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Early Assessment of the Risk Factors for Diabetic Retinopathy Can Reduce the Risk of Peripheral Arterial and Cardiovascular Diseases in Type 2 Diabetes
Backgrounds: There is still a lack of consensus about how to assess the risk of peripheral arterial disease (PAD) and cardiovascular disease (CVD) in patients with diabetic retinopathy (DR).Aims: We investigated the risk factors for DR and their association with PAD and CVD in patients with type 2 diabetes (T2D).Methods: A total of 1,421 patients diagnosed with T2D participated in this study. DR stages were classified as non-DR, nonproliferative DR (NPDR), or proliferative DR (PDR). Logistic regression analysis was employed to analyze risk factors associated with DR.Results: NPDR and PDR patients had higher systolic blood ...
Source: Ophthalmic Research - September 20, 2017 Category: Opthalmology Source Type: research

Potential Effects of Hormone Therapy in Type 2 Idiopathic Macular Telangiectasia
Conclusions: Tamoxifen treatment does not seem to accentuate structural changes in patients with MacTel type 2. Treatment with estrogens may exhibit a neuroprotective effect as suggested by the decreased frequency of ellipsoid zone breaks in corresponding patients, although corroborative studies are warranted to confirm these exploratory data.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - September 13, 2017 Category: Opthalmology Source Type: research

BAX and BCL2 Gene Polymorphisms in Rhegmatogenous Retinal Detachment
Conclusions: This is the first study evaluating the potential relationship betweenBCL2 andBAX gene polymorphisms and RRD in a Greek population, showing a significant association betweenBAX rs4645878 polymorphism and RRD susceptibility. This finding suggests that an apoptotic mechanism is implicated in the pathogenesis of RRD.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - September 7, 2017 Category: Opthalmology Source Type: research

Ganglion Cell-Inner Plexiform Layer Thickness in Different Glaucoma Stages Measured by Optical Coherence Tomography
Conclusion: GCL + IPL layer thickness is a highly specific and sensitive parameter in differentiating glaucomatous from healthy eyes showing progressive damage as glaucoma worsens. Loss of this layer is highly correlated with overall loss of visual field sensitivity.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - September 6, 2017 Category: Opthalmology Source Type: research

< b > < i > BAX < /i > < /b > and < b > < i > BCL2 < /i > < /b > Gene Polymorphisms in Rhegmatogenous Retinal Detachment
Conclusions: This is the first study evaluating the potential relationship betweenBCL2 andBAX gene polymorphisms and RRD in a Greek population, showing a significant association betweenBAX rs4645878 polymorphism and RRD susceptibility. This finding suggests that an apoptotic mechanism is implicated in the pathogenesis of RRD.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - September 6, 2017 Category: Opthalmology Source Type: research

Retinal Nerve Fiber Layer Thickness Changes in the Pseudoexfoliation Syndrome: A Meta-Analysis of Case-Control Studies
Purpose: To evaluate and compare changes in retinal nerve fiber layer (RNFL) thickness in patients with the pseudoexfoliation syndrome (PXS) and healthy controls.Methods: Case-control studies were selected through an electronic search of the Cochrane Controlled Trials Register, PubMed, and Embase. Results were reviewed to ensure that the included studies met prespecified inclusion/exclusion criteria, and the quality of each study was assessed using the Newcastle-Ottawa Scale. All included studies measured average and 4-quadrant (temporal, superior, nasal, and inferior) RNFL thickness using optical coherence tomography (OCT...
Source: Ophthalmic Research - September 6, 2017 Category: Opthalmology Source Type: research

Evaluation of the Macular Ganglion Cell-Inner Plexiform Layer and the Circumpapillary Retinal Nerve Fiber Layer in Early to Advanced Stages of Glaucoma: Correlation with Central Visual Function and Visual Field Indexes
Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 31, 2017 Category: Opthalmology Source Type: research

