Characteristics of the Filtering Bleb and the Agreement between Glaucoma Specialist and Anterior Segment OCT Assessment
Conclusion: There is fair agreement between glaucoma specialist assessment and AS OCT assessment in terms of the presence of f luid in trabeculectomy. Our findings highlight the importance of AS OCT in some patients before deciding upon a new intervention. (Source: Ophthalmic Research)
Source: Ophthalmic Research - September 17, 2020 Category: Opthalmology Source Type: research

Longitudinal retinal changes induced by hydroxychloroquine in eyes without retinal toxicity
Conclusion: Hydroxychloroquine was found to cause progressive thinning of the inner retinal layers, specifically in the GCL of the foveolar and par acentral areas, but no changes were observed in the outer retina. (Source: Ophthalmic Research)
Source: Ophthalmic Research - September 15, 2020 Category: Opthalmology Source Type: research

Real-world outcomes after 36 months treatment with ranibizumab 0.5 mg in patients with visual impairment due to diabetic macular edema (BOREAL-DME)
Purpose: To assess the efficacy, safety and follow-up of 36 months treatment with ranibizumab in patients with diabetic macular edema (DME) in real life setting. Methods This is a prospective phase 4 observational study. Between December 2013 and April 2015, 84 ophthalmologists enrolled a total of 290 adult patients initiating ranibizumab for visual impairment due to diabetic macular edema (DME) and treated them according to their routine practice. The primary outcome (mean change in best-corrected visual acuity [BCVA] after 12 months) was previously reported. Here we present outcomes after 36 months of follow-up for BC...
Source: Ophthalmic Research - September 15, 2020 Category: Opthalmology Source Type: research

Effectiveness of iStent trabecular micro-bypass system combined with phacoemulsification vs. phacoemulsification alone in patients with glaucoma and cataract depending on the initial intraocular pressure
INTRODUCTION: To assess the effect of iStent trabecular micro-bypass implantation combined with phacoemulsification on intraocular pressure (IOP) and glaucoma medications, and to compare this to outcomes of phacoemulsification alone in patients with mild to moderate primary open-angle glaucoma (POAG) depending on initial IOP. MATERIAL AND METHODS: 80 subjects with cataract and POAG were randomized 1:1 to either iStent implantation and cataract surgery (iStent group) (n=44) or cataract surgery alone (control group) (n=36). Groups were divided according to initial IOP (after wash out period) into IOP (Source: Ophthalmic Research)
Source: Ophthalmic Research - September 9, 2020 Category: Opthalmology Source Type: research

Comparison of the Icare ic100 rebound tonometer and the Goldmann applanation tonometer in 1000 eyes
The objective was to compare IOP measured using Icare ic100 and GAT. Methods This cross-sectional study measured IOP in1000 eyes (500 left, 500 right) using the ic100 and GAT. Central cornel thickness (CCT) was measured using a handheld pachymeter. IOP measurements were investigated in all eyes, by IOP sub-strata by CCT group, by number of topical glaucoma medications and diagnosis. Results There was moderate agreement between ic100 and GAT IOP measurements (intraclass correlation coefficient .73). Mean IOP was significantly lower measured by ic100 compared to GAT (12.1mmHg vs. 16.2mmHg, p (Source: Ophthalmic Research)
Source: Ophthalmic Research - September 9, 2020 Category: Opthalmology Source Type: research

The Association of Single Nucleotide Polymorphisms in ABCC5 Gene with Primary Angle Closure Glaucoma and the Ocular Biometric Parameters in a Northern Chinese Population
Conclusions: The SNP rs4148568 and a haplotype TCGGAG in ABCC5 contribute to PACG in northern Chinese people. In addition, rs4148568 might be associated with the AL and the variant allele of which may have effect of making the AL longer. Further studies are needed to elucidate the exact mechanism of ABCC5 in the progress of PACG. (Source: Ophthalmic Research)
Source: Ophthalmic Research - September 9, 2020 Category: Opthalmology Source Type: research

