Effect of Transcriptional Regulator ID3 on Pulmonary Arterial Hypertension and Hereditary Hemorrhagic Telangiectasia.
Authors: Avecilla V Abstract Pulmonary arterial hypertension (PAH) can be discovered in patients who have a loss of function mutation of activin A receptor-like type 1 (ACVRL1) gene, a bone morphogenetic protein (BMP) type 1 receptor. Additionally, ACVRL1 mutations can lead to hereditary hemorrhagic telangiectasia (HHT), also known as Rendu-Osler-Weber disease, an autosomal dominant inherited disease that results in mucocutaneous telangiectasia and arteriovenous malformations (AVMs). Transcriptional regulator Inhibitor of DNA-Binding/Differentiation-3 (ID3) has been demonstrated to be involved in both PAH and HTT; ...
Source: International Journal of Vascular Medicine - August 7, 2019 Category: Cardiology Tags: Int J Vasc Med Source Type: research

The Clinical Rationale for the Sentry Bioconvertible Inferior Vena Cava Filter for the Prevention of Pulmonary Embolism.
Authors: Dake MD, Ansel GM, Johnson MS, Mendes R, Smouse HB Abstract The Sentry inferior vena cava (IVC) filter is designed to provide temporary protection against pulmonary embolism (PE) during transient high-risk periods and then to bioconvert after 60 days after implantation. At the time of bioconversion, the device's nitinol arms retract from the filtering position into the caval wall. Subsequently, the stable stent-like nitinol frame is endothelialized. The Sentry bioconvertible IVC filter has been evaluated in a multicenter investigational-device-exemption pivotal trial (NCT01975090) of 129 patients with docu...
Source: International Journal of Vascular Medicine - July 4, 2019 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Response to: Comment on "Effect of Exercise Intervention on Flow-Mediated Dilation in Overweight and Obese Adults: Meta-Analysis".
Response to: Comment on "Effect of Exercise Intervention on Flow-Mediated Dilation in Overweight and Obese Adults: Meta-Analysis". Int J Vasc Med. 2019;2019:2470581 Authors: Son Y, Kang M, Park Y PMID: 30867966 [PubMed] (Source: International Journal of Vascular Medicine)
Source: International Journal of Vascular Medicine - March 16, 2019 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Evaluation of Arterial Stiffness Using Pulse Wave Velocity and Augmentation Index in Patients with Chronic Venous Insufficiency.
Conclusions: PWV and Aix are the most commonly used, easy, reproducible, reliable methods in the clinic to assess arterial stiffness. Logistic regression analysis showed that PWV and Aix were the independent predictors of CVI. PWV has the sensitivity of 88.9 % and specificity of 71.4 % to detect the presence of CVI. PMID: 30631600 [PubMed] (Source: International Journal of Vascular Medicine)
Source: International Journal of Vascular Medicine - January 13, 2019 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Comparative Study of Protein Expression Levels of Five Plaque Biomarkers and Relation with Carotid Plaque Type Classification in Patients after Carotid Endarterectomy.
Authors: Kyriakidis K, Antoniadis P, Choksy S, Papi RM Abstract Atherosclerosis is an inflammatory process resulting in local plaque deposition in the vessel wall of arteries with symptoms to various areas of vascular tree. Identification of patients with progressive advanced atherosclerotic disease is mainly based on the known characteristics of the vulnerable or recently ruptured plaque. Molecular and cellular features associated with the vulnerable plaque are considered potential diagnostic markers for plaque rupture and thrombosis. Here, protein expression levels of the metalloproteases MMP-1, MMP-9, osteoponti...
Source: International Journal of Vascular Medicine - December 27, 2018 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Comparison of 15-20  mmHg versus 20-30 mmHg Compression Stockings in Reducing Occupational Oedema in Standing and Seated Healthy Individuals.
