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Condition: Intermittent Claudication

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Total 179 results found since Jan 2013.

Invasive revascularisation in patients with moderate intermittent claudication provides a significant improvement in quality of life compared with conservative treatment
Commentary on: Nordanstig J, Taft C, Hensäter M, et al. Improved quality of life after 1 year with an invasive versus a noninvasive treatment strategy in claudicants: one-year results of the Invasive Revascularization or Not in Intermittent Claudication (IRONIC) Trial. Circulation 2014;130:939–47 . Context In cases of severe intermittent claudication (IC), successful revascularisation provides significant symptomatic improvement. In cases of mild IC, revascularisation has exceedingly high risks. The choice between invasive revascularisation and non-invasive treatments for moderate severity IC is often diffi...
Source: Evidence-Based Medicine - May 22, 2015 Category: Internal Medicine Authors: Kurklinsky, A. K. Tags: Epidemiologic studies, Pain (neurology), Stroke Therapeutics/Prevention Source Type: research

Endovascular intervention for peripheral artery disease.
Abstract Advances in endovascular therapies during the past decade have broadened the options for treating peripheral vascular disease percutaneously. Endovascular treatment offers a lower risk alternative to open surgery in many patients with multiple comorbidities. Noninvasive physiological tests and arterial imaging precede an endovascular intervention and help localize the disease and plan the procedure. The timing and need for revascularization are broadly related to the 3 main clinical presentations of claudication, critical limb ischemia, and acute limb ischemia. Many patients with claudication can be treat...
Source: Circulation Research - April 24, 2015 Category: Cardiology Authors: Thukkani AK, Kinlay S Tags: Circ Res Source Type: research

My Approach to Detecting and Managing Peripheral Artery Disease
Atherosclerotic peripheral artery disease (PAD) is a prevalent disorder, affecting approximately 8 million adults in the United States. As a manifestation of systemic atherosclerosis, PAD is associated with an increased risk for myocardial infarction, stroke, and cardiovascular death. Patients with PAD may be asymptomatic, but many have impaired walking capacity, symptoms of intermittent claudication, pain and numbness of the feet, skin ulcers, and necrosis threatening limb viability.
Source: Trends in Cardiovascular Medicine - April 23, 2015 Category: Cardiology Authors: Mark A. Creager Source Type: research

Post-Walking Exercise Hypotension in Patients with Intermittent Claudication
This study aimed to investigate the acute effect of intermittent walking exercise (WE) on blood pressure (BP) responses in patients with intermittent claudication (IC). Secondly, this study aimed to gain improved insight into the physiological mechanisms controlling BP regulation after intermittent WE in this patient group. Methods: Twenty patients with IC participated in two experimental sessions in a random order, as follows: WE (15 × 2-min bouts of WE interpolated with 2-min rest intervals) and control (standing rest on a treadmill for 60 min). BP, cardiac output (CO: CO2 rebreathing), and cardiovascular autonomic modu...
Source: Medicine and Science in Sports and Exercise - February 20, 2015 Category: Sports Medicine Tags: Clinical Sciences Source Type: research

Clinical Correlates and Prognostic Significance of Change in Standardized Left Ventricular Mass in a Community-Based Cohort of African Americans Epidemiology
Conclusions In our community-based sample of African Americans, baseline BMI and BP, and change in BP on follow-up were key determinants of increase in standardized log-LVMI, which in turn carried an adverse prognosis, underscoring the need for greater control of BP and weight in this group.
Source: JAHA:Journal of the American Heart Association - February 5, 2015 Category: Cardiology Authors: Fox, E. R., Musani, S. K., Samdarshi, T. E., Taylor, J. K., Beard, W. L., Sarpong, D. F., Xanthakis, V., McClendon, E. E., Liebson, P. R., Skelton, T. N., Butler, K. R., Mosley, T. H., Taylor, H., Vasan, R. S. Tags: Epidemiology Source Type: research

