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Specialty: Opthalmology

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Total 178 results found since Jan 2013.

siRNA Silencing of the Mutant Keratin 12 Allele in Corneal Limbal Epithelial Cells Grown From Patients With Meesmann's Epithelial Corneal Dystrophy Cornea
Conclusions. Combined with an effective delivery vehicle this siRNA approach represents a viable treatment option for prevention of the MECD pathology observed in K12-Leu132Pro heterozygous individuals.
Source: Investigative Ophthalmology - May 29, 2014 Category: Opthalmology Authors: Courtney, D. G., Atkinson, S. D., Allen, E. H. A., Moore, J. E., Walsh, C. P., Pedrioli, D. M. L., MacEwen, C. J., Pellegrini, G., Maurizi, E., Serafini, C., Fantacci, M., Liao, H., Irvine, A. D., McLean, W. H. I., Moore, C. B. T. Tags: Cornea Source Type: research

Dexamethasone Increases Cdc42 Expression in Human TM-1 Cells.
Conclusions: DEX increases Cdc42 expression in TM-1. This may represent a potential mechanism of DEX-induced HTM cytoskeletal rearrangement. PMID: 24871483 [PubMed - as supplied by publisher]
Source: Current Eye Research - May 28, 2014 Category: Opthalmology Authors: Qiu X, Wu K, Lin X, Liu Q, Ye Y, Yu M Tags: Curr Eye Res Source Type: research

Aldose Reductase Inhibition Prevents Endotoxin-Induced Inflammatory Responses in Retinal Microglia Retinal Cell Biology
Conclusions. These results demonstrate that the action of AR contributes to the activation of RMG. Inhibition of AR may be a therapeutic strategy to reduce inflammation associated with activation of RMG in disease.
Source: Investigative Ophthalmology - May 2, 2014 Category: Opthalmology Authors: Chang, K.-C., Ponder, J., LaBarbera, D. V., Petrash, J. M. Tags: Retinal Cell Biology Source Type: research

Knockdown of Both p120 Catenin and Kaiso Promotes Expansion of Human Corneal Endothelial Monolayers via RhoA-ROCK-Noncanonical BMP-NF{kappa}B Pathway Cornea
Conclusions. The optimized knockdown with p120 and Kaiso siRNAs further expands the size of HCEC monolayers without endothelial mesenchymal transition (EMT) via selective activation of p120/Kaiso signaling that requires the RhoA-ROCK-noncanonical BMP-NFkB signaling.
Source: Investigative Ophthalmology - March 13, 2014 Category: Opthalmology Authors: Zhu, Y.-T., Han, B., Li, F., Chen, S.-Y., Tighe, S., Zhang, S., Tseng, S. C. G. Tags: Cornea Source Type: research

Tonicity-responsive enhancer binding protein regulates the expression of aldose reductase and protein kinase C δ in a mouse model of diabetic retinopathy.
In this study, we used TonEBP heterozygote (±) mice to study the role of TonEBP in streptozotocin (STZ)-induced diabetic retinopathy. We performed immunofluorescence staining and found that retinal expressions of AR and PKCδ were significantly reduced in the heterozygotes compared to wild type littermates, particularly in ganglion cell layer. To examine further the effect of TonEBP reduction in retinal tissues, we performed intravitreal injection of TonEBP siRNA and confirmed the decrease in AR and PKCδ levels. In addition, we found that a proapoptotic factor, Bax level was reduced and a survival factor, Bcl2 level was ...
Source: Experimental Eye Research - March 12, 2014 Category: Opthalmology Authors: Park J, Kim H, Park SY, Lim SW, Kim YS, Lee DH, Roh GS, Kim HJ, Kang SS, Cho GJ, Jeong BY, Kwon HM, Choi WS Tags: Exp Eye Res Source Type: research

RTP801 Gene Expression Is Differentially Upregulated in Retinopathy and Is Silenced by PF-04523655, a 19-Mer siRNA Directed Against RTP801 Retina
Conclusions. In rodent retinopathy models, administration of the siRNA, PF-04523655, reduced RTP801 expression in the retina, consistent with the RNA-induced silencing complex (RISC) mechanism of action. The pharmacodynamic profile from the animal models could be useful to elucidate dose and exposure dependency of RTP801 expression inhibition by siRNA.
Source: Investigative Ophthalmology - March 4, 2014 Category: Opthalmology Authors: Rittenhouse, K. D., Johnson, T. R., Vicini, P., Hirakawa, B., Kalabat, D., Yang, A. H., Huang, W., Basile, A. S. Tags: Retina Source Type: research

Development of Allele-Specific Gene-Silencing siRNAs for TGFBI Arg124Cys in Lattice Corneal Dystrophy Type I Cornea
Conclusions. We have identified a lead siRNA specific to the TGFBI-Arg124Cys mutant allele associated with LCDI. Silencing of exogenous TGFBI was observed at mRNA and protein levels, and in an ex vivo model of LCDI with an efficient suppression of the endogenous mutant allele. This result indicates the potential of siRNA treatment as a personalized medicine approach for the management of heritable TGFBI-associated corneal dystrophies.
Source: Investigative Ophthalmology - February 18, 2014 Category: Opthalmology Authors: Courtney, D. G., Atkinson, S. D., Moore, J. E., Maurizi, E., Serafini, C., Pellegrini, G., Black, G. C., Manson, F. D., Yam, G. H. F., MacEwen, C. J., Allen, E. H. A., McLean, W. H. I., Moore, C. B. T. Tags: Cornea Source Type: research