Clinical Metabolomics and Glaucoma
Glaucoma is one of the leading causes of irreversible blindness worldwide. However, there are no biomarkers that accurately help clinicians perform an early diagnosis or detect patients with a high risk of progression. Metabolomics is the study of all metabolites in an organism, and it has the potential to provide a biomarker. This review summarizes the findings of metabolomics in glaucoma patients and explains why this field is promising for new research. We identified published studies that focused on metabolomics and ophthalmology. After providing an overview of metabolomics in ophthalmology, we focused on human glaucom...
Source: Ophthalmic Research - August 31, 2017 Category: Opthalmology Source Type: research

Subretinal Injection: A Review on the Novel Route of Therapeutic Delivery for Vitreoretinal Diseases
Compared to intravitreal injection, subretinal injection has more direct effects on the targeting cells in the subretinal space, which provides a new therapeutic method for vitreoretinal diseases, especially when gene therapy and/or cell therapy is involved. To date, subretinal delivery has been widely applied by scientists and clinicians as a more precise and efficient route of ocular drug delivery for gene therapies and cell therapies including stem cells in many degenerative vitreoretinal diseases, such as retinitis pigmentosa, age-related macular degeneration, and Leber's congenital amaurosis. However, clinicians shoul...
Source: Ophthalmic Research - August 31, 2017 Category: Opthalmology Source Type: research

Ophthalmic Start-Up Chief Executive Officers' Perceptions of Development Hurdles
Conclusion: The study suggests that development funding, regulatory burden, and meeting clinical endpoints are the greatest development challenges faced by ophthalmic start-up CEOs.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 25, 2017 Category: Opthalmology Source Type: research

Reliability of Entire Corneal Thickness Mapping in Normal Post-Laser in situ Keratomileusis and Keratoconus Eyes Using Long Scan Depth Spectral Domain Optical Coherence Tomography
Conclusions: The measurements of corneal pachymetric mapping by long scan depth SD-OCT can be assessed over the entire corneal area with good repeatability and reproducibility.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 18, 2017 Category: Opthalmology Source Type: research

Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray
Conclusion: This study suggested a potential role of circRNAs in the pathogenesis of DR and provides novel molecular targets for clinical therapy.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 17, 2017 Category: Opthalmology Source Type: research

Effects of Riboflavin and Ultraviolet Illumination on the Biomechanical Properties of Conjunctiva
Conclusions: The study suggested that riboflavin and ultraviolet A illumination (commercially available as collagen crosslinking) strengthened cattle conjunctiva by increasing its amount of covalent bonds, reducing its permeability, and possibly improving its resistance to rupture. This is the first study in the collagen crosslinking literature on the biomechanical properties of conjunctival tissue.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 16, 2017 Category: Opthalmology Source Type: research

Optical Coherence Tomography Angiography in Children with Leber-Coats Disease
Conclusion: This is the first case series of OCTA performed in children with Leber-Coats disease. OCTA is a non-invasive and non-contact technique, which can be considered of fundamental importance for the diagnosis, clinical management, and follow-up of the disease.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 11, 2017 Category: Opthalmology Source Type: research

Therapeutic Effect of 0.1% Tacrolimus Eye Drops in the Tarsal Form of Vernal Keratoconjunctivitis
Objective: The purpose of this study was to evaluate the efficacy and safety of 0.1% tacrolimus eye drops in the tarsal form of vernal keratoconjunctivitis (VKC) and to survey the changes of dendritic cells at the palpebral conjunctiva in patients with VKC by in vivo confocal microscopy.Methods: A total of 17 patients (34 eyes) with the tarsal form of VKC were enrolled in this prospective, nonrandomized case series. They were treated with 0.1% tacrolimus eye drops twice daily after discontinuation of all other topical medications. Subjective ocular symptoms and objective ocular signs were scored on a 4-point scale by one o...
Source: Ophthalmic Research - August 11, 2017 Category: Opthalmology Source Type: research

