Diagnostic Accuracy of Digital Retinal Fundus Image Analysis in Detecting Diabetic Maculopathy in Type 2 Diabetes Mellitus
Conclusions: Despite the low negative predictive value, the good specificity and sensitivity of DRFI in detecting DME make it a useful tool in a routine clinical setting, and its potential in diabetic eye screening is yet to be realized.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - December 14, 2018 Category: Opthalmology Source Type: research

Bilateral Lateral Rectus Recession for the Treatment of Recurrent Exotropia after Bilateral Medial Rectus Resection
Conclusion: Based on our results, BLR could be an effective and safe method for treating recurrent exotropia after a moderate to large amount of BMR.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - December 6, 2018 Category: Opthalmology Source Type: research

Contents Vol. 60, 2018
Ophthalmic Res 2018;60:I –VI (Source: Ophthalmic Research)
Source: Ophthalmic Research - November 30, 2018 Category: Opthalmology Source Type: research

Contents
Ophthalmic Res 2018;60:I –VI (Source: Ophthalmic Research)
Source: Ophthalmic Research - November 29, 2018 Category: Opthalmology Source Type: research

Proposed Classification System for Retinal Capillary Angiomatosis
Retinal angiomas are rare tumors that develop within the vascular bed of the retina. Their occurrence may be sporadic or as part of the multisystem disorder called von Hippel-Lindau disease. It is well established in literature that retinal angiomas have a natural history of evolving as small aneurysmal dilatations and progressing to vision-threatening retinal detachments. Several approaches to the management of these angiomas have been reported in the literature, but it is difficult to decipher which modality is best suited for which type of angioma. A classification of retinal angiomas is proposed herein. A classificatio...
Source: Ophthalmic Research - November 29, 2018 Category: Opthalmology Source Type: research

Vitrectomy Outcomes in Eyes with Tractional Diabetic Macular Edema
Conclusions: In our series, PPV for tDME induced an improvement in retinal thickening and visual outcome in more than 50% of the cases, with low recurrence rates and a low number of postoperative complications.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - November 23, 2018 Category: Opthalmology Source Type: research

Evaluation of 2 ex vivo Bovine Cornea Storage Protocols for Drug Delivery Applications
This study highlights the limitations of curre ntly available corneal tissue storage approaches for ex vivo drug permeation studies.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - November 22, 2018 Category: Opthalmology Source Type: research

Short-Term Progression of Diabetic Hard Exudates Monitored with High-Resolution Camera
Conclusion: Diabetic hard exudate changes occurred over a short period of time but were not assessable clinically. Adaptive optics was able to document these subtle changes precisely. Further studies using this imaging modality may improve our understanding of the natural history of exudates and eventually help assess the efficacy of the various treatments available such as lipid-lowering drugs and anti-VEGFs injections.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - November 22, 2018 Category: Opthalmology Source Type: research

Preoperative Timing of Intravitreal Bevacizumab Injection for Proliferative Diabetic Retinopathy Patients
Conclusions: IVB injection may lead to a decrease in the intraocular concentrations of VEGF after 2 –5 days and induce the formation of proliferation after 21 days, which suggests that PPV in PDR patients should take place within 1 week of the administration of preoperative IVB.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - October 31, 2018 Category: Opthalmology Source Type: research

Dry-Eye Disease in Recurrent Pterygium
Conclusion: Pterygium recurrence is associated with a greater severity of dry eye, possibly by perpetuating ocular surface inflammation in the postoperative period.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - October 31, 2018 Category: Opthalmology Source Type: research

Structural and Functional Analyses of Retinal Ischemia in Eyes with Retinal Vein Occlusion: Relationship with Macular Edema or Microaneurysm Formation
Conclusion: Deep retinal thinning in NPAs was correlated significantly with a decreased retinal sensitivity, which might be a negative predictor of ME and MA in eyes with RVO.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - October 25, 2018 Category: Opthalmology Source Type: research

Quantification of Eccentric Fixation Using Spectral-Domain Optical Coherence Tomography
Conclusions: Compared with a fixation ophthalmoscope, our method using OCT seems to be superior both in quantification and detection of eccentric fixation in amblyopic patients, without the need for mydriasis.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - October 16, 2018 Category: Opthalmology Source Type: research

