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Specialty: Rheumatology
Condition: Arthritis

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Total 260 results found since Jan 2013.

Rheumatoid Arthritis, Anti–Cyclic Citrullinated Peptide Positivity, and Cardiovascular Disease Risk in the Women's Health Initiative
ConclusionAmong postmenopausal women, RA was associated with 1.5–2.5‐fold higher CVD risk. CVD risk was strongly associated with CVD risk factors, joint pain severity, and inflammation, but not with anti‐CCP positivity or RF positivity.
Source: Arthritis and Rheumatism - August 26, 2015 Category: Rheumatology Authors: Rachel H. Mackey, Lewis H. Kuller, Kevin D. Deane, Brian T. Walitt, Yue‐Fang Chang, V. Michael Holers, William H. Robinson, Russell P. Tracy, Mark A. Hlatky, Charles B. Eaton, Simin Liu, Matthew S. Freiberg, Mehret Birru Talabi, Erik B. Schelbert, Larry Tags: Rheumatoid Arthritis Source Type: research

Brief Report: Association Between Pregnancy Outcomes and Death From Cardiovascular Causes in Parous Women With Systemic Lupus Erythematosus: A Study Using Swedish Population Registries
ConclusionMPS in pregnancy is associated with a higher risk of death from primarily cardiovascular causes in women with SLE.
Source: Arthritis and Rheumatism - August 26, 2015 Category: Rheumatology Authors: May Ching Soh, Catherine Nelson‐Piercy, Fadia Dib, Magnus Westgren, Lesley McCowan, Dharmintra Pasupathy Tags: Systemic Lupus Erythematosus Source Type: research

Subcutaneous nodules are associated with cardiovascular events in patients with rheumatoid arthritis: results from a large US registry
The objective of this study is to examine the possibility of a relationship between subcutaneous nodules and “first ever” cardiovascular disease event, i.e., myocardial infarction (MI), stroke, or cardiovascular death in a large registry-cohort of patients with RA. Patient information was collected from the CORRONA registry from October 2001 to September 2011. A total of 26,042 patients with RA were studied for the presence or absence of subcutaneous nodules. Cox proportional hazards regression models were constructed to estimate the hazard ratios (HR) for CVD events in relation to subcutaneous nodules at baseline. Thr...
Source: Clinical Rheumatology - August 4, 2015 Category: Rheumatology Source Type: research

Genetic Variants of the NLRP3 Inflammasome Are Associated with Stroke in Patients with Rheumatoid Arthritis.
CONCLUSION: Genetic variants of the NLRP3 inflammasome influence the risk of stroke/TIA, but not of MI/angina pectoris in Swedish patients with established RA. PMID: 26178285 [PubMed - as supplied by publisher]
Source: J Rheumatol - July 15, 2015 Category: Rheumatology Authors: Kastbom A, Ärlestig L, Rantapää-Dahlqvist S Tags: J Rheumatol Source Type: research

Hip Osteoarthritis and the Risk of All‐Cause and Disease‐Specific Mortality in Older Women: A Population‐Based Cohort Study
ConclusionRHOA was associated with an increased risk of all‐cause and CVD mortality among older white women followed up for 16 years. Dissemination of evidence‐based physical activity and self‐management interventions for hip OA in community and clinical settings can improve physical function and might also contribute to lower mortality.
Source: Arthritis and Rheumatism - June 26, 2015 Category: Rheumatology Authors: Kamil E. Barbour, Li‐Yung Lui, Michael C. Nevitt, Louise B. Murphy, Charles G. Helmick, Kristina A. Theis, Marc C. Hochberg, Nancy E. Lane, Jennifer M. Hootman, Jane A. Cauley, Tags: Osteoarthritis Source Type: research

Epigenetic Aspects of Systemic Lupus Erythematosus
Abstract Autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis, multiple sclerosis, autoimmune hepatitis, and inflammatory bowel disease have complex pathogeneses and the courses of events leading to these diseases are not well understood. The immune surveillance is a delicate balance between self and foreign as well as between tolerance and immune response. Exposure to certain environmental factors may impair this equilibrium, leading to autoimmune diseases, cancer, and the so-called “lifestyle diseases” such as atherosclerosis, heart attack, stroke, and obesity, among others. T...
Source: Rheumatology and Therapy - June 15, 2015 Category: Rheumatology Source Type: research

Rheumatoid arthritis: Link between RA and cardiovascular disease risk
Nature Reviews Rheumatology 11, 382 (2015). doi:10.1038/nrrheum.2015.77 Data from >160,000 postmenopausal women included in the Women's Health Initiative indicate that women with RA are at 1.5–2.5-fold higher risk of cardiovascular disease (CVD) morbidity and mortality over 10 years compared with women without RA (outcomes assessed included coronary heart disease, stroke, CVD, fatal
Source: Nature Reviews Rheumatology - June 2, 2015 Category: Rheumatology Tags: Research Highlight Source Type: research