Comparison of 15-20 mmHg versus 20-30 mmHg Compression Stockings in Reducing Occupational Oedema in Standing and Seated Healthy Individuals. Int J Vasc Med. 2018;2018:2053985 Authors: Quilici Belczak CE, Pereira de Godoy JM, Seidel AC, Belczak S, Neves Ramos R, Caffaro RA Abstract Background: Elastic compression stockings (ECS) are effective in preventing and reducing occupational edema (OE), but the optimal pressure according to the prevalent working position during the day is still controversial. Objective: To compare the effectiveness of ECS with different pressures (15-20 m...
Source: International Journal of Vascular Medicine - October 28, 2018 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Vascular Protective Effects of Morinda citrifolia Leaf Extract on Postmenopausal Rats Fed with Thermoxidized Palm Oil Diet: Evidence at Microscopic Level.
This study aimed to investigate the effectiveness of Morinda citrifolia leaf extract (MCLE) treatment at histological and ultrastructural level, comparing it with Simvastatin. Thirty-eight female Sprague Dawley rats were divided into five groups: Sham (Sham), ovariectomized (OVX), ovariectomized with Simvastatin 10 mg/kg (OVX+ST), ovariectomized with low dose MC 500 mg/kg (OVX+MCLD), and ovariectomized with high dose MC 1000 mg/kg (OVX+MCHD). Atherosclerosis was induced by producing oestrogen deficiency through ovariectomy and feeding with thermoxidized palm oil (TPO) diet for 12 weeks along with the t...
Source: International Journal of Vascular Medicine - September 28, 2018 Category: Cardiology Tags: Int J Vasc Med Source Type: research

The Association between Earlobe Crease (Frank's Sign) and Abnormal Ankle-Brachial Index Determination Is Related to Age: A Population-Based Study.
Conclusions: The association between ELC and abnormal ABI determinations is probably attenuated by the high prevalence of both conditions in older persons. ELC might not be useful for identifying candidates for ABI determination. PMID: 30245883 [PubMed] (Source: International Journal of Vascular Medicine)
Source: International Journal of Vascular Medicine - September 26, 2018 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Dilating Vascular Diseases: Pathophysiology and Clinical Aspects.
Authors: Yetkin E, Ozturk S Abstract Atherosclerotic disease of the vessels is a significant problem affecting mortality and morbidity all over the world. However, dilatation of the vessels either in the arterial system or in the venous territory is another vessel disease. Varicocele, pelvic, and peripheral varicose veins and hemorrhoids are aneurysms of the venous vascular regions and have been defined as dilating venous disease, recently. Coronary artery ectasia, intracranial aneurysm, and abdominal aortic aneurysm are examples of arterial dilating vascular diseases. Mostly, they have been defined as variants of ...
Source: International Journal of Vascular Medicine - September 19, 2018 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Risk and Outcome after Simultaneous Carotid Surgery and Cardiac Surgery: Single Centre Experience.
Conclusion: Simultaneous carotid artery surgery and open-heart surgery have low risk. The underlying cardiac disease influences outcome. PMID: 30186634 [PubMed] (Source: International Journal of Vascular Medicine)
Source: International Journal of Vascular Medicine - September 8, 2018 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Association between Carotid Wall Shear Rate and Arterial Stiffness in Patients with Hypertension and Atherosclerosis of Peripheral Arteries.
Conclusion: In patients with HTN and atherosclerotic lesions of peripheral arteries, it is registered that the carotid WSR decreased with increasing severity of atherosclerosis. Decreased carotid WSR is associated with increased local carotid stiffness, regional vascular stiffness of muscular, and elastic vessels. PMID: 30155305 [PubMed] (Source: International Journal of Vascular Medicine)
Source: International Journal of Vascular Medicine - August 30, 2018 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Clinical Arterial Peripheral Vascular Pathology Does Not Impact Short- or Long-Term Survival after Transcatheter Aortic Valve Replacement.
Conclusion: This study gives evidence to suggest that patients with a comorbid clinical peripheral arterial pathology at the time of TAVR do not have a statistically significant increase in mortality out to 2 years after TAVR and no increase in procedural complications. These results affirm the safety and feasibility of TAVR in patients with AAA, CAS, and/or PAD. PMID: 30112212 [PubMed] (Source: International Journal of Vascular Medicine)
Source: International Journal of Vascular Medicine - August 17, 2018 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Sentry Bioconvertible Inferior Vena Cava Filter: Study of Stages of Incorporation in an Experimental Ovine Model.
