elena Osto, Francesca Dassie, Giulia Famoso, Roberta Montisci, Chiara Martini, Francesco Fallo, Martina Perazzolo Marra, Roberto Mioni, Sabino Iliceto, Roberto Vettor, Francesco Tona Source Type: research

Mapping AcroQOL scores to Eq-5d to obtain utility values for patients with acromegaly.
CONCLUSIONS: A mapping algorithm was developed for mapping of AcroQoL to EQ-5D, using patient level data from 3 previously published studies, and including validation in confirmatory sub-sample. Mean (SD) utilities index in this study population was estimated as 0.71(0.28). Additional research may be needed to test this mapping algorithm in other acromegaly populations. PMID: 29261359 [PubMed - as supplied by publisher] (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - December 22, 2017 Category: Health Management Tags: J Med Econ Source Type: research

Effects of growth hormone on thyroid function are mediated by type 2 iodothyronine deiodinase in humans
AbstractPurposeGrowth hormone (GH) therapy in adults alters thyroid function, and acromegaly often involves thyroid disease. The present study aimed to elucidate roles and mechanisms of GH in regulating thyroid function.MethodsWe performed two retrospective observational studies, which focused on consecutive patients with severe adult GH deficiency who received recombinant human GH (rhGH) therapy (n = 20) and consecutive patients with acromegaly who underwent transsphenoidal surgery (TSS) (n = 25). In both studies, serum free triiodothyronine (fT3), free thyroxine (fT4), and fT3/fT4 ratio were e...
Source: Endocrine - December 22, 2017 Category: Endocrinology Source Type: research

Association between dopamine and somatostatin receptor expression and pharmacological response to somatostatin analogues in acromegaly.
DA, Soto-Moreno A Abstract Acromegaly is a hormonal disorder resulting from excessive growth hormone (GH) secretion frequently produced by pituitary adenomas and consequent increase in insulin-like growth factor 1 (IGF-I). Elevated GH and IGF-I levels result in a wide range of somatic, cardiovascular, endocrine, metabolic and gastrointestinal morbidities. Somatostatin analogues (SSAs) form the basis of medical therapy for acromegaly and are currently used as first-line treatment or as second-line therapy in patients undergoing unsuccessful surgery. However, a considerable percentage of patients do not respond to S...
Source: J Cell Mol Med - December 21, 2017 Category: Molecular Biology Authors: Venegas-Moreno E, Vazquez-Borrego MC, Dios E, Gros-Herguido N, Flores-Martinez A, Rivero-Cortés E, Madrazo-Atutxa A, Japón MA, Luque RM, Castaño JP, Cano DA, Soto-Moreno A Tags: J Cell Mol Med Source Type: research

Surgical treatment in a case of giant macrodystrophia lipomatosa of the forefoot.
We report the case of a 37-month-old boy, with no prior past medical history, who presented with a gigantic dystrophy of the left forefoot. The location of the deformity was involving the plantar and dorsal aspect of the foot, and digits 1 to 4. After clinical examination, imaging study assessment, and differential diagnosis considerations, it was established that macrodystrophia lipomatosa was the cause of the deformity. A reconstructive surgical intervention was planned. The hypertrophied tissues were excised, resulting in a reduction in the forefoot's volume. The patient had a favorable postoperative course and ambulati...
Source: Romanian Journal of Morphology and Embryology - December 20, 2017 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Age- and Sex-Specific Differences as Predictors of Surgical Remission among Patients with Acromegaly.
Abstract Context: Sex and age are factors conferring resistance to medical treatment in patients with acromegaly. However, their impact on outcomes of transsphenoidal adenomectomy (TSA) has not been evaluated. Objective: The purpose of this study was to analyze age- and sex-related differences concerning surgical outcomes of growth hormone (GH)-secreting pituitary adenomas. Design: Retrospective. Setting: Single-center tertiary hospital. Participants: Patients with acromegaly (n=463) who underwent TSA between January 2000 and July 2014. Intervention: TSA. Main outcome: Tumor character...
Source: The Journal of Clinical Endocrinology and Metabolism - December 20, 2017 Category: Endocrinology Authors: Park SH, Ku CR, Moon JH, Kim EH, Kim SH, Lee EJ Tags: J Clin Endocrinol Metab Source Type: research

