Log in to search using one of your social media accounts:

How does pregnancy affect the patients with pituitary adenomas: a study on 113 pregnancies from Turkey
ConclusionMedical treatment can be safely done stopped in patients with prolactinoma and acromegaly when pregnancy is confirmed and reinstituted when necessary. Prospective studies may help to determine the effects of medical treatment during gestation on the mother and fetus. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - June 20, 2017 Category: Endocrinology Source Type: research

Hearing Loss in Acromegaly - A Review
Conclusion The results are not consistent, but led to different conclusions. Therefore, more studies with greater numbers of patients with acromegaly are needed. [...] Thieme Revinter Publicações Ltda Rio de Janeiro, BrazilArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: International Archives of Otorhinolaryngology)
Source: International Archives of Otorhinolaryngology - June 16, 2017 Category: ENT & OMF Authors: Teixeira, Liane Sousa Silva, Isabelle Braz de Oliveira Sampaio, Andre Luiz Lopes Oliveira, Carlos Augusto Pires de Bahamad J únior, Fayez Tags: Systematic Review Source Type: research

High levels of IGF-1 predict difficult intubation of patients with acromegaly
ConclusionsIn patients with acromegaly, neck movement is confined, the time of tracheal intubation is prolonged, and the neck circumference is enlarged, and these patients suffer from an increased incidence of difficult intubation (62.5%) during anesthesia induction. The apnea/hypoxia index and insulin-like growth factor 1 levels are both increased in acromegalic patients with difficult intubation, and elevated insulin-like growth factor 1 levels are an independent risk factor of difficult intubation in acromegalic patients. (Source: Endocrine)
Source: Endocrine - June 15, 2017 Category: Endocrinology Source Type: research

Efficacy and safety of long-acting pasireotide in Japanese patients with acromegaly or pituitary gigantism: results from a multicenter, open-label, randomized, phase 2 study.
Authors: Tahara S, Murakami M, Kaneko T, Shimatsu A Abstract A multicenter, open-label, phase 2 study was conducted to investigate the efficacy and safety of long-acting pasireotide formulation in Japanese patients with acromegaly or pituitary gigantism. Medically naïve or inadequately controlled patients (on somatostatin analogues or dopamine agonists) were included. Primary end point was the proportion of all patients who achieved biochemical control (mean growth hormone [GH] levels
Source: Endocrine Journal - June 9, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Cytopathologic evaluation of patients submitted to radiotherapy for uterine cervix cancer
Summary Cervical cancer is an important public health problem. Pap smear is the leading strategy of screening programs for cervical cancer worldwide. However, delayed diagnosis leads to more aggressive and less effective treatments. Patients with uterine cervix malignancies who are referred for radiotherapy have advanced-stage disease, which results in high rates of locoregional recurrence. The use of radiotherapy as a treatment for cervical cancer causes morphological changes in neoplastic and non-neoplastic epithelial cells, as well as in stromal cells, which make it difficult to diagnose the residual lesion, resulting i...
Source: Revista da Associacao Medica Brasileira - June 9, 2017 Category: General Medicine Source Type: research

Pachydermoperiostosis of the complete type: A novel missense mutation c.101T   >  C in the SLCO2A1 gene.
We report on a rare case of pachydermoperiostosis (PDP) in a 25-year-old male who was admitted to our hospital because of enlargement of fingers and toes. Through examination, we found some typical features on the patient including finger clubbing, periostosis, pachydermia, and cutis verticis gyrata (CVG). But laboratory tests were almost within normal ranges, which ruled out rheumatic arthritis, osteopulmonary arthropathy, thyroid acropathy, and acromegaly. Then, we diagnosed this case as PDP, which was confirmed by gene sequencing. The pathogenesis is concerned with abnormal rise of the level of PGE2 that results from th...
Source: European Journal of Medical Genetics - June 8, 2017 Category: Genetics & Stem Cells Authors: Ma W, Guo S, Li Y, Li Z Tags: Eur J Med Genet Source Type: research

Acromegaly: surgical results in 548 patients
ConclusionsSurgery remains the first line of therapy for a majority of acromegalic patients. This series proves to be very valuable in circumscribed adenomas but also in invasive tumours. Levels of GH and IGF-I were decreased in almost all the patients without remission. (Source: Pituitary)
Source: Pituitary - June 6, 2017 Category: Endocrinology Source Type: research

