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Condition: Intermittent Claudication

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Total 179 results found since Jan 2013.

Evidence-Experience Gap and Future Perspective on the Treatment of Peripheral Artery Disease
J Atheroscler Thromb. 2021 Jun 2. doi: 10.5551/jat.RV17058. Online ahead of print.ABSTRACTPeripheral artery disease (PAD) is a systemic disease associated with impaired limb function, poor quality of life, and increased cardiovascular morbidity. Its incidence has been dramatically increasing over years because of the emergence of an aging society and the increase in the number of patients with atherosclerotic risk factors. The clustering of these risk factors promotes disease development, reportedly leading to the differential location of atherosclerotic lesions in lower extremity arteries. The clinical presentations of PA...
Source: Journal of Atherosclerosis and Thrombosis - June 3, 2021 Category: Cardiology Authors: Osamu Iida Mitsuyoshi Takahara Toshiaki Mano Source Type: research

P211  Aortitis: clinical experience within a tertiary centre
Conclusion Systemic inflammatory response syndrome was the commonest presenting feature. Those without GCA-like symptoms received a delayed diagnosis, which increases the risk of preventable vascular events. CT-PET remained the main diagnostic tool. Prednisolone treatment was prolonged with burdensome side- effects. Methotrexate remained the DMARD of choice, but leflunomide also showed good results. Vascular complications are common and need attention.Disclosure R.S. Andev: None.N. Ahmad: None.R. Luqmani: None.S. Dubey: None.
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research

Cilostazol: a Review of Basic Mechanisms and Clinical Uses
AbstractPrimarily used in the treatment of intermittent claudication, cilostazol is a 2-oxyquinolone derivative that works through the inhibition of phosphodiesterase III and related increases in cyclic adenosine monophosphate (cAMP) levels. However, cilostazol has been implicated in a number of other basic pathways including the inhibition of adenosine reuptake, the inhibition of multidrug resistance protein 4, among others. It has been observed to exhibit antiplatelet, antiproliferative, vasodilatory, and ischemic-reperfusion protective properties. As such, cilostazol has been investigated for clinical use in a variety o...
Source: Cardiovascular Drugs and Therapy - April 16, 2021 Category: Cardiology Source Type: research

Higher long-term cardiovascular morbidity after open surgery for intermittent claudication caused by infrainguinal atherosclerotic disease in patients with diabetes - a nationwide observational cohort study.
Conclusions: DM patients showed higher rates of MACE and AMI in propensity score adjusted analysis five years after planned infrainguinal open surgery for IC. Higher HbA1c was associated with MACE, stroke, and total mortality in patients with DM, whereas longer duration of DM was associated with major amputation. PMID: 33334201 [PubMed - as supplied by publisher]
Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases - December 18, 2020 Category: Surgery Authors: Dakhel A, Zarrouk M, Ekelund J, Acosta S, Miftaraj M, Eliasson B, Svensson AM, Gottsäter A Tags: Vasa Source Type: research

Winslow pathway collaterals: an unusual arterial network in Takayasu arteritis.
We present a case of a young male with Takayasu arteritis with middle aortic syndrome and Winslow pathway collaterals with lower limb ischaemia, hypertension, coronary occlusion and stroke. The extensive collateral formation was visible as a clinical finding over the abdominal wall. The identification of these collateral pathways is essential in understanding the extent of haemodynamically significant disease and it alerts to the possibility of surgical injury during procedures like laparotomy or harvesting of internal thoracic artery for coronary artery bypass graft. PMID: 32936107 [PubMed - as supplied by publisher]
Source: Journal of the Royal College of Physicians of Edinburgh - September 17, 2020 Category: General Medicine Tags: J R Coll Physicians Edinb Source Type: research

Biologics May Prevent Cardiovascular Events in Rheumatoid Arthritis by Inhibiting Coronary Plaque Formation and Stabilizing High ‐Risk Lesions
ConclusionOur findings indicate that in RA, biologic DMARD use is associated with reduced CVD risk, protective calcification of noncalcified lesions, and lower likelihood of new plaque formation in patients with early atherosclerosis.
Source: Arthritis and Rheumatology - August 6, 2020 Category: Rheumatology Authors: George A. Karpouzas, Sarah R. Ormseth, Elizabeth Hernandez, Matthew J. Budoff Tags: Original Article Source Type: research

