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Condition: Osteoporosis
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Total 356 results found since Jan 2013.
Statins and Osteoporosis, Fracture Risks in Stroke Patients Statins and Osteoporosis, Fracture Risks in Stroke Patients
Could daily doses of statins help prevent osteoporosis and bone fractures after a stroke?Journal of Clinical Endocrinology & Metabolism
Source: Medscape Today Headlines - October 1, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news
Bone mineral loss and cognitive impairment: The PRESENT project
Low bone mineral density (BMD) is correlated with Alzheimer's disease and its severity, but the association remains unclear in adults (≥50 years) without a history of stroke or dementia.
We assessed BMD and cognitive function using the Mini-Mental Status Examination (MMSE) in 650 stroke- and dementia-free subjects (≥50 years) who were recruited for an early health check-up program between January 2009 and December 2010.
The mean age was 62.9 ± 8.0 years and mean MMSE score was 27.6 ± 3.6. A total of 361 subjects had reduced BMD: 197 (30.3%) had osteopenia and 154 (23.6%) had osteoporosis, based on criteria ...
Source: Medicine - October 1, 2018 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Real-world retrospective cohort study ARCTIC shows burden of comorbidities in Swedish COPD versus non-COPD patients.
This study aimed to generate real-world evidence to assess the burden of comorbidities in COPD patients, to effectively manage these patients and optimize the associated healthcare resource allocation. ARCTIC is a large, real-world, retrospective cohort study conducted in Swedish COPD patients using electronic medical record data collected between 2000 and 2014. These patients were studied for prevalence of various comorbidities and for association of these comorbidities with exacerbations, mortality, and healthcare costs compared with an age-, sex-, and comorbidities-matched non-COPD reference population. A total of 17,47...
Source: Primary Care - September 10, 2018 Category: Primary Care Authors: Ställberg B, Janson C, Larsson K, Johansson G, Kostikas K, Gruenberger JB, Gutzwiller FS, Jorgensen L, Uhde M, Lisspers K Tags: NPJ Prim Care Respir Med Source Type: research
Bringing Attention to Lesser-known Bone Remodeling Pathways
AbstractOsteoporosis, a disease of low bone mass, places individuals at enhanced risk for fracture, disability, and death. In the USA, hospitalizations for osteoporotic fractures exceed those for heart attack, stroke, and breast cancer and, by 2025, the number of fractures due to osteoporosis is expected to rise to nearly three million in the USA alone. Pharmacological treatments for osteoporosis are aimed at stabilizing or increasing bone mass. However, there are significant drawbacks to current pharmacological options, particularly for long-term management of this chronic condition. Moreover, the drug development pipelin...
Source: Clinical Reviews in Bone and Mineral Metabolism - September 1, 2018 Category: Internal Medicine Source Type: research
Lower risk of osteoporosis in new stroke patients treated with statins
Patients diagnosed with a stroke and treated with statins may be at less risk of developing osteoporosis, according to research published in theJournal of Clinical Endocrinology& Metabolism.Neurology Advisor
Source: Society for Endocrinology - August 30, 2018 Category: Endocrinology Source Type: news
Emerging strategies targeting cb2 cannabinoid receptor: biased agonism and allosterism.
Abstract
During these last years, the CB2 cannabinoid receptor has emerged as a potential anti-inflammatory target in diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Huntington's disease, ischemic stroke, autoimmune diseases, osteoporosis, and cancer. However, the development of clinically useful CB2 agonists reveals to be very challenging. Allosterism and biased-signaling mechanisms at CB2 receptor may offer new avenues for the development of improved CB2 receptor-targeted therapies. Although there has been some exploration of CB1 receptor activation by new CB1 allosteric or biased-signaling l...
Source: Biochemical Pharmacology - July 25, 2018 Category: Drugs & Pharmacology Authors: Morales P, Goya P, Jagerovic N Tags: Biochem Pharmacol Source Type: research
Timed up and go test and self-perceived health in elderly: population-based study
Abstract Due to the aging process, chronic diseases arise with increased use of medications and there is a need to evaluate the elderly to prevent functional dependence and falls. The aim of this study was to compare gender, sociodemographic characteristics, fall occurrences, self-reported diseases, quantity of drugs with timed up and go test (TUG) and TUG-cognitive, and to associate these factors with the self-perception of health of the elderly in the community. Were selected 513 elderly people, with 384 that completed the TUG test to evaluate the functional capacity. There was difference between the female and male, in ...