Recurrent Kidney Stone Episodes Leading to a Diagnosis of Occult Acromegaly
We present a case of occult acromegaly secondary to a pituitary tumor discovered 20 years after the patient's first stone episode. (Source: Urology Case Reports)
Source: Urology Case Reports - June 3, 2017 Category: Urology & Nephrology Source Type: research

Effects of anti-somatostatin agents on glucose metabolism.
e;s B Abstract The anti-somatostatin agents used to treat acromegaly, Cushing's disease and neuroendocrine tumours also have hyperglycaemic effects. This is particularly true for pasireotide. Hyperglycaemic events are seen in 57-73% of patients with Cushing's treated with pasireotide, with a need to initiate antidiabetic treatment in about 50% of these patients. In acromegaly, treatment with pasireotide induces hyperglycaemia in 29-61% of patients. Pasireotide-induced hyperglycemia occurs early, within the first 3 months of treatment, due to a decrease in insulin secretion secondary to a fall in secretion of GLP-1...
Source: Diabetes and Metabolism - June 1, 2017 Category: Endocrinology Authors: Vergès B Tags: Diabetes Metab Source Type: research

Tyrannosauroid integument reveals conflicting patterns of gigantism and feather evolution.
We describe fossil integument from Tyrannosaurus and other tyrannosaurids (Albertosaurus, Daspletosaurus, Gorgosaurus and Tarbosaurus), confirming that these large-bodied forms possessed scaly, reptilian-like skin. Body size evolution in tyrannosauroids reveals two independent occurrences of gigantism; specifically, the large sizes in Yutyrannus and tyrannosaurids were independently derived. These new findings demonstrate that extensive feather coverings observed in some early tyrannosauroids were lost by the Albian, basal to Tyrannosauridae. This loss is unrelated to palaeoclimate but possibly tied to the evolution of gig...
Source: Biology Letters - June 1, 2017 Category: Biology Authors: Bell PR, Campione NE, Persons WS, Currie PJ, Larson PL, Tanke DH, Bakker RT Tags: Biol Lett Source Type: research

[Correspondence] Acromegaly in Lorenzo the Magnificent, father of the Renaissance
Lorenzo de' Medici (1449 –92), also known as the Magnificent, was a statesman, patron of arts, and a key supporter of the Renaissance, a cultural movement in Italy that spread throughout Europe, marking the beginning of the Early Modern Age (from the 14th to the 17th century). (Source: LANCET)
Source: LANCET - May 26, 2017 Category: General Medicine Authors: Donatella Lippi, Philippe Charlier, Paola Romagnani Tags: Correspondence Source Type: research

Anti-tumoral effects of somatostatin analogs: a lesson from the CLARINET study
AbstractOctreotide and lanreotide, the first-generation somatostatin analogs, successfully control hormone hyperproduction, and related syndromes, in patients with acromegaly and neuroendocrine tumors. However, their anti-tumor effect, rather evident in large number of pituitary adenomas in acromegalic patients, has been hypothesized for a long time in patients with neuroendocrine tumors as well, although a significant tumor shrinkage has rarely been observed. However, the recent publication of the CLARINET study has strengthened the evidence, already emerged with the PROMID trial, that the long-term treatment with the fir...
Source: Journal of Endocrinological Investigation - May 26, 2017 Category: Endocrinology Source Type: research

Acromegaly in Lorenzo the Magnificent, father of the Renaissance
Publication date: 27 May–2 June 2017 Source:The Lancet, Volume 389, Issue 10084 Author(s): Donatella Lippi, Philippe Charlier, Paola Romagnani (Source: The Lancet)
Source: The Lancet - May 26, 2017 Category: General Medicine Source Type: research

