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Condition: Intermittent Claudication

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Total 179 results found since Jan 2013.

Cervical rib resulting in amaurosis fugax and stroke
We report a patient with right cervical rib causing amaurosis fugax which was followed by right middle cerebral artery territory stroke.
Source: Clinical Neurology and Neurosurgery - September 16, 2013 Category: Neurosurgery Authors: Jayantee Kalita, Pankaj Kumar, Usha Kant Misra Tags: Case reports Source Type: research

Secondhand smoke exposure and intermittent claudication: a Scotland-wide study of 4231 non-smokers
Conclusions As with coronary heart disease and stroke, SHS exposure was independently associated with IC. Our findings add to the published evidence in support of protecting the general public from SHS exposure.
Source: Heart - August 15, 2013 Category: Cardiology Authors: Lu, L., Mackay, D. F., Pell, J. P. Tags: Health policy, Drugs: cardiovascular system, Epidemiology, Tobacco use Peripheral vascular disease Source Type: research

Neuraxial anaesthesia for lower-limb revascularization.
CONCLUSIONS: Available evidence from included trials that compared neuraxial anaesthesia with general anaesthesia was insufficient to rule out clinically important differences for most clinical outcomes. Neuraxial anaesthesia may reduce pneumonia. No conclusions can be drawn with regard to mortality, myocardial infarction and rate of lower-limb amputation, or less common outcomes. PMID: 23897485 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - August 3, 2013 Category: Journals (General) Authors: Barbosa FT, Jucá MJ, Castro AA, Cavalcante JC Tags: Cochrane Database Syst Rev Source Type: research

Low levels of a natural IgM antibody are associated with vein graft stenosis and failure
Conclusions: A naturally occurring IgM antibody directed against the proinflammatory epitope PC may be protective against vein graft stenosis and failure, through anti-inflammatory mechanisms. Measurement of this antibody may be a useful prognostic indicator, although larger studies of more diverse populations will be needed to confirm these results. The biological actions of anti-PC IgM suggest it may be useful in developing immunotherapies to improve bypass longevity.
Source: Journal of Vascular Surgery - July 15, 2013 Category: Surgery Authors: Michael Sobel, Katherine I. Moreno, Mayumi Yagi, Ted R. Kohler, Gale L. Tang, Alexander W. Clowes, Xiao-Hua A. Zhou, Evercita Eugenio Tags: Clinical research studies Source Type: research

Risk factor burden predicts long‐term mortality after cerebral infarction
ConclusionIncreasing number of traditional risk factors is associated with long‐term mortality in patients with cerebral infarction, irrespective of age. Careful long‐term follow‐up is important, especially among patients with several risk factors.
Source: Acta Neurologica Scandinavica - June 27, 2013 Category: Neurology Authors: G. Gjerde, H. Naess Tags: Original Article Source Type: research

Smoking cessation and outcome in stable outpatients with coronary, cerebrovascular, or peripheral artery disease
Conclusions: Smoking cessation was associated with a significant decrease in mortality in patients with CAD, a non-significant decrease in those with CVD, and a non-significant increase in those with PAD.
Source: European Journal of Preventive Cardiology - May 14, 2013 Category: Cardiology Authors: Alvarez, L. R., Balibrea, J. M., Surinach, J. M., Coll, R., Pascual, M. T., Toril, J., Lopez-Jimenez, L., Monreal, M., the FRENA Investigators Tags: Original scientific paper Source Type: research

Doppler ultrasonography in lower extremity peripheral arterial disease.
Abstract Systemic atherosclerosis is a condition which progresses with age, decreases quality of life, and life expectancy. Lower extremity peripheral arterial disease (PAD) is a common manifestation of systemic atherosclerosis in the elderly. These individuals have a 2 to 4 fold higher risk of coronary heart disease and stroke. In addition, systemic atherosclerosis causes overall functional disability including restricted lower extremity movements. When used alone for diagnostic purposes, claudication is an unreliable sign of PAD in all age groups especially the elderly. Moreover, claudication is difficult to def...
Source: Turk Kardiyoloji Dernegi arsivi - May 1, 2013 Category: Cardiology Authors: Verim S, Taşçı I Tags: Turk Kardiyol Dern Ars Source Type: research