Conclusions. Through 180 days, there were no filter-related complications, and the study devices were all bioconverted and stably incorporated, leaving all IVCs patent. PMID: 30112213 [PubMed] (Source: International Journal of Vascular Medicine)
Source: International Journal of Vascular Medicine - August 17, 2018 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Appropriateness of Pharmacologic Prophylaxis against Deep Vein Thrombosis in Medical Wards of an Ethiopian Referral Hospital.
Conclusion: There is underutilization of pharmacologic thromboprophylaxis in medical ward patients. Physicians working there should be aware of risk factors for DVT and indications for pharmacologic thromboprophylaxis and should adhere to guideline recommendations. PMID: 30105097 [PubMed] (Source: International Journal of Vascular Medicine)
Source: International Journal of Vascular Medicine - August 16, 2018 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Comment on "Effect of Exercise Intervention on Flow-Mediated Dilation in Overweight and Obese Adults: Meta-Analysis".
Comment on "Effect of Exercise Intervention on Flow-Mediated Dilation in Overweight and Obese Adults: Meta-Analysis". Int J Vasc Med. 2018;2018:5082903 Authors: Alwardat M PMID: 29973991 [PubMed] (Source: International Journal of Vascular Medicine)
Source: International Journal of Vascular Medicine - July 7, 2018 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Treatment of Aortic and Iliac Artery Aneurysms with Multilayer Flow Modulator: Single Centre Experiences.
Conclusion: MFM can be preferred as an alternative approach in the treatment of aorta and iliac artery aneurysms including major lateral branches. The present results should be confirmed with additional future studies conducted with larger patient groups for longer periods. PMID: 29955396 [PubMed] (Source: International Journal of Vascular Medicine)
Source: International Journal of Vascular Medicine - July 1, 2018 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Effect of N-Acetylcysteine on Dyslipidemia and Carbohydrate Metabolism in STZ-Induced Diabetic Rats.
Authors: Kaga AK, Barbanera PO, do Carmo NOL, Rosa LRO, Fernandes AAH Abstract Background: Type 1 diabetes mellitus (T1DM) is characterized by insulin-deficient production leading to hyperglycemia, which is associated with diabetic complications such as cardiovascular diseases. Antioxidants have been proving a good alternative to diabetic complications, with N-acetylcysteine (NAC) having antioxidant characteristics. The aim of this study was to assess the effect of NAC on the lipid profile and the atherogenic index (AI) in streptozotocin- (STZ-) induced diabetic rats. Method: 32 male Wistar rats (60 days of age...
Source: International Journal of Vascular Medicine - May 30, 2018 Category: Cardiology Tags: Int J Vasc Med Source Type: research

A Review of Percutaneous Transluminal Angioplasty in Hemodialysis Fistula.
Authors: Bountouris I, Kritikou G, Degermetzoglou N, Avgerinos KI Abstract The number of patients in dialysis increases every year. In this review, we will evaluate the role of percutaneous transluminal angioplasty (PTA) according to patency of arteriovenous fistula and grafts. The main indication of PΤΑ is stenosis> 50% or obstruction of the vascular lumen of an arteriovenous fistula and graft. It is usually performed under local anesthesia. The infection rate is as low as the number of complications. Fistula can be used in dialysis in the same day without the need for a central venous catheter. Prima...
Source: International Journal of Vascular Medicine - May 24, 2018 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Swirling Flow and Wall Shear: Evaluating the BioMimics 3D Helical Centerline Stent for the Femoropopliteal Segment.
Authors: Sullivan TM, Zeller T, Nakamura M, Caro CG, Lichtenberg M Abstract The BioMimics 3D self-expanding nitinol stent represents a strategy for femoropopliteal intervention that is alternative or complementary to deployment of drug-coated stents or balloons. Whereas conventional straight stents reduce arterial curvature and disturb blood flow, creating areas of low wall shear, where neointimal hyperplasia predominantly develops, the helical centerline geometry of the BioMimics 3D maintains or imparts arterial curvature, promotes laminar swirling blood flow, and elevates wall shear to protect against atheroscler...
