Methodologic Assessment of the Systematic Reviews of Ophthalmic Adverse Drug Reactions Published in Ophthalmology Journals: A Systematic Review
Conclusion: The systematic reviews reporting ophthalmic adverse drug reactions diverged in some methodological aspects. Such an issue deserves further investigation, since discrepancies may lead to biased conclusions and, consequently, impact clinical and/or regulatory decisions.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - July 5, 2018 Category: Opthalmology Source Type: research

Topical Eugenol Successfully Treats Experimental < b > < i > Candida albicans < /i > < /b > -Induced Keratitis
Conclusions: Eugenol can act as a natural, safe, and effective treatment for fungal keratitis, regardless of whether treatment is started immediately or after 4 days of keratitis induction.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - July 3, 2018 Category: Opthalmology Source Type: research

SIREV-OFTARED Joined Congress Abstracts
Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - July 2, 2018 Category: Opthalmology Source Type: research

Diagnostic Ability and Discriminant Values of OCT-Angiography Parameters in Early Glaucoma Diagnosis
Conclusions: Vessel densities in POAG eyes are significantly lower than in healthy eyes, and they show good discriminatory abilities. A diminished microvascular network is associated with RNFL thinning more strongly in POAG than in PPG eyes.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 28, 2018 Category: Opthalmology Source Type: research

Scotopic Microperimetric Assessment of Rod Function in Stargardt Disease (SMART) Study: Design and Baseline Characteristics (Report No. 1)
Conclusions: Rod function is impaired in STGD1 and can be assessed by sMP. Testing rod function may serve as a potential outcome measure for future clinical treatment trials. This is evaluated in the SMART study.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 25, 2018 Category: Opthalmology Source Type: research

One-Year Results after Internal Limiting Membrane Flap Transposition for Surgical Repair of Macular Holes with Respect to Microperimetry
Conclusions: Beside visual acuity, foveal and perifoveal macular sensitivity improved, underlining the functional success of surgery after ILM peeling with ILM flap transposition.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 22, 2018 Category: Opthalmology Source Type: research

Age-Related Dry Eye Lactoferrin and Lactobionic Acid
Dry eye is the most prominent pathology among those involving the ocular surface: a decrease of the aqueous (less frequent) or the lipid (more frequent) component of the tear film is the cause of the diminished stability of tears that is observed in this pathology. Dry eye shows a clear distribution linked to both sex (being more frequent among women) and age (increasing with aging). Therefore, specific treatments taking into account the etiology of the disease would be desired. The role of lactoferrin and its functional mimetic lactobionic acid are reported here as a possible remedy for age-related dry eye.Ophthalmic Res ...
Source: Ophthalmic Research - June 19, 2018 Category: Opthalmology Source Type: research

Association between the Frequency of Optic Disk Hemorrhage and Progression of NTG Related with the Initial Location of RNFL Defect
Conclusions: More careful examination and caution are required when NTG patients show recurrent DH in the inferior hemifield related to the initial RNFL defect.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 12, 2018 Category: Opthalmology Source Type: research

Plasma Rich in Growth Factors for the Treatment of Dry Eye after LASIK Surgery
Conclusions: These results suggest that PRGF eye drops are effective for the improvement of dry eye symptoms in patients who underwent LASIK surgery in comparison to the conventional therapy. The treatment with PRGF is an alternative for patients who suffer from postoperative dry eye.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 8, 2018 Category: Opthalmology Source Type: research

The Modification of Fluorescein Angiography and Its Applications in Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy
Conclusions: The absorption coefficients in RFA provided more detailed images for AMD and PCV diagnosis. RFA is therefore a promising approach to supplement FFA.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 7, 2018 Category: Opthalmology Source Type: research

The Role of Retinal Vascular Density as a Screening Tool for Ageing and Stroke
Conclusion: Age and stroke are significant risk factors for decreased RVD. Diabetes and arterial hypertension are additional significant risk factors in patients with stroke with respect to RVD.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 6, 2018 Category: Opthalmology Source Type: research

IL-1 α and MMP-9 Tear Levels of Patients with Active Ocular Rosacea before and after Treatment with Systemic Azithromycin or Doxycycline
Conclusions: While IL-1 α levels decreased after azithromycin therapy, MMP-9 did so after doxycycline treatment. Baseline cytokine tear levels tend to be markedly elevated in patients with antibiotic failure, suggesting their potential role as therapeutic biomarkers for the disease.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 6, 2018 Category: Opthalmology Source Type: research