Independent evolution of baleen whale gigantism linked to Plio-Pleistocene ocean dynamics
Vertebrates have evolved to gigantic sizes repeatedly over the past 250 Myr, reaching their extreme in today's baleen whales (Mysticeti). Hypotheses for the evolution of exceptionally large size in mysticetes range from niche partitioning to predator avoidance, but there has been no quantitative examination of body size evolutionary dynamics in this clade and it remains unclear when, why or how gigantism evolved. By fitting phylogenetic macroevolutionary models to a dataset consisting of living and extinct species, we show that mysticetes underwent a clade-wide shift in their mode of body size evolution during the Plio-Ple...
Source: Proceedings of the Royal Society B: Biological Sciences - May 24, 2017 Category: Biology Authors: Slater, G. J., Goldbogen, J. A., Pyenson, N. D. Tags: palaeontology, evolution Palaeobiology Source Type: research

Cross-sectional prevalence of pancreatic cystic lesions in patients with acromegaly, a single-center experience
AbstractPurposeAcromegaly is a disease associated with an increased risk for several kinds of neoplasms including colon and thyroid cancer. Although the association between acromegaly and pancreatic neoplasms has not been elucidated, it has recently been reported thatGNAS gene mutations were found in 58% of intraductal papillary mucinous neoplasms (IPMNs), which are representative pancreatic cystic lesions, suggesting a link between IPMNs and acromegaly. To assess the prevalence of pancreatic cystic lesions in patients with acromegaly, we performed a retrospective cross-sectional single institute study.MethodsThirty consec...
Source: Pituitary - May 24, 2017 Category: Endocrinology Source Type: research

Standardization of Growth Hormone and Insulin-like Growth Factor-I Measurements.
Authors: Katsumata N Abstract Measurement of the levels of growth hormone (GH) and its related factor insulin-like growth factor I (IGF-I) is essential for the diagnosis and treatment of GH deficiency (GHD) and conditions related to excess GH such as acromegaly and pituitary gigantism. Measurement of GH levels is also used as an indicator of hypothalamic-pituitary function. Because of the marked variability in GH measurements among kits, the Study Committee for GH and Its Related Factors of The Foundation for Growth Science, Japan standardized GH values measured with various commercially available GH assay kits in ...
Source: Pediatric Endocrinology Reviews - May 19, 2017 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research

Alveoli, teeth, and tooth loss: Understanding the homology of internal mandibular structures in mysticete cetaceans
by Carlos Mauricio Peredo, Nicholas D. Pyenson, Mark D. Uhen, Christopher D. Marshall The evolution of filter feeding in baleen whales (Mysticeti) facilitated a wide range of ecological diversity and extreme gigantism. The innovation of filter feeding evolved in a shift from a mineralized upper and lower dentition in stem mysticetes to keratinous baleen plates that hang only from t he roof of the mouth in extant species, which are all edentulous as adults. While all extant mysticetes are born with a mandible lacking a specialized feeding structure (i.e., baleen), the bony surface retains small foramina with elongated sulc...
Source: PLoS One - May 19, 2017 Category: Biomedical Science Authors: Carlos Mauricio Peredo Source Type: research

Somatotropinomas inadequately controlled with octreotide may over-respond to pasireotide: the importance of dose adjustment to achieve long-term biochemical control.
CONCLUSION: These patients achieved long-term biochemical control, tumour volume reduction and improvement of clinical signs/symptoms after switching from octreotide to pasireotide. IGF-1 over-suppression is observed in a few patients and requires dose adjustment of pasireotide. PMID: 28500831 [PubMed - in process] (Source: Hormones)
Source: Hormones - May 15, 2017 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Evaluation of macular and peripapillary choroidal thickness, macular volume and retinal nerve fiber layer in acromegaly patients
AbstractPurposeTo evaluate macular volume, retinal nerve fiber layer, and macular and peripapillary choroidal thickness in acromegaly patients.MethodIn this prospective, case –control study, 31 patients with acromegaly and 32 healthy subjects were recruited. Only right eyes were evaluated. Macular choroidal thickness (CT) was measured at three points, peripapillary CT was measured at eight points, and macular volume was measured at nine areas in the central 6 mm circl e zone by spectraldomain optical coherence tomography (OCT). Retinal nerve fiber layer (RNFL) was measured automatically at six segments by OCT.Re...
Source: International Ophthalmology - May 15, 2017 Category: Opthalmology Source Type: research