Source: Revista Brasileira de Cineantropometria e Desempenho Humano - July 16, 2018 Category: Sports Medicine Source Type: research
S-adenosylhomocysteine hydrolase over-expression does not alter S-adenosylmethionine or S-adenosylhomocysteine levels in CBS deficient mice
Publication date: June 2018Source: Molecular Genetics and Metabolism Reports, Volume 15Author(s): Hyung-Ok Lee, Liqun Wang, Yin-Ming Kuo, Andrew J. Andrews, Sapna Gupta, Warren D. KrugerAbstractElevated plasma total homocysteine (tHcy) is associated with a number of human diseases including coronary artery disease, stroke, osteoporosis and dementia. It is highly correlated with intracellular S-adenosylhomocysteine (SAH). Since SAH is a strong inhibitor of methyl-transfer reactions involving the methyl-donor S-adenosylmethionine (SAM), elevation in SAH could be an explanation for the wide association of tHcy and human disea...
Source: Molecular Genetics and Metabolism Reports - July 10, 2018 Category: Genetics & Stem Cells Source Type: research
Vascular Involvement in Axial Spondyloarthropathies
Publication date: Available online 19 May 2018Source: Joint Bone SpineAuthor(s): Clément Prati, Céline Demougeot, Xavier Guillot, Maxime Sondag, Frank Verhoeven, Daniel WendlingAbstractAnkylosing spondylitis (AS) is a chronic inflammatory joint disease that involves the entheses, causing inflammatory pain and functional impairments. Patients may experience extraarticular manifestations such as uveitis, psoriasis, and inflammatory bowel disease. These, together with the increased risk of cardiovascular disease and osteoporosis and the development of spinal fusion, are the main determinants of adverse disease outcomes. As ...
Source: Joint Bone Spine - July 10, 2018 Category: Orthopaedics Source Type: research
S-adenosylhomocysteine hydrolase over-expression does not alter S-adenosylmethionine or S-adenosylhomocysteine levels in CBS deficient mice
Publication date: June 2018Source: Molecular Genetics and Metabolism Reports, Volume 15Author(s): Hyung-Ok Lee, Liqun Wang, Yin-Ming Kuo, Andrew J. Andrews, Sapna Gupta, Warren D. KrugerAbstractElevated plasma total homocysteine (tHcy) is associated with a number of human diseases including coronary artery disease, stroke, osteoporosis and dementia. It is highly correlated with intracellular S-adenosylhomocysteine (SAH). Since SAH is a strong inhibitor of methyl-transfer reactions involving the methyl-donor S-adenosylmethionine (SAM), elevation in SAH could be an explanation for the wide association of tHcy and human disea...
Source: Molecular Genetics and Metabolism Reports - July 6, 2018 Category: Genetics & Stem Cells Source Type: research
Vascular Involvement in Axial Spondyloarthropathies
Publication date: Available online 19 May 2018Source: Joint Bone SpineAuthor(s): Clément Prati, Céline Demougeot, Xavier Guillot, Maxime Sondag, Frank Verhoeven, Daniel WendlingAbstractAnkylosing spondylitis (AS) is a chronic inflammatory joint disease that involves the entheses, causing inflammatory pain and functional impairments. Patients may experience extraarticular manifestations such as uveitis, psoriasis, and inflammatory bowel disease. These, together with the increased risk of cardiovascular disease and osteoporosis and the development of spinal fusion, are the main determinants of adverse disease outcomes. As ...
Source: Joint Bone Spine - July 5, 2018 Category: Orthopaedics Source Type: research
Statin use is associated with decreased osteoporosis and fracture risks in stroke patients.
Conclusions: Statin use is associated with decreased risks of osteoporosis, hip fracture, and vertebral fracture in stroke patients.
PMID: 29982482 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - July 2, 2018 Category: Endocrinology Authors: Lin SM, Wang JH, Liang CC, Huang HK Tags: J Clin Endocrinol Metab Source Type: research
Effect of Atrial Fibrillation on the Incidence and Outcome of Osteoporotic Fracture - A Nationwide Population-Based Study.
CONCLUSIONS: Comorbid AF in patients with osteoporosis was associated with an increased risk of bone fracture and death after fracture.
PMID: 29794400 [PubMed - as supplied by publisher]
Source: Circulation Journal - May 24, 2018 Category: Cardiology Authors: Kim D, Yang PS, Kim TH, Uhm JS, Park J, Pak HN, Lee MH, Joung B Tags: Circ J Source Type: research
Vascular Involvement in Axial Spondyloarthropathies
Publication date: Available online 19 May 2018 Source:Joint Bone Spine Author(s): Clément Prati, Céline Demougeot, Xavier Guillot, Maxime Sondag, Frank Verhoeven, Daniel Wendling Ankylosing spondylitis (AS) is a chronic inflammatory joint disease that involves the entheses, causing inflammatory pain and functional impairments. Patients may experience extraarticular manifestations such as uveitis, psoriasis, and inflammatory bowel disease. These, together with the increased risk of cardiovascular disease and osteoporosis and the development of spinal fusion, are the main determinants of adverse disease outcomes. As with ...
Source: Joint Bone Spine - May 20, 2018 Category: Orthopaedics Source Type: research