Short-Term Intraocular Pressure Rise during Locally Induced Force by Ophthalmologic Surgery Applications
Conclusion: The values of the forces applied can be converted into the resulting IOP based on the specific action. Surgical or diagnostic procedures should, therefore, be evaluated with regard to preexisting pathologies, such as glaucoma.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - May 31, 2018 Category: Opthalmology Source Type: research

Autologous Neurosensory Retinal Transplantation for Unclosed and Large Macular Holes
Conclusions: Autologous neurosensory retinal patch transplantation is an effective addition to the surgical options for large MH-induced retinal detachment after failed surgery with ILM removal or transplantation.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - May 29, 2018 Category: Opthalmology Source Type: research

Peripheral Microvascular Abnormalities Detected by Wide-Field Fluorescein Angiography in Eyes with Branch Retinal Vein Occlusion
Conclusion: The presence of peripheral abnormalities or scatter PC for NPAs did not affect the visual outcome in eyes with BRVO.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - May 29, 2018 Category: Opthalmology Source Type: research

Optical Coherence Tomography Angiography in Glaucoma: A Review
Conclusion: OCTA shows potential to become a part of everyday glaucoma management.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - May 29, 2018 Category: Opthalmology Source Type: research

Comparing Cytokine Kinetics between Ranibizumab and Aflibercept in Central Retinal Vein Occlusion with Macular Edema
Conclusions: In CRVO patients, both ranibizumab and aflibercept achieved similar improvement in clinical parameters and similar reductions in aqueous VEGF, PlGF, MCP-1, and IL-6 levels.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - May 29, 2018 Category: Opthalmology Source Type: research

Optimizing Genipin Concentration for Corneal Collagen Cross-Linking: An ex vivo Study
Conclusions: Genipin 0.5%, in a 140- µL drop applied hourly for 2 h, showed better potential to enhance corneal stiffness and stability through inducing CXL.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - May 29, 2018 Category: Opthalmology Source Type: research

Ultrasound Cyclo-Plasty in Patients with Glaucoma: 1-Year Results from a Multicentre Prospective Study
Conclusions: UCP is safe and effective for reducing IOP. The procedure determines a greater IOP reduction in patients with higher preoperative IOP. Second-generation probes improve outcomes without detrimental effects on safety.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - May 16, 2018 Category: Opthalmology Source Type: research

Animal Models of Proliferative Vitreoretinopathy and Their Use in Pharmaceutical Investigations
Animal models are indispensable for pharmaceutical investigations. However, investigators often have difficulty choosing the appropriate modal for their research. To provide a comprehensive and convenient source of information about animal models of proliferative vitreoretinopathy (PVR), the current review sorted and analyzed representative animal models for pharmacotherapy of PVR since 1976.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - May 3, 2018 Category: Opthalmology Source Type: research

Autophagy: A Role in the Apoptosis, Survival, Inflammation, and Development of the Retina
Autophagy is a lysosomal degradation process that maintains cellular homeostasis by removing dysfunctional organelles and unfolded proteins. Increasing evidence has shown that autophagy proteins are involved in retinal physiology and pathology and that defective autophagy contributes to retinal degeneration. In retinal diseases, autophagy plays a dual role: promoting retinal cell survival and death. Autophagy at a normal level helps retinal cells defend themselves against harmful stress; however, excessive autophagy results in retinal deterioration. Both synergistic and antagonistic roles of autophagy and apoptosis in the ...
Source: Ophthalmic Research - April 25, 2018 Category: Opthalmology Source Type: research

Findings of Optical Coherence Tomography Angiography in Best Vitelliform Macular Dystrophy
Conclusions: Vascular changes in BVMD were apparent in the choriocapillary layer. The changes became more striking in late stages of the disease. OCTA provides useful quantitative measurements for staging and monitoring the progression of BVMD.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - April 13, 2018 Category: Opthalmology Source Type: research

Visual Field Variability after Gene Therapy for Leber ’s Hereditary Optic Neuropathy
Conclusion: There was a statistically significant VF improvement after gene therapy. This suggests that monocular intravitreal injection of AAV2-ND4 can improve binocular VF values. This study also suggests that gene therapy can be effective in patients with a disease duration of #x3e; 2 years.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - April 12, 2018 Category: Opthalmology Source Type: research

