[Correspondence] Acromegaly in Lorenzo the Magnificent, father of the Renaissance
Lorenzo de' Medici (1449 –92), also known as the Magnificent, was a statesman, patron of arts, and a key supporter of the Renaissance, a cultural movement in Italy that spread throughout Europe, marking the beginning of the Early Modern Age (from the 14th to the 17th century). (Source: LANCET)
Source: LANCET - May 26, 2017 Category: General Medicine Authors: Donatella Lippi, Philippe Charlier, Paola Romagnani Tags: Correspondence Source Type: research
Anti-tumoral effects of somatostatin analogs: a lesson from the CLARINET study
AbstractOctreotide and lanreotide, the first-generation somatostatin analogs, successfully control hormone hyperproduction, and related syndromes, in patients with acromegaly and neuroendocrine tumors. However, their anti-tumor effect, rather evident in large number of pituitary adenomas in acromegalic patients, has been hypothesized for a long time in patients with neuroendocrine tumors as well, although a significant tumor shrinkage has rarely been observed. However, the recent publication of the CLARINET study has strengthened the evidence, already emerged with the PROMID trial, that the long-term treatment with the fir...
Source: Journal of Endocrinological Investigation - May 26, 2017 Category: Endocrinology Source Type: research
Acromegaly in Lorenzo the Magnificent, father of the Renaissance
Publication date: 27 May–2 June 2017 Source:The Lancet, Volume 389, Issue 10084 Author(s): Donatella Lippi, Philippe Charlier, Paola Romagnani (Source: The Lancet)
Source: The Lancet - May 26, 2017 Category: General Medicine Source Type: research
Independent evolution of baleen whale gigantism linked to Plio-Pleistocene ocean dynamics
Vertebrates have evolved to gigantic sizes repeatedly over the past 250 Myr, reaching their extreme in today's baleen whales (Mysticeti). Hypotheses for the evolution of exceptionally large size in mysticetes range from niche partitioning to predator avoidance, but there has been no quantitative examination of body size evolutionary dynamics in this clade and it remains unclear when, why or how gigantism evolved. By fitting phylogenetic macroevolutionary models to a dataset consisting of living and extinct species, we show that mysticetes underwent a clade-wide shift in their mode of body size evolution during the Plio-Ple...
Source: Proceedings of the Royal Society B: Biological Sciences - May 24, 2017 Category: Biology Authors: Slater, G. J., Goldbogen, J. A., Pyenson, N. D. Tags: palaeontology, evolution Palaeobiology Source Type: research
Cross-sectional prevalence of pancreatic cystic lesions in patients with acromegaly, a single-center experience
AbstractPurposeAcromegaly is a disease associated with an increased risk for several kinds of neoplasms including colon and thyroid cancer. Although the association between acromegaly and pancreatic neoplasms has not been elucidated, it has recently been reported thatGNAS gene mutations were found in 58% of intraductal papillary mucinous neoplasms (IPMNs), which are representative pancreatic cystic lesions, suggesting a link between IPMNs and acromegaly. To assess the prevalence of pancreatic cystic lesions in patients with acromegaly, we performed a retrospective cross-sectional single institute study.MethodsThirty consec...
Source: Pituitary - May 24, 2017 Category: Endocrinology Source Type: research
Standardization of Growth Hormone and Insulin-like Growth Factor-I Measurements.
Authors: Katsumata N Abstract Measurement of the levels of growth hormone (GH) and its related factor insulin-like growth factor I (IGF-I) is essential for the diagnosis and treatment of GH deficiency (GHD) and conditions related to excess GH such as acromegaly and pituitary gigantism. Measurement of GH levels is also used as an indicator of hypothalamic-pituitary function. Because of the marked variability in GH measurements among kits, the Study Committee for GH and Its Related Factors of The Foundation for Growth Science, Japan standardized GH values measured with various commercially available GH assay kits in ...
Source: Pediatric Endocrinology Reviews - May 19, 2017 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Alveoli, teeth, and tooth loss: Understanding the homology of internal mandibular structures in mysticete cetaceans
by Carlos Mauricio Peredo, Nicholas D. Pyenson, Mark D. Uhen, Christopher D. Marshall The evolution of filter feeding in baleen whales (Mysticeti) facilitated a wide range of ecological diversity and extreme gigantism. The innovation of filter feeding evolved in a shift from a mineralized upper and lower dentition in stem mysticetes to keratinous baleen plates that hang only from t he roof of the mouth in extant species, which are all edentulous as adults. While all extant mysticetes are born with a mandible lacking a specialized feeding structure (i.e., baleen), the bony surface retains small foramina with elongated sulc...
