Evaluation of the relation between subclinical systolic dysfunction defined by four-dimensional speckle-tracking echocardiography and growth differentiation factor-15 levels in patients with acromegaly
CONCLUSION: Our study demonstrates that while LVEF was within normal limits, global strain parameters (GLS, GCS, GAS, and GRS) measured by using a novel imaging technique, 4DSTE, were lower in patients with acromegaly, suggesting the presence of subclinical systolic dysfunction in patients with acromegaly. GDF-15 can be a potential predictor of cardiovascular risk in patients with acromegaly.PMID:38632216 | DOI:10.1007/s42000-024-00558-7 (Source: Hormones)
Source: Hormones - April 17, 2024 Category: Endocrinology Authors: Busra Firlatan Ugur Nadir Karakulak Vedat Hekimsoy Burcin Gonul Iremli Incilay Lay Deniz Yuce Selcuk Dagdelen Giray Kabakci Tomris Erbas Source Type: research
The spectrum of growth hormone excess in Carney complex and genotype-phenotype correlations
CONCLUSION: Dysregulation of GH secretion is a common finding in CNC. The clinical spectrum of this disorder and its association with genetic and imaging characteristics of the patient make prompt diagnosis and management more successful.PMID:38626285 | DOI:10.1210/clinem/dgae253 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 16, 2024 Category: Endocrinology Authors: Christina Tatsi Georgia Pitsava Fabio R Faucz Meg Keil Constantine A Stratakis Source Type: research
The spectrum of growth hormone excess in Carney complex and genotype-phenotype correlations
CONCLUSION: Dysregulation of GH secretion is a common finding in CNC. The clinical spectrum of this disorder and its association with genetic and imaging characteristics of the patient make prompt diagnosis and management more successful.PMID:38626285 | DOI:10.1210/clinem/dgae253 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 16, 2024 Category: Endocrinology Authors: Christina Tatsi Georgia Pitsava Fabio R Faucz Meg Keil Constantine A Stratakis Source Type: research
The effect of coping strategies on health –related quality of life in acromegaly patients
ConclusionOur results show that maladaptive coping styles have a substantial negative impact on psychological HRQoL in patients with acromegaly, whereas physical HRQoL is influenced to a lesser extent. Specialized training programs aimed at improving coping strategies could reduce long-term disease burden and increase HRQoL in the affected patients. (Source: Endocrine)
Source: Endocrine - April 13, 2024 Category: Endocrinology Source Type: research
Assessment of multimodal treatment options in recurrent and persistent acromegaly: a systematic review and meta-analysis
ConclusionsThe management of persistent and recurrent acromegaly optimally requires a multimodal approach. In different scenarios of refractory acromegaly based on previous treatment, secondary treatments may vary in terms of remission rate and complications. Medical agents provide considerable effectiveness as a second-line therapy for recurrent or persistent disease. In selected cases, however, reoperation still provides an opportunity for cure or freedom from medications. The findings of this study may help clinicians to prioritize varying options involved in this multifaceted decision-making process. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 8, 2024 Category: Cancer & Oncology Source Type: research
Double pituitary adenomas: report of two cases and systematic review of the literature
ConclusionsThe double lesion detected by surgical exploration is independently associated with a better prognosis for DPA patients. Comprehensive intraoperative exploration are crucial measures to avoid missing causative lesions. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - April 2, 2024 Category: Endocrinology Source Type: research
Tall stature and gigantism in transition age: clinical and genetic aspects—a literature review and recommendations
ConclusionThe aim of our review is to provide a practical clinical approach to recognise adolescents, potentially affected by gigantism, as early as possible. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 29, 2024 Category: Endocrinology Source Type: research
Establishing a valid cohort of patients with acromegaly by combining the National Patient Register with the Swedish Pituitary Register
ConclusionThe combination of the SPR and NPR established a valid cohort of patients diagnosed with acromegaly and increased the estimated incidence in Sweden. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 29, 2024 Category: Endocrinology Source Type: research
Tall stature and gigantism in transition age: clinical and genetic aspects—a literature review and recommendations
ConclusionThe aim of our review is to provide a practical clinical approach to recognise adolescents, potentially affected by gigantism, as early as possible. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 27, 2024 Category: Endocrinology Source Type: research
Establishing a valid cohort of patients with acromegaly by combining the National Patient Register with the Swedish Pituitary Register
ConclusionThe combination of the SPR and NPR established a valid cohort of patients diagnosed with acromegaly and increased the estimated incidence in Sweden. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 27, 2024 Category: Endocrinology Source Type: research
Trends of correlations between serum levels of growth hormone and insulin-like growth factor-I in general practice
Serum levels of growth hormone (GH) and insulin-like growth factor (IGF)-I are crucial in the diagnosis and management of GH-related diseases. However, these levels are affected by nutritional and metabolic status. To elucidate the correlations between GH and IGF-I in various conditions, a retrospective analysis was performed for adult patients in which GH levels were examined by general practitioners during the period from January 2019 to December 2021. Of 642 patients, 33 patients were diagnosed with acromegaly, 21 were diagnosed with GH deficiency (GHD), and 588 were diagnosed with non-GH-related diseases (NGRD). In con...
Source: Frontiers in Endocrinology - March 26, 2024 Category: Endocrinology Source Type: research
Long-term pasireotide therapy in acromegaly: extensive real-life experience of a referral center
ConclusionPasireotide is effective and safe in the long-term. Hyperglycemia is a common event and is manageable even without insulin treatment. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 26, 2024 Category: Endocrinology Source Type: research
Validity of galactin-3 in acromegaly: comparison with traditional markers
ConclusionIn a summary, this study recommended clinicians measure serum Gal-3 as biomarkers for patients with acromegaly. In addition, the result above shed light on role of Gal-3 on acromegaly pathogenesis and might provide a therapeutic target of acromegaly patients. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 23, 2024 Category: General Medicine Source Type: research
Changes in multi-modality management of acromegaly in a tertiary centre over 2 decades
ConclusionThe vast majority of patients with acromegaly now have successful disease control with a multimodal approach. They reached biochemical control sooner in the most recent half of the study period. Future work should focus on those patients who are still uncontrolled and on the sequelae of the disease. (Source: Pituitary)
Source: Pituitary - March 23, 2024 Category: Endocrinology Source Type: research
