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Specialty: Rheumatology
Condition: Arthritis

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Total 260 results found since Jan 2013.

Adverse Events in Giant Cell Arteritis and Rheumatoid Arthritis Patient Populations: Analyses of Tocilizumab Clinical Trials and Claims Data
ConclusionHigher IRs of AESI were observed in patients with GCA versus those with RA in both TCZ-na ïve and -treated cohorts. Differences in underlying disease, age, and glucocorticoid use may influence AESI incidence, irrespective of intervention.FundingThis study was funded by F. Hoffmann-La Roche Ltd and Genentech, Inc. Article processing charges were funded by F. Hoffmann-La Roche Ltd.Plain Language SummaryPlain language summary is available for this article.
Source: Rheumatology and Therapy - February 1, 2019 Category: Rheumatology Source Type: research

Cardiovascular comorbidities in rheumatoid arthritis.
Abstract Approximately 80% of patients with rheumatoid arthritis (RA) suffer from comorbidities including more than 50% from cardiovascular (CV) diseases. Inflammatory activity is the main factor connecting RA with atherosclerosis, coronary heart disease, stroke, thromboembolic events and heart failure. Altogether these affect RA patients twice as frequently as the general population and CV events are the major cause of death in RA. Besides inflammatory activity, which can be reduced or eliminated by optimal treatment and controlling the RA activity, traditional CV risk factors also contribute to the total CV ris...
Source: Zeitschrift fur Rheumatologie - January 17, 2019 Category: Rheumatology Authors: Krüger K, Nüßlein H Tags: Z Rheumatol Source Type: research

Reduced right ventricular output reserve in patients with systemic sclerosis and mildly elevated pulmonary arterial pressures
ConclusionThe results of this study suggest that impaired 6MWD in SSc ‐patients with mildly elevated mPAP might be caused by reduced PAC during exercise and reduced RV output reserve, presumably due to impaired coupling between the right ventricle and the pulmonary vasculature. These findings give further evidence for the clinical relevance of mildly elevated mPAP i n patients with SSc.This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatology - January 7, 2019 Category: Rheumatology Authors: Christian Nagel, Alberto M. Marra, Nicola Benjamin, Norbert Blank, Antonio Cittadini, Gerry Coghlan, Oliver Distler, Christopher P Denton, Benjamin Egenlauf, Christoph Fiehn, Christine Fischer, Satenik Harutyunova, Marius M Hoeper, Hanns ‐M Tags: Full Length Source Type: research

Mourning the Loss of NIAMS Director Stephen Katz, MD, PhD
“It is with a profoundly heavy heart that I share with you the sad news that we have lost one of our most beloved leaders at NIH. Steve Katz, MD, PhD, the long-time director of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), died early this morning after suffering a catastrophic stroke.... [Read More]
Source: The Rheumatologist - December 20, 2018 Category: Rheumatology Authors: Francis S. Collins, MD, PhD, NIH Director Tags: Profiles Katz obituary Source Type: research

Ibudilast inhibits chemokine expression in rheumatoid synovial fibroblasts and exhibits immunomodulatory activity in experimental arthritis
ConclusionIbudilast reduced the expression and/or secretion of inflammatory mediators from activated human leukocytes and RASF, inhibited Th17 responses in vivo and improved established arthritis. Given the established safety profile of ibudilast in man, its clinical evaluation in RA, either alone or in combination with a TNF inhibitor, should be considered.This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatology - November 26, 2018 Category: Rheumatology Authors: Felix I.L. Clanchy, Richard O. Williams Tags: Full Length Source Type: research

Video Education: Patient Outreach Effort Offers Education about Cardiovascular Risks
Experts in rheumatoid arthritis, cardiovascular health and education have joined forces to create a video intervention designed to help patients understand their risks for heart attack and stroke, as well as how to reduce these risks. Early research into this educational intervention shows the video is effective...
Source: The Rheumatologist - June 27, 2018 Category: Rheumatology Authors: Carina Stanton Tags: Conditions Rheumatoid Arthritis cardiovascular Education patient education risk video Source Type: research

Cardiovascular (CV) Risk after Initiation of Abatacept versus TNF Inhibitors in Rheumatoid Arthritis Patients with and without Baseline CV Disease.
CONCLUSION: In this large cohort of publicly or privately insured patients with RA in the United States, ABA was associated with a 20% reduced risk of CVD versus TNFi. While this observational study is subject to potential residual confounding, our results were consistent in patients with baseline CVD. PMID: 29764964 [PubMed - as supplied by publisher]
Source: J Rheumatol - May 15, 2018 Category: Rheumatology Authors: Jin Y, Kang EH, Brill G, Desai RJ, Kim SC Tags: J Rheumatol Source Type: research