Source: PLoS One - May 19, 2017 Category: Biomedical Science Authors: Carlos Mauricio Peredo Source Type: research
Somatotropinomas inadequately controlled with octreotide may over-respond to pasireotide: the importance of dose adjustment to achieve long-term biochemical control.
CONCLUSION: These patients achieved long-term biochemical control, tumour volume reduction and improvement of clinical signs/symptoms after switching from octreotide to pasireotide. IGF-1 over-suppression is observed in a few patients and requires dose adjustment of pasireotide. PMID: 28500831 [PubMed - in process] (Source: Hormones)
Source: Hormones - May 15, 2017 Category: Endocrinology Tags: Hormones (Athens) Source Type: research
Evaluation of macular and peripapillary choroidal thickness, macular volume and retinal nerve fiber layer in acromegaly patients
AbstractPurposeTo evaluate macular volume, retinal nerve fiber layer, and macular and peripapillary choroidal thickness in acromegaly patients.MethodIn this prospective, case –control study, 31 patients with acromegaly and 32 healthy subjects were recruited. Only right eyes were evaluated. Macular choroidal thickness (CT) was measured at three points, peripapillary CT was measured at eight points, and macular volume was measured at nine areas in the central 6 mm circl e zone by spectraldomain optical coherence tomography (OCT). Retinal nerve fiber layer (RNFL) was measured automatically at six segments by OCT.Re...
Source: International Ophthalmology - May 15, 2017 Category: Opthalmology Source Type: research
Classification of patients with GH disorders may vary according to the IGF-I assay.
Conclusion: Even when using normative data obtained in the same large population of healthy subjects and when using calculated IGF-I SD scores, agreement among IGF-I assay methods is only moderate to good. Differences in assay performance must be taken into account when evaluating and monitoring patients with GH disorders. This argues for the use of the same IGF-I assay for a given patient throughout follow-up. PMID: 28505364 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - May 12, 2017 Category: Endocrinology Authors: Mavromati M, Kuhn E, Agostini H, Brailly-Tabard S, Massart C, Piketty ML, Arnoux A, Young J, Souberbielle JC, Chanson P Tags: J Clin Endocrinol Metab Source Type: research
Octreotide ‐Associated Neutropenia
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 10, 2017 Category: Drugs & Pharmacology Authors: Stacy S. Tse, Troy Kish Tags: Case Report Source Type: research
GH-secreting pituitary macroadenoma (acromegaly) associated with progressive dental malocclusion and refractory CPAP treatment
A link between progressive dental malocclusion, the use of a continuous positive airway pressure mask and GH-secreting pituitary macroadenoma (acromegaly) has not been previously reported. The present clinicop... (Source: Head and Face Medicine)
Source: Head and Face Medicine - May 10, 2017 Category: ENT & OMF Authors: Jaume Miranda-Rius, Llu ís Brunet-LLobet, Eduard Lahor-Soler, David de Dios-Miranda and Josep Anton Giménez-Rubio Source Type: research
Melvin M. Grumbach 1925-2016 [Retrospectives]
Generations of clinicians have been faced with often striking developmental and acquired hormonal syndromes associated with reproductive, growth, and metabolic phenotypes. These syndromes have included ambiguous genitalia, anomalies of sexual development, intersex forms, accelerated or delayed puberty, gigantism, and short stature. Although clinical phenotypes of these disorders have been well-established,... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - May 9, 2017 Category: Science Authors: Shlomo Melmed Tags: Retrospectives Source Type: research
How to investigate a child with excessive growth?
uet N Abstract The diagnostic approach to tall stature in children is based on collecting birth data (macrosomia), sizes and family puberty, a family history of constitutional or pathological tall stature, search for a delay of development, dysmorphia, disproportion, analysis of the growth velocity (normal or accelerated), general examination and assessment of puberty, and bone age. When there is a history of psychomotor retardation, a family history of pathological tall stature, or a disproportion in the clinical examination, the genetic causes of tall stature will be mentioned. The most frequent causes are Marfa...
