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Interocular Symmetry of Choroidal Thickness and Volume in Healthy Eyes on Optical Coherence Tomography
Background: We aimed to determine the physiological symmetry, with spectral-domain optical coherence tomography, of choroidal measurements in a healthy population in all the areas defined in the Early Treatment Diabetic Retinopathy Study (ETDRS).Methods: One hundred and fifty-four eyes of 77 healthy young adults between the ages of 19 and 32 years were enrolled. Differences in choroidal thickness (CT) and volume (CV) between the left and right eyes were calculated. Normal ranges of absolute interocular differences were established as the 95th percentile.Results: The mean ± SD subfoveal CT (SFCT) and total CV values ...
Source: Ophthalmic Research - November 9, 2017 Category: Opthalmology Source Type: research

The Effect of a Decrease in Intraocular Pressure on Optic Nerve Function in Patients with Optic Nerve Drusen
Conclusions: A decrease in IOP in eyes with ODD results in improvement of retinal ganglion cell function and delays the progression of optic neuropathy. PERG should be performed in patients with ODD as it is a sensitive test for monitoring optic neuropathy.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - October 30, 2017 Category: Opthalmology Source Type: research

Modulation of the Proteasome Pathway by Nano-Curcumin and Curcumin in Retinal Pigment Epithelial Cells
Conclusions: Nano-curcumin is less toxic to RPE cells and less prone to induce ROS production than curcumin. Both nano-curcumin and curcumin increase proteasome-mediated proteolytic activity. These results suggest that nano-curcumin may be regarded as a proteasome-modulating agent of limited cytotoxicity for RPE cells.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - October 26, 2017 Category: Opthalmology Source Type: research

Peripapillary Choroidal Thickness Analysis Using Swept-Source Optical Coherence Tomography in Glaucoma Patients: A Broader Approach
Conclusions: Peripapillary choroidal tissue shows a concentric pattern in both groups, and glaucoma patients present with peripapillary choroidal thinning compared with healthy subjects, especially in areas further away from the optic disk.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - October 25, 2017 Category: Opthalmology Source Type: research

Effect of Biodegradable Scleral Plugs Containing Curcumin on Proliferative Vitreoretinopathy
This study aimed to explore the inhibitory effect of biodegradable scleral plugs containing curcumin on rabbits with proliferative vitreoretinopathy (PVR).Materials and Methods: The biodegradable scleral plugs containing curcumin were prepared by dissolving PLGA [poly(lactide-co-glycolide)] and curcumin. In total, 30 rabbits were divided into 2 groups: the model group received a vitreous injection of self-blood, and the treatment group received a vitreous injection of self-blood plus biodegradable scleral implants containing 1.5 mg of curcumin. On days 1, 3, 7, 14, 21, and 28 after the operation, clinical observations and ...
Source: Ophthalmic Research - October 25, 2017 Category: Opthalmology Source Type: research

Epilutein for Early-Stage Age-Related Macular Degeneration: A Randomized and Prospective Study
Purpose: The hypothesis that oral supplementation of the epilutein/lutein combination could augment the macular pigment optical density (MPOD) in patients with age-related macular degeneration (AMD) was tested.Methods: In a prospective randomized interventional study, 40 consecutive patients with early-stage AMD were recruited. After a 2-week run-in period, patients were randomly treated with a daily oral administration of 8 mg epilutein and 2 mg lutein (group 1) or 10 mg lutein (group 2) for 2 months. At baseline (BL) and 1-month (M1) and 2-month visits (M2), all patients underwent a complete ophthalmological examination,...
Source: Ophthalmic Research - October 25, 2017 Category: Opthalmology Source Type: research

Tomographic Structural Changes of Retinal Layers after Internal Limiting Membrane Peeling for Macular Hole Surgery
Conclusion: ILM peeling is associated with important alterations in the inner retinal layer architecture, with thinning of the RNFL-GCL-IPL complex and thickening of OPL, ONL, and ORL. These structural alterations can help explain functional outcome and could give indications regarding the extent of ILM peeling, even though peeling seems important for higher rate of hole closure.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - October 25, 2017 Category: Opthalmology Source Type: research

