Evaluating changes in apparent chord mu after pharmacological pupil dilatation
Introduction: Preoperative measurements of apparent chord mu length above 0.6 mm have been associated with higher risks for photic phenomena after cataract surgery with multifocal intraocular lenses (MFIOLs).
Methods: This retrospective study evaluated patients scheduled for elective cataract surgery at a single tertiary medical center between 2021-2022. Pupil diameter and apparent chord mu length were analyzed for eyes with biometry measurements from IOLMaster 700 (Carl Zeiss Meditec, AG) under photop ic light conditions, before and after pharmacological pupil dilatation. Exclusion criteria were visual acuity worse than...
Source: Ophthalmic Research - May 2, 2023 Category: Opthalmology Source Type: research
A novel intronic deletion in PDE6B causes autosomal recessive retinitis pigmentosa by interfering with RNA splicing
Conclusion: Our findings further expand the mutational spectrum of the PDE6B gene. (Source: Ophthalmic Research)
Source: Ophthalmic Research - April 24, 2023 Category: Opthalmology Source Type: research
The efficacy and safety of air tamponade in the repair of rhegmatogenous retinal detachment: a systematic review and meta-analysis.
This study aimed to evaluate the efficacy and safety of PPV combined air tamponade in patients with RRD compared with PPV combined gas tamponade and whether it could be a safe alternative to PPV combined gas tamponade.
Methods: The PubMed, Embase, and Cochrane Library databases published until September 2022 were comprehensively searched for studies that compared PPV combined with air tamponade and gas tamponade in patients with RRD. The rate of primary treatment success, best-corrected visual acuity (BCVA), and postoperative complications were extracted from the final eligible studies. The mean difference (MD) and risk r...
Source: Ophthalmic Research - April 21, 2023 Category: Opthalmology Source Type: research
Comparisons of Handheld Retinal Imaging with Optical Coherence Tomography for the Identification of Macular Pathology in Patients with Diabetes
Conclusions: Compared to SDOCT, handheld macular imaging attained high specificity but low sensitivity in identifying macular pathology. This suggests the importance of SDOCT evaluation for patients suspected to have DME on fundus photography, leading to more appropriate referral refinement. (Source: Ophthalmic Research)
Source: Ophthalmic Research - April 20, 2023 Category: Opthalmology Source Type: research
Downregulation of miR-210-3p attenuates high glucose-induced angiogenesis of vascular endothelial cells via targeting FGFRL1
Conclusion: Our study revealed that miR-210-3p might be a promising target for the treatment of diabetic-associated vascular injury. (Source: Ophthalmic Research)
Source: Ophthalmic Research - April 14, 2023 Category: Opthalmology Source Type: research
The Patterns of Visual Field Defects in Primary Angle-Closure Glaucoma Compared to High-Tension Glaucoma and Normal-Tension Glaucoma
Introduction: To compare the patterns of visual field (VF) defects in primary angle-closure glaucoma (PACG) to control groups of eyes with high-tension glaucoma (HTG) and normal-tension glaucoma (NTG).
Methods: Forty-eight eyes with PACG were enrolled, and control eyes with HTG and NTG matched for age, sex, and mean deviation (MD) of VF defect were selected. VF tests were performed using the 24-2 program of HFA. VF defects were classified into six patterns with the Ocular Hypertension Treatment Study classification system and were categorized into three stages (early, moderate, and advanced). Each hemifield was divided i...
Source: Ophthalmic Research - April 14, 2023 Category: Opthalmology Source Type: research
Multimodel imaging evidence of traction component in lamellar macular hole with epiretinal proliferation
Conclusion: Our findings indicated that epiretinal traction, evaluated by multimodal imaging, is the norm rather than the exception in LMHs showing LHEP. The presence of tractional forces should be taken into consideration when treatment was planned in LMHs. (Source: Ophthalmic Research)
Source: Ophthalmic Research - April 11, 2023 Category: Opthalmology Source Type: research
The influence of part-time occlusion therapy on control of intermittent exotropia: A meta-analysis of randomized clinical trials
Objective To compare the effectiveness of part-time occlusion therapy （PTO） and observation in the treatment of intermittent exotropia(IXT). Methods An exhaustive search of the literature from Pubmed, EMBASE, Web of Science, and Cochrane Library databases was carried out until July 2022. No language restrictions were applied. The literature was rigorously screened against eligibility criteria. Weighted mean differences (WMD) and 95% confidence interval (CI) was calculated. Results A total of 4 articles with 617 participants were included in this meta-analysis. Our pooled results showed that PTO exhibited superior effec...