Source: Annales d'Endocrinologie - May 5, 2017 Category: Endocrinology Authors: Coutant R, Donzeau A, Decrequy A, Louvigné M, Bouhours-Nouet N Tags: Ann Endocrinol (Paris) Source Type: research
AIP mutations and gigantism.
Abstract AIP mutations are rare in sporadic acromegaly but they are seen at a higher frequency among certain specific populations of pituitary adenoma patients (pituitary gigantism cases, familial isolated pituitary adenoma (FIPA) kindreds, and patients with macroadenomas who are diagnosed ≤30 years). AIP mutations are most prevalent in patients with pituitary gigantism (29% of this group were found to have mutations in AIP gene). These data support targeted genetic screening for AIP mutations/deletions in these groups of pituitary adenoma patients. Earlier diagnosis of AIP-related acromegaly-gigantism cases en...
Source: Annales d'Endocrinologie - May 5, 2017 Category: Endocrinology Authors: Rostomyan L, Potorac I, Beckers P, Daly AF, Beckers A Tags: Ann Endocrinol (Paris) Source Type: research
Treatment of acromegaly patients at the Federal University of Triângulo Mineiro (UFTM): Experience Report
CONCLUSION: The current treatment options enable patients seen in regional reference centers to achieve strict control parameters, which allows them to be treated close to their homes. (Source: Clinics)
Source: Clinics - May 4, 2017 Category: Journals (General) Source Type: research
Spontaneous Remission of Acromegaly after Pituitary Apoplexy
We report herein a patient with acromegaly (Source: Annals of Saudi Medicine)
Source: Annals of Saudi Medicine - May 4, 2017 Category: Journals (General) Tags: ISSUE 2 Source Type: research
3D Volumetric Measurements of GH Secreting Adenomas Correlate with Baseline Pituitary Function, Initial Surgery Success Rate, and Disease Control
Horm Metab Res DOI: 10.1055/s-0043-107245There is scarce data on the clinical utility of volume measurement for growth hormone (GH)-secreting pituitary adenomas. The current study objective was to assess the association between pituitary adenoma volumes and baseline endocrine evaluation, initial surgical success rate, and disease control among patients with acromegaly. A retrospective cohort study was conducted at a clinical research center including patients with acromegaly due to GH-secreting pituitary adenomas. Baseline hormonal evaluation and adenoma characteristics according to MRI were collected. Volumetric measureme...
Source: Hormone and Metabolic Research - May 4, 2017 Category: Endocrinology Authors: Tirosh, Amit Papadakis, Georgios Z. Chittiboina, Prashant Lyssikatos, Charalampos Belyavskaya, Elena Keil, Meg Lodish, Maya B. Stratakis, Constantine A. Tags: Endocrine Care Source Type: research
Assessment of Nasal Carriage of Staphylococcus Aureus and Axillar Flora in Patients With Acromegaly
Conclusion: The authors demonstrated that compared with healthy subjects, acromegalic patients had low percentage of nasal carriage of Staphylococcus aureus and more gram-negative basili in the axillar flora. These nasal and axillar flora changes should be considered for prophylactic antibiotics use before surgery and ampiric antibiotics use after surgery. (Source: Journal of Craniofacial Surgery)
Source: Journal of Craniofacial Surgery - May 1, 2017 Category: Surgery Tags: Original Articles Source Type: research
Beckwith-Wiedemann Syndrome Review: A Guide for the Neonatal Nurse.
This article focuses on the presentation of BWS as an aid to early detection. PMID: 28494824 [PubMed - in process] (Source: Neonatal Network)
Source: Neonatal Network - May 1, 2017 Category: Perinatology & Neonatology Authors: Zammit M, Caruana E, Cassar D, Calleja-Agius J Tags: Neonatal Netw Source Type: research
Outcome of Endoscopic Transsphenoidal Surgery for Acromegaly
Endoscopic transsphenoidal surgery has recently been introduced in pituitary surgery. We investigated outcomes and complications of endoscopic surgery in two referral centers in Korea. (Source: World Neurosurgery)
Source: World Neurosurgery - April 29, 2017 Category: Neurosurgery Authors: Jung Hee Kim, Kyu Yeon Hur, Jung Hyun Lee, Ji Hyun Lee, Young-Bem Se, Hey In Kim, Seung Hoon Lee, Do-Hyun Nam, Seong Yeon Kim, Kwang-Won Kim, Doo-Sik Kong, Yong Hwy Kim Tags: Original article Source Type: research
X-LAG: How did they grow so tall?