Dynamics of Inflammatory Factors in Aqueous Humor during Ranibizumab or Aflibercept Treatment for Age-Related Macular Degeneration
Conclusions: These findings suggest that the inflammatory factors are involved in the pathogenesis of AMD and also the possibility that the interaction between these inflammatory factors and IRI or IAI is different.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 10, 2017 Category: Opthalmology Source Type: research

Calcium Dobesilate Is Protective against Inflammation and Oxidative/Nitrosative Stress in the Retina of a Type 1 Diabetic Rat Model
Calcium dobesilate (CaD) has been prescribed to some patients in the early stages of diabetic retinopathy to delay its progression. We previously reported that the treatment of diabetic animals (4 weeks of diabetes) with CaD, during the last 10 days of diabetes, prevents blood-retinal barrier breakdown. Here, we aimed to investigate whether later treatment of diabetic rats with CaD would reverse inflammatory processes in the retina. Diabetes was induced with streptozotocin, and 6 weeks after diabetes onset, CaD (100 mg/kg/day) was administered for 2 weeks. The treatment with CaD significantly increased glial fibrillary aci...
Source: Ophthalmic Research - August 9, 2017 Category: Opthalmology Source Type: research

Screening for Retinopathy of Prematurity: Insight into Optimizing Screening
Purpose: To determine the factors influencing the time from preterm birth and retinopathy of prematurity (ROP) detection to optimize the timing of the initial screening.Methods: This multicenter retrospective study enrolled preterm infants born before 32 weeks of gestational age (GA) and/or weighing less than 1,500 g between January 1, 2011, and December 31, 2015. ROP screening was performed using fundus photography with a wide-field camera. Population and follow-up characteristics were recorded.Results: Among the 1,266 preterm infants observed, 795 were retained for analysis. One hundred seventy-four (21.6%) cases of ROP ...
Source: Ophthalmic Research - July 26, 2017 Category: Opthalmology Source Type: research

Retinal Penetration of Intravitreally Injected Tissue Plasminogen Activator: A Rat Model Study
Conclusions: This experimental study shows that unconjugated tPA administered into the vitreous is capable of penetrating the deep retinal layers and the subretinal space. These findings suggest that further clinical research is warranted on the benefits of intravitreal tPA in the treatment of submacular hemorrhage.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - July 20, 2017 Category: Opthalmology Source Type: research

Combined 23-G Pars Plana Vitrectomy and Lensectomy in the Management of Glaucoma Associated with Nanophthalmos
This study enrolled 21 eyes of 21 patients. The mean follow-up was 18.6 ± 7.0 months. At the final follow-up visit, the mean IOP was significantly reduced (from 47.4 ± 5.7 to 18.6 ± 3.6 mm Hg). The mean number of antiglaucoma medications dropped from 5 to 0. BCVA improved in 3 (14.3%) eyes. The complete success rate (IOP>6 and (Source: Ophthalmic Research)
Source: Ophthalmic Research - July 18, 2017 Category: Opthalmology Source Type: research

Dexamethasone Implants in Diabetic Macular Edema Patients with High Visual Acuity
Purpose: To evaluate the effects of intravitreal dexamethasone (DEX) implants in patients affected by diabetic macular edema (DME) with high best-corrected visual acuity (BCVA) and contraindications to therapy with anti-vascular endothelial growth factor over a 12-month follow-up.Methods: In this interventional nonrandomized clinical study, 14 consecutive patients (14 eyes) affected by DME with a BCVA of 0.3 LogMAR or better were prospectively enrolled. All patients were treated with a sustained-release 700- μg DEX implant at baseline, revaluated every 6 weeks, and retreated on a pro re nata basis. Primary outcomes incl...
Source: Ophthalmic Research - July 13, 2017 Category: Opthalmology Source Type: research

Spatially Resolved Spectral Sensitivities as a Potential Read-out Parameter in Clinical Gene Therapeutic Trials
Conclusion: In the present study, residual vision was cone mediated both under photopic and scotopic conditions in young patients with EOSRD associated withRPE65 mutations, but S cone function was severely reduced early on. In rod monochromats, vision was rod mediated both under conditions of dark and light adaptation. These observations are important for ongoing and future clinical trials employing gene therapeutic strategies in both rod-cone dystrophies and achromatopsia.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - July 11, 2017 Category: Opthalmology Source Type: research