Safety, Clinical Outcome, and Fracture Rate of Femoropopliteal Stenting Using a 4F Compatible Delivery System.
CONCLUSION: Femoropopliteal stenting using a 4F compatible delivery system can be accomplished with a low complication rate, acceptable fracture rate, and with similar 12 month patency and revascularization rates as their 6F counterparts. PMID: 25579877 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - January 8, 2015 Category: Surgery Authors: Sarkadi H, Bérczi V, Kollár A, Kiss D, Jakabfi P, Végh EM, Nemes B, Merkely B, Hüttl K, Dósa E Tags: Eur J Vasc Endovasc Surg Source Type: research

Bilateral scalp necrosis as a rare but devastating complication of giant cell arteritis
We report a case of a man who presented with a 4-week history of bilateral scalp necrosis associated with headache, jaw claudication, temporal artery tenderness, and raised inflammatory markers. He did not have any visual loss. A diagnosis of GCA was made and he was started on high-dose steroids immediately. The scalp lesions did improve and his symptoms resolved without any visual loss but, sadly he died due to severe sepsis. This case report is important as it describes a rare but severe complication of a common large vessel vasculitis seen by both primary care physicians and rheumatologists. Prompt recognition and early...
Source: Clinical Rheumatology - January 1, 2015 Category: Rheumatology Source Type: research

Prevalence, correlates, and prognosis of peripheral artery disease in rural ecuador-rationale, protocol, and phase I results of a population-based survey: an atahualpa project-ancillary study.
Conclusions. Prevalence of suspected PAD in this underserved population is high. Subsequent phases of this study will determine whether prompt detection of PAD is useful to reduce the incidence of catastrophic vascular diseases in the region. PMID: 25389500 [PubMed]
Source: International Journal of Vascular Medicine - December 1, 2014 Category: Cardiology Tags: Int J Vasc Med Source Type: research

A stroke of bad luck.
Abstract Giant cell arteritis is a common cause of headache in patients aged more than 50 years. It is an easy diagnosis to make if classical features, ie temporal headache, jaw claudication, visual symptoms, systemic symptoms of fever or weight loss with high erythrocyte sedimentation rate and anemia, are present. However, it may present atypically and stroke can be the presenting feature. A high index of suspicion is needed in atypical presentations such as stroke. Once a diagnosis is suspected it is imperative to start high dose steroids to prevent visual and neurological complications. PMID: 25468861 [PubMed - in process]
Source: Clinical Medicine - December 1, 2014 Category: Journals (General) Authors: Nagasayi S, White S, Joshi Y Tags: Clin Med Source Type: research

Prolonged P wave duration predicts stroke mortality among type 2 diabetic patients with prevalent non-major macrovascular disease
Conclusions: As an easily measurable factor P wave duration merits further studies with higher number of patients to evaluate its importance in the estimation of stroke risk in type 2 diabetic patients with PNMMVD.
Source: BMC Cardiovascular Disorders - November 25, 2014 Category: Cardiology Authors: Teemu VepsäläinenMarkku LaaksoSeppo LehtoAuni JuutilainenJuhani AiraksinenTapani Rönnemaa Source Type: research

Latest developments in antithrombotic therapy in patients with lower extremity arterial disease
Publication date: March 2014 Source:Reviews in Vascular Medicine, Volume 2, Issue 1 Author(s): M. Beatrice Forte , Cecilia Becattini , Giancarlo Agnelli Lower extremity arterial disease (LEAD) is one of the manifestations of systemic atherosclerosis causing the narrowing in the vessels of the lower limbs. Clinically it can go from an asymptomatic plaque to intermittent claudication to critical limb ischemia, the most severe clinical manifestation. LEAD is associated with increased risk of other cardiovascular events such as myocardial infarction and ischemic stroke. The treatment of LEAD consists mainly in revascularizat...
Source: Reviews in Vascular Medicine - November 6, 2014 Category: Cardiology Source Type: research