Abstract X-linked acrogigantism (XLAG) is a new, pediatric-onset genetic syndrome, due to Xq26.3 microduplications encompassing the GPR101 gene. XLAG has a remarkably distinct phenotype with disease onset occurring before the age of 5 in all cases described to date, which is significantly younger than in other forms of pituitary gigantism. These patients have mixed GH and prolactin positive adenomas and/or mixed-cell hyperplasia and highly elevated levels of GH/IGF-1 and prolactin. Given their particularly young age of onset, the significant GH hypersecretion can lead to a phenotype of severe gigantism with very a...
Source: Annales d'Endocrinologie - April 27, 2017 Category: Endocrinology Authors: Beckers A, Rostomyan L, Potorac I, Beckers P, Daly AF Tags: Ann Endocrinol (Paris) Source Type: research
Treatment of GPR101-Related, Growth Hormone-Related Disorders Such as Gigantism, Dwarfism or Acromegaly
Microduplications of theGPR101 gene (located on chromosome Xq26.3 and encodes a G-protein coupled receptor) can result in an excess of growth hormone causing gigantism, that has an onset in early childhood. It is also associated with the growth of sporadic growth hormone producing adenomas in some patients with acromegaly.Current therapies (such as surgical resection of tumors or treatment with somatostatin analogs) for acromegaly, gigantism and other disorders of pituitary hormone hypersecretion can be ineffective, thereby creating a need for alternative therapies in this space.The inventors at NICHD have developed a cell...
Source: NIH OTT Licensing Opportunities - April 26, 2017 Category: Research Authors: ajoyprabhu3 Source Type: research
Clinical Importance of Somatostatin Receptor 2 (SSTR2) and Somatostatin Receptor 5 (SSTR5) Expression in Thyrotropin-Producing Pituitary Adenoma (TSHoma).
Authors: Yu B, Zhang Z, Song H, Chi Y, Shi C, Xu M Abstract BACKGROUND Thyrotropin-secreting pituitary adenomas (TSHomas) are a rare cause of hyperthyroidism. Somatostatin analogs have proved to be effective for inhibiting pituitary hormones secretion, working via interactions with somatostatin receptors (SSTRs). Moreover, antiproliferative activity of somatostatin analog is now demonstrated in several studies. In the present study, we determined the relative predominance of SSTR2 and SSTR5 subtypes among the different types of adenomas, especially TSHoma, and investigated the relationship between efficacy of short...
Source: Medical Science Monitor - April 25, 2017 Category: Research Tags: Med Sci Monit Source Type: research
Suffocation due to Thoracic Deformity Caused by Acromegaly.
Authors: Yoshizawa T, Iwazaki M, Jitsuiki K, Ishikawa K, Ohsaka H, Yanagawa Y Abstract A 61-year-old man with gigantism and acromegaly choked and fell into a coma. Immediate tracheal intubation resulted in a return of his consciousness. Enhanced computed tomography indicated that the trachea and left main bronchus were compressed by the thoracic spine and sternum. He required tracheotomy and positive end-expiratory pressure to maintain his pulmonary function. This is the first case of suffocation due to a thoracic deformity associated with acromegaly. Physicians should focus on clearing the tracheal airway using co...
Source: Internal Medicine - April 22, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research
Efficacy and optimal timing of tongue reduction surgery in three patients with Beckwith –Wiedemann syndrome
We report three cases with BWS who were considered efficacy and optimal timing of tongue reduction surgery and had positive outcome. It is concluded that the capable timing for tongue surgery to mitigate macroglossia should be between 2 to 3 years of age. (Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology)
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - April 21, 2017 Category: ENT & OMF Source Type: research
Role of Phosphodiesterases on the Function of Aryl Hydrocarbon Receptor-Interacting Protein (AIP) in the Pituitary Gland and on the Evaluation of AIP Gene Variants
Horm Metab Res 2017; 49: 286-295 DOI: 10.1055/s-0043-104700Familial isolated pituitary adenoma (FIPA) is caused in about 20% of cases by loss-of-function germline mutations in the AIP gene. Patients harboring AIP mutations usually present with somatotropinomas resulting either in gigantism or young-onset acromegaly. AIP encodes for a co-chaperone protein endowed with tumor suppressor properties in somatotroph cells. Among other mechanisms proposed to explain this function, a regulatory effect over the 3′,5′-cyclic adenosine monophosphate (cAMP) signaling pathway seems to play a prominent role. In this setting, ...