Is Rheumatoid Arthritis a Cardiovascular Risk Equivalent to Diabetes?
ConclusionFindings from the present study suggest that while CVD risk in RA is elevated, it is lower in magnitude compared to the CVD risk associated with diabetes. It therefore may not be appropriate to consider RA a diabetes risk‐equivalent with respect to hyperlipidemia management.This article is protected by copyright. All rights reserved.
Source: Arthritis Care and Research - February 6, 2018 Category: Rheumatology Authors: Jeffrey R Curtis, Shuo Yang, Jasvinder A. Singh, Fenglong Xie, Lang Chen, Huifeng Yun, Paul Muntner, Shia T Kent, Emily B. Levitan, Monika M. Safford, Kenneth G. Saag, Jie Zhang Tags: Brief Report Source Type: research

Methotrexate might reduce ischemic stroke in patients with rheumatoid arthritis: a population ‐based retrospective cohort study
International Journal of Rheumatic Diseases, EarlyView.
Source: APLAR Journal of Rheumatology - January 25, 2018 Category: Rheumatology Source Type: research

Association Between Glucocorticoid Exposure and Healthcare Expenditures for Potential Glucocorticoid-related Adverse Events in Patients with Rheumatoid Arthritis.
CONCLUSION: Chronic exposure to low to medium doses of OGC was associated with significantly increased risk of potential OGC-related AE in patients with RA, and greater cumulative OGC dose was associated with substantially higher AE-related healthcare expenditures among patients with AE. PMID: 29335343 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - January 18, 2018 Category: Rheumatology Tags: J Rheumatol Source Type: research

Comparison of the risks of hospitalisation for cardiovascular events in patients with rheumatoid arthritis treated with tocilizumab and etanercept.
CONCLUSIONS: RA patients with TCZ do not have a medium-term excess of CV risk in patients compared with ETN. PMID: 29303702 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - January 6, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Cerebrovascular Events in Systemic Lupus Erythematosus
ConclusionCerVEs, the fourth most frequent NP event in SLE, are usually attributable to lupus. In contrast to good physician reported outcomes, patients report a sustained reduction in health‐related quality of life following CerVEs.This article is protected by copyright. All rights reserved.
Source: Arthritis Care and Research - January 5, 2018 Category: Rheumatology Authors: John G. Hanly, Qiuju Li, Li Su, Murray B. Urowitz, Caroline Gordon, Sang ‐Cheol Bae, Juanita Romero‐Diaz, Jorge Sanchez‐Guerrero, Sasha Bernatsky, Ann E. Clarke, Daniel J Wallace, David A. Isenberg, Anisur Rahman, Joan T. Merrill, Paul Fortin, Dafna Tags: Original Article Source Type: research

Methotrexate might reduce ischemic stroke in patients with rheumatoid arthritis: a population ‐based retrospective cohort study
ConclusionsAt a dosage of > 0.5 defined daily dose, short‐term methotrexate might decrease ischemic stroke risk in RA patients, while hydroxychloroquine and sulfasalazine were neutral.
Source: APLAR Journal of Rheumatology - January 1, 2018 Category: Rheumatology Authors: Hong ‐Wei Tam, Chyong‐Mei Chen, Pui‐Ying Leong, Chao‐Hsi Chen, Yuan‐Chao Li, Yu‐Hsun Wang, Li‐Chi Lin, Jeng‐Yuan Chiou, James Cheng‐Chung Wei Tags: Original Article Source Type: research

Is gout a risk equivalent to diabetes for stroke and myocardial infarction? A retrospective claims database study
Gout is a risk factor for cardiovascular disease, but associations with specific cardiovascular outcomes, myocardial infarction (MI), and stroke are unclear. Our objective in the present study was to assess wh...
Source: Arthritis Research and Therapy - October 17, 2017 Category: Rheumatology Authors: Jasvinder A. Singh, Rekha Ramachandaran, Shaohua Yu, Shuo Yang, Fenglong Xie, Huifeng Yun, Jie Zhang and Jeffrey R. Curtis Tags: Research article Source Type: research

Assessment of intracranial vessels in association with carotid atherosclerosis and brain vascular lesions in rheumatoid arthritis
Stroke has been associated with rheumatoid arthritis (RA). We assessed patients with RA and healthy control subjects by transcranial Doppler (TCD), carotid ultrasonography and brain magnetic resonance imaging ...
Source: Arthritis Research and Therapy - September 26, 2017 Category: Rheumatology Authors: Csaba Ol áh, Zsófia Kardos, Mariann Sepsi, Attila Sas, László Kostyál, Harjit Pal Bhattoa, Katalin Hodosi, György Kerekes, László Tamási, Attila Valikovics, Dániel Bereczki and Zoltán Szekanecz Tags: Research article Source Type: research