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Specialty: Opthalmology

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Total 178 results found since Jan 2013.

Agonism of GPR120 Prevented High Glucose-Induced Apoptosis of Retinal Endothelial Cells through Inhibiting NLRP3 Inflammasome
CONCLUSIONS: Activation of GPR120 protects retinal vascular endothelial cells from HG through inhibiting NLRP3 inflammasome. Thus, GPR120 might be a potential therapeutic target to reduce retinal endothelial damage in diabetic retinopathy.PMID:35584771 | DOI:10.1055/a-1811-7099
Source: Klinische Monatsblatter fur Augenheilkunde - May 18, 2022 Category: Opthalmology Authors: Xiaoju Ding Haijuan Xie Wuqiang Shan Ligang Li Source Type: research

TNFAIP3 may be key to TLR4-activation of the inflammasome in the retinal vasculature
Exp Eye Res. 2022 May 11:109108. doi: 10.1016/j.exer.2022.109108. Online ahead of print.ABSTRACTThe goal of these studies were to determine whether tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) regulated toll-like receptor 4 (TLR4) actions on the NOD-like receptor protein 3 (NLRP3) inflammasome. Western blotting was done on retinal lysates from TLR4 floxed and endothelial cell specific TLR4 knockout mice for TNFAIP3, TLR4, and NLRP3 pathway proteins. Retinal endothelial cells (REC) were grown in normal (5mM) and high glucose (25mM) and treated with TNFAIP3 siRNA, followed by Western blotting for TLR4 and NLRP3 p...
Source: Experimental Eye Research - May 14, 2022 Category: Opthalmology Authors: Li Liu Youde Jiang Jena J Steinle Source Type: research

Inhibition of Drp1 ameliorates diabetic retinopathy by regulating mitochondrial homeostasis
Exp Eye Res. 2022 Apr 28:109095. doi: 10.1016/j.exer.2022.109095. Online ahead of print.ABSTRACTDiabetic retinopathy (DR) is a potentially blinding complication resulting from diabetes mellitus (DM). Retinal vascular endothelial cells (RMECs) dysfunction occupies an important position in the pathogenesis of DR, and mitochondrial disorders play a vital role in RMECs dysfunction. However, the detailed mechanisms underlying DR-induced mitochondrial disorders in RMECs remain elusive. In the present study, we used High glucose (HG)-induced RMECs in vitro and streptozotocin (STZ)-induced Sprague-Dawley rats in vivo to explore th...
Source: Experimental Eye Research - May 1, 2022 Category: Opthalmology Authors: Meng-Yuan Zhang Lingpeng Zhu Xun Bao Tian-Hua Xie Jiping Cai Jian Zou Wenjuan Wang Shun Gu Yan Li Hong-Ying Li Yong Yao Ting-Ting Wei Source Type: research

Therapeutic potential of topical administration of siRNAs against HIF-1 α for corneal neovascularization
In conclusion, the topical application of siRNA towards HIF-1α seems to be an effective and reliable method to stop neovascularization.PMID:35367249 | DOI:10.1016/j.exer.2022.109036
Source: Experimental Eye Research - April 3, 2022 Category: Opthalmology Authors: Assumpta Peral Jes ús Mateo Carmen O Dom ínguez-Godínez Gonzalo Carracedo Jose Antonio G ómez Almudena Crooke Jes ús Pintor Source Type: research

C-terminal binding protein 2 promotes high-glucose-triggered cell proliferation, angiogenesis and cellular adhesion of human retinal endothelial cell line
ConclusionThis study implicates that CtBP2 promotes HG-induced cell proliferation, angiogenesis and cellular adhesion, and CtBP2 might be a potential target in the prevention of DR.
Source: International Ophthalmology - March 30, 2022 Category: Opthalmology Source Type: research

Copolymer micelle-administered melatonin ameliorates hyperosmolarity-induced ocular surface damage through regulating PINK1 mediated mitophagy
CONCLUSIONS: Our findings demonstrated that Mel-Mic ameliorates hyperosmolarity induced ocular surface damage via PINK1 mediated mitophagy and may represent an effective treatment for DED possibly through acting MT1 receptor.PMID:35179400 | DOI:10.1080/02713683.2021.2022163
Source: Current Eye Research - February 18, 2022 Category: Opthalmology Authors: Jing Xu Peng Chen Guangfen Zhao Susu Wei Qiqi Li Chuanlong Guo Qilong Cao Xianggen Wu Guohu Di Source Type: research

Decreased FABP5 and DSG1 protein expression following PAX6 knockdown of differentiated human limbal epithelial cells
Exp Eye Res. 2021 Dec 23:108904. doi: 10.1016/j.exer.2021.108904. Online ahead of print.ABSTRACTPAX6 haploinsufficiency related aniridia is characterized by disorder of limbal epithelial cells (LECs) and aniridia related keratopathy. In the limbal epithelial cells of aniridia patients, deregulated retinoic acid (RA) signaling components were identified. We aimed to visualize differentiation marker and RA signaling component expression in LECs, combining a differentiation triggering growth condition with a small interfering RNA (siRNA) based aniridia cell model (PAX6 knock down). Primary LECs were isolated from corneosclera...
Source: Experimental Eye Research - December 26, 2021 Category: Opthalmology Authors: Priya Katiyar Tanja Stachon Fabian N Fries Frederika Parow Myriam Ulrich Achim Langenbucher Alan Cayless Berthold Seitz Barbara K äsmann-Kellner Lorenz Latta N óra Szentmáry Source Type: research

Potential Protective Role of TRPM7 and Involvement of PKC/ERK Pathway in Blue Light–Induced Apoptosis in Retinal Pigment Epithelium Cells in Vitro
Purpose: Blue light triggers apoptosis of retinal pigment epithelium (RPE) cells and causes retinal damage. The aim of this study was to elucidate the protective role of transient receptor potential melastatin 7 (TRPM7) in photodamaged RPE cells. Methods: RPE cells were isolated from Sprague-Dawley (SD) rats and exposed to varying intensities of blue light (500–5000 lux) in vitro. Cell proliferation and metabolic activity were respectively assessed by bromodeoxyuridine (BrdU) incorporation and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assays. Real-time polymerase chain reaction (RT...
Source: Asia-Pacific Journal of Ophthalmology - November 1, 2021 Category: Opthalmology Tags: Original Study Source Type: research

Hypoxic and osmotic expression of Kir2.1 potassium channels in retinal pigment epithelial cells: Contribution to vascular endothelial growth factor expression
Exp Eye Res. 2021 Aug 20:108741. doi: 10.1016/j.exer.2021.108741. Online ahead of print.ABSTRACTRetinal pigment epithelial (RPE) cells express different subtypes of inwardly rectifying potassium (Kir) channels. We investigated whether human and rat RPE cells express genes of strongly rectifying Kir2 channels. We also determined the hypoxic and hyperosmotic regulation of Kir2.1 gene expression in cultured human RPE cells and the effects of siRNA-mediated knockdown of Kir2.1 on VEGFA expression, VEGF secretion, proliferation, and viability of the cells. Extracellular hyperosmolarity was induced by addition of NaCl or sucrose...
Source: Experimental Eye Research - August 23, 2021 Category: Opthalmology Authors: Eva Klose Heidrun Kuhrt Leon Kohen Peter Wiedemann Andreas Bringmann Margrit Hollborn Source Type: research