Source: Hormone and Metabolic Research - April 20, 2017 Category: Endocrinology Authors: Hern ández-Ramírez, Laura C. Trivellin, Giampaolo Stratakis, Constantine A. Tags: Review Source Type: research
Endocrine Comorbidities in Patients with Psoriatic Arthritis: A Population-based Case-controlled Study.
Authors: Haddad A, Ashkenazi RI, Bitterman H, Feldhamer I, Greenberg-Dotan S, Lavi I, Batat E, Bergman I, Cohen AD, Zisman D Abstract OBJECTIVE: To investigate endocrine comorbidities in patients with psoriatic arthritis (PsA). METHODS: A retrospective, cross-sectional study was performed with the database of Clalit Health Services, the largest healthcare provider in Israel, between 2002 and 2014. Patients with PsA were identified and matched by age and sex to healthy controls. The following morbidities were analyzed: hypo/hyperthyroidism, hypo/hyperparathyroidism, hyperprolactinemia, Cushing disease, Addison d...
Source: Journal of Rheumatology - April 17, 2017 Category: Rheumatology Tags: J Rheumatol Source Type: research
High-dose and high-frequency lanreotide autogel in acromegaly: a randomized, multicenter study.
HIGH-DOSE AND HIGH-FREQUENCY LANREOTIDE AUTOGEL IN ACROMEGALY: A RANDOMIZED, MULTICENTER STUDY. J Clin Endocrinol Metab. 2017 Apr 17;: Authors: Giustina A, Mazziotti G, Cannavò S, Castello R, Arnaldi G, Bugari G, Cozzi R, Ferone D, Formenti AM, Gatti E, Grottoli S, Maffei P, Maffezzoni F, Montini M, Terzolo M, Ghigo E Abstract Context: The increase in drug frequency or dose is recommended for acromegaly patients with partial response to long-acting somatostatin receptor ligands (SRLs). However, the efficacy and safety data with lanreotide autogel (LAN-ATG) at high-dose (HD) or high-frequency (H...
Source: The Journal of Clinical Endocrinology and Metabolism - April 17, 2017 Category: Endocrinology Authors: Giustina A, Mazziotti G, Cannavò S, Castello R, Arnaldi G, Bugari G, Cozzi R, Ferone D, Formenti AM, Gatti E, Grottoli S, Maffei P, Maffezzoni F, Montini M, Terzolo M, Ghigo E Tags: J Clin Endocrinol Metab Source Type: research
A case of neuronal gigantism and cortical thickening: A rare complication of therapeutic radiation (P6.187)
Conclusions:Our case presented only 2 years after radiotherapy suggesting this toxicity can be an earlier complication that clinicians should be aware of.Disclosure: Dr. Shaikh has nothing to disclose. Dr. kumthekar has nothing to disclose. Dr. Raizer has received personal compensation for activities with Genentech/Roche, Abbvie, Stemline, Foundation Medicine, Novocure, Proximagene, Bristol-Meyers Squibb, and Aurasense as a speaker and advisory board member. Dr. Raizer has received research support from Genentech, Plexxikon, Novartis, Ziopharm, and Celldex. Dr. dixit has nothing to disclose. (Source: Neurology)
Source: Neurology - April 17, 2017 Category: Neurology Authors: Shaikh, N., Kumthekar, P., Raizer, J., Dixit, K. S. Tags: Neurologic Complications of Cancer Source Type: research
Mixed Gangliocytoma-Pituitary Adenoma: Insights on the Pathogenesis of a Rare Sellar Tumor
Gangliocytomas originating in the sellar region are rare; most are tumors composed of gangliocytic and pituitary adenomatous elements, forming the so-called mixed gangliocytoma-pituitary adenoma. The majority of mixed gangliocytoma adenomas are associated with endocrinopathies, mainly acromegaly and less often Cushing disease and hyperprolactinemia. In the present study, 10 cases of mixed gangliocytoma and somatotroph adenomas were evaluated for patterns of cellular differentiation and expression of lineage-specific transcription factors. The tumors were characterized by immunohistochemistry for pituitary hormones, cytoker...