Binocular Fixation Reduces Fixational Eye Movements in the Worst Eye of Patients with Center-Involving Diabetic Macular Edema
Conclusion: Binocular fixation can reduce the area of fixation and the amplitude of fixational saccades in the worst eye of patients with diabetic maculopathy. Fixational saccades in diabetic maculopathy should be studied during monocular fixation.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - July 6, 2017 Category: Opthalmology Source Type: research

Title Page / Table of Contents
Ophthalmic Res 2017;58(suppl 1):I-IV (Source: Ophthalmic Research)
Source: Ophthalmic Research - July 4, 2017 Category: Opthalmology Source Type: research

17th ESASO Retina Academy. June 29-July 1, 2017, Berlin, Germany: Abstracts
Ophthalmic Res 2017;58(suppl 1):1-20 (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 29, 2017 Category: Opthalmology Source Type: research

Title Page
Ophthalmic Res 2017;58(suppl 1):I-IV (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 29, 2017 Category: Opthalmology Source Type: research

EVICR. net. European Network of Clinical Research in Ophthalmology. Information Update - June 2017
Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 29, 2017 Category: Opthalmology Source Type: research

Association of IL-6 Gene (-174 and -572 G/C) Polymorphisms with Proliferative Diabetic Retinopathy of Type 2 Diabetes in a Chinese Population
Conclusions: IL-6 genotypes of rs1800795 GC and rs1800796 GG might point to a relatively high risk for T2D patients suffering from PDR in a Chinese population and they were associated with elevation of IL-6 expression in both mRNA and protein.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 26, 2017 Category: Opthalmology Source Type: research

Association of the CFH Y402H Polymorphism with the 1-Year Response of Exudative AMD to Intravitreal Anti-VEGF Treatment in the Brazilian Population
Aim: Evidence of the relationship between the polymorphism of the complement factor H (CFH) gene at position 402 (Y402H) and the response to the treatment of wet AMD is controversial. The aim of this study was to compare the functional and morphological 1-year evolution of patients with exudative AMD treated with antivascular endothelial growth factor (VEGF) drugs with theCFH Y402H polymorphism in the Brazilian population.Methods: Forty-six patients treated for wet AMD with bevacizumab or ranibizumab in a pro re nata regimen were included. The evolution of best-corrected visual acuity (BCVA) and central retinal thickness (...
Source: Ophthalmic Research - June 23, 2017 Category: Opthalmology Source Type: research

Association of the < b > < i > CFH < /i > < /b > Y402H Polymorphism with the 1-Year Response of Exudative AMD to Intravitreal Anti-VEGF Treatment in the Brazilian Population
Aim: Evidence of the relationship between the polymorphism of the complement factor H (CFH) gene at position 402 (Y402H) and the response to the treatment of wet AMD is controversial. The aim of this study was to compare the functional and morphological 1-year evolution of patients with exudative AMD treated with antivascular endothelial growth factor (VEGF) drugs with theCFH Y402H polymorphism in the Brazilian population.Methods: Forty-six patients treated for wet AMD with bevacizumab or ranibizumab in a pro re nata regimen were included. The evolution of best-corrected visual acuity (BCVA) and central retinal thickness (...
Source: Ophthalmic Research - June 22, 2017 Category: Opthalmology Source Type: research

7-Hexagon Multifocal Electroretinography for an Objective Functional Assessment of the Macula in 14 Seconds
We present the multifocal electroretinogram (mfERG) with a 7-hexagon array as an objective test of macular function that can be recorded in 14 s. We provide normal values and investigate its reproducibility and validity.Methods: Healthy participants underwent mfERG testing according to International Society for Clinical Electrophysiology of Vision (ISCEV) standards using the Espion Profile/D310 multifocal ERG system (Diagnosys, LLC, Lowell, MA, USA). One standard recording of a 61-hexagon array and 2 repeated recordings of a custom 7-hexagon array were obtained.Results: A total of 13 subjects (mean age 46.9 years) were inc...
Source: Ophthalmic Research - June 22, 2017 Category: Opthalmology Source Type: research