The Relationship between Macular Pigment and Vessel Density in Patients with Type 1 Diabetes Mellitus
Conclusions: There was a reduction in macular pigment and in OCTA vessel density in T1DM patients with retinopathy, which may have prognostic value in determining disease progression.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - October 11, 2018 Category: Opthalmology Source Type: research

Effect of Leaking Foveal Microaneurysms on the Treatment of Center-Involving Diabetic Macular Edema: A Pilot Study
Conclusions: A combination therapy of short-pulse focal/grid laser and reduced IVR injections appeared noninferior to previous reports of IVR monotherapy. Further large-scale investigations are warranted.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - October 10, 2018 Category: Opthalmology Source Type: research

Abstracts 18th ESASO Retina Academy
Ophthalmic Res 2018;60:1 –26 (Source: Ophthalmic Research)
Source: Ophthalmic Research - October 5, 2018 Category: Opthalmology Source Type: research

Title Page/ Table of Contents
Ophthalmic Res 2018;60:I –IV (Source: Ophthalmic Research)
Source: Ophthalmic Research - October 5, 2018 Category: Opthalmology Source Type: research

Is Thicker Choroid a Risk Factor for Malignant Glaucoma?
Conclusions: Thicker foveal CT is an anatomic risk factor for MG. The results of our study were consistent with the hypothesis that choroidal expansion may play a significant role for the development of MG.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - September 7, 2018 Category: Opthalmology Source Type: research

Evaluation of Vascular Changes with Optical Coherence Tomography Angiography after Plaque Radiotherapy of Choroidal Melanoma
Conclusions: OCT-A is a noninvasive, reliable method with which to quantify the vessel changes in radiation maculopathy and, given the association between vascularization and malignancy, this procedure may be an aid in treatment decision-making and in monitoring the efficacy of treatment.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 17, 2018 Category: Opthalmology Source Type: research

The Progression of the Stargardt Disease Type 4 (ProgStar-4) Study: Design and Baseline Characteristics (ProgStar-4 Report No. 1)
Conclusions: Data on disease progression inPROM1-related retinopathy from this study will contribute to the characterization of the natural history of disease and the exploration of the utility of several modalities to track progression and therefore to potentially be used in future interventional clinical trials.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 15, 2018 Category: Opthalmology Source Type: research

Multimodal Imaging in Autosomal Dominant Cone-Rod Dystrophy Caused by Novel < b > < i > CRX < /i > < /b > Variant
Conclusions: Multimodal study allowed the characterization of a peculiar form of CRD. The novel pathogenic variant seems to have a different effect on the phenotype if compared with a previously described similar one, giving an insight into the pathogenic mechanism ofCRX-related retinal dystrophies and offering valuable information that could lead to the development of possible future therapies.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - August 3, 2018 Category: Opthalmology Source Type: research

Retinopathy of Type 1 Diabetes in Arab Countries: Systematic Review and Meta-Analysis
Conclusion: Almost one fifth of T1D patients in 15 Arab countries have diabetic retinopathy, therefore it is important to improve the care of patients with T1D and in Arab countries to avoid the development of such a devastating complication.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - July 25, 2018 Category: Opthalmology Source Type: research

Methodologic Assessment of the Systematic Reviews of Ophthalmic Adverse Drug Reactions Published in Ophthalmology Journals: A Systematic Review
Conclusion: The systematic reviews reporting ophthalmic adverse drug reactions diverged in some methodological aspects. Such an issue deserves further investigation, since discrepancies may lead to biased conclusions and, consequently, impact clinical and/or regulatory decisions.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - July 5, 2018 Category: Opthalmology Source Type: research

Topical Eugenol Successfully Treats Experimental < b > < i > Candida albicans < /i > < /b > -Induced Keratitis
Conclusions: Eugenol can act as a natural, safe, and effective treatment for fungal keratitis, regardless of whether treatment is started immediately or after 4 days of keratitis induction.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - July 3, 2018 Category: Opthalmology Source Type: research

SIREV-OFTARED Joined Congress Abstracts
Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - July 2, 2018 Category: Opthalmology Source Type: research