A Pathogenetic Classification of Diabetic Macular Edema
Conclusion: The study offers a new pathogenetic classification able to detect significant differences among DME subtypes. A tailored therapeutic approach could take into consideration specific changes associated with the different DME subtypes.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - April 11, 2018 Category: Opthalmology Source Type: research

Cyclophosphamide or Rituximab Treatment of Scleritis and Uveitis for Patients with Granulomatosis with Polyangiitis
Conclusions: Cyclophosphamide and rituximab are safe and effective agents for controlling scleritis and uveitis associated with GPA, with eventual progression towards steroid-sparing remission.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - April 10, 2018 Category: Opthalmology Source Type: research

Meibomian Gland Dysfunction in Primary and Secondary Sj ögren Syndrome
Conclusions: Our findings support our hypothesis and show that individuals with pSS, sSS + SLE, and sSS + RA have MGD. In addition, our study indicates that patients with pSS and sSS have both aqueous-deficient and evaporative DED.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - April 6, 2018 Category: Opthalmology Source Type: research

Assessment of Corneal Changes Associated with Topical Antiglaucoma Therapy Using in vivo Confocal Microscopy
Purpose: Ocular surface disease (OSD) is highly prevalent in eyes treated with chronic, topical antiglaucoma (A/G) therapy. The purpose of this study was to utilize in vivo confocal microscopy (IVCM) to evaluate the corneal morphology, including characteristics of corneal epithelial cells, presence of epithelial dendritic cells (DCs), and characteristics of subbasal nerve plexus, of eyes under topical A/G therapy versus normal eyes.Methods: Central corneal images were prospectively captured from 30 eyes of 16 patients under topical A/G therapy (>6 months) and 20 normal control eyes, using IVCM (HRT 3 RCM, Heidelberg, Ge...
Source: Ophthalmic Research - April 6, 2018 Category: Opthalmology Source Type: research

Peripheral Retinal Imaging Biomarkers for Alzheimer ’s Disease: A Pilot Study
Conclusions: UWF retinal imaging revealed a significant association between AD and peripheral hard drusen formation and changes to the vasculature beyond the posterior pole, at BL and after clinical progression over 2 years, suggesting that monitoring pathological changes in the peripheral retina might become a valuable tool in AD monitoring.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - April 5, 2018 Category: Opthalmology Source Type: research

Curcumin Alleviates Diabetic Retinopathy in Experimental Diabetic Rats
Conclusions: Taken together, these results suggest that curcumin may have great therapeutic potential in the treatment of diabetic retinopathy which could be attributed to the hypoglycemic, antioxidant, VEGF-downregulating and neuroprotection properties of curcumin.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - March 29, 2018 Category: Opthalmology Source Type: research

Iterative Variance Stabilizing Transformation Denoising of Spectral Domain Optical Coherence Tomography Images Applied to Retinoblastoma
Conclusions: On a single denoised image, the proposed method provides results similar to those expected from the SD-OCT averaging. Because of the friendly user interface, it can be easily used by clinicians and researchers in ophthalmology.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - March 26, 2018 Category: Opthalmology Source Type: research

Spectral-Domain Optical Coherence Tomography-Driven Treat-and-Extend and Pro Re Nata Regimen in Patients with Macular Oedema due to Retinal Vein Occlusion: 24-Month Evaluation and Outcome Predictors
Conclusions: In CME, due to BRVO/CRVO, TER provides better morphological outcome using more injections than PRN.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - March 23, 2018 Category: Opthalmology Source Type: research

Efficacy and Safety of Bevacizumab Combined with Mitomycin C or 5-Fluorouracil in Primary Trabeculectomy: A Meta-Analysis of Randomized Clinical Trials
Conclusions: Results of the meta-analysis demonstrated that the combination of bevacizumab (1.25 mg/mL) with a regular concentration of antimetabolite did not show more benefit or harm compared with using antimetabolite alone. Further randomized controlled trials are needed to evaluate the efficacy and safety of bevacizumab combined with lower concentrations and a shorter application time of antimetabolite.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - March 13, 2018 Category: Opthalmology Source Type: research

Tissue Plasminogen Activator as an Antiangiogenic Agent in Experimental Corneal Neovascularization in Rabbits
Conclusion: Although tPA has no direct impact on the vascular endothelial cells in vitro, the fibrinolytic effects of tPA might markedly suppress neovascularization in vivo.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - March 13, 2018 Category: Opthalmology Source Type: research