Insulin Resistance, Small LDL Particles, and Risk for Atherosclerotic Disease.
Abstract There is a global epidemic of obesity, metabolic syndrome, and diabetes mellitus. Insulin resistance (IR) is etiologic for both metabolic syndrome and diabetes mellitus. IR induces a broad range of toxic systemic effects, including dyslipidemia, hypertension, hyperglycemia, increased production of advanced glycosylation end products, increased inflammatory tone, as well as a prothrombotic and pro-oxidative state. Patients with IR are highly vulnerable to the development of accelerated atherosclerosis as well its clinical sequelae, including coronary artery disease and myocardial infarction, carotid artery...
Source: Current Vascular Pharmacology - April 25, 2013 Category: Drugs & Pharmacology Authors: Toth PP Tags: Curr Vasc Pharmacol Source Type: research

Long‐term results of primary stenting for subclavian artery disease
ConclusionsEVT for SCA disease is an effective treatment with regard to initial success rate, clinical efficacy, and long‐term primary patency. This minimally invasive procedure is appropriate as the treatment of first choice for proximal subclavian arterial obstructive disease. © 2013 Wiley Periodicals, Inc.
Source: Catheterization and Cardiovascular Interventions - April 8, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Akihiro Higashimori, Nobuyuki Morioka, Shinnji Shiotani, Masahiko Fujihara, Keisuke Fukuda, Yoshiaki Yokoi Tags: Peripheral Vascular Disease Source Type: research

ACE inhibitor helps in intermittent claudication
Patients taking ramipril walked for longer without painRelated items from OnMedicaRecurrent stroke more likely at very low BPPolypill could halve cardiovascular events Caution urged over intensive glucose controlDaily aspirin use linked to major bleedingStroke rate higher in HIV patients
Source: OnMedica Latest News - February 7, 2013 Category: UK Health Source Type: news

Nationwide Experience of Cardio- and Cerebrovascular Complications During Infrainguinal Endovascular Intervention for Peripheral Arterial Disease and Acute Limb Ischaemia
Conclusions: In this population-based study we found a low risk of cardiac complications, but catheter-administered thrombolytic therapy entailed a non-negligible risk of major stroke.
Source: European Journal of Vascular and Endovascular Surgery - January 21, 2013 Category: Surgery Authors: J. Nordanstig, K. Smidfelt, M. Langenskiöld, B. Kragsterman Tags: Peripheral Arterial Disease Source Type: research

Nationwide Experience of Cardio- and Cerebrovascular Complications During Infrainguinal Endovascular Intervention for Peripheral Arterial Disease and Acute Limb Ischaemia.
CONCLUSIONS: In this population-based study we found a low risk of cardiac complications, but catheter-administered thrombolytic therapy entailed a non-negligible risk of major stroke. PMID: 23333098 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - January 17, 2013 Category: Surgery Authors: Nordanstig J, Smidfelt K, Langenskiöld M, Kragsterman B Tags: Eur J Vasc Endovasc Surg Source Type: research

Effects of successful percutaneous lower extremity revascularization on cardiovascular outcome in patients with peripheral arterial disease
Conclusions: This study shows that successful revascularization of LE-PAD patients affected by intermittent claudication, in addition to improving functional status, reduces the occurrence of future major cardiovascular events.
Source: International Journal of Cardiology - July 12, 2012 Category: Cardiology Authors: Giuseppe Giugliano, Luigi Di Serafino, Cinzia Perrino, Vittorio Schiano, Eugenio Laurenzano, Salvatore Cassese, Mario De Laurentis, Gabriele Giacomo Schiattarella, Linda Brevetti, Anna Sannino, Giuseppe Gargiulo, Anna Franzone, Ciro Indolfi, Federico Pisc Tags: Original Articles Source Type: research

ApoA-1 Mimetic Peptides Promoting Lipid Efflux from Cells for Treatment of Vascular Disorders
This invention involves ApoA-1 mimetic peptides with multiple amphipathic alpha-helical domains that promote lipid efflux from cells and are useful in the treatment and prevention of dyslipidemic, inflammatory and vascular disorders. IND-enabling studies for one of the peptides, named Fx-5A, are completed in preparation for an IND filing at the FDA, to be followed by a Phase I clinical trial planned for 2017. Disorders amenable to treatment with the peptides include hyperlipidemia, hyperlipoproteinemia, hypercholesterolemia, HDL deficiency, hypertriglyceridemia, apoA-I deficiency, acute coronary syndrome, angina pectoris, ...
Source: NIH OTT Licensing Opportunities - February 1, 2008 Category: Research Authors: ajoyprabhu3 Source Type: research