Association of VEGF gene family variants with central macular thickness and visual acuity after Aflibercept short-term treatment in diabetic patients: A pilot study
Introduction: Diabetic Retinopathy (DR) is one of the major vision-threatening causes worldwide. Searching for an individualized therapeutic strategy to prevent its progress is challenging. Objective: This work aimed to investigate the association of angiogenesis-inducer vascular endothelial growth factor (VEGF) gene family and related receptor variants (rs833069, rs12366035, rs7664413, rs7993418, and rs2305948) with susceptibility of diabetic retinopathy (DR) and the response to one dose of aflibercept treatment in type 2 diabetes mellitus (T2DM). Methods: Consecutive eligible patients with T2DM (n=125) and 110 unrelated ...
Source: Ophthalmic Research - August 24, 2020 Category: Opthalmology Source Type: research

Clinical outcomes of endoscope-assisted 30-gauge single-needle technique for intrascleral intraocular lens fixation
Conclusions: The endoscope-assisted single needle technique is a safe and effective method of intrascleral IOL fixation surgery. (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 21, 2020 Category: Opthalmology Source Type: research

Evaluation of refractive status and ocular biometric parameters in primary angle closure disease.
Introduction: To evaluate the refractive status and ocular biometric parameters in subjects with angle-closure in Malaysia. Methods: This cross-sectional study was conducted on 171 primary angle closure patients (268 eyes). Visual acuity, refraction and ocular biometry (central anterior chamber depth (ACD), axial length (AXL), and lens thickness) were recorded. Vitreous cavity length and relative lens position (RLP) were calculated. Results: A total of 92 Primary Angle Closure Suspect (PACS), 30 Primary Angle Closure (PAC), and 146 Primary Angle Closure Glaucoma (PACG) eyes were included. Chinese ethnicity formed the maj...
Source: Ophthalmic Research - August 18, 2020 Category: Opthalmology Source Type: research

Automatic Classification of Anterior Chamber Angle Based on Ultrasound Biomicroscopy Images
Conclusions: Our method of automatic angle localization and classification based on UBM images is feasible and reliable. The automatic classification of ACA provides a basis and reference for future studies. (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 18, 2020 Category: Opthalmology Source Type: research

Combined Orthokeratology with Atropine for children with Myopia: A Meta-analysis
Conclusion: Our study suggests that the combination of OK and 0.01% atropine is more effective in slowing axial elongation than OK monotherapy in children with myopia in a relatively short duration of treatment. In addition, the combination therapy has no negative influence on uncorrected distant visual acuity, corneal endothelial cell density, and intraocular pressure. (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 11, 2020 Category: Opthalmology Source Type: research

Asthma Promotes Choroidal Neovascularization via the Transforming Growth Factor beta1/Smad Signaling Pathway in a Mouse Model
Conclusion: We provide new evidence that asthma could be a risk factor for CNV development via the TGF-β1/Smad signalling pathway. A TGF-β inhibitor can be applied as a useful, adjunctive therapeutic strategy for preventing CNV formation in asthmatic patients. (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 11, 2020 Category: Opthalmology Source Type: research

Quantitative analysis of perfusion characteristics using contrast-enhanced ultrasound in patients with choroidal metastasis
Purpose: To quantitatively analyze the perfusion characteristics of choroidal metastasis using contrast-enhanced ultrasound (CEUS), and compare its perfusion characteristics with these of choroidal hemangioma and choroidal melanoma. Methods: The patients who were clinically diagnosed as choroidal metastasis were recruited as the study group and the patients who were diagnosed as choroidal hemangioma and choroidal melanoma during the same period were included as the comparison group. All patients underwent CEUS examination, and Sonoliver was used to obtain the data on quantitative parameters of the tumor and the adjacent no...
Source: Ophthalmic Research - August 11, 2020 Category: Opthalmology Source Type: research