Association between pregnancy outcomes and cardiovascular deaths in women with systemic lupus erythematousus utilising Swedish population registries
Conclusion: MPS in pregnancy is associated with a higher risk of future primary cardiovascular death in women with SLE. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - May 27, 2015 Category: Rheumatology Authors: May Ching Soh, Catherine Nelson‐Piercy, Fadia Dib, Magnus Westgren, Lesley McCowan, Dharmintra Pasupathy Tags: Brief Report Source Type: research

Rheumatoid arthritis, anti‐CCP positivity, and cardiovascular disease risk in the Women's Health Initiative
Conclusion: Among postmenopausal women, RA was associated with 1.5‐2.5 higher CVD risk, strongly associated with CV risk factors, joint pain severity, and inflammation, but similar for anti‐CCP+ and RF+. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - May 18, 2015 Category: Rheumatology Authors: Rachel H. Mackey, Lewis H. Kuller, Kevin D. Deane, Brian T. Walitt, Yuefang F. Chang, V. Michael Holers, William H. Robinson, Russell P. Tracy, Mark A. Hlatky, Charles Eaton, Simin Liu, Matthew S. Freiberg, Mehret Birru Talabi, Erik B. Schelbert, Larry W. Tags: Full Length Source Type: research

Risk of ischemic stroke in patients with polymyositis and dermatomyositis: a systematic review and meta-analysis
Abstract Several chronic inflammatory disorders, such as rheumatoid arthritis and systemic lupus erythematosus, have been demonstrated to increase ischemic stroke risk, but the data on polymyositis (PM) and dermatomyositis (DM) remain unclear. We conducted a systematic review and meta-analysis of observational studies that reported odds ratio, relative risk, hazard ratio or standardized incidence ratio comparing ischemic risk in patients with PM/DM versus non-PM/DM participants. Pooled risk ratio and 95 % confidence intervals were calculated using a random-effect, generic inverse variance method of DerSimonian a...
Source: Rheumatology International - April 23, 2015 Category: Rheumatology Source Type: research

Prevalence and risk factors of arthritis in a middle-aged and older Chinese population: the China Health and Retirement Longitudinal Study
Conclusion. Middle-aged and older Chinese adults had a high prevalence of arthritis. Cardiovascular disease is a novel risk factor for arthritis in this population.
Source: Rheumatology - March 24, 2015 Category: Rheumatology Authors: Li, C., Liu, T., Sun, W., Wu, L., Zou, Z.-Y. Tags: Rheumatoid Arthritis CLINICAL SCIENCE Source Type: research

Hip osteoarthritis and the risk of all‐cause and disease‐specific mortality in older women: Population‐based cohort study
Conclusion RHOA was associated with an increased risk of all‐cause and CVD mortality among older white women followed for 16 years. Dissemination of evidence‐based physical activity and self‐management interventions for hip OA in community and clinical settings can improve physical function and might also contribute to lower mortality. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - March 16, 2015 Category: Rheumatology Authors: Kamil E. Barbour, Li‐Yung Lui, Michael C. Nevitt, Louise B. Murphy, Charles G. Helmick, Kristina A. Theis, Marc C. Hochberg, Nancy E. Lane, Jennifer M. Hootman, Jane A. Cauley, Tags: Full Length Source Type: research

Disease activity in rheumatoid arthritis and the risk of cardiovascular events
Conclusions: Reduced time‐averaged disease activity in RA is associated with fewer CV events. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - March 16, 2015 Category: Rheumatology Authors: D.H. Solomon, G Reed, J.M. Kremer, J.R. Curtis, M.E. Farkouh, L.R. Harrold, M.C. Hochberg, P Tsao, J Greenberg Tags: Full Length Source Type: research

Psoriasis, psoriatic arthritis and cardiovascular risk: are we closer to a clinical recommendation?
The issue of vascular risk in chronic arthropathies and especially the magnitude of such risk and its clinical implications in daily practice are of considerable current importance. Similarly, the relative risk across distinct arthropathies and other chronic inflammatory conditions is debated. Ogdie et al1 report associations between psoriasis, psoriatic arthritis (PsA), rheumatoid arthritis (RA) and an increased risk of major adverse cardiovascular events (MACE—myocardial infarction, stroke and cardiovascular death) in data derived from the UK primary care registry. Results are stratified by use of disease-modifying...
Source: Annals of the Rheumatic Diseases - January 7, 2015 Category: Rheumatology Authors: Kristensen, S. L., McInnes, I. B., Sattar, N. Tags: Immunology (including allergy), Inflammation, Biological agents, Connective tissue disease, Degenerative joint disease, Drugs: musculoskeletal and joint diseases, Musculoskeletal syndromes, Rheumatoid arthritis, Epidemiology Editorials Source Type: research

Racial and ethnic differences in mortality and cardiovascular events among patients with end‐stage renal disease due to lupus nephritis
Conclusion: Among patients with LN ESRD, Asians and Hispanics experienced lower mortality and CV event risks, while African Americans had higher mortality and CV event risks compared to Whites. This article is protected by copyright. All rights reserved.
Source: Arthritis Care and Research - January 1, 2015 Category: Rheumatology Authors: Jose A. Gómez‐Puerta, Candace H. Feldman, Graciela S. Alarcón, Hongshu Guan, Wolfgang C. Winkelmayer, Karen H. Costenbader Tags: Original Article Source Type: research