Incidence and Characteristics of Congenital Cataract Surgery in France from 2010 to 2012: The EPISAFE Program
Conclusions: The incidence of congenital cataract surgery observed in France is close to that in the literature in the industrialized world, which is estimated at 1-3/10,000 births. The timing of surgery is critical for visual development. Surgery was performed younger in children with monocular cataracts than in those with bilateral cataracts.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 20, 2017 Category: Opthalmology Source Type: research

Importance of Light Filters in Modern Vitreoretinal Surgery: An Update of the Literature
Conclusion: The choice of light sources coupled to spectral filters is strongly suggested, especially in dye-assisted chromovitrectomy. Histological donor eye studies and large multicenter trials are needed to validate the amount of photoprotection provided by spectral filters before a general recommendation can be made.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 1, 2017 Category: Opthalmology Source Type: research

MicroRNA-200b Expression in the Vitreous Humor of Patients with Proliferative Diabetic Retinopathy
Conclusion: Both miRNA-200b and VEGF are increased in the vitreous of patients with PDR but in a noncorrelated pattern. miRNA-200b may be involved in the pathogenesis of PDR but through VEGF-independent mechanisms. Further studies are needed to identify the miRNA-200b-targeted genes involved in the pathogenesis of PDR and to examine the potential role of miRNA-200b as a target for PDR treatment.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 1, 2017 Category: Opthalmology Source Type: research

Relationship between Elevated Intraocular Pressure and Divided Peripapillary Sector Retinal Nerve Fiber Layer Thickness in a Cynomolgus Monkey Laser-Induced Ocular Hypertension Model
Conclusions: These results suggest that this model reflected the pathology of clinical glaucoma in terms of the specific pattern of RNFL thinning around the ONH.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - May 31, 2017 Category: Opthalmology Source Type: research

Can DMCO Detect Visual Field Loss in Neurological Patients A Secondary Validation Study
Unrecognized visual field loss is caused by a range of blinding eye conditions as well as serious brain diseases. The commonest cause of asymptomatic visual field loss is glaucoma. No screening tools have been proven cost-effective. Damato Multifixation Campimetry Online (DMCO), an inexpensive online test, has been evaluated as a future cost-beneficial tool to detect glaucoma. To further validate DMCO, this study aimed to test DMCO in a preselected population with neurological visual field loss.Methods: The study design was an evaluation of a diagnostic test. Patients were included if they had undergone surgery for epileps...
Source: Ophthalmic Research - May 24, 2017 Category: Opthalmology Source Type: research

Retinal Microvasculature in Nonproliferative Diabetic Retinopathy: Automated Quantitative Optical Coherence Tomography Angiography Assessment
Purpose: To perform a qualitative and quantitative assessment of the foveal microvasculature in eyes with diabetic maculopathy using optical coherence tomography angiography (OCT-A).Methods: Retrospective case series of 48 eyes with diabetic maculopathy and 47 healthy eyes evaluated by Spectralis OCT-A. Perifoveal arcade disruptions, linear vascular dilations, microaneurysms, intraretinal microvascular abnormalities and flow-void areas were qualitatively analyzed on OCT angiograms both for the superficial (SCP) and deep (DCP) capillary plexuses. A fully automated microstructural analysis of the foveal avascular zone (FAZ) ...
Source: Ophthalmic Research - May 24, 2017 Category: Opthalmology Source Type: research