Interocular Asymmetry of Visual Field Loss, Intraocular Pressure and Corneal Parameters in Primary Open-angle Glaucoma
Objectives: To assess the association between the corneal biomechanical parameters and visual field (VF) loss in patients with asymmetric primary open-angle glaucoma (POAG). Methods: A total of 89 POAG patients (50 males, 56.2%) with asymmetric VF loss, aged 65.2 ± 13.3 years old, were enrolled in this study. Asymmetric VF loss was defined as an interocular difference of the global index mean deviation (MD)>2dB. Intraocular pressure (IOP), central corneal thickness (CCT) and corneal biomechanical parameters such as maximum amplitude at the apex of highest concavity (Def ampl HC) were measured. The worse eye was ...
Source: Ophthalmic Research - August 6, 2020 Category: Opthalmology Source Type: research

Choroidal Thickness Changes After Orthokeratology Lens Wearing in Young Adults with Myopia
Conclusions: In the beginning of orthokeratology treatment, choroidal thickness of the horizontal axis was 248.9 ± 45.7 µm in the temporal regio n, 259.9 ± 55.3 µm in the macular region, and 219.2 ± 46.4 µm in the nasal region. Three months after orthokeratology treatment, thickness values of choroids in the three divided areas increased significantly (P (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 6, 2020 Category: Opthalmology Source Type: research

Morphological changes and potential mechanisms of intraocular pressure reduction after micropulse transscleral cyclophotocoagulation in rabbits
Conclusion: A potential mechanism for IOP reduction in pigmented rabbits is aqueou s humor transport dysfunction due to damage to the nonpigmented epithelial cells of the pars plicata and destruction of basal infoldings. The power of MP-TSCPC was consistent with both morphological changes and IOP reduction. (Source: Ophthalmic Research)
Source: Ophthalmic Research - July 31, 2020 Category: Opthalmology Source Type: research

Associations of Ganglion Cell-Inner Plexiform Layer and Optic Nerve Head Parameters with Visual Field Sensitivity in Advanced Glaucoma
Purpose: To evaluate the associations of optical coherence tomography (OCT)-derived macular ganglion cell-inner plexiform layer thickness (mGCIPLT), circumpapillary retinal nerve fiber layer thickness (cpRNFLT) and optic nerve head (ONH) parameters with visual field (VF) sensitivity in advanced glaucoma. Methods: In this cross-sectional study, 102 eyes from 102 patients with advanced glaucoma (defined as a 24-2 VF mean deviation (MD) ≤ -12 dB) were included. mGCIPLT, cpRNFLT and ONH parameters (including the rim area, average cup-to-disc (C:D) ratio and vertical C:D ratio) were measured using Cirrus high-definition OCT...
Source: Ophthalmic Research - July 30, 2020 Category: Opthalmology Source Type: research

Growth Rate of Geographic Atrophy Secondary to Age-related Macular Degeneration: A Meta-analysis of Natural History Studies and Implications for Designing Future Trials
Introduction: There is no effective treatment for geographic atrophy (GA). To help design future GA treatment trials, we conducted a meta-analysis for GA growth rate and its variability in natural history studies. Methods: Literatures were searched up to April 30, 2020. Data were extracted independently by 2 authors and analyzed using random-effects models. Results: The pooled mean GA growth rate was 1.66 mm2/year (SD=1.27 mm2/year, I2=97.0%, p (Source: Ophthalmic Research)
Source: Ophthalmic Research - July 28, 2020 Category: Opthalmology Source Type: research

The Role of Gut Microbiome in Autoimmune Uveitis
The gut microbiome has important physiological functions and plays an indispensable role in the human body. Currently, there are an increasing number of studies revealing the close correlation between dysbiosis of the gut microbiome and a variety of autoimmune diseases, including autoimmune uveitis. This brief review summarizes recent literature regarding the relationship between dysbiosis and the occurrence and development of autoimmune uveitis. Dysbiosis participates in the pathogenesis of autoimmune uveitis largely by four mechanisms: antigenic mimicry, disturbance of intestinal immune homeostasis, destruction of the in...
Source: Ophthalmic Research - July 16, 2020 Category: Opthalmology Source Type: research