Classification of patients with GH disorders may vary according to the IGF-I assay.
Conclusion: Even when using normative data obtained in the same large population of healthy subjects and when using calculated IGF-I SD scores, agreement among IGF-I assay methods is only moderate to good. Differences in assay performance must be taken into account when evaluating and monitoring patients with GH disorders. This argues for the use of the same IGF-I assay for a given patient throughout follow-up. PMID: 28505364 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - May 12, 2017 Category: Endocrinology Authors: Mavromati M, Kuhn E, Agostini H, Brailly-Tabard S, Massart C, Piketty ML, Arnoux A, Young J, Souberbielle JC, Chanson P Tags: J Clin Endocrinol Metab Source Type: research

Octreotide ‐Associated Neutropenia
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 10, 2017 Category: Drugs & Pharmacology Authors: Stacy S. Tse, Troy Kish Tags: Case Report Source Type: research

GH-secreting pituitary macroadenoma (acromegaly) associated with progressive dental malocclusion and refractory CPAP treatment
A link between progressive dental malocclusion, the use of a continuous positive airway pressure mask and GH-secreting pituitary macroadenoma (acromegaly) has not been previously reported. The present clinicop... (Source: Head and Face Medicine)
Source: Head and Face Medicine - May 10, 2017 Category: ENT & OMF Authors: Jaume Miranda-Rius, Llu ís Brunet-LLobet, Eduard Lahor-Soler, David de Dios-Miranda and Josep Anton Giménez-Rubio Source Type: research

Melvin M. Grumbach 1925-2016 [Retrospectives]
Generations of clinicians have been faced with often striking developmental and acquired hormonal syndromes associated with reproductive, growth, and metabolic phenotypes. These syndromes have included ambiguous genitalia, anomalies of sexual development, intersex forms, accelerated or delayed puberty, gigantism, and short stature. Although clinical phenotypes of these disorders have been well-established,... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - May 9, 2017 Category: Science Authors: Shlomo Melmed Tags: Retrospectives Source Type: research

How to investigate a child with excessive growth?
uet N Abstract The diagnostic approach to tall stature in children is based on collecting birth data (macrosomia), sizes and family puberty, a family history of constitutional or pathological tall stature, search for a delay of development, dysmorphia, disproportion, analysis of the growth velocity (normal or accelerated), general examination and assessment of puberty, and bone age. When there is a history of psychomotor retardation, a family history of pathological tall stature, or a disproportion in the clinical examination, the genetic causes of tall stature will be mentioned. The most frequent causes are Marfa...
Source: Annales d'Endocrinologie - May 5, 2017 Category: Endocrinology Authors: Coutant R, Donzeau A, Decrequy A, Louvigné M, Bouhours-Nouet N Tags: Ann Endocrinol (Paris) Source Type: research

AIP mutations and gigantism.
Abstract AIP mutations are rare in sporadic acromegaly but they are seen at a higher frequency among certain specific populations of pituitary adenoma patients (pituitary gigantism cases, familial isolated pituitary adenoma (FIPA) kindreds, and patients with macroadenomas who are diagnosed ≤30 years). AIP mutations are most prevalent in patients with pituitary gigantism (29% of this group were found to have mutations in AIP gene). These data support targeted genetic screening for AIP mutations/deletions in these groups of pituitary adenoma patients. Earlier diagnosis of AIP-related acromegaly-gigantism cases en...
Source: Annales d'Endocrinologie - May 5, 2017 Category: Endocrinology Authors: Rostomyan L, Potorac I, Beckers P, Daly AF, Beckers A Tags: Ann Endocrinol (Paris) Source Type: research

Treatment of acromegaly patients at the Federal University of Triângulo Mineiro (UFTM): Experience Report
CONCLUSION: The current treatment options enable patients seen in regional reference centers to achieve strict control parameters, which allows them to be treated close to their homes. (Source: Clinics)
Source: Clinics - May 4, 2017 Category: Journals (General) Source Type: research

Spontaneous Remission of Acromegaly after Pituitary Apoplexy
We report herein a patient with acromegaly (Source: Annals of Saudi Medicine)
Source: Annals of Saudi Medicine - May 4, 2017 Category: Journals (General) Tags: ISSUE 2 Source Type: research