Can DMCO Detect Visual Field Loss in Neurological Patients? A Secondary Validation Study
Unrecognized visual field loss is caused by a range of blinding eye conditions as well as serious brain diseases. The commonest cause of asymptomatic visual field loss is glaucoma. No screening tools have been proven cost-effective. Damato Multifixation Campimetry Online (DMCO), an inexpensive online test, has been evaluated as a future cost-beneficial tool to detect glaucoma. To further validate DMCO, this study aimed to test DMCO in a preselected population with neurological visual field loss.Methods: The study design was an evaluation of a diagnostic test. Patients were included if they had undergone surgery for epileps...
Source: Ophthalmic Research - May 23, 2017 Category: Opthalmology Source Type: research

Comparison of the Outcomes of Trabeculectomy with 5-Fluorouracil versus Ologen Implant in Primary Open-Angle Glaucoma
Purpose: To compare the outcomes of trabeculectomy with 5-fluorouracil (5-FU) versus Ologen ™ implant in patients with primary open-angle glaucoma.Methods: A retrospective chart review was performed of patients with primary open-angle glaucoma who underwent trabeculectomy using either Ologen or 5-FU over 12 consecutive months. The patients had moderate-to-advanced primary open-angle glaucoma and uncontrolled intraocular pressure (IOP) on maximally tolerated medical treatment. Fornix-based trabeculectomy was performed on all patients by the same surgeon. The outcomes that were recorded and analyzed included the IOP le...
Source: Ophthalmic Research - May 3, 2017 Category: Opthalmology Source Type: research

Visual Outcomes of Pars Plana Vitrectomy with Epiretinal Membrane Peeling in Patients with Asteroid Hyalosis: A Matched Cohort Study
Conclusion: Vitrectomy with ERM peeling in patients with AH was beneficial and showed similar functional and anatomical outcomes in both groups. AH does not seem to affect visual improvement or the complication rate after ERM peeling. Therefore, the indications for vitrectomy in case of ERM should not be prompted by the presence of AH.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - May 2, 2017 Category: Opthalmology Source Type: research

Three-Year Follow-Up of Trabeculectomy with 5-Fluorouracil
Conclusions: Trabeculectomy with 5-FU is an efficient surgical procedure for glaucoma treatment when combined with intensified postsurgical care.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - April 27, 2017 Category: Opthalmology Source Type: research

Choroidal Thickness and Microperimetry Sensitivity in Age-Related Macular Degeneration
Purpose: To assess choroidal thickness (CT) and its relationship to retinal sensitivity in mild/moderate age-related macular degeneration (AMD).Methods: Seventy-two eyes of 51 participants with mild/moderate AMD and 36 eyes of 18 age-matched normal participants were prospectively recruited to undergo enhanced-depth imaging optical coherence tomography (EDI-OCT) imaging and microperimetry (MP) functional assessment. OCT-measured CT and retinal thickness (RT) were matched with MP sensitivity at 13 retinal loci, and correlations were analysed.Results: Patients with AMD had an average RT 56.5 μm greater than those without A...
Source: Ophthalmic Research - April 20, 2017 Category: Opthalmology Source Type: research

Long-Term Anatomical and Functional Outcomes in Patients with Ischemic Central Retinal Vein Occlusion Treated with Anti-Vascular Endothelial Growth Factor Agents
Conclusions: Our study showed that anti-VEGF treatment was effective in patients with ischemic CRVO, since it reduces macular edema and maintains or improves VA in the long term (24-month follow-up). It is worthy of note that in a small proportion of patients (13.3%) peripheral ischemia progressed to macular ischemia over time. In cases where macular ischemia is present, anti-VEGF treatment does not seem to offer any improvement in VA.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - April 20, 2017 Category: Opthalmology Source Type: research

Contents Vol. 57, 2017
Ophthalmic Res 2017;57:I-IV (Source: Ophthalmic Research)
Source: Ophthalmic Research - April 18, 2017 Category: Opthalmology Source Type: research

Receptor of Advanced Glycation End Products Gene Polymorphism and Primary Open-Angle Glaucoma
Conclusions: Our study did not find any significant association between AGER polymorphism and primary open-angle glaucoma. Since we cannot reject the possibility that oxidative stress is a crucial factor for the development of primary open-angle glaucoma, further studies may be needed to confirm the importance of the AGER gene in the glaucoma pathogenesis.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - April 11, 2017 Category: Opthalmology Source Type: research