Subfoveal Choroidal and Macular Thickness Changes after Phacoemulsification Using Enhanced Depth Imaging Optical Coherence Tomography
Purpose: To assess changes in the thickness of the subfoveal retina and choroid after phacoemulsification using enhanced depth imaging optical coherence tomography (EDI-OCT).Methods: A prospective study was conducted on 100 patients. The subfoveal choroidal thickness (SFCT) was measured at 7 points and the retinal thickness was measured at 5 points (before surgery, and 1 day, 1 week, 1 month, and 3 months after surgery).Results: The foveal choroidal thickness showed a thickening trend (butp> 0.05). Compared to the change from baseline to day 1, the changes from baseline were significantly different at nasal 3 mm and 6 m...
Source: Ophthalmic Research - October 25, 2017 Category: Opthalmology Source Type: research

Expression of Angiogenic and Inflammatory Factors in Choroidal Neovascularisation-Derived Retinal Pigment Epithelium
Conclusion: In late-stage CNV membrane-derived RPE, gene expression was shifted towards a pro-inflammatory state. Angiogenesis-associated factors were regulated differently in the 2 CNV-derived RPE membranes. While inflammation seems to be continuously stimulated by RPE associated with late exudative AMD, this appears not to be the case with regard to angioregulatory mechanisms.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - October 25, 2017 Category: Opthalmology Source Type: research

Acknowledgements to the Referees
Ophthalmic Res 2017;58:243 (Source: Ophthalmic Research)
Source: Ophthalmic Research - October 25, 2017 Category: Opthalmology Source Type: research

Contents Vol. 58, 2017
Ophthalmic Res 2017;58:I-IV (Source: Ophthalmic Research)
Source: Ophthalmic Research - October 25, 2017 Category: Opthalmology Source Type: research

Multimodal Evaluation of the Fellow Eye of Patients with Retinal Angiomatous Proliferation
Introduction: We conducted a multimodal, cross-sectional evaluation.Methods: Eyes were divided into 4 study groups: controls, early/intermediate age-related macular degeneration (AMD), fellow eyes of retinal angiomatous proliferation (RAP), and RAP eyes. Patients were evaluated with spectral-domain optical coherence tomography (OCT), enhanced depth imaging-OCT, and OCT angiography (OCTA). OCTA images were processed to generate maps of the vessel density and perfusion density of the superficial and deep retinal layers (SRL and DRL) and the choriocapillaris level (CL). The thickness of the outer nuclear layer and choroid was...
Source: Ophthalmic Research - October 25, 2017 Category: Opthalmology Source Type: research

Intraocular Pressure Spikes within First Postoperative Hours following Standard Trabeculectomy: Incidence and Associated Factors
Purpose: To evaluate the incidence of intraocular pressure (IOP) spikes within the first postoperative hours following trabeculectomy (TRAB) and to determine possible associated factors.Methods: An observational study was carried out. We enrolled consecutive patients undergoing standard TRAB with mitomycin C. They were examined twice within the first few postoperative hours (hours 1-2 and 4-6) and 3 times after TRAB (on days 1, 7, and 30). Demographic and ocular data were collected. Main outcome measurements were postoperative IOP values at each time point and the frequency of IOP spikes, defined as IOP ≥25 mm Hg.Result...
Source: Ophthalmic Research - October 25, 2017 Category: Opthalmology Source Type: research

Multimodal Evaluation of the Fellow Eye of Patients with Retinal Angiomatous Proliferation
Introduction: We conducted a multimodal, cross-sectional evaluation.Methods: Eyes were divided into 4 study groups: controls, early/intermediate age-related macular degeneration (AMD), fellow eyes of retinal angiomatous proliferation (RAP), and RAP eyes. Patients were evaluated with spectral-domain optical coherence tomography (OCT), enhanced depth imaging-OCT, and OCT angiography (OCTA). OCTA images were processed to generate maps of the vessel density and perfusion density of the superficial and deep retinal layers (SRL and DRL) and the choriocapillaris level (CL). The thickness of the outer nuclear layer and choroid was...
Source: Ophthalmic Research - October 24, 2017 Category: Opthalmology Source Type: research

Acknowledgements to the Referees
Ophthalmic Res 2017;58:243 (Source: Ophthalmic Research)
Source: Ophthalmic Research - October 24, 2017 Category: Opthalmology Source Type: research

Contents Vol. 58, 2017
Ophthalmic Res 2017;58:I-IV (Source: Ophthalmic Research)
Source: Ophthalmic Research - October 24, 2017 Category: Opthalmology Source Type: research