Expression of E-cadherin, Slug and NCAM and its relationship to tumor invasiveness in patients with acromegaly.
The objective of this study was to evaluate E-cadherin, Slug and neural cell adhesion molecule (NCAM) expression in GH-secreting pituitary adenomas and its relationship to tumor invasiveness. A cross-sectional study of patients who underwent hypophysectomy due to GH-secreting pituitary adenoma from April 2007 to December 2014 was carried out. The medical records were reviewed to collect clinical data. Immediately after surgery, tumor samples were frozen in liquid nitrogen and stored in a biofreezer at -80°C for assessment of E-cadherin 1 (CDH1), SLUG (SNAI2), and NCAM (NCAM1) by real-time PCR. The samples were fixed in...
Source: Braz J Med Biol Res - December 11, 2017 Category: Research Authors: Mendes GA, Haag T, Trott G, Rech CGSL, Ferreira NP, Oliveira MC, Kohek MB, Pereira-Lima JFS Tags: Braz J Med Biol Res Source Type: research

Discordance between mass spectrometry and immunometric IGF-1 assay in pituitary disease: a prospective study
ConclusionsIGF-1 results may differ after switching from an older immunoassay to a consensus-compliant assay such as LC-MS. Clinicians should consider the potential impact of assay switching before altering treatment due to discrepant results, particularly in patients monitored over time, such as those with acromegaly and GH deficiency. (Source: Pituitary)
Source: Pituitary - December 7, 2017 Category: Endocrinology Source Type: research

Neuroendocrine tumors of the thymus.
Authors: Filosso PL, Ruffini E, Solidoro P, Roffinella M, Lausi PO, Lyberis P, Oliaro A, Guerrera F Abstract Primary neuroendocrine tumors of the thymus (NETTs) are rare and biologically very aggressive neoplasms, usually located in the anterior mediastinal space. They are more frequently observed in males, in their fourth/fifth decades of life. In 50% of cases, NETTs are associated with endocrinopaties [Cushing's syndrome, acromegaly or Multiple Endocrine Neoplasia-1 (MEN-1) syndrome]. NETTs very often present with invasion of the surrounding mediastinal anatomical structures. Surgery, even in advanced stages, is ...
Source: Journal of Thoracic Disease - December 6, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Bone histomorphometry in acromegaly patients with fragility vertebral fractures
ConclusionsThe apparent paradox of bone fragility in acromegaly patients with a normal BMD can be explained by increased cortical thickness and porosity and reduced trabecular thickness with increased trabecular separation. These structural and microarchitectural abnormalities persist in the controlled phase of acromegaly despite bone turnover normalization. The main determinant of bone disease after hormonal control is severe osteoblastic dysfunction. (Source: Pituitary)
Source: Pituitary - December 6, 2017 Category: Endocrinology Source Type: research

Synchrotron scanning reveals amphibious ecomorphology in a new clade of bird-like dinosaurs
Nature advance online publication 06 December 2017. doi:10.1038/nature24679 Authors: Andrea Cau, Vincent Beyrand, Dennis F. A. E. Voeten, Vincent Fernandez, Paul Tafforeau, Koen Stein, Rinchen Barsbold, Khishigjav Tsogtbaatar, Philip J. Currie & Pascal Godefroit Maniraptora includes birds and their closest relatives among theropod dinosaurs. During the Cretaceous period, several maniraptoran lineages diverged from the ancestral coelurosaurian bauplan and evolved novel ecomorphologies, including active flight, gigantism, cursoriality and herbivory. Propagation X-ray phase-contrast synchrotron microtomography of a well-...
Source: Nature AOP - December 6, 2017 Category: Research Authors: Andrea Cau Vincent Beyrand Dennis F. A. E. Voeten Vincent Fernandez Paul Tafforeau Koen Stein Rinchen Barsbold Khishigjav Tsogtbaatar Philip J. Currie Pascal Godefroit Tags: Letter Source Type: research