3D Volumetric Measurements of GH Secreting Adenomas Correlate with Baseline Pituitary Function, Initial Surgery Success Rate, and Disease Control
Horm Metab Res DOI: 10.1055/s-0043-107245There is scarce data on the clinical utility of volume measurement for growth hormone (GH)-secreting pituitary adenomas. The current study objective was to assess the association between pituitary adenoma volumes and baseline endocrine evaluation, initial surgical success rate, and disease control among patients with acromegaly. A retrospective cohort study was conducted at a clinical research center including patients with acromegaly due to GH-secreting pituitary adenomas. Baseline hormonal evaluation and adenoma characteristics according to MRI were collected. Volumetric measureme...
Source: Hormone and Metabolic Research - May 4, 2017 Category: Endocrinology Authors: Tirosh, Amit Papadakis, Georgios Z. Chittiboina, Prashant Lyssikatos, Charalampos Belyavskaya, Elena Keil, Meg Lodish, Maya B. Stratakis, Constantine A. Tags: Endocrine Care Source Type: research

Assessment of Nasal Carriage of Staphylococcus Aureus and Axillar Flora in Patients With Acromegaly
Conclusion: The authors demonstrated that compared with healthy subjects, acromegalic patients had low percentage of nasal carriage of Staphylococcus aureus and more gram-negative basili in the axillar flora. These nasal and axillar flora changes should be considered for prophylactic antibiotics use before surgery and ampiric antibiotics use after surgery. (Source: Journal of Craniofacial Surgery)
Source: Journal of Craniofacial Surgery - May 1, 2017 Category: Surgery Tags: Original Articles Source Type: research

Beckwith-Wiedemann Syndrome Review: A Guide for the Neonatal Nurse.
This article focuses on the presentation of BWS as an aid to early detection. PMID: 28494824 [PubMed - in process] (Source: Neonatal Network)
Source: Neonatal Network - May 1, 2017 Category: Perinatology & Neonatology Authors: Zammit M, Caruana E, Cassar D, Calleja-Agius J Tags: Neonatal Netw Source Type: research

Outcome of Endoscopic Transsphenoidal Surgery for Acromegaly
Endoscopic transsphenoidal surgery has recently been introduced in pituitary surgery. We investigated outcomes and complications of endoscopic surgery in two referral centers in Korea. (Source: World Neurosurgery)
Source: World Neurosurgery - April 29, 2017 Category: Neurosurgery Authors: Jung Hee Kim, Kyu Yeon Hur, Jung Hyun Lee, Ji Hyun Lee, Young-Bem Se, Hey In Kim, Seung Hoon Lee, Do-Hyun Nam, Seong Yeon Kim, Kwang-Won Kim, Doo-Sik Kong, Yong Hwy Kim Tags: Original article Source Type: research

X-LAG: How did they grow so tall?
Abstract X-linked acrogigantism (XLAG) is a new, pediatric-onset genetic syndrome, due to Xq26.3 microduplications encompassing the GPR101 gene. XLAG has a remarkably distinct phenotype with disease onset occurring before the age of 5 in all cases described to date, which is significantly younger than in other forms of pituitary gigantism. These patients have mixed GH and prolactin positive adenomas and/or mixed-cell hyperplasia and highly elevated levels of GH/IGF-1 and prolactin. Given their particularly young age of onset, the significant GH hypersecretion can lead to a phenotype of severe gigantism with very a...
Source: Annales d'Endocrinologie - April 27, 2017 Category: Endocrinology Authors: Beckers A, Rostomyan L, Potorac I, Beckers P, Daly AF Tags: Ann Endocrinol (Paris) Source Type: research

Treatment of GPR101-Related, Growth Hormone-Related Disorders Such as Gigantism, Dwarfism or Acromegaly
Microduplications of theGPR101 gene (located on chromosome Xq26.3 and encodes a G-protein coupled receptor) can result in an excess of growth hormone causing gigantism, that has an onset in early childhood. It is also associated with the growth of sporadic growth hormone producing adenomas in some patients with acromegaly.Current therapies (such as surgical resection of tumors or treatment with somatostatin analogs) for acromegaly, gigantism and other disorders of pituitary hormone hypersecretion can be ineffective, thereby creating a need for alternative therapies in this space.The inventors at NICHD have developed a cell...
Source: NIH OTT Licensing Opportunities - April 26, 2017 Category: Research Authors: ajoyprabhu3 Source Type: research