Expression of Angiogenic and Inflammatory Factors in Choroidal Neovascularisation-Derived Retinal Pigment Epithelium
Conclusion: In late-stage CNV membrane-derived RPE, gene expression was shifted towards a pro-inflammatory state. Angiogenesis-associated factors were regulated differently in the 2 CNV-derived RPE membranes. While inflammation seems to be continuously stimulated by RPE associated with late exudative AMD, this appears not to be the case with regard to angioregulatory mechanisms.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - October 19, 2017 Category: Opthalmology Source Type: research

Subfoveal Choroidal and Macular Thickness Changes after Phacoemulsification Using Enhanced Depth Imaging Optical Coherence Tomography
Purpose: To assess changes in the thickness of the subfoveal retina and choroid after phacoemulsification using enhanced depth imaging optical coherence tomography (EDI-OCT).Methods: A prospective study was conducted on 100 patients. The subfoveal choroidal thickness (SFCT) was measured at 7 points and the retinal thickness was measured at 5 points (before surgery, and 1 day, 1 week, 1 month, and 3 months after surgery).Results: The foveal choroidal thickness showed a thickening trend (butp> 0.05). Compared to the change from baseline to day 1, the changes from baseline were significantly different at nasal 3 mm and 6 m...
Source: Ophthalmic Research - October 18, 2017 Category: Opthalmology Source Type: research

Tomographic Structural Changes of Retinal Layers after Internal Limiting Membrane Peeling for Macular Hole Surgery
Conclusion: ILM peeling is associated with important alterations in the inner retinal layer architecture, with thinning of the RNFL-GCL-IPL complex and thickening of OPL, ONL, and ORL. These structural alterations can help explain functional outcome and could give indications regarding the extent of ILM peeling, even though peeling seems important for higher rate of hole closure.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - October 4, 2017 Category: Opthalmology Source Type: research

Epilutein for Early-Stage Age-Related Macular Degeneration: A Randomized and Prospective Study
Purpose: The hypothesis that oral supplementation of the epilutein/lutein combination could augment the macular pigment optical density (MPOD) in patients with age-related macular degeneration (AMD) was tested.Methods: In a prospective randomized interventional study, 40 consecutive patients with early-stage AMD were recruited. After a 2-week run-in period, patients were randomly treated with a daily oral administration of 8 mg epilutein and 2 mg lutein (group 1) or 10 mg lutein (group 2) for 2 months. At baseline (BL) and 1-month (M1) and 2-month visits (M2), all patients underwent a complete ophthalmological examination,...
Source: Ophthalmic Research - September 28, 2017 Category: Opthalmology Source Type: research

Peripapillary Choroidal Thickness Analysis Using Swept-Source Optical Coherence Tomography in Glaucoma Patients: A Broader Approach
Conclusions: Peripapillary choroidal tissue shows a concentric pattern in both groups, and glaucoma patients present with peripapillary choroidal thinning compared with healthy subjects, especially in areas further away from the optic disk.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - September 22, 2017 Category: Opthalmology Source Type: research

Effect of Biodegradable Scleral Plugs Containing Curcumin on Proliferative Vitreoretinopathy
This study aimed to explore the inhibitory effect of biodegradable scleral plugs containing curcumin on rabbits with proliferative vitreoretinopathy (PVR).Materials and Methods: The biodegradable scleral plugs containing curcumin were prepared by dissolving PLGA [poly(lactide-co-glycolide)] and curcumin. In total, 30 rabbits were divided into 2 groups: the model group received a vitreous injection of self-blood, and the treatment group received a vitreous injection of self-blood plus biodegradable scleral implants containing 1.5 mg of curcumin. On days 1, 3, 7, 14, 21, and 28 after the operation, clinical observations and ...
Source: Ophthalmic Research - September 22, 2017 Category: Opthalmology Source Type: research

Early Assessment of the Risk Factors for Diabetic Retinopathy Can Reduce the Risk of Peripheral Arterial and Cardiovascular Diseases in Type 2 Diabetes
Backgrounds: There is still a lack of consensus about how to assess the risk of peripheral arterial disease (PAD) and cardiovascular disease (CVD) in patients with diabetic retinopathy (DR).Aims: We investigated the risk factors for DR and their association with PAD and CVD in patients with type 2 diabetes (T2D).Methods: A total of 1,421 patients diagnosed with T2D participated in this study. DR stages were classified as non-DR, nonproliferative DR (NPDR), or proliferative DR (PDR). Logistic regression analysis was employed to analyze risk factors associated with DR.Results: NPDR and PDR patients had higher systolic blood ...
Source: Ophthalmic Research - September 20, 2017 Category: Opthalmology Source Type: research