Subclinical Macular Edema as a Predictor of Progression to Central-Involved Macular Edema in Type 2 Diabetes
Conclusions: In patients with mild NPDR, the presence of SCME is a good predictor of progression to CIME.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - March 6, 2018 Category: Opthalmology Source Type: research

Repeatability and Reproducibility of Foveal Avascular Zone Area Measurement on Normal Eyes by Different Optical Coherence Tomography Angiography Instruments
Conclusions: FAZ measurements obtained with different OCTA devices differ. These findings should be considered in follow-up studies of patients with retinal vascular diseases.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - February 8, 2018 Category: Opthalmology Source Type: research

Choroidal Thickness with Swept-Source Optical Coherence Tomography versus Foveal Morphology in Young Children with a History of Prematurity
Conclusions: Reduced CT in children with a history of ROP is linked to ROP severity. These findings overlap with the degree of MDA. CT appears to be involved in ROP, but MDA showed a higher impact on the BCVA of the examined cohort.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - February 7, 2018 Category: Opthalmology Source Type: research

Optical Coherence Tomography-Based Angiography in Retinal Artery Occlusion in Children
Conclusions: OCTA enables clear visualization of progressive impairment of the retinal vascular perfusion in children with RAO and may be an alternative to the standard FA. Further studies are needed to confirm our results and establish the role of OCTA in pediatric patients.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - January 23, 2018 Category: Opthalmology Source Type: research

Automated Screening for Diabetic Retinopathy – A Systematic Review
Conclusion: The study demonstrates that despite limited specificity, automated retinal image analysis may potentially be valuable in different DR screening scenarios with a relatively high sensitivity and a substantial workload reduction.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - January 16, 2018 Category: Opthalmology Source Type: research

Corneal Collagen Crosslinking Combined with Phototherapeutic Keratectomy and Photorefractive Keratectomy for Corneal Ectasia after Laser in situ Keratomileusis
Purpose: The aim of this study was to analyze the effects of corneal crosslinking (CXL) combined with phototherapeutic keratectomy (PTK) and photorefractive keratectomy (PRK) in halting the progression and improving the visual function of corneal ectasia after laser in situ keratomileusis (LASIK).Methods: PTK-PRK-CXL was performed on 14 eyes of 14 patients who developed corneal ectasia after LASIK. The visual acuity, spherical refraction and cylinder, corneal topography indices, thinnest corneal thickness (TCT), and endothelial cell count were evaluated at baseline and at 1, 3, 6, and 12 months postoperatively.Results: The...
Source: Ophthalmic Research - January 16, 2018 Category: Opthalmology Source Type: research

Structure-Function Correlation in Hemianopic Vision Loss in Children Aged 3-6 Years Using OCT and SVOP, and Comparison with Adult Eyes
Conclusions: All children underwent SVOP with minimal restrictions, allowing functional evaluation of peripheral visual field positions. Parafoveal positions showed multiple false-positive results. The function-structure relationship is measurable even in young children by using the GCL+ analysis. This combination of novel child-friendly techniques allows collecting objectively measured values and simplifies diagnosis and follow-up in treatment.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - January 12, 2018 Category: Opthalmology Source Type: research

Different Phenotypes of Mild Nonproliferative Diabetic Retinopathy with Different Risks for Development of Macular Edema (C-TRACER Study)
Conclusion: Eyes in the initial stages of DR show different phenotypes with different risks of progression to ME. The phenotypes associated with increased risks of progression show different distributions in patients of different ethnicities.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - December 21, 2017 Category: Opthalmology Source Type: research

Fluocinolone Acetonide Intravitreal Implant 190 μg (ILUVIEN®) in Vitrectomized versus Nonvitrectomized Eyes for the Treatment of Chronic Diabetic Macular Edema
Conclusion: The results from the real-life practice study demonstrate that the 0.2 μg/day FAc implant is effective and well tolerated in vitrectomized and nonvitrectomized eyes of patients with chronic DME. Our results support the use of a 0.2 μg/day FAc implant to obtain long-term functional and anatomical improvements (mean, 8.5 months; median, 6.0 months) in vitrectomized and nonvitrectomized eyes.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - December 15, 2017 Category: Opthalmology Source Type: research

Outer Retina and Choroidal Thickness in Intermediate Age-Related Macular Degeneration: Reticular Pseudodrusen Findings
Conclusions: The greatest differences between eyes with and without RPD are found at the level of the choroidal thickness and at the level of the photoreceptors.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - December 13, 2017 Category: Opthalmology Source Type: research

