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Condition: Osteoporosis

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Total 356 results found since Jan 2013.

No impact of anti-Rank ligand and PTH analogs on cardiovascular risk in postmenopausal osteoporosis: a systematic literature review and meta-analysis
ConclusionsThe anti-Rank ligand and PTH analogs have no impact on cardiovascular risk and overall mortality in idiopathic osteoporosis. To better answer the question whether these treatments can reduce the long-term cardiovascular risk, further comparative studies with longer duration are required.
Source: Archives of Orthopaedic and Trauma Surgery - January 2, 2020 Category: Orthopaedics Source Type: research

How Doctors, Researchers Are Already Using A.I.
From osteoporosis, to stroke and drug interactions, here are several ways artificial intelligence is already affecting health care.
Source: WebMD Health - January 2, 2020 Category: Consumer Health News Source Type: news

Natto Intake is Inversely Associated with Osteoporotic Fracture Risk in Postmenopausal Japanese Women
ConclusionsHabitual natto intake may be associated with a reduced risk of osteoporotic fractures independent of confounding factors, including BMD, in Japanese postmenopausal women. This trial was registered atumin.ac.jp as UMIN 000032869.
Source: Journal of Nutrition - December 11, 2019 Category: Nutrition Source Type: research

Potassium binding for conservative and preservative management of chronic kidney disease
In conclusion, there are new well tolerated and effective K+-binding agents for acutely and chronically managing hyperkalemia.
Source: Current Opinion in Nephrology and Hypertension - November 29, 2019 Category: Urology & Nephrology Tags: NOVEL THERAPEUTIC APPROACHES IN NEPHROLOGY AND HYPERTENSION: Edited by Kamyar Kalantar-Zadeh and Ekamol Tantisattamo Source Type: research

The impact of stroke on bone properties and muscle-bone relationship: a systematic review and meta-analysis
AbstractTo systematically review available evidence related to the characteristics of bone changes post-stroke and the relationship between various aspects of muscle function (e.g., strength, spasticity) and bone properties after stroke onset. An extensive online database search was undertaken (last search in January 2019). Articles that examined the bone properties in stroke patients were included. The quality of the studies was evaluated with the National Institutes of Health (NIH) Study Quality Assessment Tools. Publication bias of meta-analyses was assessed using the Egger ’s regression asymmetry test. The selection ...
Source: Osteoporosis International - November 12, 2019 Category: Orthopaedics Source Type: research

Odanacatib for the treatment of postmenopausal osteoporosis: results of the LOFT multicentre, randomised, double-blind, placebo-controlled trial and LOFT Extension study
Publication date: Available online 31 October 2019Source: The Lancet Diabetes & EndocrinologyAuthor(s): Michael R McClung, Michelle L O'Donoghue, Socrates E Papapoulos, Henry Bone, Bente Langdahl, Kenneth G Saag, Ian R Reid, Douglas P Kiel, Ilaria Cavallari, Marc P Bonaca, Stephen D Wiviott, Tobias de Villiers, Xu Ling, Kurt Lippuner, Toshitaka Nakamura, Jean-Yves Reginster, Jose Adolfo Rodriguez-Portales, Christian Roux, José Zanchetta, Cristiano A F ZerbiniSummaryBackgroundOdanacatib, a cathepsin K inhibitor, reduces bone resorption while maintaining bone formation. Previous work has shown that odanacatib increases bone...
Source: The Lancet Diabetes and Endocrinology - November 2, 2019 Category: Endocrinology Source Type: research

Introduction to Purinergic Signaling.
Abstract Purinergic signaling was proposed in 1972, after it was demonstrated that adenosine 5'-triphosphate (ATP) was a transmitter in nonadrenergic, noncholinergic inhibitory nerves supplying the guinea-pig taenia coli. Later, ATP was identified as an excitatory cotransmitter in sympathetic and parasympathetic nerves, and it is now apparent that ATP acts as a cotransmitter in most, if not all, nerves in both the peripheral nervous system and central nervous system (CNS). ATP acts as a short-term signaling molecule in neurotransmission, neuromodulation, and neurosecretion. It also has potent, long-term (trophic) ...
Source: Mol Biol Cell - October 27, 2019 Category: Molecular Biology Authors: Burnstock G Tags: Methods Mol Biol Source Type: research