Potential Effects of Hormone Therapy in Type 2 Idiopathic Macular Telangiectasia
Conclusions: Tamoxifen treatment does not seem to accentuate structural changes in patients with MacTel type 2. Treatment with estrogens may exhibit a neuroprotective effect as suggested by the decreased frequency of ellipsoid zone breaks in corresponding patients, although corroborative studies are warranted to confirm these exploratory data.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - September 13, 2017 Category: Opthalmology Source Type: research

BAX and BCL2 Gene Polymorphisms in Rhegmatogenous Retinal Detachment
Conclusions: This is the first study evaluating the potential relationship betweenBCL2 andBAX gene polymorphisms and RRD in a Greek population, showing a significant association betweenBAX rs4645878 polymorphism and RRD susceptibility. This finding suggests that an apoptotic mechanism is implicated in the pathogenesis of RRD.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - September 7, 2017 Category: Opthalmology Source Type: research

Ganglion Cell-Inner Plexiform Layer Thickness in Different Glaucoma Stages Measured by Optical Coherence Tomography
Conclusion: GCL + IPL layer thickness is a highly specific and sensitive parameter in differentiating glaucomatous from healthy eyes showing progressive damage as glaucoma worsens. Loss of this layer is highly correlated with overall loss of visual field sensitivity.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - September 6, 2017 Category: Opthalmology Source Type: research

< b > < i > BAX < /i > < /b > and < b > < i > BCL2 < /i > < /b > Gene Polymorphisms in Rhegmatogenous Retinal Detachment
Conclusions: This is the first study evaluating the potential relationship betweenBCL2 andBAX gene polymorphisms and RRD in a Greek population, showing a significant association betweenBAX rs4645878 polymorphism and RRD susceptibility. This finding suggests that an apoptotic mechanism is implicated in the pathogenesis of RRD.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - September 6, 2017 Category: Opthalmology Source Type: research

Retinal Nerve Fiber Layer Thickness Changes in the Pseudoexfoliation Syndrome: A Meta-Analysis of Case-Control Studies
Purpose: To evaluate and compare changes in retinal nerve fiber layer (RNFL) thickness in patients with the pseudoexfoliation syndrome (PXS) and healthy controls.Methods: Case-control studies were selected through an electronic search of the Cochrane Controlled Trials Register, PubMed, and Embase. Results were reviewed to ensure that the included studies met prespecified inclusion/exclusion criteria, and the quality of each study was assessed using the Newcastle-Ottawa Scale. All included studies measured average and 4-quadrant (temporal, superior, nasal, and inferior) RNFL thickness using optical coherence tomography (OCT...
Source: Ophthalmic Research - September 6, 2017 Category: Opthalmology Source Type: research

Evaluation of the Macular Ganglion Cell-Inner Plexiform Layer and the Circumpapillary Retinal Nerve Fiber Layer in Early to Advanced Stages of Glaucoma: Correlation with Central Visual Function and Visual Field Indexes
Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 31, 2017 Category: Opthalmology Source Type: research

Clinical Metabolomics and Glaucoma
Glaucoma is one of the leading causes of irreversible blindness worldwide. However, there are no biomarkers that accurately help clinicians perform an early diagnosis or detect patients with a high risk of progression. Metabolomics is the study of all metabolites in an organism, and it has the potential to provide a biomarker. This review summarizes the findings of metabolomics in glaucoma patients and explains why this field is promising for new research. We identified published studies that focused on metabolomics and ophthalmology. After providing an overview of metabolomics in ophthalmology, we focused on human glaucom...
Source: Ophthalmic Research - August 31, 2017 Category: Opthalmology Source Type: research

Subretinal Injection: A Review on the Novel Route of Therapeutic Delivery for Vitreoretinal Diseases
Compared to intravitreal injection, subretinal injection has more direct effects on the targeting cells in the subretinal space, which provides a new therapeutic method for vitreoretinal diseases, especially when gene therapy and/or cell therapy is involved. To date, subretinal delivery has been widely applied by scientists and clinicians as a more precise and efficient route of ocular drug delivery for gene therapies and cell therapies including stem cells in many degenerative vitreoretinal diseases, such as retinitis pigmentosa, age-related macular degeneration, and Leber's congenital amaurosis. However, clinicians shoul...
Source: Ophthalmic Research - August 31, 2017 Category: Opthalmology Source Type: research