Clinical Importance of Somatostatin Receptor 2 (SSTR2) and Somatostatin Receptor 5 (SSTR5) Expression in Thyrotropin-Producing Pituitary Adenoma (TSHoma).
Authors: Yu B, Zhang Z, Song H, Chi Y, Shi C, Xu M Abstract BACKGROUND Thyrotropin-secreting pituitary adenomas (TSHomas) are a rare cause of hyperthyroidism. Somatostatin analogs have proved to be effective for inhibiting pituitary hormones secretion, working via interactions with somatostatin receptors (SSTRs). Moreover, antiproliferative activity of somatostatin analog is now demonstrated in several studies. In the present study, we determined the relative predominance of SSTR2 and SSTR5 subtypes among the different types of adenomas, especially TSHoma, and investigated the relationship between efficacy of short...
Source: Medical Science Monitor - April 25, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Suffocation due to Thoracic Deformity Caused by Acromegaly.
Authors: Yoshizawa T, Iwazaki M, Jitsuiki K, Ishikawa K, Ohsaka H, Yanagawa Y Abstract A 61-year-old man with gigantism and acromegaly choked and fell into a coma. Immediate tracheal intubation resulted in a return of his consciousness. Enhanced computed tomography indicated that the trachea and left main bronchus were compressed by the thoracic spine and sternum. He required tracheotomy and positive end-expiratory pressure to maintain his pulmonary function. This is the first case of suffocation due to a thoracic deformity associated with acromegaly. Physicians should focus on clearing the tracheal airway using co...
Source: Internal Medicine - April 22, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Efficacy and optimal timing of tongue reduction surgery in three patients with Beckwith –Wiedemann syndrome
We report three cases with BWS who were considered efficacy and optimal timing of tongue reduction surgery and had positive outcome. It is concluded that the capable timing for tongue surgery to mitigate macroglossia should be between 2 to 3 years of age. (Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology)
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - April 21, 2017 Category: ENT & OMF Source Type: research

Role of Phosphodiesterases on the Function of Aryl Hydrocarbon Receptor-Interacting Protein (AIP) in the Pituitary Gland and on the Evaluation of AIP Gene Variants
Horm Metab Res 2017; 49: 286-295 DOI: 10.1055/s-0043-104700Familial isolated pituitary adenoma (FIPA) is caused in about 20% of cases by loss-of-function germline mutations in the AIP gene. Patients harboring AIP mutations usually present with somatotropinomas resulting either in gigantism or young-onset acromegaly. AIP encodes for a co-chaperone protein endowed with tumor suppressor properties in somatotroph cells. Among other mechanisms proposed to explain this function, a regulatory effect over the 3′,5′-cyclic adenosine monophosphate (cAMP) signaling pathway seems to play a prominent role. In this setting, ...
Source: Hormone and Metabolic Research - April 20, 2017 Category: Endocrinology Authors: Hern ández-Ramírez, Laura C. Trivellin, Giampaolo Stratakis, Constantine A. Tags: Review Source Type: research

Endocrine Comorbidities in Patients with Psoriatic Arthritis: A Population-based Case-controlled Study.
Authors: Haddad A, Ashkenazi RI, Bitterman H, Feldhamer I, Greenberg-Dotan S, Lavi I, Batat E, Bergman I, Cohen AD, Zisman D Abstract OBJECTIVE: To investigate endocrine comorbidities in patients with psoriatic arthritis (PsA). METHODS: A retrospective, cross-sectional study was performed with the database of Clalit Health Services, the largest healthcare provider in Israel, between 2002 and 2014. Patients with PsA were identified and matched by age and sex to healthy controls. The following morbidities were analyzed: hypo/hyperthyroidism, hypo/hyperparathyroidism, hyperprolactinemia, Cushing disease, Addison d...
Source: Journal of Rheumatology - April 17, 2017 Category: Rheumatology Tags: J Rheumatol Source Type: research