Source: The American Journal of Surgical Pathology - April 15, 2017 Category: Pathology Tags: Original Articles Source Type: research
Expression of Somatostatin Receptor 2 in Somatotropinoma Correlated with the Short-Term Efficacy of Somatostatin Analogues.
In conclusion, the protein expression of SSTR2, but not of SSTR5, is a valuable indicator in predicting biochemical and tumor size response to short-term SSA treatment in acromegalic patients. PMID: 28396686 [PubMed - in process] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - April 12, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research
Calcium and bone turnover markers in acromegaly: a prospective controlled study.
Abstract Context: Acromegaly has been associated with calcium-phosphate and bone turnover alterations. Controlled studies of these interactions are sparse. Objective: To evaluate calcium and bone metabolism in active and treated acromegaly. Design/Setting/Patients: We conducted a controlled prospective study at a tertiary referral center. We studied 22 patients with acromegaly referred for surgical or medical therapy (ACM) and 22 with nonfunctioning pituitary adenomas referred for surgery (control). Main outcome measures: Calcium (serum and urine), phosphorus, PTH, 25-hydroxy- and 1,25-dihydroxy-vitamin ...
Source: The Journal of Clinical Endocrinology and Metabolism - April 12, 2017 Category: Endocrinology Authors: Constantin T, Tangpricha V, Shah R, Oyesiku NM, Ioachimescu OC, Ritchie J, Ioachimescu AG Tags: J Clin Endocrinol Metab Source Type: research
The acylated/unacylated ghrelin ratio is similar in acromegaly patients during different treatment regimens.
Conclusions: Although plasma AG and UAG are suppressed during combination treatment of LA-SSA and PEGV, the AG/UAG ratio remained similar. This shows that somatostatin analogues decrease both AG and UAG, which suggest that they do not alter metabolism significantly in acromegaly patients. PMID: 28402548 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 11, 2017 Category: Endocrinology Authors: Muhammad A, Delhanty PJ, Huisman M, Visser JA, van der Lelij AJ, Neggers SJ Tags: J Clin Endocrinol Metab Source Type: research
Marked alteration of glycemic profile surrounding lanreotide administration in acromegaly: a case report
This article is protected by copyright. All rights reserved. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 8, 2017 Category: Endocrinology Authors: Sho Tanaka, Akira Haketa, Shun Yamamuro, Toshiko Suzuki, Hiroki Kobayashi, Yoshinari Hatanaka, Takahiro Ueno, Noboru Fukuda, Masanori Abe, Atsuo Yoshino, Masayoshi Soma Tags: Case Report Source Type: research
Treatment adherence and persistence with long-acting somatostatin analog therapy for the treatment of acromegaly: a retrospective analysis.
CONCLUSIONS: Treatment adherence was similarly good for both injectable SSA treatments studied, at 87% or greater. Persistence was greater with lanreotide than octreotide and the risk of discontinuing therapy was lower with lanreotide than octreotide. Further studies to determine factors leading to these differences in persistence or to predict discontinuation of therapy may aid in clinical management of these patients. PMID: 28372573 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - April 6, 2017 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
Treatment adherence and persistence with long-acting somatostatin analog therapy for the treatment of acromegaly: a retrospective analysis
Many patients with acromegaly require medical treatment that includes somatostatin analogs (SSAs). Long-acting SSA formulations are widely used, due in part to increased patient convenience and increased treat... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - April 4, 2017 Category: Drugs & Pharmacology Authors: Michelle H. Gurel, Yi Han, Andrea L. Stevens, Aaron Furtado and David Cox Source Type: research
Clinical Images: Widening of joint spaces in acromegaly
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - April 4, 2017 Category: Rheumatology Authors: Masei Suda, Yasuhiro Suyama, Masato Okada Tags: Clinical Image Source Type: research
Vitamin D across growth hormone (GH) disorders: From GH deficiency to GH excess.
Abstract The interplay between vitamin D and the growth hormone (GH)/insulin-like growth factor (IGF)-I system is very complex and to date it is not fully understood. GH directly regulates renal 1 alpha-hydroxylase activity, although the action of GH in modulating vitamin D metabolism may also be IGF-I mediated. On the other hand, vitamin D increases circulating IGF-I and the vitamin D deficiency should be normalized before measurement of IGF-I concentrations to obtain reliable and unbiased IGF-I values. Indeed, linear growth after treatment of nutritional vitamin D deficiency seems to be mediated through activati...