Inhibition of Polo-Like Kinase 1 Promotes Hyperthermia Sensitivity via Inactivation of Heat Shock Transcription Factor 1 in Human Retinoblastoma Cells New Developments
Conclusions. Polo-like kinase 1 inhibition may attenuate the thermoresistance of HT through the inactivation of HSF1 concomitant with reductions in HSPs and BAG3. The combination of PLK1 inhibition and HT may become an option for HT therapy in patients with retinoblastoma.
Source: Investigative Ophthalmology - December 23, 2013 Category: Opthalmology Authors: Yunoki, T., Tabuchi, Y., Hayashi, A., Kondo, T. Tags: New Developments Source Type: research

Triple Combination of siRNAs Targeting TGF{beta}1, TGF{beta}R2, and CTGF Enhances Reduction of Collagen I and Smooth Muscle Actin in Corneal Fibroblasts Cornea
Conclusions. Simultaneous targeting of TGFβ1, TGFβR2, and CTGF genes by effective triple siRNA combination produced high knockdown of target and downstream scarring genes without cell toxicity, which may have clinical applications in reducing corneal fibrosis and scarring in other tissues.
Source: Investigative Ophthalmology - December 17, 2013 Category: Opthalmology Authors: Sriram, S., Robinson, P., Pi, L., Lewin, A. S., Schultz, G. Tags: Cornea Source Type: research

Heat Shock Protein 27 Phosphorylation Is Involved in Epithelial Cell Apoptosis as well as Epithelial Migration during Corneal Epithelial Wound Healing.
In conclusion, the role of HSP27 in corneal epithelial wound healing can be epithelial cell apoptosis, as well as epithelial migration. HSP27 is involved in HCEC migration by the reorganization of actin cytoskeleton. PMID: 24239511 [PubMed - as supplied by publisher]
Source: Experimental Eye Research - November 14, 2013 Category: Opthalmology Authors: Song IS, Kang SS, Kim ES, Park HM, Choi CY, Tchah H, Kim JY Tags: Exp Eye Res Source Type: research

Expression and Distribution of Claudin Subtypes in Human Corneal Endothelium Cornea
Conclusions. The expression pattern of claudin-10b+/claudin-14– was specific in corneal endothelium among the three corneal layers. Claudin-10b may play an important role in the tight junction of corneal endothelium.
Source: Investigative Ophthalmology - November 8, 2013 Category: Opthalmology Authors: Inagaki, E., Hatou, S., Yoshida, S., Miyashita, H., Tsubota, K., Shimmura, S. Tags: Cornea Source Type: research

Migration of Retinal Pigment Epithelium Cells Is Regulated by Protein Kinase C{alpha} In Vitro Retinal Cell Biology
Conclusions. Retinal pigment epithelium cell migration is enhanced by a PKCα agonist and suppressed by a PKCα antagonist. The results suggest that a PKCα-mediated signal transduction pathway plays a crucial role in hRPE cell migration and may be a potential therapeutic target against hRPE cell migration and PVR disease.
Source: Investigative Ophthalmology - October 29, 2013 Category: Opthalmology Authors: Qiu, S., Jiang, Z., Huang, Z., Chen, X., Qian, X., Gao, Q., Zheng, H. Tags: Retinal Cell Biology Source Type: research

Endogenous IgG Affects the Cell Biology of RPE Cells and Involves the TLR4 Pathway Immunology and Microbiology
Conclusions. These data suggest that endogenous IgG may be a molecule that is essential for the physiological function of RPE, and suggest IgG is important for regulating intraocular immune responses under physiologic and pathologic conditions.
Source: Investigative Ophthalmology - October 25, 2013 Category: Opthalmology Authors: Niu, N., Zhang, J., McNutt, M. A. Tags: Immunology and Microbiology Source Type: research

Inhibitory Effect of MicroRNA-34a on Retinal Pigment Epithelial Cell Proliferation and Migration Retinal Cell Biology
Conclusions. MicroRNA-34a is downregulated in subconfluent RPE cells. MicroRNA-34a can inhibit the proliferation and migration of RPE cells through downregulation of its targets c-Met and other cell cycle–related molecules. Our results indicated that miR-34a is involved in the regulation of RPE cells.
Source: Investigative Ophthalmology - October 3, 2013 Category: Opthalmology Authors: Hou, Q., Tang, J., Wang, Z., Wang, C., Chen, X., Hou, L., Dong, X. D., Tu, L. Tags: Retinal Cell Biology Source Type: research

Effects of High Glucose-Induced Cx43 Downregulation on Occludin and ZO-1 Expression and Tight Junction Barrier Function in Retinal Endothelial Cells Retinal Cell Biology
Conclusions. Our findings indicate that HG-induced downregulation of Cx43 expression and GJIC may contribute to the breakdown of endothelial barrier tight junctions associated with diabetic retinopathy.
Source: Investigative Ophthalmology - October 3, 2013 Category: Opthalmology Authors: Tien, T., Barrette, K. F., Chronopoulos, A., Roy, S. Tags: Retinal Cell Biology Source Type: research