Source: International Journal of Vascular Medicine - April 25, 2018 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Circulating Angiogenic Growth Factors in Diabetes Patients with Peripheral Arterial Disease and Exertional Leg Pain in Ghana.
Conclusion: Diabetes patients with PAD and exertional leg pain have imbalance in angiogenic growth factors, indicating impaired angiogenesis. In patients with exertional leg pains, Ang-2 may be an important biomarker. PMID: 29445546 [PubMed] (Source: International Journal of Vascular Medicine)
Source: International Journal of Vascular Medicine - February 17, 2018 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Relationship of Common Vascular Anatomy to Cannulated Catheters.
Authors: Gagne P, Sharma K Abstract Superficial veins of the upper extremity are the primary location for placement of peripheral IV catheters (PIVC). It is believed that a significant portion of PIVCs placed may cross or abut valves and branching veins or occlude a significant portion of the vein, limiting the ability to aspirate blood from the PIVC. Two separate clinical investigations using ultrasound were performed to understand the potential interaction between PIVCs and the vein lumen and the venous valves and branches of the superficial veins of the upper extremity. One study with 35 adult volunteers interro...
Source: International Journal of Vascular Medicine - February 9, 2018 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Identification of Factors Influencing Cumulative Long-Term Radiation Exposure in Patients Undergoing EVAR.
Authors: Kalender G, Lisy M, Stock UA, Endisch A, Kornberger A Abstract Patients who undergo endovascular repair of aortic aneurysms (EVAR) require life-long surveillance because complications including, in particular, endoleaks, aneurysm rupture, and graft dislocation are diagnosed in a certain share of the patient population and may occur at any time after the original procedure. Radiation exposure in patients undergoing EVAR and post-EVAR surveillance has been investigated by previous authors. Arriving at realistic exposure data is essential because radiation doses resulting from CT were shown to be not irreleva...
Source: International Journal of Vascular Medicine - December 19, 2017 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Effect of Exercise Intervention on Flow-Mediated Dilation in Overweight and Obese Adults: Meta-Analysis.
The objective of this meta-analysis is to summarize the effect of exercise intervention on flow-mediated dilatation (FMD) in overweight and obese adults. We searched four electronic databases (PubMed/Medline, Scopus, and CINAHL) through June 2016 for relevant studies pertaining to the effectiveness of exercise intervention on FMD. Seventeen of the 91 studies identified met the inclusion criteria. Comprehensive Meta-Analysis software (version 3) was used to compute the standardized mean difference effect size (ES) and 95% CI using a random effects model. We calculated 34 ESs. We found that exercise intervention had medium a...
Source: International Journal of Vascular Medicine - November 5, 2017 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Impact of Modified Transesophageal Echocardiography on Mortality and Stroke after Cardiac Surgery: A Large Cohort Study.
Authors: Jansen Klomp WW, Moons CGM, Nierich AP, Brandon Bravo Bruinsma GJ, Van't Hof AWJ, Grandjean JG, Peelen LM Abstract The aim of this study was to investigate the impact of perioperative screening with modified transesophageal echocardiography (A-View method). We compared, in consecutive patients who underwent cardiac surgery between 2006 and 2014, 30-day mortality and in-hospital stroke incidence, operated either with perioperative modified TEE screening (intervention group) or only with conventional TEE screening (control group). Of the 8,605 study patients, modified TEE was applied in 1,391 patients (16.2%...
Source: International Journal of Vascular Medicine - November 2, 2017 Category: Cardiology Tags: Int J Vasc Med Source Type: research

A Simple Blood Test, Such as Complete Blood Count, Can Predict Calcification Grade of Abdominal Aortic Aneurysm.