Tear 1H NMR-based metabolomics application to the molecular diagnosis of aqueous tear deficiency and Meibomian gland dysfunction
Conclusions: Our key distinctive findings support that DE-MGD induces tear metabolomics profile changes. Metabolites contributing to a higher separation from the CG can presumably be used, in the foreseeable future, as DE-MGD biomarkers for better managing the diagnosis and therapy of this disease. (Source: Ophthalmic Research)
Source: Ophthalmic Research - July 16, 2020 Category: Opthalmology Source Type: research

New Technologies in Clinical Trials in Corneal Diseases and Limbal Stem Cell Deficiency - Review from the European Vision Institute (EVI) Special Interest Focus Group Meeting
To discuss and evaluate new technologies for a better diagnosis of corneal diseases and limbal stem cell deficiency the outcomes of a consensus process within the European Vision Institute ((EVI), and of a workshop at the University of Cologne) are outlined. Various technologies are presented and analyzed for their potential clinical use also in defining new endpoints in clinical trials. The disease areas which are discussed comprise Dry eye and ocular surface inflammation, imaging and corneal neovascularization and corneal grafting/stem cell and cell transplantation. The unmet needs in the above mentioned disease areas ar...
Source: Ophthalmic Research - July 7, 2020 Category: Opthalmology Source Type: research

Comparing reading speeds for reading standardized single sentences and paragraphs in patients with maculopathy
Conclusion In patients with maculopathy, single sentences are well suited for single measurement of reading speed. For repeated measurements (e.g. monitoring the course of a reading disord er or assessing effects of interventions), paragraphs are preferable because of their lower variability of RS between the paragraphs. (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 25, 2020 Category: Opthalmology Source Type: research

Vitamin D levels in young adult cataract patients: A case control study
Conclusion: We found vitamin D deficiency to be associated with early age-related cataract in a statistically significant manner. We believe it is worth investigatin g the reason of this concurrence with large longitudinal studies. (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 23, 2020 Category: Opthalmology Source Type: research

Cerebral Neurovascular Coupling Impairment in Central Serous Chorioretinopathy
Conclusions CSCR patients presented a significantly impaired cerebral NVC compared to controls, supporting the theory of a potential systemic vascular dysfunction. Stress could be related to this NVC impairment. (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 19, 2020 Category: Opthalmology Source Type: research

Retinal layers changes in patients with diabetic macular edema treated with intravitreal anti-VEGF agents: Long-term outcomes of a spectral-domain OCT study
Purpose: The purpose of this study is to investigate retinal layers ’ changes in patients with diabetic macular edema (DME) treated with anti-vascular endothelial growth factor (anti-VEGF) agents and to evaluate if these changes may affect treatment response. Methods: Participants in this prospective study were 110 treatment-naïve patients with center involved D ME, who were treated with anti-VEGF agents and followed-up for at least 12 months. A qualitative and quantitative analysis of retinal layers that can affect visual acuity was performed. Patients with persistent DME were defined and factors, which could ...
Source: Ophthalmic Research - June 19, 2020 Category: Opthalmology Source Type: research

A Comparison of Subconjunctival Wound Healing between Different Methods of Dissecting Subconjunctival Tissues
Conclusions: Dissecting subconjunctival tissues subepithelially inhibits subconjunctival fibrosis, which may be instructive in tenonectomy in filtration surgery. (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 19, 2020 Category: Opthalmology Source Type: research