Ophthalmic Start-Up Chief Executive Officers' Perceptions of Development Hurdles
Conclusion: The study suggests that development funding, regulatory burden, and meeting clinical endpoints are the greatest development challenges faced by ophthalmic start-up CEOs.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 25, 2017 Category: Opthalmology Source Type: research

Reliability of Entire Corneal Thickness Mapping in Normal Post-Laser in situ Keratomileusis and Keratoconus Eyes Using Long Scan Depth Spectral Domain Optical Coherence Tomography
Conclusions: The measurements of corneal pachymetric mapping by long scan depth SD-OCT can be assessed over the entire corneal area with good repeatability and reproducibility.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 18, 2017 Category: Opthalmology Source Type: research

Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray
Conclusion: This study suggested a potential role of circRNAs in the pathogenesis of DR and provides novel molecular targets for clinical therapy.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 17, 2017 Category: Opthalmology Source Type: research

Effects of Riboflavin and Ultraviolet Illumination on the Biomechanical Properties of Conjunctiva
Conclusions: The study suggested that riboflavin and ultraviolet A illumination (commercially available as collagen crosslinking) strengthened cattle conjunctiva by increasing its amount of covalent bonds, reducing its permeability, and possibly improving its resistance to rupture. This is the first study in the collagen crosslinking literature on the biomechanical properties of conjunctival tissue.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 16, 2017 Category: Opthalmology Source Type: research

Optical Coherence Tomography Angiography in Children with Leber-Coats Disease
Conclusion: This is the first case series of OCTA performed in children with Leber-Coats disease. OCTA is a non-invasive and non-contact technique, which can be considered of fundamental importance for the diagnosis, clinical management, and follow-up of the disease.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 11, 2017 Category: Opthalmology Source Type: research

Therapeutic Effect of 0.1% Tacrolimus Eye Drops in the Tarsal Form of Vernal Keratoconjunctivitis
Objective: The purpose of this study was to evaluate the efficacy and safety of 0.1% tacrolimus eye drops in the tarsal form of vernal keratoconjunctivitis (VKC) and to survey the changes of dendritic cells at the palpebral conjunctiva in patients with VKC by in vivo confocal microscopy.Methods: A total of 17 patients (34 eyes) with the tarsal form of VKC were enrolled in this prospective, nonrandomized case series. They were treated with 0.1% tacrolimus eye drops twice daily after discontinuation of all other topical medications. Subjective ocular symptoms and objective ocular signs were scored on a 4-point scale by one o...
Source: Ophthalmic Research - August 11, 2017 Category: Opthalmology Source Type: research

Dynamics of Inflammatory Factors in Aqueous Humor during Ranibizumab or Aflibercept Treatment for Age-Related Macular Degeneration
Conclusions: These findings suggest that the inflammatory factors are involved in the pathogenesis of AMD and also the possibility that the interaction between these inflammatory factors and IRI or IAI is different.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 10, 2017 Category: Opthalmology Source Type: research

Calcium Dobesilate Is Protective against Inflammation and Oxidative/Nitrosative Stress in the Retina of a Type 1 Diabetic Rat Model
Calcium dobesilate (CaD) has been prescribed to some patients in the early stages of diabetic retinopathy to delay its progression. We previously reported that the treatment of diabetic animals (4 weeks of diabetes) with CaD, during the last 10 days of diabetes, prevents blood-retinal barrier breakdown. Here, we aimed to investigate whether later treatment of diabetic rats with CaD would reverse inflammatory processes in the retina. Diabetes was induced with streptozotocin, and 6 weeks after diabetes onset, CaD (100 mg/kg/day) was administered for 2 weeks. The treatment with CaD significantly increased glial fibrillary aci...
Source: Ophthalmic Research - August 9, 2017 Category: Opthalmology Source Type: research

Screening for Retinopathy of Prematurity: Insight into Optimizing Screening
Purpose: To determine the factors influencing the time from preterm birth and retinopathy of prematurity (ROP) detection to optimize the timing of the initial screening.Methods: This multicenter retrospective study enrolled preterm infants born before 32 weeks of gestational age (GA) and/or weighing less than 1,500 g between January 1, 2011, and December 31, 2015. ROP screening was performed using fundus photography with a wide-field camera. Population and follow-up characteristics were recorded.Results: Among the 1,266 preterm infants observed, 795 were retained for analysis. One hundred seventy-four (21.6%) cases of ROP ...
Source: Ophthalmic Research - July 26, 2017 Category: Opthalmology Source Type: research

