RTP801 Gene Expression Is Differentially Upregulated in Retinopathy and Is Silenced by PF-04523655, a 19-Mer siRNA Directed Against RTP801 [Retina]

Conclusions.
In rodent retinopathy models, administration of the siRNA, PF-04523655, reduced RTP801 expression in the retina, consistent with the RNA-induced silencing complex (RISC) mechanism of action. The pharmacodynamic profile from the animal models could be useful to elucidate dose and exposure dependency of RTP801 expression inhibition by siRNA.

Source: Investigative Ophthalmology - March 4, 2014 Category: Opthalmology Authors: Rittenhouse, K. D., Johnson, T. R., Vicini, P., Hirakawa, B., Kalabat, D., Yang, A. H., Huang, W., Basile, A. S. Tags: Retina Source Type: research