Feasibility study of a docosahexaenoic acid optimized nutraceutical formulation on the macular levels of lutein in a healthy Mediterranean population
This study analyzes the influence of a supplementation containing lutein and antioxidant vitamins either with or without docosahexaenoic acid (DHA), with the main objective of identifying macular pigment optical density (MPOD) changes in both eyes at the end of the follow-up using the V isucam® retinograph. The secondary endpoint was to determine variation in the lutein and DHA levels in plasma and red blood cell membranes respectively. Methods: One hundred healthy participants (200 eyes) aged 40-70 years (mean age 49.3 years, SEM=13.7) were randomized in a 1:1 ratio to receive daily one of the following supplements ...
Source: Ophthalmic Research - June 16, 2020 Category: Opthalmology Source Type: research

Efficacy of Aflibercept Treatment and its Effect on the Retinal Perfusion in the Oxygen-Induced Retinopathy Mouse Model of Retinopathy of Prematurity
This study investigates the efficacy of aflibercept at reducing areas of non-perfused retina and studies its effect on normal angiogenesis in the oxygen-induced retinopathy (OIR) mouse model of ROP. Methods: C57BL/6J mice were assigned to room air control (n=21 eyes) or hyperoxia with 75% oxygen (n=84 eyes). The hyperoxic mice were assigned to one of three groups: 0 ng (n=14 eyes), 100 ng (n=35 eyes), or 1000 ng (n=35 eyes) of intravitreal aflibercept administered on postnatal day 14 (PN14). Eyes were enucleated at PN17 and PN25 post-injection. Retinas were stained with anti-collagen IV antibody and photographed with micr...
Source: Ophthalmic Research - June 12, 2020 Category: Opthalmology Source Type: research

The role of serum in flammation-based factors in Anti-VEGF treatment for macular edema secondary to retinal vein occlusion and its subtypes
Conclusion: Higher pretreatment PLR was associated with BCVA in patients with RVO-ME and its subtypes who were treated with anti-VEGF drugs. The PLR may be used as a predictive and prognostic tool for effective intravitreal injection treatmen t outcomes. (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 5, 2020 Category: Opthalmology Source Type: research

Evaluation of bleb characteristics after trabeculectomy and glaucoma implant surgery in rabbit
The characteristics of the conjunctival bleb are some of the most important factors for the surgical success of glaucoma filtering surgery. To improve surgical outcome, we investigated histology of bleb after three glaucoma surgeries. Surgery was performed in the 21 white rabbits. Rabbits were randomized and underwent trabeculectomy (TRAB), or implantation with EX-PRESS or a silicone tube (each n = 7). Bleb survival, intraocular pressure (IOP), and vascularity were evaluated. At 6 weeks, eyes were enucleated for histological analysis. Postoperative IOP at 2 weeks was significantly lower in the TRAB and EX-PRESS groups than...
Source: Ophthalmic Research - June 4, 2020 Category: Opthalmology Source Type: research

Comparison of Corneal Epithelial and Stromal Thickness between Keratoconic and Normal Eyes in an Asian Population
Conclusions: Corneal epithelial thickness was markedly thinner and varied in keratoconic eyes compared to controls. Epithelial thinning occurred secondary to the abnormal elevation of the stroma. These findings are useful in detecting early keratoconus and in the evaluation of refractive surgery candidates.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - July 2, 2019 Category: Opthalmology Source Type: research

Diagnostic Performance of Retinopathy in the Detection of Diabetic Nephropathy in Type 2 Diabetes: A Systematic Review and Meta-Analysis of 45 Studies
Conclusions: DR is helpful in diagnosing DN in persons with type 2 diabetes and kidney disease, but the severity of DR may not parallel the presence of DN.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 28, 2019 Category: Opthalmology Source Type: research

Management and Systemic Implications of Diabetic Neovascular Glaucoma
Conclusions: Ahmed implant surgery is a safe and effective treatment option for diabetic NVG. Medical treatment alone is not the best option for most cases. Advanced NVG could be an indicator of higher mortality risk in diabetic patients.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 5, 2019 Category: Opthalmology Source Type: research