Retinal Penetration of Intravitreally Injected Tissue Plasminogen Activator: A Rat Model Study
Conclusions: This experimental study shows that unconjugated tPA administered into the vitreous is capable of penetrating the deep retinal layers and the subretinal space. These findings suggest that further clinical research is warranted on the benefits of intravitreal tPA in the treatment of submacular hemorrhage.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - July 20, 2017 Category: Opthalmology Source Type: research

Combined 23-G Pars Plana Vitrectomy and Lensectomy in the Management of Glaucoma Associated with Nanophthalmos
This study enrolled 21 eyes of 21 patients. The mean follow-up was 18.6 ± 7.0 months. At the final follow-up visit, the mean IOP was significantly reduced (from 47.4 ± 5.7 to 18.6 ± 3.6 mm Hg). The mean number of antiglaucoma medications dropped from 5 to 0. BCVA improved in 3 (14.3%) eyes. The complete success rate (IOP>6 and (Source: Ophthalmic Research)
Source: Ophthalmic Research - July 18, 2017 Category: Opthalmology Source Type: research

Dexamethasone Implants in Diabetic Macular Edema Patients with High Visual Acuity
Purpose: To evaluate the effects of intravitreal dexamethasone (DEX) implants in patients affected by diabetic macular edema (DME) with high best-corrected visual acuity (BCVA) and contraindications to therapy with anti-vascular endothelial growth factor over a 12-month follow-up.Methods: In this interventional nonrandomized clinical study, 14 consecutive patients (14 eyes) affected by DME with a BCVA of 0.3 LogMAR or better were prospectively enrolled. All patients were treated with a sustained-release 700- μg DEX implant at baseline, revaluated every 6 weeks, and retreated on a pro re nata basis. Primary outcomes incl...
Source: Ophthalmic Research - July 13, 2017 Category: Opthalmology Source Type: research

Spatially Resolved Spectral Sensitivities as a Potential Read-out Parameter in Clinical Gene Therapeutic Trials
Conclusion: In the present study, residual vision was cone mediated both under photopic and scotopic conditions in young patients with EOSRD associated withRPE65 mutations, but S cone function was severely reduced early on. In rod monochromats, vision was rod mediated both under conditions of dark and light adaptation. These observations are important for ongoing and future clinical trials employing gene therapeutic strategies in both rod-cone dystrophies and achromatopsia.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - July 11, 2017 Category: Opthalmology Source Type: research

Binocular Fixation Reduces Fixational Eye Movements in the Worst Eye of Patients with Center-Involving Diabetic Macular Edema
Conclusion: Binocular fixation can reduce the area of fixation and the amplitude of fixational saccades in the worst eye of patients with diabetic maculopathy. Fixational saccades in diabetic maculopathy should be studied during monocular fixation.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - July 6, 2017 Category: Opthalmology Source Type: research

Title Page / Table of Contents
Ophthalmic Res 2017;58(suppl 1):I-IV (Source: Ophthalmic Research)
Source: Ophthalmic Research - July 4, 2017 Category: Opthalmology Source Type: research

17th ESASO Retina Academy. June 29-July 1, 2017, Berlin, Germany: Abstracts
Ophthalmic Res 2017;58(suppl 1):1-20 (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 29, 2017 Category: Opthalmology Source Type: research

Title Page
Ophthalmic Res 2017;58(suppl 1):I-IV (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 29, 2017 Category: Opthalmology Source Type: research

EVICR. net. European Network of Clinical Research in Ophthalmology. Information Update - June 2017
Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 29, 2017 Category: Opthalmology Source Type: research

Association of IL-6 Gene (-174 and -572 G/C) Polymorphisms with Proliferative Diabetic Retinopathy of Type 2 Diabetes in a Chinese Population
Conclusions: IL-6 genotypes of rs1800795 GC and rs1800796 GG might point to a relatively high risk for T2D patients suffering from PDR in a Chinese population and they were associated with elevation of IL-6 expression in both mRNA and protein.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 26, 2017 Category: Opthalmology Source Type: research