Source: Ophthalmic Research - March 30, 2023 Category: Opthalmology Source Type: research
Randomized Control Trial of the Impact of Patient Decision Aid Developed for Chinese Primary Open-Angle Glaucoma Patients
Conclusion: PDA led to improvement in disease knowledge and self-confidence in medication adherence and reduced decision conflict compared to control group for at least 6 months. (Source: Ophthalmic Research)
Source: Ophthalmic Research - March 27, 2023 Category: Opthalmology Source Type: research
A systematic review and meta-analysis of clinical outcomes of small gauge vitrectomy with or without intravitreal antivascular endothelial growth factor agents pretreatment for proliferative diabetic retinopathy
Background: Proliferative diabetic retinopathy (PDR) is a common visual threatening ocular disease, patients with nonclearing vitreous hemorrhage (VH), traction retinal detachment (RD), or extensive fibrovascular proliferation are always in need for surgical treatment. Although several studies reported better surgical outcome in patients underwent surgery after anti-VEGF injection, the effect of anti-VEGF pretreatment for small gauge vitrectomy in PDR patients remains to be elucidated. Objectives: To evaluate the benefits of preoperative anti-VEGF treatment in small gauge vitrectomy for PDR patients. Methods: A comprehensi...
Source: Ophthalmic Research - March 27, 2023 Category: Opthalmology Source Type: research
Real-world outcomes of ranibizumab treatment in French patients with visual impairment due to Macular Edema secondary to Retinal Vein Occlusion: 24-month results from the BOREAL-RVO study.
Conclusion
Major improvements in BCVA and CRT were observed at Month 3 after the induction phase, and then was sustained up to Month 24, with a slight decrease, probably due to under-treatm ent. This study demonstrated ranibizumab to be a safe and effective treatment for BRVO and CRVO in the real-world setting, although more regular or pro-active treatment could further improve outcomes. (Source: Ophthalmic Research)
Source: Ophthalmic Research - March 27, 2023 Category: Opthalmology Source Type: research
Air versus Gas Tamponade for Primary Rhegmatogenous Retinal Detachment: A Systematic Review and Meta-analysis
Discussion: The current evidence base for tamponade selection in treatment of RRD has several major limitations. Further appropriately designed studies are needed to guide tamponade selection. (Source: Ophthalmic Research)
Source: Ophthalmic Research - March 27, 2023 Category: Opthalmology Source Type: research
Multifocal electroretinography changes over 12 months after resolution of central serous chorioretinopathy: prospective observational study
Purpose: To evaluate the changes in retinal function after anatomical resolution of central serous chorioretinopathy by multifocal electroretinography.
Design: Prospective observational study.
Methods: Thirty-two eyes of 32 patients with unilaterally resolved central serous chorioretinopathy were prospectively studied. Serial multifocal electroretinography examinations were performed at the initial visit for active central serous chorioretinopathy, the time of anatomical resolution (resolved central serous chorioretinopathy), and 3, 6, and 12 months after resolution. The peak amplitudes of the first kernel responses wer...
Source: Ophthalmic Research - March 24, 2023 Category: Opthalmology Source Type: research
Corneal Biomechanical Properties of various types of glaucoma and their impact on measurement of intraocular pressure
Introduction Corneal biomechanical properties could affect intraocular pressure (IOP) measurement. To evaluate the differences of corneal biomechanical properties of various types of glaucoma, assess their effect on IOP measurements.
Methods An observational clinical study of 486 subjects including 102 normal subjects, 104 ocular hypertension (OHT), 89 normal tension glaucoma (NTG) and 191 high tension glaucoma (HTG). Corneal biomechanical parameters were measured using ocular response analyzer (ORA). The main parameters assessed were corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated pressure m...
Source: Ophthalmic Research - March 23, 2023 Category: Opthalmology Source Type: research
Evaluation of retinal microvascular features in patients with amblyopia based on optical coherence tomography angiography: a systematic review and Meta-analysis
Conclusions: The retinal vessel density of superficial and deep capillary plexus in amblyopic and fellow eyes was lower than in normal controls, and differences were more likely discovered using 6 × 6 mm2 scans . Consequently, OCTA may be utilized as a diagnostic tool to identify and monitor patients with amblyopia. (Source: Ophthalmic Research)
Source: Ophthalmic Research - March 14, 2023 Category: Opthalmology Source Type: research