Vector Analysis of Femtosecond Laser-Assisted Arcuate Keratotomy for Post-Keratoplasty Astigmatic Correction
Conclusions: FS-AK improves the visual outcome and reduces the refractive cylinder in post-penetrating keratoplasty astigmatism. The predictability of astigmatism correction was variable in reducing post-keratoplasty astigmatism. Refinement of the treatment nomogram for such cases is highly recommended.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 5, 2019 Category: Opthalmology Source Type: research

Comparison of Choroidal Thickness in Preeclamptic, Healthy Pregnant, and Nonpregnant Women: A Systematic Review and Meta-Analysis
Conclusions: This meta-analysis suggested that the CT of the healthy pregnant women was significantly higher than that of the nonpregnant women. The presence of preeclampsia might complicate this situation. Most studies found that the CT decreased in the preeclamptic patients because of the increases in the systemic vasospasm and the blood pressure, which led to no significant difference compared with the nonpregnant women.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - May 29, 2019 Category: Opthalmology Source Type: research

Update on Screening for Sight-Threatening Diabetic Retinopathy
Conclusions: There have been many recent advances in technology that may be adopted in the future by screening programmes for sight-threatening diabetic retinopathy but each device will need to demonstrate effectiveness and cost-effectiveness before more widespread adoption.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - May 27, 2019 Category: Opthalmology Source Type: research

Diabetic Retinopathy in the Context of Patients with Diabetes
Diabetic retinopathy (DR) is the most frequent complication of diabetes. The main risk factors are disease duration, a poor glycemic control, and the presence of hypertension. However, there is an important variation in risk which indicates that other factors, such as genetic heritability or glycemic variability, play an important role in accounting for the susceptibility to DR development. Another important concept is that DR is an independent predictor of both microvascular and macrovascular complications. Thus, the presence of DR should be taken into account when evaluating the cardiovascular risk of a diabetic subject....
Source: Ophthalmic Research - May 24, 2019 Category: Opthalmology Source Type: research

One-Year Outcomes of Intravitreal Conbercept for Treatment-Resistant Neovascular Age-Related Macular Degeneration
Conclusions: Intravitreal injections of conbercept appear to be beneficial in patients with nvAMD who exhibit persistent fluid despite previous treatment with ranibizumab.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - May 23, 2019 Category: Opthalmology Source Type: research

Semifluorinated Alkane Eye Drops in Chronic Ocular Graft-versus-Host Disease: A Prospective, Multicenter, Noninterventional Study
Conclusions: This study showed no change in clinical signs in severe DED due to oGvHD, which was not unexpected due to the underlying pathomechanisms. However, the study showed improvement of symptoms in individual patients allowing application of perfluorohexyloctane as an additional symptomatic therapy in oGvHD.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - May 22, 2019 Category: Opthalmology Source Type: research

Comparison of Subconjunctival Aflibercept and Betamethasone for the Treatment of Formed Corneal Neovascularization in a Rabbit Model
Conclusions: In this rabbit model, corneal neovascularization induced by chemical burn failed to regress with treatment with aflibercept, betamethasone, or their combination.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - May 22, 2019 Category: Opthalmology Source Type: research

The Short-Term Safety Evaluation of Corneal Crosslinking Agent-Genipin
Conclusions: Treatment of rabbit corneas with ≤0.25% GP resulted in minimal toxicity to keratocytes and endothelial cells, suggesting that it is a safe crosslinking agent at those concentrations.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - May 22, 2019 Category: Opthalmology Source Type: research

A Prediction Model for the Intraocular Pharmacokinetics of Intravitreally Injected Drugs Based on Molecular Physicochemical Properties
Conclusion: The present study indicates that intravitreal half-life could be predicted based on molecular physicochemical properties (MW and lipophilicity). Also, increasing MW while reducing lipophilicity would be a reliable method for prolonging the intravitreal half-life of small chemical drugs, while MW is the single major determinant for large biologic drugs.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - May 22, 2019 Category: Opthalmology Source Type: research