Source: Growth Hormone and IGF Research - April 1, 2017 Category: Endocrinology Authors: Ciresi A, Giordano C Tags: Growth Horm IGF Res Source Type: research
Utility of baseline serum phosphorus levels for predicting remission in acromegaly patients
AbstractPurposeHigh GH and IGF I levels increase tubular phosphate reabsorption in patients with acromegaly. We aimed to investigate the utility of serum phosphorus levels as an indicator for predicting chance of remission in acromegaly patients.DesignFifty-one patients (n: 51;F: 24,M: 27) with diagnosis of acromegaly were included in the study. Plasma IGF-1, Phosphorus (P) and nadir GH levels on oral glucose tolerance test (OGTT) at the time of diagnosis were analysed retrospectively. Patients were classified into two groups according to their plasma P levels;P ≤ 4.5 mg/dl (Group-1,n: 23, 45.1%),P&nb...
Source: Journal of Endocrinological Investigation - March 29, 2017 Category: Endocrinology Source Type: research
Growth hormone deficiency in treated acromegaly and active Cushing's syndrome
Publication date: Available online 9 March 2017 Source:Best Practice & Research Clinical Endocrinology & Metabolism Author(s): Anna Maria Formenti, Filippo Maffezzoni, Mauro Doga, Gherardo Mazziotti, Andrea Giustina Growth hormone deficiency (GHD) in adults is characterized by reduced quality of life and physical fitness, skeletal fragility, increased weight and cardiovascular risk. It may be found in (over-) treated acromegaly as well as in active Cushing's syndrome. Hypopituitarism may develop in patients after definitive treatment of acromegaly, although the exact prevalence of GHD in this population is...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - March 27, 2017 Category: Endocrinology Source Type: research
Body mass index and insulin-like growth factor 1 as risk factors for discordant growth hormone and insulin-like growth factor 1 levels following pituitary surgery in acromegaly
Conclusion Body mass index and percentage of upper limit of normal range IGF-1 before TSA might constitute prognostic risk factors for discordance in IGF-1 and GH levels in acromegaly. Additional attention should be devoted to potential risk factors for this phenomenon, and methods for modifying the cure and control criteria for acromegaly should be developed. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - March 22, 2017 Category: Journals (General) Source Type: research
Matrix metalloproteinase 2 (MMP-2) levels are increased in active acromegaly patients
This study was planned to investigate an association of serum levels of matrix metalloproteinase-2, matrix metalloproteinase-9, and cathepsin B with disease activity in acromegaly patients.MethodsIn this study, 64 acromegaly patients followed in our clinic were divided into two groups according to the 2010 consensus criteria for cure of acromegaly as patients with active disease (n = 24) and patients with controlled disease (n = 40). Serum matrix metalloproteinase-2, matrix metalloproteinase-9, and cathepsin B levels were measured by the enzyme-linked immunosorbent assay method.ResultsThe mean s...
Source: Endocrine - March 22, 2017 Category: Endocrinology Source Type: research
Body mass index and insulin-like growth factor 1 as risk factors for discordant growth hormone and insulin-like growth factor 1 levels following pituitary surgery in acromegaly.
CONCLUSION: Body mass index and percentage of upper limit of normal range IGF-1 before TSA might constitute prognostic risk factors for discordance in IGF-1 and GH levels in acromegaly. Additional attention should be devoted to potential risk factors for this phenomenon, and methods for modifying the cure and control criteria for acromegaly should be developed. PMID: 28341329 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - March 21, 2017 Category: Journals (General) Authors: Zhang S, Li Y, Guo X, Gao L, Lian W, Yao Y, Feng M, Bao X, Wang R, Xing B Tags: J Formos Med Assoc Source Type: research
Efficacy of transsphenoidal surgery in achieving biochemical cure of growth hormone-secreting pituitary adenomas among patients with cavernous sinus invasion: a systematic review and meta-analysis.
Authors: Briceno V, Zaidi HA, Doucette JA, Onomichi KB, Alreshidi A, Mekary RA, Smith TR Abstract OBJECTIVES: Growth hormone-secreting pituitary adenomas in adults can result in severe craniofacial disfigurement and potentially fatal medical complications. Surgical resection leading to remission of the disease is dependent on complete surgical resection of the tumor. Lesions that invade the cavernous sinus may not be safely accessible via an endonasal transsphenoidal surgery (TSS), and the rates of biochemical remission of patients with residual disease vary widely in the literature. We conducted a meta-analysis to...
