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Specialty: Opthalmology
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Total 178 results found since Jan 2013.
Inhibition of diabetes-induced Drp1 deSUMOylation prevents retinal vascular lesions associated with diabetic retinopathy
Exp Eye Res. 2022 Nov 23:109334. doi: 10.1016/j.exer.2022.109334. Online ahead of print.ABSTRACTRetinal microvascular endothelial cell (RMEC) injury plays an important role in the pathophysiology diabetic retinopathy (DR). The GTPase dynamin-related protein 1 (Drp1), crucial to mitochondrial dynamics, has been implicated in hyperglycaemia-induced microvascular damage. Moreover, Drp1 can be deSUMOylated by the enzyme sentrin/SUMO-specific protease 3 (SENP3). Whether SENP3/deSUMOylated Drp1 can aggravate DR is unclear. Therefore, we designed this experiment to investigate the role of SENP3/desumoylated Drp1 in DR in vitro an...
Source: Experimental Eye Research - November 26, 2022 Category: Opthalmology Authors: Min Chen Qianhui Zhang Shun Wang Feng Zheng Source Type: research
Complement 3a Mediates CCN2/CTGF in Human Retinal Pigment Epithelial Cells
CONCLUSIONS: C3 was elevated in RPE under environmental stimulus and long-term exposure to specified concentration of C3a increased CCN2/CTGF expression in RPE, which could be partially reversed by C3 siRNA.PMID:36276919 | PMC:PMC9581697 | DOI:10.1155/2022/3259453
Source: Journal of Ophthalmology - October 24, 2022 Category: Opthalmology Authors: Kang Xiao Zhiyan Xu Zhengyu Chen Qin Long Youxin Chen Source Type: research
siRNA high throughput screening identifies regulators of chloropicrin and hydrogen fluoride injury in human corneal epithelial cell models
Exp Eye Res. 2022 Jul 9:109169. doi: 10.1016/j.exer.2022.109169. Online ahead of print.ABSTRACTCorneal injuries induced by various toxicants result in similar clinical presentations such as corneal opacity and neovascularization. Many studies suggest that several weeks post-exposure a convergence of the molecular mechanisms drives these progressive pathologies. However, chemical agents vary in toxicological properties, and early molecular responses are anticipated to be somewhat dissimilar for different toxicants. We chose 3120 targets from the Dharmacon Human Druggable genome to screen for chloropicrin (CP) and hydrogen f...
Source: Experimental Eye Research - July 12, 2022 Category: Opthalmology Authors: Albert L Ruff Robert D Causey Jeffrey A Koenig Cristina V LaGrasta Amber M Gomez Bailey T Chalmers John G Lehman Source Type: research
Suppression of EZH2 inhibits TGF- β1-induced EMT in human retinal pigment epithelial cells
This study aimed to investigate the role of enhancer of zeste homolog 2 (EZH2) in EMT of human primary RPE cells and the underlying mechanisms of the anti-fibrotic effect of EZH2 suppression. Primary cultures of human RPE cells were treated with TGF-β1 for EMT induction. EZH2 was silenced by siRNA to assess the expression levels of epithelial and fibrotic markers using qRT-PCR, Western blot, and immunofluorescence staining assay. Furthermore, the cellular migration, proliferation and barrier function of RPE cells were evaluated. RNA-sequencing analyses were performed to investigate the underlying mechanisms of EZH2 inhibi...
Source: Experimental Eye Research - July 5, 2022 Category: Opthalmology Authors: Yu Peng Kai Liao Feng Tan Yuqin Liang Xihao Sun Zekai Cui Bo Ye Zhongping Chen Shibo Tang Jiansu Chen Source Type: research
7-Methylxanthine Influences the Behavior of ADORA2A-DRD2 Heterodimers in Human Retinal Pigment Epithelial Cells
Conclusions: ADORA2A and DRD2 heterodimers were present in RPE cells. 7-MX may affect the behaviors of RPE cel ls through the ADORA2A-DRD2 receptor pathway. 7-MX is an inhibitor of ADORA2A receptors that can prevent inhibition of the D2 receptor pathway and increase D2 receptor pathway activity. This phenomenon may explain the mechanism of action through which 7-MX can control myopia progression.
Source: Ophthalmic Research - June 20, 2022 Category: Opthalmology Source Type: research
Expression and activation of the ketone body receptor HCAR2/GPR109A promotes preservation of retinal endothelial cell barrier function
Exp Eye Res. 2022 May 29:109129. doi: 10.1016/j.exer.2022.109129. Online ahead of print.ABSTRACTPreservation of retinal barrier function is critical to maintenance of retinal health. Therefore, it is not surprising that loss of barrier integrity is a pathologic feature common to degenerative retinal diseases such as diabetic retinopathy. Our prior studies demonstrate the importance of hydroxycarboxylic acid receptor 2/GPR109A (HCAR2/GPR109A) expression in the retinal pigment epithelium (RPE) to outer retinal barrier integrity. However, whether HCAR2/GPR109A is expressed in retinal endothelial cells and has a similar relati...
Source: Experimental Eye Research - June 1, 2022 Category: Opthalmology Authors: Ammar A Abdelrahman Folami L Powell Ravirajsinh N Jadeja Malita A Jones Menaka C Thounaojam Manuela Bartoli Mohamed Al-Shabrawey Pamela M Martin Source Type: research
Agonism of GPR120 Prevented High Glucose-Induced Apoptosis of Retinal Endothelial Cells through Inhibiting NLRP3 Inflammasome
CONCLUSIONS: Activation of GPR120 protects retinal vascular endothelial cells from HG through inhibiting NLRP3 inflammasome. Thus, GPR120 might be a potential therapeutic target to reduce retinal endothelial damage in diabetic retinopathy.PMID:35584771 | DOI:10.1055/a-1811-7099
Source: Klinische Monatsblatter fur Augenheilkunde - May 18, 2022 Category: Opthalmology Authors: Xiaoju Ding Haijuan Xie Wuqiang Shan Ligang Li Source Type: research