Isolated Absent Thelarche in a Patient With Neurofibromatosis Type 1 and Acromegaly.
CONCLUSIONS: Neither neurofibromatosis type 1, acromegaly, nor neurofibromatosis 1 microdeletion syndrome are linked to absent thelarche. After attempting hormone therapy, patients with absent thelarche should be evaluated for congenital breast anomalies, estrogen receptor abnormalities, or gene defects. Psychological and surgical consultation should also be offered. PMID: 29215515 [PubMed - as supplied by publisher] (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - December 4, 2017 Category: OBGYN Authors: Martini AE, Zolton JR, DeCherney AH Tags: Obstet Gynecol Source Type: research

Increased prevalence of proliferative retinopathy in patients with acromegaly
Conclusion The high proliferative, but absence of non-proliferative retinopathy in our patients with acromegaly may reflect the pathogenic effect of IGF-1 on neovascularization. IGF-1 may play an important role in proliferative retinopathy, but may play no role in non-proliferative retinopathy. (Source: Journal of the Chinese Medical Association)
Source: Journal of the Chinese Medical Association - December 2, 2017 Category: General Medicine Source Type: research

Association between dopamine and somatostatin receptor expression and pharmacological response to somatostatin analogues in acromegaly
Abstract Acromegaly is a hormonal disorder resulting from excessive growth hormone (GH) secretion frequently produced by pituitary adenomas and consequent increase in insulin‐like growth factor 1 (IGF‐I). Elevated GH and IGF‐I levels result in a wide range of somatic, cardiovascular, endocrine, metabolic and gastrointestinal morbidities. Somatostatin analogues (SSAs) form the basis of medical therapy for acromegaly and are currently used as first‐line treatment or as second‐line therapy in patients undergoing unsuccessful surgery. However, a considerable percentage of patients do not respond to SSAs treatment. So...
Source: Journal of Cellular and Molecular Medicine - December 1, 2017 Category: Molecular Biology Authors: Eva Venegas ‐Moreno, Mari C. Vazquez‐Borrego, Elena Dios, Noelia Gros‐Herguido, Alvaro Flores‐Martinez, Esther Rivero‐Cortés, Ainara Madrazo‐Atutxa, Miguel A. Japón, Raúl M. Luque, Justo P. Castaño, David A. Cano, Alfonso Soto‐Moreno Tags: Original Article Source Type: research

Detecting of sleep apnea in hospitalized patients with endocrin disorders
Introduction: Cardiovascular diseases are main risk factor of death and disability in patient with type 2 diabetes mellitus (T2DM), acromegaly, hypercortisolism, thyrotoxicosis . Sleep apnea (SA) plays an important role in development of cardiovascular complications in patients with different endocrine disorders. Screening for sleep apnea is not included in the standards of examination of patients with endocrinopathies. The aim of study was to estimate need of sleep apnea screening in patients with endocrine disorders. (Source: Sleep Medicine)
Source: Sleep Medicine - December 1, 2017 Category: Sleep Medicine Authors: I. Misnikova, Y. Kovaleva, V. Gubkina, A. Dreval Tags: Sleep Breathing Disorders Source Type: research

Obstructive sleep apnea characteristics in patients with well-controlled acromegaly and their compliance with positive airway pressure therapy
Conclusion: Our results confirm OSAS as a common disorder in acromegaly patients as well as PAP therapy being required for a majority of patients. Therefore, all acromegaly patients should be assessed in terms of OSAS and be followed closely for the evaluation of PAP adherence. PMID: 29151303 [PubMed] (Source: Turkish Journal of Medical Sciences)
Source: Turkish Journal of Medical Sciences - November 22, 2017 Category: General Medicine Tags: Turk J Med Sci Source Type: research