High-dose and high-frequency lanreotide autogel in acromegaly: a randomized, multicenter study.
HIGH-DOSE AND HIGH-FREQUENCY LANREOTIDE AUTOGEL IN ACROMEGALY: A RANDOMIZED, MULTICENTER STUDY. J Clin Endocrinol Metab. 2017 Apr 17;: Authors: Giustina A, Mazziotti G, Cannavò S, Castello R, Arnaldi G, Bugari G, Cozzi R, Ferone D, Formenti AM, Gatti E, Grottoli S, Maffei P, Maffezzoni F, Montini M, Terzolo M, Ghigo E Abstract Context: The increase in drug frequency or dose is recommended for acromegaly patients with partial response to long-acting somatostatin receptor ligands (SRLs). However, the efficacy and safety data with lanreotide autogel (LAN-ATG) at high-dose (HD) or high-frequency (H...
Source: The Journal of Clinical Endocrinology and Metabolism - April 17, 2017 Category: Endocrinology Authors: Giustina A, Mazziotti G, Cannavò S, Castello R, Arnaldi G, Bugari G, Cozzi R, Ferone D, Formenti AM, Gatti E, Grottoli S, Maffei P, Maffezzoni F, Montini M, Terzolo M, Ghigo E Tags: J Clin Endocrinol Metab Source Type: research

A case of neuronal gigantism and cortical thickening: A rare complication of therapeutic radiation (P6.187)
Conclusions:Our case presented only 2 years after radiotherapy suggesting this toxicity can be an earlier complication that clinicians should be aware of.Disclosure: Dr. Shaikh has nothing to disclose. Dr. kumthekar has nothing to disclose. Dr. Raizer has received personal compensation for activities with Genentech/Roche, Abbvie, Stemline, Foundation Medicine, Novocure, Proximagene, Bristol-Meyers Squibb, and Aurasense as a speaker and advisory board member. Dr. Raizer has received research support from Genentech, Plexxikon, Novartis, Ziopharm, and Celldex. Dr. dixit has nothing to disclose. (Source: Neurology)
Source: Neurology - April 17, 2017 Category: Neurology Authors: Shaikh, N., Kumthekar, P., Raizer, J., Dixit, K. S. Tags: Neurologic Complications of Cancer Source Type: research

Mixed Gangliocytoma-Pituitary Adenoma: Insights on the Pathogenesis of a Rare Sellar Tumor
Gangliocytomas originating in the sellar region are rare; most are tumors composed of gangliocytic and pituitary adenomatous elements, forming the so-called mixed gangliocytoma-pituitary adenoma. The majority of mixed gangliocytoma adenomas are associated with endocrinopathies, mainly acromegaly and less often Cushing disease and hyperprolactinemia. In the present study, 10 cases of mixed gangliocytoma and somatotroph adenomas were evaluated for patterns of cellular differentiation and expression of lineage-specific transcription factors. The tumors were characterized by immunohistochemistry for pituitary hormones, cytoker...
Source: The American Journal of Surgical Pathology - April 15, 2017 Category: Pathology Tags: Original Articles Source Type: research

Expression of Somatostatin Receptor 2 in Somatotropinoma Correlated with the Short-Term Efficacy of Somatostatin Analogues.
In conclusion, the protein expression of SSTR2, but not of SSTR5, is a valuable indicator in predicting biochemical and tumor size response to short-term SSA treatment in acromegalic patients. PMID: 28396686 [PubMed - in process] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - April 12, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Calcium and bone turnover markers in acromegaly: a prospective controlled study.
Abstract Context: Acromegaly has been associated with calcium-phosphate and bone turnover alterations. Controlled studies of these interactions are sparse. Objective: To evaluate calcium and bone metabolism in active and treated acromegaly. Design/Setting/Patients: We conducted a controlled prospective study at a tertiary referral center. We studied 22 patients with acromegaly referred for surgical or medical therapy (ACM) and 22 with nonfunctioning pituitary adenomas referred for surgery (control). Main outcome measures: Calcium (serum and urine), phosphorus, PTH, 25-hydroxy- and 1,25-dihydroxy-vitamin ...
Source: The Journal of Clinical Endocrinology and Metabolism - April 12, 2017 Category: Endocrinology Authors: Constantin T, Tangpricha V, Shah R, Oyesiku NM, Ioachimescu OC, Ritchie J, Ioachimescu AG Tags: J Clin Endocrinol Metab Source Type: research

