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Condition: Intermittent Claudication

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Total 179 results found since Jan 2013.

Socioeconomic Position and Incidence of Ischemic Stroke in Denmark 2003-2012. A Nationwide Hospital-Based Study Stroke
Conclusions In Denmark, there is a strong relation between low socioeconomic position and risk for hospitalization for stroke. Lifestyle, as indicated by smoking, obesity, and alcohol consumption, and diabetes appears to increase the risk for stroke in people with lower socioeconomic position.
Source: JAHA:Journal of the American Heart Association - July 16, 2014 Category: Cardiology Authors: Andersen, K. K., Steding-Jessen, M., Dalton, S. O., Olsen, T. S. Tags: Stroke Source Type: research

The role of heat shock proteins in atherosclerosis
Nature Reviews Cardiology 11, 516 (2014). doi:10.1038/nrcardio.2014.91 Authors: Georg Wick, Bojana Jakic, Maja Buszko, Marius C. Wick & Cecilia Grundtman Atherosclerosis is a chronic, multifactorial disease that starts in youth, manifests clinically later in life, and can lead to myocardial infarction, stroke, claudication, and death. Although inflammatory processes have long been known to be involved in atherogenesis, interest in this subject has grown in the
Source: Nature Reviews Cardiology - July 15, 2014 Category: Cardiology Authors: Georg WickBojana JakicMaja BuszkoMarius C. WickCecilia Grundtman Tags: Review Source Type: research

Herpes zoster as a risk factor for stroke and TIA: A retrospective cohort study in the UK
Conclusion: HZ is an independent risk factor for vascular disease in the UK population, particularly for stroke, TIA, and MI in subjects affected before the age of 40 years. In older subjects, better ascertainment of vascular risk factors and earlier intervention may explain the reduction in risk of stroke after HZ infection.
Source: Neurology - July 7, 2014 Category: Neurology Authors: Breuer, J., Pacou, M., Gautier, A., Brown, M. M. Tags: CORRECTED AND REPUBLISHED ARTICLES Source Type: research

Abstract 312: Anatomic Runoff Score Predicts Cardiovascular Outcomes in Patients with Lower Extremity Peripheral Artery Disease Session Title: Poster Session III
Conclusions: After adjustment for clinical factors, the LE-PAD anatomic runoff score, age and indication for procedure were the most significant predictors of future cardiovascular morbidity and mortality in a broadly-representative patient population undergoing revascularization for symptomatic PAD. The use of a clinically useful anatomic scoring system, if validated, may assist clinicians in risk-stratifying patients during the course of clinical decision-making.
Source: Circulation: Cardiovascular Quality and Outcomes - June 2, 2014 Category: Cardiology Authors: Jones, W. S., Patel, M. R., Tsai, T. T., Go, A. S., Gupta, R., Hedayati, N., Ho, P. M., Jazaeri, O., Rogers, R. K., Shetterly, S. M., Wagner, N. M., Magid, D. J. Tags: Session Title: Poster Session III Source Type: research

Lessons From the Heart Troponin Elevations in Patients With Established Peripheral Artery Disease ∗
The prevalence of peripheral artery disease (PAD) is estimated to be approximately 4.3% among U.S. adults older than 40 years of age and close to 15% in those 75 years and older (1). Patients with established PAD have a high probability of atherosclerosis in other vascular beds (2) and are at increased risk for myocardial infarction, stroke, and death, as well as limb ischemic events that lead to peripheral revascularization procedures and amputations (3). Data from the international REACH (REduction of Atherothrombosis for Continued Health) registry indicate that the annual risk of cardiovascular death, myocardial infarct...
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - April 14, 2014 Category: Radiology Source Type: research

Adherence to Guideline-Recommended Therapy Is Associated With Decreased Major Adverse Cardiovascular Events and Major Adverse Limb Events Among Patients With Peripheral Arterial Disease Heart Failure
Conclusions In patients with claudication or CLI, combination treatment with four guideline-recommended therapies is associated with significant reductions in MACE, MALE, and mortality.
Source: JAHA:Journal of the American Heart Association - April 10, 2014 Category: Cardiology Authors: Armstrong, E. J., Chen, D. C., Westin, G. G., Singh, S., McCoach, C. E., Bang, H., Yeo, K.-K., Anderson, D., Amsterdam, E. A., Laird, J. R. Tags: Heart Failure Source Type: research

Screening for peripheral arterial disease.
CONCLUSIONS: Unfortunately, no randomised controlled trial data are available regarding screening for PAD. Therefore, we are unable to determine the effects of screening for PAD in order to guide decision making by healthcare providers and planners. High quality randomised controlled trials evaluating the effectiveness of screening for PAD in asymptomatic and undiagnosed individuals in terms of reduction of all-cause mortality, cardiovascular events (for example myocardial infarction and stroke), morbidity from PAD (intermittent claudication, amputation, reduced walking distance) and improvement in quality of life are need...
Source: Cochrane Database of Systematic Reviews - April 7, 2014 Category: Journals (General) Authors: Andras A, Ferket B Tags: Cochrane Database Syst Rev Source Type: research

Minimal Thoracotomy Thoracic Bifemoral Bypass in the Endovascular Era
Conclusions: Mini-TBF bypass provides another alternative to successfully revascularize Trans-Atlantic Inter-Society Consensus II type D lesions in patients with prior abdominal revascularization, pelvic anatomy with a critical IMA, or calcification/thrombus of the infrarenal/juxtarenal aorta precludes control.
Source: Annals of Vascular Surgery - April 3, 2014 Category: Surgery Authors: Amy E. Reppert, Omid Jazaeri, Ashok Babu, Joshua I. Greenberg, Erica Deluka, Mark R. Nehler, Thomas B. Reece Tags: Clinical Research Source Type: research