Postoperative Gamma Knife radiosurgery for cavernous sinus-invading growth hormone-secreting pituitary adenomas
We aimed to determine the long-term effects of Gamma knife radiosurgery (GKS) on remnants in the cavernous sinus (CS) after transsphenoidal surgery (TSS) for acromegaly and to identify its possible adverse effects. (Source: World Neurosurgery)
Source: World Neurosurgery - November 16, 2017 Category: Neurosurgery Authors: Eui Hyun Kim, Min Chul Oh, Jong Hee Chang, Ju Hyung Moon, Cheol Ryong Ku, Won-Seok Chang, Eun Jig Lee, Sun Ho Kim Tags: Original article Source Type: research

A case of piezogenic pedal papules in a man with acromegaly
Endocrine Practice, Ahead of Print. (Source: Endocrine Practice)
Source: Endocrine Practice - November 16, 2017 Category: Endocrinology Authors: Kenyon C. Bolton Matthew P. Gilbert Source Type: research

Postoperative Gamma Knife Radiosurgery for Cavernous Sinus –Invading Growth Hormone–Secreting Pituitary Adenomas
We aimed to determine the long-term effects of Gamma knife radiosurgery (GKS) on remnants in the cavernous sinus (CS) after transsphenoidal surgery (TSS) for acromegaly and to identify its possible adverse effects. (Source: World Neurosurgery)
Source: World Neurosurgery - November 16, 2017 Category: Neurosurgery Authors: Eui Hyun Kim, Min Chul Oh, Jong Hee Chang, Ju Hyung Moon, Cheol Ryong Ku, Won-Seok Chang, Eun Jig Lee, Sun Ho Kim Tags: Original Article Source Type: research

Efficacy and safety of switching to pasireotide in acromegaly patients controlled with pegvisomant and first-generation somatostatin analogues (PAPE study).
Conclusions: Switching to PAS-LAR, either as monotherapy, or combination with pegvisomant, can control IGF-I levels in the majority of patients. PAS-LAR demonstrated a pegvisomant sparing effect of 66% compared to the combination with LA-SSAs. Hyperglycemia was the most important safety issue. PMID: 29155991 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - November 15, 2017 Category: Endocrinology Authors: Muhammad A, van der Lely AJ, Delhanty PJD, Dallenga AHG, Haitsma IK, Janssen JAMJL, Neggers SJCMM Tags: J Clin Endocrinol Metab Source Type: research

Cardiomyopathy in acromegaly and the effect of trans-sphenoidal surgery
Subhash Yadav, Eesh BhatiaNeurology India 2017 65(6):1223-1224 (Source: Neurology India)
Source: Neurology India - November 10, 2017 Category: Neurology Authors: Subhash Yadav Eesh Bhatia Source Type: research

Echocardiographic improvements following transsphenoidal surgery for acromegaly
Antonio Ribeiro-Oliveira, Márta Korbonits, Claudia M V FreireNeurology India 2017 65(6):1225-1226 (Source: Neurology India)
Source: Neurology India - November 10, 2017 Category: Neurology Authors: Antonio Ribeiro-Oliveira M & #225;rta Korbonits Claudia M V Freire Source Type: research

Impact of transsphenoidal surgery on asymptomatic cardiomyopathy in patients with acromegaly. A single-blinded study
Conclusion: Reduction in growth hormone levels and insulin-like growth factor type 1 can decrease the LVM and LVMI, which directly or indirectly contributes to the improvement in diastolic as well as systolic function and probably mortality. (Source: Neurology India)
Source: Neurology India - November 10, 2017 Category: Neurology Authors: Anirudh Srinivasan Ajay Bahl Hemant Bhagat Pinaki Dutta Ashutosh Rai Jagtar S Devgun Rupinder Kaur Kanchan Kumar Mukherjee Source Type: research