SLC2A1 Tag SNPs in Greek Patients with Diabetic Retinopathy and Nephropathy
Conclusions: This study provides evidence thatSLC2A1gene variants might be implicated in the development of T2DM microvascular complications.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - December 5, 2017 Category: Opthalmology Source Type: research

Optical Coherence Tomography Angiography in Optic Nerve Drusen
Aim: To determine the efficacy of optical coherence tomography angiography (OCT-A) in diagnosing optic nerve head flow impairment in patients with optic nerve drusen.Methods: Patients affected by optic-nerve head drusen (ONHD) attending the Eye Clinic of the Federico II University of Naples were enrolled in this prospective case series between October 2015 and October 2016. Each patient underwent evaluation of best corrected visual acuity (BCVA), Goldman applanation tonometry, slit-lamp biomicroscopy, fundus examination, standard visual-field testing (perimetry), spectral domain (SD)-OCT and OCT-A.Results: Thirteen patient...
Source: Ophthalmic Research - November 29, 2017 Category: Opthalmology Source Type: research

The Recovery of Microvascular Status Evaluated by Optical Coherence Tomography Angiography in Patients after Successful Macular Hole Surgery
Purpose: The aim of this study was to evaluate the optical coherence tomography angiography (OCTA) features of patients who underwent successful macular hole (MH) surgery.Methods: Nineteen patients who underwent surgery in a single eye due to MH and 13 healthy subjects as a control group were included in the study. Vascular densities, flow indexes, and the foveal avascular zone (FAZ) area in superficial and deep retinal capillary plexuses were evaluated by OCTA in the right eyes of the control group, and both the surgical and healthy fellow eyes of the patients.Results: The mean vascular densities of the superficial and de...
Source: Ophthalmic Research - November 28, 2017 Category: Opthalmology Source Type: research

Subconjunctival PRGF Fibrin Membrane as an Adjuvant to Nonpenetrating Deep Sclerectomy: A 2-Year Pilot Study
Purpose: To evaluate the potential role of the autologous PRGF (plasma rich in growth factors) fibrin membrane in tissue regeneration after glaucoma filtering surgery.Materials and Methods: Ten patients with medically uncontrolled primary open-angle glaucoma underwent nonpenetrating deep sclerectomy and were treated with PRGF fibrin membrane as adjuvant. Intraocular pressure reduction was the primary outcome. This variable was measured preoperatively and also at each follow-up visit. Secondary outcomes included the number of antiglaucoma medications, anterior segment optical coherence tomography bleb examination, photograp...
Source: Ophthalmic Research - November 21, 2017 Category: Opthalmology Source Type: research

Interocular Symmetry of Choroidal Thickness and Volume in Healthy Eyes on Optical Coherence Tomography
Background: We aimed to determine the physiological symmetry, with spectral-domain optical coherence tomography, of choroidal measurements in a healthy population in all the areas defined in the Early Treatment Diabetic Retinopathy Study (ETDRS).Methods: One hundred and fifty-four eyes of 77 healthy young adults between the ages of 19 and 32 years were enrolled. Differences in choroidal thickness (CT) and volume (CV) between the left and right eyes were calculated. Normal ranges of absolute interocular differences were established as the 95th percentile.Results: The mean ± SD subfoveal CT (SFCT) and total CV values ...
Source: Ophthalmic Research - November 9, 2017 Category: Opthalmology Source Type: research

The Effect of a Decrease in Intraocular Pressure on Optic Nerve Function in Patients with Optic Nerve Drusen
Conclusions: A decrease in IOP in eyes with ODD results in improvement of retinal ganglion cell function and delays the progression of optic neuropathy. PERG should be performed in patients with ODD as it is a sensitive test for monitoring optic neuropathy.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - October 30, 2017 Category: Opthalmology Source Type: research

Modulation of the Proteasome Pathway by Nano-Curcumin and Curcumin in Retinal Pigment Epithelial Cells
Conclusions: Nano-curcumin is less toxic to RPE cells and less prone to induce ROS production than curcumin. Both nano-curcumin and curcumin increase proteasome-mediated proteolytic activity. These results suggest that nano-curcumin may be regarded as a proteasome-modulating agent of limited cytotoxicity for RPE cells.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - October 26, 2017 Category: Opthalmology Source Type: research