CONCLUSIONS: In this study, we demonstrate that biomarkers such as MCV and MCH could have potential important information about AAA calcification progression and could be useful to discriminate between those patients that should undergo a rapid imaging, thus allowing prompt initiation of treatment of suspicious patients that do not need imaging repetition. PMID: 28948050 [PubMed] (Source: International Journal of Vascular Medicine)
Source: International Journal of Vascular Medicine - September 29, 2017 Category: Cardiology Tags: Int J Vasc Med Source Type: research

The Role of Endoplasmic Reticulum Stress in Cardiovascular Disease and Exercise.
Authors: Hong J, Kim K, Kim JH, Park Y Abstract Endoplasmic reticulum (ER) stress, which is highly associated with cardiovascular disease, is triggered by a disturbance in ER function because of protein misfolding or an increase in protein secretion. Prolonged disruption of ER causes ER stress and activation of the unfolded protein response (UPR) and leads to various diseases. Eukaryotic cells respond to ER stress via three major sensors that are bound to the ER membrane: activating transcription factor 6 (ATF6), inositol-requiring protein 1α (IRE1α), and protein kinase RNA-like ER kinase (PERK). Chroni...
Source: International Journal of Vascular Medicine - September 8, 2017 Category: Cardiology Tags: Int J Vasc Med Source Type: research

A Protocol for Diagnosis and Management of Aortic Atherosclerosis in Cardiac Surgery Patients.
Authors: Jansen Klomp WW, Brandon Bravo Bruinsma GJ, Van 't Hof AWJ, Grandjean JG, Nierich AP Abstract In patients undergoing cardiac surgery, use of perioperative screening for aortic atherosclerosis with modified TEE (A-View method) was associated with lower postoperative mortality, but not stroke, as compared to patients operated on without such screening. At the time of clinical implementation and validation, we did not yet standardize the indications for modified TEE and the changes in patient management in the presence of aortic atherosclerosis. Therefore, we designed a protocol, which combined the diagnosis ...
Source: International Journal of Vascular Medicine - September 1, 2017 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Maintenance of the Results of Stage II Lower Limb Lymphedema Treatment after Normalization of Leg Size.
CONCLUSION: Higher compression of elastic stockings is better than lower compression but the inelastic grosgrain stocking is even better than both to maintain the results. PMID: 28835857 [PubMed] (Source: International Journal of Vascular Medicine)
Source: International Journal of Vascular Medicine - August 26, 2017 Category: Cardiology Tags: Int J Vasc Med Source Type: research

ABO Gene Polymorphism and Thrombomodulin -33G > A Polymorphism Were Not Risk Factors for Myocardial Infarction in Javanese Men.
ABO Gene Polymorphism and Thrombomodulin -33G>A Polymorphism Were Not Risk Factors for Myocardial Infarction in Javanese Men. Int J Vasc Med. 2017;2017:2943467 Authors: Lukitasari M, Sadewa AH, Rohman MS Abstract Genetic factors contribute to about a half of coronary artery diseases. During the last several decades, some studies suggested that non-O blood group and thrombomodulin polymorphism -33G>A are the risk factors of coronary artery disease especially in Asia. There was no prior study in Indonesia regarding this issue. Hence, this study was designed to investigate the correlation of ABO pol...
Source: International Journal of Vascular Medicine - August 17, 2017 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Polygamy and Risk of Coronary Artery Disease in Men Undergoing Angiography: An Observational Study.
In conclusion, among married men undergoing coronary angiography for clinical indications, polygamy is associated with the presence of significant CAD, MVD, and LMD. PMID: 28250991 [PubMed - in process] (Source: International Journal of Vascular Medicine)
Source: International Journal of Vascular Medicine - March 4, 2017 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Dyslipidemia in Patients with a Cardiovascular Risk and Disease at the University Teaching Hospital of Yaound é, Cameroon.
Conclusion. Low levels of HDL cholesterol and hypertriglyceridemia are more prevalent in our study population. More studies are needed to confirm this finding in our environment. PMID: 28163932 [PubMed - in process] (Source: International Journal of Vascular Medicine)
Source: International Journal of Vascular Medicine - February 7, 2017 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Predictors of Improved Walking after a Supervised Walking Exercise Program in Men and Women with Peripheral Artery Disease.