Cilostazol for intermittent claudication.
CONCLUSIONS: Cilostazol has been shown to be of benefit in improving walking distance in people with intermittent claudication secondary to PAD. Although there is an increase in adverse side effects, they are generally mild and treatable. There is currently insufficient data on whether taking cilostazol results in a reduction of all-cause mortality and cardiovascular events or an improvement in quality of life. Future research into the effect of cilostazol on intermittent claudication should carefully consider comparability, sample size and homogeneity when designing a study. PMID: 25358850 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - November 5, 2014 Category: Journals (General) Authors: Bedenis R, Stewart M, Cleanthis M, Robless P, Mikhailidis DP, Stansby G Tags: Cochrane Database Syst Rev Source Type: research

Statin therapy and long-term adverse limb outcomes in patients with peripheral artery disease: insights from the REACH registry
Conclusion Among patients with PAD in the REACH registry, statin use was associated with an ~18% lower rate of adverse limb outcomes, including worsening symptoms, peripheral revascularization, and ischaemic amputations. These findings suggest that statin therapy not only reduces the risk of adverse cardiovascular events, but also favourably affects limb prognosis in patients with PAD.
Source: European Heart Journal - November 1, 2014 Category: Cardiology Authors: Kumbhani, D. J., Steg, P. G., Cannon, C. P., Eagle, K. A., Smith, S. C., Goto, S., Ohman, E. M., Elbez, Y., Sritara, P., Baumgartner, I., Banerjee, S., Creager, M. A., Bhatt, D. L., on Behalf of the REACH Registry Investigators Tags: Vascular medicine Source Type: research

Diurnal and Twenty-Four-Hour Patterning of Human Diseases: Cardiac, Vascular, and Respiratory Diseases, Conditions, and Syndromes
Various medical conditions, disorders, and syndromes exhibit predictable-in-time diurnal and 24-hour patterning in the signs, symptoms, and grave nonfatal and fatal events, e.g., respiratory ones of viral and allergic rhinorrhea, reversible (asthma) and non-reversible (bronchitis and emphysema) chronic obstructive pulmonary disease, cystic fibrosis, high altitude pulmonary edema, and decompression sickness; cardiac ones of atrial premature beats and tachycardia, paroxysmal atrial fibrillation, 3rd degree atrial-ventricular block, paroxysmal supraventricular tachycardia, ventricular premature beats, ventricular tachyarrhyth...
Source: Sleep Medicine Reviews - July 18, 2014 Category: Sleep Medicine Authors: Michael H. Smolensky, Francesco Portaluppi, Roberto Manfredini, Ramon C. Hermida, Ruana Tiseo, Linda L. Sackett-Lundeen, Erhard Haus Source Type: research

Diurnal and twenty-four hour patterning of human diseases: Cardiac, vascular, and respiratory diseases, conditions, and syndromes
Various medical conditions, disorders, and syndromes exhibit predictable-in-time diurnal and 24 h patterning in the signs, symptoms, and grave nonfatal and fatal events, e.g., respiratory ones of viral and allergic rhinorrhea, reversible (asthma) and non-reversible (bronchitis and emphysema) chronic obstructive pulmonary disease, cystic fibrosis, high altitude pulmonary edema, and decompression sickness; cardiac ones of atrial premature beats and tachycardia, paroxysmal atrial fibrillation, 3rd degree atrial-ventricular block, paroxysmal supraventricular tachycardia, ventricular premature beats, ventricular tachyarrhythm...
Source: Sleep Medicine Reviews - July 18, 2014 Category: Sleep Medicine Authors: Michael H. Smolensky, Francesco Portaluppi, Roberto Manfredini, Ramon C. Hermida, Ruana Tiseo, Linda L. Sackett-Lundeen, Erhard L. Haus Tags: Clinical review Source Type: research