Aortoiliac Occlusive Disease Presenting as Sudden Onset Paraplegia
Thromboembolism and atherosclerotic stenosis both can cause arterial occlusion. Aortoiliac occlusive disease involving bifurcation of the aortoiliac artery induces symptoms of ischemia such as claudication and pain of buttocks and thighs, decreased bilateral femoral pulses, and impotence. Here, we describe a 58-year-old woman with a past history of atrial fibrillation and lacuna stroke with minimal right side weakness. She presented to our emergency department with sudden onset bilateral pain in the legs and paraplegia. A comprehensive examination revealed paresthesia and decreasing bilateral distal pulses. Computed tomogr...
Source: Annals of Vascular Surgery - February 6, 2014 Category: Surgery Authors: Chien-Hung Lai, Cheng-Hsien Wang, Shih-Yun Wu, Hong-Mo Shih Tags: Case Report Abstracts Source Type: research

Ramipril improves walking times and quality of life in patients with stable intermittent claudication
Commentary on: Ahimastos AA, Walker PJ, Askew C, et al.. Effect of ramipril on walking times and quality of life among patients with peripheral artery disease and intermittent claudication: a randomized controlled trial. JAMA 2013;309:453–60. Context Intermittent claudication (IC) is a common condition that may be associated with significant disability and reduction in quality of life. Pharmacological options for the treatment of the symptoms of this condition are very limited. Naftidrofuryl oxalate is recommended in the National Institute for Health and Care Excellence (NICE) guidelines,1 and while this has been sho...
Source: Evidence-Based Medicine - January 22, 2014 Category: Internal Medicine Authors: Brittenden, J. Tags: Health policy, Clinical trials (epidemiology), Epidemiologic studies, Drugs: cardiovascular system, Stroke, Hypertension, Health service research Therapeutics Source Type: research

Prognostic Effect of High-Sensitive Troponin T Assessment in Elderly Patients With Chronic Heart Failure: Results From the CORONA Trial Original Articles
Conclusions— Elevated hs-cTnT levels provide strong and independent prognostic information in older patients with chronic ischemic HF. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00206310.
Source: Circulation: Heart Failure - January 21, 2014 Category: Cardiology Authors: Gravning, J., Askevold, E. T., Nymo, S. H., Ueland, T., Wikstrand, J., McMurray, J. J. V., Aukrust, P., Gullestad, L., Kjekshus, J., on behalf of the CORONA Study Group Tags: Congestive Original Articles Source Type: research

Efficacy and safety of rivaroxaban compared with warfarin in patients with peripheral artery disease and non-valvular atrial fibrillation: insights from ROCKET AF
Conclusion Patients with PAD in ROCKET AF did not have a statistically significant higher risk of stroke or systemic embolism than patients without PAD, and there were similar efficacy outcomes in patients treated with rivaroxaban and warfarin. In PAD patients, there was a higher risk of major bleeding or NMCR bleeding with rivaroxaban when compared with warfarin (interaction P = 0.037). Further investigation is warranted to validate this subgroup analysis and determine the optimal treatment in this high-risk cohort of AF patients with PAD.
Source: European Heart Journal - January 21, 2014 Category: Cardiology Authors: Jones, W. S., Hellkamp, A. S., Halperin, J., Piccini, J. P., Breithardt, G., Singer, D. E., Fox, K. A. A., Hankey, G. J., Mahaffey, K. W., Califf, R. M., Patel, M. R. Tags: Atrial fibrillation Source Type: research

Herpes zoster as a risk factor for stroke and TIA: A retrospective cohort study in the UK
Conclusion: HZ is an independent risk factor for vascular disease in the UK population, particularly for stroke, TIA, and MI in subjects affected before the age of 40 years. In older subjects, better ascertainment of vascular risk factors and earlier intervention may explain the reduction in risk of stroke after the occurrence of HZ.
Source: Neurology - January 20, 2014 Category: Neurology Authors: Breuer, J., Pacou, M., Gauthier, A., Brown, M. M. Tags: Stroke in young adults, Viral infections, All Cerebrovascular disease/Stroke, Cohort studies, Risk factors in epidemiology ARTICLE Source Type: research

Study may bust myth of 'fat and fit' healthy obesity
Conclusion This meta-analysis provides further evidence about the known risk factors for cardiovascular disease and mortality. What this study adds is the indication that people who are metabolically unhealthy regardless of their weight are at increased risk. However, interestingly, no increase in risk was seen for the category of people who are metabolically healthy though overweight. A strength of this meta-analysis is the large sample size. However, the results should be interpreted with caution as: The studies did not use the same criteria for assessing metabolic status. The studies did not use the same criteri...
Source: NHS News Feed - December 4, 2013 Category: Consumer Health News Tags: Food/diet Lifestyle/exercise Obesity Source Type: news

Physiology in Medicine: Peripheral arterial disease
Peripheral arterial disease (PAD) is an atherosclerotic condition that can provoke symptoms of leg pain ("intermittent claudication") during exercise. Because PAD is often observed with comorbid conditions such hypertension, dyslipidemia, diabetes, cigarette smoking, and/or physical inactivity, the pathophysiology of PAD is certainly complex and involves multiple organ systems. Patients with PAD are at high risk for myocardial infarction, stroke, and all-cause mortality. For this reason, a better physiological understanding of the pathogenesis and treatment options for PAD patients is necessary and forms the basis of this ...
Source: Journal of Applied Physiology - November 1, 2013 Category: Physiology Authors: Muller, M. D., Reed, A. B., Leuenberger, U. A., Sinoway, L. I. Tags: PHYSIOLOGY IN MEDICINE Source Type: research