Authors: Gardner AW, Parker DE, Montgomery PS Abstract We compared the changes in ambulatory outcomes between men and women with symptomatic peripheral arterial disease (PAD) following completion of a supervised, on-site, treadmill exercise program, and we determined whether exercise training variables and baseline clinical characteristics were predictive of changes in ambulatory outcomes in men and women. Twenty-three men and 25 women completed the supervised exercise program, consisting of intermittent walking to mild-to-moderate claudication pain for three months. Men and women significantly increased claudicati...
Source: International Journal of Vascular Medicine - January 25, 2017 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Venous Adventitial Cystic Disease: A Review of 45 Cases Treated Since 1963.
Conclusion. Venous ACD most commonly affects the common femoral vein. When unilateral leg swelling occurs with or without a noticeable mass, ACD should be considered. It is best confirmed with CT venography and the treatment of choice is transluminal cyst evacuation and excision. PMID: 27885342 [PubMed - in process] (Source: International Journal of Vascular Medicine)
Source: International Journal of Vascular Medicine - November 26, 2016 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Endothelial Dysfunction of Patients with Peripheral Arterial Disease Measured by Peripheral Arterial Tonometry.
Conclusion. This study showed a significant correlation between RHI and ABI. The PAT test is a useful tool for evaluating not only endothelial dysfunction but also the hemodynamical state in patients with PAD. PMID: 27853624 [PubMed - in process] (Source: International Journal of Vascular Medicine)
Source: International Journal of Vascular Medicine - November 19, 2016 Category: Cardiology Tags: Int J Vasc Med Source Type: research

New Indices of Endothelial Function Measured by Digital Thermal Monitoring of Vascular Reactivity: Data from 6084 Patients Registry.
Authors: Naghavi M, Yen AA, Lin AW, Tanaka H, Kleis S Abstract Background. Endothelial function is viewed as a barometer of cardiovascular health and plays a central role in vascular reactivity. Several studies showed digital thermal monitoring (DTM) as a simple noninvasive method to measure vascular reactivity that is correlated with atherosclerosis risk factors and coronary artery disease. Objectives. To further evaluate the relations between patient characteristics and DTM indices in a large patient registry. Methods. DTM measures were correlated with age, sex, heart rate, and systolic and diastolic blood pressu...
Source: International Journal of Vascular Medicine - November 12, 2016 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Relationship of Inflammatory Biomarkers with Severity of Peripheral Arterial Disease.
Conclusion. We demonstrated that PTX3 might be a better marker of PAD than hs-CRP and SAP. Furthermore, PTX3 might be a prognostic marker to evaluate the severity of PAD. PMID: 27559483 [PubMed] (Source: International Journal of Vascular Medicine)
Source: International Journal of Vascular Medicine - August 26, 2016 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Simple In-Hospital Interventions to Reduce Door-to-CT Time in Acute Stroke.
This study was designed to assess the effect of simple in-hospital interventions on reducing door-to-CT (DTC) time and reaching door-to-needle (DTN) time of less than 60 minutes. Methods. Before any intervention, DTC time was recorded for 213 patients over a one-year period at our center. Five simple quality-improvement interventions were implemented, namely, call notification, prioritizing patients for CT scan, prioritizing patients for lab analysis, specifying a bed for acute stroke patients, and staff education. After intervention, over a course of 44 months, DTC time was recorded for 276 patients with the stroke code. ...
Source: International Journal of Vascular Medicine - August 2, 2016 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Paraoxonase-1 and Simvastatin Treatment in Patients with Stable Coronary Artery Disease.
Conclusions. The present study confirms a positive effect of simvastatin therapy on endothelial function and inflammatory markers in secondary prevention. Simvastatin treatment shows no effects on PON1 activity and 8-isoprostanes level. The effect of simvastatin therapy on PON1 activity is not modulated by Q192R and M55L polymorphisms. PMID: 27213056 [PubMed] (Source: International Journal of Vascular Medicine)
Source: International Journal of Vascular Medicine - May 24, 2016 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Carotid Intima Media Thickness in Nondiabetic Hypertensive Nigerians: Role of Fasting and Postprandial Blood Glucose.