The acylated/unacylated ghrelin ratio is similar in acromegaly patients during different treatment regimens.
Conclusions: Although plasma AG and UAG are suppressed during combination treatment of LA-SSA and PEGV, the AG/UAG ratio remained similar. This shows that somatostatin analogues decrease both AG and UAG, which suggest that they do not alter metabolism significantly in acromegaly patients. PMID: 28402548 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 11, 2017 Category: Endocrinology Authors: Muhammad A, Delhanty PJ, Huisman M, Visser JA, van der Lelij AJ, Neggers SJ Tags: J Clin Endocrinol Metab Source Type: research

Marked alteration of glycemic profile surrounding lanreotide administration in acromegaly: a case report
This article is protected by copyright. All rights reserved. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 8, 2017 Category: Endocrinology Authors: Sho Tanaka, Akira Haketa, Shun Yamamuro, Toshiko Suzuki, Hiroki Kobayashi, Yoshinari Hatanaka, Takahiro Ueno, Noboru Fukuda, Masanori Abe, Atsuo Yoshino, Masayoshi Soma Tags: Case Report Source Type: research

Treatment adherence and persistence with long-acting somatostatin analog therapy for the treatment of acromegaly: a retrospective analysis.
CONCLUSIONS: Treatment adherence was similarly good for both injectable SSA treatments studied, at 87% or greater. Persistence was greater with lanreotide than octreotide and the risk of discontinuing therapy was lower with lanreotide than octreotide. Further studies to determine factors leading to these differences in persistence or to predict discontinuation of therapy may aid in clinical management of these patients. PMID: 28372573 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - April 6, 2017 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Treatment adherence and persistence with long-acting somatostatin analog therapy for the treatment of acromegaly: a retrospective analysis
Many patients with acromegaly require medical treatment that includes somatostatin analogs (SSAs). Long-acting SSA formulations are widely used, due in part to increased patient convenience and increased treat... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - April 4, 2017 Category: Drugs & Pharmacology Authors: Michelle H. Gurel, Yi Han, Andrea L. Stevens, Aaron Furtado and David Cox Source Type: research

Clinical Images: Widening of joint spaces in acromegaly
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - April 4, 2017 Category: Rheumatology Authors: Masei Suda, Yasuhiro Suyama, Masato Okada Tags: Clinical Image Source Type: research

Vitamin D across growth hormone (GH) disorders: From GH deficiency to GH excess.
Abstract The interplay between vitamin D and the growth hormone (GH)/insulin-like growth factor (IGF)-I system is very complex and to date it is not fully understood. GH directly regulates renal 1 alpha-hydroxylase activity, although the action of GH in modulating vitamin D metabolism may also be IGF-I mediated. On the other hand, vitamin D increases circulating IGF-I and the vitamin D deficiency should be normalized before measurement of IGF-I concentrations to obtain reliable and unbiased IGF-I values. Indeed, linear growth after treatment of nutritional vitamin D deficiency seems to be mediated through activati...
Source: Growth Hormone and IGF Research - April 1, 2017 Category: Endocrinology Authors: Ciresi A, Giordano C Tags: Growth Horm IGF Res Source Type: research

Utility of baseline serum phosphorus levels for predicting remission in acromegaly patients
AbstractPurposeHigh GH and IGF I levels increase tubular phosphate reabsorption in patients with acromegaly. We aimed to investigate the utility of serum phosphorus levels as an indicator for predicting chance of remission in acromegaly patients.DesignFifty-one patients (n: 51;F: 24,M: 27) with diagnosis of acromegaly were included in the study. Plasma IGF-1, Phosphorus (P) and nadir GH levels on oral glucose tolerance test (OGTT) at the time of diagnosis were analysed retrospectively. Patients were classified into two groups according to their plasma P levels;P ≤ 4.5 mg/dl (Group-1,n: 23, 45.1%),P&nb...
Source: Journal of Endocrinological Investigation - March 29, 2017 Category: Endocrinology Source Type: research