Vascular Regeneration in Peripheral Artery Disease.
Vascular Regeneration in Peripheral Artery Disease. Arterioscler Thromb Vasc Biol. 2020 May 21;:ATVBAHA120312862 Authors: Cooke JP, Meng S Abstract Peripheral artery disease is a common disorder and a major cause of morbidity and mortality worldwide. Therapy is directed at reducing the risk of major adverse cardiovascular events and at ameliorating symptoms. Medical therapy is effective at reducing the incidence of myocardial infarction and stroke to which these patients are prone but is inadequate in relieving limb-related symptoms, such as intermittent claudication, rest pain, and ischemic ulceration. Limb-related morbidity is best addressed with surgical and endovascular interventions that restore perfusion. Current medical therapies have only modest effects on limb blood flow. Accordingly, there is an opportunity to develop medical approaches to restore limb perfusion. Vascular regeneration to enhance limb blood flow includes methods to enhance angiogenesis, arteriogenesis, and vasculogenesis using angiogenic cytokines and cell therapies. We review the molecular mechanisms of these processes; briefly discuss what we have learned from the clinical trials of angiogenic and cell therapies; and conclude with an overview of a potential new approach based upon transdifferentiation to enhance vascular regeneration in peripheral artery disease. PMID: 32434408 [PubMed - as supplied by publisher]
Conclusion: Our work represents the initial experience in the liver transplantation technique for thrombectomy in distinct and well-selected patients with atrial tumor thrombi. The effectiveness of this approach needs further study. The video presentation of our research took place in March 2019 at the 34th Annual EAU Congress in Barcelona. PMID: 32612649 [PubMed]
Authors: Au SY, Chan KS, Fong KM, Yung SK, Ng WYG, Leung KHA Abstract Termination of peripheral veno-arterial extracorporeal membrane oxygenation support by managing the arteriotomy wound using a percutaneous closure device was reported successful and effective. However, careful assessment by clinical examination and also ultrasound Doppler assessment of the lower limb vasculature after closure is of paramount importance. Complications including pseudoaneurysm, arterial stenosis, and acute thrombosis are not uncommon. In this case report, commercial microbubbles were used as ultrasound contrast to enhance the image...
CONCLUSION: Subcutaneously anchored securement is a very promising strategy for avoiding dislodgment. Further studies are warranted, in particular for the purpose of defining (a) the best management of the anchoring device so to avoid local problems, (b) the patient populations in which it may be considered highly cost-effective and even mandatory, (c) the possible benefit in terms of reduction of other catheter-related complications such as venous thrombosis and/or infection, and-last but not least-(d) their impact on the workload and stress level of nurses taking care of the devices. PMID: 32613887 [PubMed - as supplied by publisher]
Conclusions: Operative laparoscopy under conscious sedation and local anesthesia appears to be a feasible technique in gynecologic surgery with no adverse patient outcomes. PMID: 32612345 [PubMed - in process]
Publication date: Available online 24 June 2020Source: Saudi Journal of Biological SciencesAuthor(s): Neda M. Bogari, Ashwag Aljohani, Anas Dannoun, Osama Elkhateeb, Masimo Porqueddu, Amr A. Amin, Dema N. Bogari, Mohiuddin M. Taher, Faruk Buba, Reem M. Allam, Mustafa N. Bogari, Francesco Alamanni
CONCLUSIONS: negative pressure wound therapy has few complications, but with discomfort to patients. PMID: 32609220 [PubMed - in process]
CONCLUSIONS: in this theoretical reflection, we argue that in order to promote health equity and quality of care in the Unified Health System (Brazilian SUS) it is important to translate scientific knowledge to various practice settings and create opportunities for exchange with users of this knowledge, such as health professionals, managers, policy makers, patients, family members and other stakeholders. PMID: 32609213 [PubMed - in process]
CONCLUSIONS: workers evaluated their quality of life as good or very good and reported to be satisfied or very satisfied with their health. They also reported pains in lower back, neck, shoulders, wrists/hands/fingers and knees. Pain has influenced the quality of life. PMID: 32609208 [PubMed - in process]
CONCLUSIONS: it highlights the importance of directing health promotion for caregivers, inserting them in the care process, recognizing their needs and intensifying practices that promote empowerment for care, bypassing curative actions. PMID: 32609175 [PubMed - in process]
BACKGROUND: Orthopedic trauma patients have the risk to experience mental disorders, including depression, anxiety, post-traumatic stress disorder (PTSD), and other mental disorders. However, studies that analyze the relationship between mental disorders i...