Conclusion. Though expected from other studies, we did not show any significant correlation between FBG and 2hPPBG status and CIMT. This may be our pattern as the degree of excursion of 2hPPBG was low. There may be a threshold level above which PPBG starts to impact CIMT. PMID: 27144025 [PubMed] (Source: International Journal of Vascular Medicine)
Source: International Journal of Vascular Medicine - May 5, 2016 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Investigation of TGFβ1-Induced Long Noncoding RNAs in Endothelial Cells.
Investigation of TGFβ1-Induced Long Noncoding RNAs in Endothelial Cells. Int J Vasc Med. 2016;2016:2459687 Authors: Singh KK, Matkar PN, Quan A, Mantella LE, Teoh H, Al-Omran M, Verma S Abstract Objective. To evaluate the relationship between TGFβ signaling and endothelial lncRNA expression. Methods. Human umbilical vein endothelial cell (HUVECs) lncRNAs and mRNAs were profiled with the Arraystar Human lncRNA Expression Microarray V3.0 after 24 hours of exposure to TGFβ1 (10 ng/mL). Results. Of the 30,584 lncRNAs screened, 2,051 were significantly upregulated and 2,393 were apprec...
Source: International Journal of Vascular Medicine - May 5, 2016 Category: Cardiology Tags: Int J Vasc Med Source Type: research

CT Angiography Analysis of Axillary Artery Diameter versus Common Femoral Artery Diameter: Implications for Axillary Approach for Transcatheter Aortic Valve Replacement in Patients with Hostile Aortoiliac Segment and Advanced Lung Disease.
Conclusions. Although typically smaller, the axillary artery is often of comparable size to the CFA, significantly less frequently calcified or diseased, and in almost all observed cases large enough to accommodate a sheath with up to 18 French. PMID: 27110403 [PubMed] (Source: International Journal of Vascular Medicine)
Source: International Journal of Vascular Medicine - April 26, 2016 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Renal Blood Flow Response to Angiotensin 1-7 versus Hypertonic Sodium Chloride 7.5% Administration after Acute Hemorrhagic Shock in Rats.
Authors: Maleki M, Nematbakhsh M Abstract Background. Angiotensin 1-7 (Ang1-7) plays an important role in renal circulation. Hemorrhagic shock (HS) may cause kidney circulation disturbance, and this study was designed to investigate the renal blood flow (RBF) response to Ang1-7 after HS. Methods. 27 male Wistar rats were subjected to blood withdrawal to reduce mean arterial pressure (MAP) to 45 mmHg for 45 min. The animals were treated with saline (group 1), Ang1-7 (300 ng·kg(-1) min(-1)), Ang1-7 in hypertonic sodium chloride 7.5% (group 3), and hypertonic solution alone (group 4)...
Source: International Journal of Vascular Medicine - April 14, 2016 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Children and Adolescent Obesity Associates with Pressure-Dependent and Age-Related Increase in Carotid and Femoral Arteries' Stiffness and Not in Brachial Artery, Indicative of Nonintrinsic Arterial Wall Alteration.
Conclusion. OB associates with BP-dependent and age-related increase in carotid and femoral (but not brachial) stiffness. Stiffness changes would not be explained by intrinsic arterial wall alterations but could be associated with the higher BP levels observed in obese children. PMID: 27066273 [PubMed - as supplied by publisher] (Source: International Journal of Vascular Medicine)
Source: International Journal of Vascular Medicine - April 13, 2016 Category: Cardiology Tags: Int J Vasc Med Source Type: research

ABPI against Colour Duplex Scan: A Screening Tool for Detection of Peripheral Arterial Disease in Low Resource Setting Approach to Validation.
Conclusion. ABPI ≤ 0.89 could be used as the best cut off value to detect PAD. PMID: 27034837 [PubMed] (Source: International Journal of Vascular Medicine)
Source: International Journal of Vascular Medicine - April 2, 2016 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Single Low-Density Lipoprotein Apheresis Does Not Improve Vascular Endothelial Function in Chronically Treated Hypercholesterolemic Patients.