Practical tips for prescribing exercise for fall prevention
ConclusionDepending on the population, exercise as a single or as part of a multifactorial intervention may be beneficial in reducing falls.
Source: Osteoporosis International - September 30, 2019 Category: Orthopaedics Source Type: research

Vitamin D and cardiovascular disorders
In conclusion, preclinical data generated a plausible hypothesis of a link between vitamin D status and extra-skeletal events, including cardiovascular endpoints. Whether the vitamin D endocrine system is redundant for the human vascular system or whether the RCTs have not been optimally designed to answer the research question is thus not yet settled.
Source: Osteoporosis International - August 10, 2019 Category: Orthopaedics Source Type: research

Increased Risk of Musculoskeletal Disorders and Mental Health Problems in Retired Professional Jockeys: A Cross-Sectional Study
Int J Sports Med DOI: 10.1055/a-0902-8601To examine the prevalence of chronic disease and mental health problems in retired professional, male jockeys compared to an age-matched reference population. A cross-sectional study comparing data from a cohort of retired professional jockeys with an age-matched general population sample. Male participants (age range: 50–89 years old) were used to compare health outcomes of self-reported physician-diagnosed conditions: heart disease, stroke, diabetes, hypertension, osteoporosis, osteoarthritis, depression and anxiety between study populations. Conditional logistic regression mode...
Source: International Journal of Sports Medicine - August 6, 2019 Category: Sports Medicine Authors: Mackinnon, Anna-Louise Jackson, Kate Kuznik, Kerry Turner, Alison Hill, Jerry Davies, Madeleine A. M. Jones, Mary Elizabeth Delmestri, Antonella Sanchez-Santos, Maria T. Newton, Julia Tags: Clinical Sciences Source Type: research

Quantification of Risk Factors for Cervical Ossification of the Posterior Longitudinal Ligament in Korean Populations: A Nationwide Population-based Case-control Study
Conclusion. OPLL was significantly associated with comorbidities such as hypertension, ischemic stroke diabetes mellitus, hypothyroidism, and osteoporosis. Our findings can provide helpful information for OPLL prediction and offer important health benefits. Level of Evidence: 3
Source: Spine - August 3, 2019 Category: Orthopaedics Tags: EPIDEMIOLOGY Source Type: research

Functional capability and associated factors in the elderly living in the community
Conclusion Functional capacity was associated with osteoporosis and stroke and was correlated with self-reported diseases.
Source: Acta Paulista de Enfermagem - July 29, 2019 Category: Nursing Source Type: research

Characteristics of arterial hypertension in menopausal diabetic women
ConclusionHigh blood pressure is a public health problem most often associated with other cardiovascular risk factors. An evaluation of cardiovascular risk is necessary in postmenopausal hypertensive diabetic women and effective management of risk factors is recommended.
Source: Archives of Cardiovascular Diseases Supplements - July 24, 2019 Category: Cardiology Source Type: research

History of cardiovascular disease and cardiovascular biomarkers are associated with 30-day mortality in patients with hip fracture
ConclusionPreexisting CVD was associated with increased 30-day mortality after a hip fracture. Furthermore, high levels of NT-proBNP and low levels of HDL cholesterol were associated with increased 30-day mortality.
Source: Osteoporosis International - July 3, 2019 Category: Orthopaedics Source Type: research

Decreased physical health-related quality of life —a persisting state for older women with clinical vertebral fracture
ConclusionsClinical vertebral fracture was associated with lower self-rated physical HRQoL, for up to 18.9  years after time of fracture.
Source: Osteoporosis International - June 20, 2019 Category: Orthopaedics Source Type: research