Suppression of Retinal Neovascularization by Anti-CCR3 Treatment in an Oxygen-Induced Retinopathy Model in Mice
Purpose: To investigate the association between retinal neovascularization and the CC chemokine receptor-3 (CCR3) in a mouse model of oxygen-induced retinopathy (OIR).Methods: An OIR model in C57BL/6J mice was used as a retinal neovascularization model. An enzyme-linked immunosorbent assay was performed to evaluate the chronological change in vascular endothelial growth factor A (VEGF-A) and eotaxin expressions. CCR3 and VEGF subtype expression in the retina was examined using real-time RT-PCR, and CCR3, eotaxin, VEGF-A, and CD31 expression was examined immunohistochemically. A CCR3 neutralizing antibody (Ab) was injected ...
Source: Ophthalmic Research - April 4, 2017 Category: Opthalmology Source Type: research

French Medical-Administrative Database for Epidemiology and Safety in Ophthalmology (EPISAFE): The EPISAFE Collaboration Program in Cataract Surgery
We describe the French national health insurance system databases and the Epidemiology and Safety (EPISAFE) collaboration program in ophthalmology and illustrate the paper with recent studies that used the databases to investigate cataract surgery. The Syst ème national d'information inter-régime de l'assurance maladie (SNIIR-AM) is one of the largest databases of medical and administrative data for a general population, covering nearly 65 million people. The SNIIR-AM database links data for all outpatient-reimbursed health expenditures, hospitalizat ion in all 1,546 French private or public healthcare facili...
Source: Ophthalmic Research - April 3, 2017 Category: Opthalmology Source Type: research

Intravitreal Dexamethasone Implant versus Intravitreal Ranibizumab for the Treatment of Macular Edema Secondary to Retinal Vein Occlusion in a Chinese Population
Conclusions: Intravitreal injection of Ozurdex and ranibizumab can effectively control ME secondary to RVO and increase a patient's BCVA. The advantages of Ozurdex are fewer injections and longer efficacy, while the advantages of ranibizumab include fewer side effects.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - March 23, 2017 Category: Opthalmology Source Type: research

Quantitative Analysis of Uveitis Macular Edema in Multiple Sclerosis Patients Receiving Deep Posterior Sub-Tenon Triamcinolone Acetonide Injection
Aim: We aimed to analyze the effects of adjunctive posterior sub-Tenon capsule triamcinolone acetonide injection in the treatment of intermediate uveitis macular edema in multiple sclerosis patients that could not be controlled by systemic corticosteroid medications and immunomodulators.Methods: The study included 30 eyes of 25 patients with multiple sclerosis who received a posterior sub-Tenon injection of 40 mg/mL triamcinolone acetonide. Parameters monitored for therapy efficiency were best-corrected visual acuity, intraocular pressure, central foveal thickness (CFT), and fluorescein angiography (FA) scores.Results: Mea...
Source: Ophthalmic Research - March 21, 2017 Category: Opthalmology Source Type: research

Influence of Vitreomacular Adhesion on Anti-Vascular Endothelial Growth Factor Treatment for Neovascular Age-Related Macular Degeneration
Purpose: To investigate the effect of vitreomacular adhesion (VMA) on the outcome of antiangiogenic treatment for neovascular age-related macular degeneration (AMD).Methods: Ninety-nine eyes of 83 patients were used in our cohort study. We prospectively evaluated best corrected visual acuity (BCVA) and central retinal thickness (CRT) in patients with neovascular AMD at baseline and 1, 2, 3, 6, and 12 months after treatment with anti-vascular endothelial growth factor (anti-VEGF) agents. All patients were stratified by spectral domain optical coherence tomography into 2 groups (i.e., VMA[+] and VMA[-]) according to the pres...
Source: Ophthalmic Research - March 16, 2017 Category: Opthalmology Source Type: research