Authors: Ballard KD, Mah E, Guo Y, Bruno RS, Taylor BA, Beam JE, Polk DM, Thompson PD Abstract Objective. To investigate vascular endothelial function (VEF) responses to a single low-density lipoprotein (LDL) apheresis session in hypercholesterolemic patients undergoing chronic treatment. Methods. We measured brachial artery flow-mediated dilation (FMD), plasma lipids, vitamin E (α- and γ-tocopherol), markers of oxidative/nitrative stress (malondialdehyde (MDA) and nitro-γ-tocopherol (NGT)), and regulators of NO metabolism (arginine (ARG) and asymmetric dimethylarginine (ADMA)) prior to (Pre) and ...
Source: International Journal of Vascular Medicine - March 23, 2016 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Imaging Techniques for Diagnosis of Thoracic Aortic Atherosclerosis.
Authors: Jansen Klomp WW, Brandon Bravo Bruinsma GJ, van 't Hof AW, Grandjean JG, Nierich AP Abstract The most severe complications after cardiac surgery are neurological complications including stroke which is often caused by emboli merging from atherosclerosis in the ascending aorta to the brain. Information about the thoracic aorta is crucial in reducing the embolization risk for both surgical open and closed chest procedures such as transaortic heart valve implantation. Several techniques are available to screen the ascending aorta, for example, transesophageal echocardiography (TEE), epiaortic ultrasound, TEE ...
Source: International Journal of Vascular Medicine - March 12, 2016 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Dependence of Proximal GC Boxes and Binding Transcription Factors in the Regulation of Basal and Valproic Acid-Induced Expression of t-PA.
Conclusion. VPA-induced t-PA expression is dependent on the proximal GC boxes in the t-PA promoter and may involve interactions with Sp2, Sp4, and KLF5. PMID: 26966581 [PubMed] (Source: International Journal of Vascular Medicine)
Source: International Journal of Vascular Medicine - March 12, 2016 Category: Cardiology Tags: Int J Vasc Med Source Type: research

A Comparison of Measures of Endothelial Function in Patients with Peripheral Arterial Disease and Age and Gender Matched Controls.
This study compared flow-mediated dilatation (FMD), peripheral artery tonometry (PAT), and serum nitric oxide (NO) measures of endothelial function in patients with peripheral artery disease (PAD) against age/gender matched controls. 25 patients (mean age: 72.4 years, M : F 18 : 7) with established PAD and an age/gender matched group of 25 healthy controls (mean age: 72.4 years, M : F 18 : 7) were studied. Endothelial function was measured using the % FMD, reactive hyperemia index (RHI) using PAT and serum NO (μmol). Difference for each method between PAD and contr...
Source: International Journal of Vascular Medicine - March 6, 2016 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Phenotypic and Functional Changes of Endothelial and Smooth Muscle Cells in Thoracic Aortic Aneurysms.
In conclusion both endothelial and smooth muscle cells from aneurysms of the ascending aorta have downregulated specific cellular markers and altered functional properties, such as growth rate, apoptosis induction, and extracellular matrix synthesis. PMID: 26904289 [PubMed] (Source: International Journal of Vascular Medicine)
Source: International Journal of Vascular Medicine - February 25, 2016 Category: Cardiology Tags: Int J Vasc Med Source Type: research

Retrievable Inferior Vena Cava Filters in Patients with Cancer: Complications and Retrieval Success Rate.
Authors: Casanegra AI, Landrum LM, Tafur AJ Abstract Active cancer (ACa) is strongly associated with venous thromboembolism and bleeding. Retrievable inferior vena cava filters (RIVCF) are frequently placed in these patients when anticoagulation cannot be continued. Objectives. To describe the complications and retrieval rate of inferior vena cava filters in patients with ACa. Methods. Retrospective review of 251 consecutive patients with RIVCF in a single institution. Results. We included 251 patients with RIVCF with a mean age of 58.1 years and a median follow-up of 5.4 months (164 days, IQR: 34-385). Of these pa...
Source: International Journal of Vascular Medicine - February 25, 2016 Category: Cardiology Tags: Int J Vasc Med Source Type: research