Source: Neurological Research - March 20, 2017 Category: Neurology Tags: Neurol Res Source Type: research
Impaired quality of life in patients with treated acromegaly despite long ‐term biochemically stable disease: results from a 5‐year prospective study
ConclusionsPatients with biochemically controlled acromegaly demonstrate impaired QoL, which persists despite long‐term disease control. This primarily consists of impaired physical function and secondly of impaired psycho‐social well‐being. Duration of biochemical disease control and current use of GH lowering therapy were the predominant factors determining patients’ QoL.This article is protected by copyright. All rights reserved. (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - March 19, 2017 Category: Endocrinology Authors: Nikolaos Kyriakakis, Julie Lynch, Stephen G Gilbey, Susan M Webb, Robert D Murray Tags: Original Article Source Type: research
Persistent reduction of circulating myeloid calcifying cells in acromegaly. Relevance to the bone-vascular axis.
Abstract Context: Acromegaly is a systemic disease characterized by persistent bone pathology and excess cardiovascular mortality. Despite multiple concomitant risk factors, atherosclerosis does not seem to be accelerated in acromegaly. Objective: To compare the levels of circulating myeloid calcifying cells (MCCs), which promote ectopic calcification and inhibit angiogenesis, in individuals with or without acromegaly. Design: Cross-sectional case-control study. Setting: Tertiary ambulatory referral Endocrinology centre. Patients: 44 acromegalic patients (25 active; 19 inactive), 44 control sub...
Source: The Journal of Clinical Endocrinology and Metabolism - March 17, 2017 Category: Endocrinology Authors: Fadini GP, Dassie F, Cappellari R, Persano M, Vigili de Kreutzenberg S, Martini C, Parolin M, Avogaro A, Vettor R, Maffei P Tags: J Clin Endocrinol Metab Source Type: research
Focal gigantism in tuberous sclerosis
Publication date: Available online 17 March 2017 Source:International Journal of Epilepsy Author(s): Sanat R. Bhatkar, Aastha Takkar A 38 year lady had recurrent generalized and myoclonic seizures since 6 years of age. On examination she had facial adenoma sebaceum and periungal fibromas, cutaneous angiofibromas on the back. Contrast enhanced magnetic Resonance Imaging of brain was suggestive of multiple cortical tubers with sub ependymal nodules consistent with the diagnosis of Tuberous sclerosis. Focal hypertrophy of the skin of the dorsal aspect of the left hand with focal gigantism was noted. (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - March 16, 2017 Category: Neurology Source Type: research
Airway and sleep disorders in patients with acromegaly
ConclusionSDB seems to be common and clinically important in patients with acromegaly, particularly in men. The most frequent type of apnea in acromegalics is obstructive. Hormonal activity of acromegaly does not seem to have an effect on the development of SAS. Despite its high prevalence, SAS is frequently under‐assessed in patients with acromegaly. Systemic complications and SDB should be researched in acromegalics. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 13, 2017 Category: Respiratory Medicine Authors: Onur Turan, Bar ış Akinci, Ahmet Omer Ikiz, Oya Itil, Ibrahim Oztura, Emel Ada, Bahri Akdeniz, Serkan Yener, Murat Kaya, Arzu Gedik, Abdurrahman Comlekci Tags: ORIGINAL ARTICLE Source Type: research
In vitro head-to-head comparison between octreotide and pasireotide in GH-secreting pituitary adenomas.
Conclusions: Overall, OCT and PAS equally reduced GH secretion in vitro. Adenomas with lower sst2 mRNA expression and a lower sst2/sst5 mRNA ratio showed a better response to PAS compared to OCT (6/33, 18%). SSTR evaluation in GH-omas may become a tool for tailored SSA treatment in acromegaly patients. PMID: 28323931 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 13, 2017 Category: Endocrinology Authors: Gatto F, Feelders RA, Franck SE, van Koetsveld PM, Dogan F, Kros JM, Neggers SJ, van der Lely AJ, Lamberts SW, Ferone D, Hofland LJ Tags: J Clin Endocrinol Metab Source Type: research