Correlation between Basal Macular Circulation and Following Glaucomatous Damage in Progressed High-Tension and Normal-Tension Glaucoma
Conclusion: The progressed HTG and NTG patients showed an impaired vascular intake before significant disease development compared to well-controlled cases.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - May 17, 2019 Category: Opthalmology Source Type: research

Bleb Needling with Mitomycin C as Adjunctive Therapy in Failing Blebs: A Retrospective Study
Conclusions: Needling bleb revision augmented with the use of MMC appears to be a more useful tool in the management of failing bleb.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - May 10, 2019 Category: Opthalmology Source Type: research

Single-Field Non-Mydriatic Fundus Photography for Diabetic Retinopathy Screening: A Systematic Review and Meta-Analysis
Conclusions: Single-field NMFP is inadequate to detect DR. Additionally, it showed higher sensitivity and lower specificity when 7SF was used as reference standard, as compared to slit-lamp biomicroscopy, suggesting that different reference standards used in DR screening might have affected the diagnostic results.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - May 8, 2019 Category: Opthalmology Source Type: research

The Role of Steroids in the Management of Diabetic Macular Edema
Inflammation is substantially contributing to the development and worsening of diabetic retinopathy in general and diabetic macular edema (DME) in particular, which provides the rationale to treat DME with corticosteroids. While anti-vascular endothelial growth factor (VEGF) agents are mostly chosen as a first-line treatment, there is an important role for steroids in the treatment algorithm for DME. A slow-release bioerodible dexamethasone implant and an extended-release nonbioerodible fluocinolone acetonide insert are both approved for the treatment of DME and provide the advantage of sustained drug delivery and reduced ...
Source: Ophthalmic Research - May 5, 2019 Category: Opthalmology Source Type: research

The Role of Disorganization of Retinal Inner Layers as Predictive Factor of Postoperative Outcome in Patients with Epiretinal Membrane
Conclusions: Baseline DRIL has been shown to be predictive of postoperative visual outcome in patients with iERM, treated with PPV.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - April 24, 2019 Category: Opthalmology Source Type: research

Long-Term Outcome of Patients Operated with Pars Plana Vitrectomy for Primary Rhegmatogenous Retinal Detachment
Conclusion: The majority of patients operated for primary RRD achieved a reasonable long-term visual outcome. Notably, female gender was associated with poor visual outcome, indicating a need for closer follow-up.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - April 24, 2019 Category: Opthalmology Source Type: research

Characterization of Initial Stages of Diabetic Macular Edema
Conclusions: Eyes from diabetic patients in the initial stages of DR with different Early Treatment Diabetic Retinopathy Study gradings show similar prevalence of SCME and CIME, independent of the severity of the retinopathy. Retinal edema is located mainly in the INL and appears to be mostly extracellular except in the earliest stages of diabetic retinal disease where intracellular edema predominates.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - April 24, 2019 Category: Opthalmology Source Type: research

The Protective Roles of Folic Acid in Preventing Diabetic Retinopathy Are Potentially Associated with Suppressions on Angiogenesis, Inflammation, and Oxidative Stress
This study aimed to evaluate the therapeutic effect of folic acid (FA) on diabetic retinopathy (DR) in a genetic mouse model of obese type 2 diabetes mellitus (T2D). C57BL/KsJ-db/db(db/db) T2D mice were divided into control, FA, metformin (MET), and FA plus MET groups (n = 10/group). Serum levels of glucose, glycated hemoglobin, and insulin were determined weekly. The retinal thickness was measured using optical coherence tomography (OCT) at 4 weeks after treatments. The retinal expression and serum levels of vascular formation, inflammation, and oxidative stress-associated molecules were examined. Our results demonstrated...
Source: Ophthalmic Research - April 24, 2019 Category: Opthalmology Source Type: research