Vascular Regeneration in Peripheral Artery Disease.
Abstract Peripheral artery disease is a common disorder and a major cause of morbidity and mortality worldwide. Therapy is directed at reducing the risk of major adverse cardiovascular events and at ameliorating symptoms. Medical therapy is effective at reducing the incidence of myocardial infarction and stroke to which these patients are prone but is inadequate in relieving limb-related symptoms, such as intermittent claudication, rest pain, and ischemic ulceration. Limb-related morbidity is best addressed with surgical and endovascular interventions that restore perfusion. Current medical therapies have only mod...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 20, 2020 Category: Cardiology Authors: Cooke JP, Meng S Tags: Arterioscler Thromb Vasc Biol Source Type: research

Biologics may prevent cardiovascular events in rheumatoid arthritis by inhibiting coronary plaque formation and stabilizing high ‐risk lesions
ConclusionIn rheumatoid arthritis, bDMARD use associated with reduced CVD risk, protective calcification of non ‐calcified lesions and lower likelihood of new plaque formation in patients with early atherosclerosis.
Source: Arthritis and Rheumatology - April 20, 2020 Category: Rheumatology Authors: George A Karpouzas, Sarah R Ormseth, Elizabeth Hernandez, Matthew J Budoff Tags: FULL LENGTH Source Type: research

COVID-19 Business Updates Provide Some Clarity
The unknowns still outnumber the knowns, but recent business updates provide some clarity around how the medical device industry is fairing during the COVID-19 pandemic. First and foremost, it is clear that companies are hurting in the areas of elective procedures, which are being deferred. But there may be some silver linings hidden amongst the bad news. Needham & Co. medtech analyst Mike Matson estimates that medical device sales across the industry will continue to drop by an average of 40% to 50% until the economy begins to reopen and hospitals start to resume elective procedures. Matson's e...
Source: MDDI - April 10, 2020 Category: Medical Devices Authors: Amanda Pedersen Tags: COVID-19 Business Source Type: news

Risk factors for severe cranial ischaemic complications in giant cell arteritis
ConclusionIncreasing age, jaw claudication and smoking predicted sCIC, while higher CRP decreased the risk of sCIC in our GCA cohort.
Source: Rheumatology - March 3, 2020 Category: Rheumatology Source Type: research

Surgical excision of a free floating ascending aortic thrombus
ConclusionFree ‐floating ascending aortic thrombus is a rare source of peripheral embolization. We advocate for emergent surgical resection to prevent further embolization and stroke.
Source: Journal of Cardiac Surgery - December 11, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Alex R. Dalal, Armita Kabirpour, John W. MacArthur Tags: IMAGES IN CARDIAC SURGERY Source Type: research

Left Subclavian Artery Revascularization for Thoracic Aortic Stentgrafting: Single Center Experience in 101 Patients
Introduction - Endovascular treatment of thoracic aortic pathology (TEVAR) requires a landing zone of at least 20mm in length, necessitating coverage of the left subclavian artery (LSA) in approximately 40% of the patients.1 Coverage of the LSA may increase the risk of ischaemic stroke, spinal cord ischaemia (SCI) and/or left arm claudication. Besides some endovascular options to preserve LSA flow, in the majority of cases the LSA is surgically revascularized by either a carotid-to-subclavian bypass graft or subclavian-carotid transposition.
Source: European Journal of Vascular and Endovascular Surgery - November 30, 2019 Category: Surgery Authors: Emma Van Der Weijde, Nabil Saouti, Olaf J. Bakker, Robin H. Heijmen Source Type: research

Metabolic-vascular coupling in skeletal muscle: a potential role for capillary pericytes?
Abstract The matching of capillary blood flow to metabolic rate of the cells within organs and tissues is a critical microvascular function which ensures appropriate delivery of hormones and nutrients, and the removal of waste products. This relationship is particularly important in tissues where local metabolism, and hence capillary blood flow, must be regulated to avoid a mismatch between nutrient demand and supply that would compromise normal function. The consequences of a mismatch in microvascular blood flow and metabolism are acutely apparent in the brain and heart, where a sudden cessation of blood flow, fo...
Source: Clinical and Experimental Pharmacology and Physiology - November 6, 2019 Category: Drugs & Pharmacology Authors: Attrill E, Ramsay C, Ross R, Richards S, Sutherland BA, Keske MA, Eringa E, Premilovac D Tags: Clin Exp Pharmacol Physiol Source Type: research

Arterial hypertension and diabetes association in the elderly
ConclusionVascular metabolic complications are serious in hypertensive elderly diabetic subjects; thus, multidisciplinary care and regular monitoring is required to detect these complications early and improve life expectancy.
Source: Archives of Cardiovascular Diseases Supplements - July 24, 2019 Category: Cardiology Source Type: research