Diagnostic Ability and Discriminant Values of OCT-Angiography Parameters in Early Glaucoma Diagnosis
Conclusions: Vessel densities in POAG eyes are significantly lower than in healthy eyes, and they show good discriminatory abilities. A diminished microvascular network is associated with RNFL thinning more strongly in POAG than in PPG eyes.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 28, 2018 Category: Opthalmology Source Type: research

Scotopic Microperimetric Assessment of Rod Function in Stargardt Disease (SMART) Study: Design and Baseline Characteristics (Report No. 1)
Conclusions: Rod function is impaired in STGD1 and can be assessed by sMP. Testing rod function may serve as a potential outcome measure for future clinical treatment trials. This is evaluated in the SMART study.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 25, 2018 Category: Opthalmology Source Type: research

One-Year Results after Internal Limiting Membrane Flap Transposition for Surgical Repair of Macular Holes with Respect to Microperimetry
Conclusions: Beside visual acuity, foveal and perifoveal macular sensitivity improved, underlining the functional success of surgery after ILM peeling with ILM flap transposition.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 22, 2018 Category: Opthalmology Source Type: research

Age-Related Dry Eye Lactoferrin and Lactobionic Acid
Dry eye is the most prominent pathology among those involving the ocular surface: a decrease of the aqueous (less frequent) or the lipid (more frequent) component of the tear film is the cause of the diminished stability of tears that is observed in this pathology. Dry eye shows a clear distribution linked to both sex (being more frequent among women) and age (increasing with aging). Therefore, specific treatments taking into account the etiology of the disease would be desired. The role of lactoferrin and its functional mimetic lactobionic acid are reported here as a possible remedy for age-related dry eye.Ophthalmic Res ...
Source: Ophthalmic Research - June 19, 2018 Category: Opthalmology Source Type: research

Association between the Frequency of Optic Disk Hemorrhage and Progression of NTG Related with the Initial Location of RNFL Defect
Conclusions: More careful examination and caution are required when NTG patients show recurrent DH in the inferior hemifield related to the initial RNFL defect.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 12, 2018 Category: Opthalmology Source Type: research

Plasma Rich in Growth Factors for the Treatment of Dry Eye after LASIK Surgery
Conclusions: These results suggest that PRGF eye drops are effective for the improvement of dry eye symptoms in patients who underwent LASIK surgery in comparison to the conventional therapy. The treatment with PRGF is an alternative for patients who suffer from postoperative dry eye.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 8, 2018 Category: Opthalmology Source Type: research

The Modification of Fluorescein Angiography and Its Applications in Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy
Conclusions: The absorption coefficients in RFA provided more detailed images for AMD and PCV diagnosis. RFA is therefore a promising approach to supplement FFA.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 7, 2018 Category: Opthalmology Source Type: research

The Role of Retinal Vascular Density as a Screening Tool for Ageing and Stroke
Conclusion: Age and stroke are significant risk factors for decreased RVD. Diabetes and arterial hypertension are additional significant risk factors in patients with stroke with respect to RVD.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 6, 2018 Category: Opthalmology Source Type: research

IL-1 α and MMP-9 Tear Levels of Patients with Active Ocular Rosacea before and after Treatment with Systemic Azithromycin or Doxycycline
Conclusions: While IL-1 α levels decreased after azithromycin therapy, MMP-9 did so after doxycycline treatment. Baseline cytokine tear levels tend to be markedly elevated in patients with antibiotic failure, suggesting their potential role as therapeutic biomarkers for the disease.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - June 6, 2018 Category: Opthalmology Source Type: research

Short-Term Intraocular Pressure Rise during Locally Induced Force by Ophthalmologic Surgery Applications
Conclusion: The values of the forces applied can be converted into the resulting IOP based on the specific action. Surgical or diagnostic procedures should, therefore, be evaluated with regard to preexisting pathologies, such as glaucoma.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - May 31, 2018 Category: Opthalmology Source Type: research

Autologous Neurosensory Retinal Transplantation for Unclosed and Large Macular Holes
Conclusions: Autologous neurosensory retinal patch transplantation is an effective addition to the surgical options for large MH-induced retinal detachment after failed surgery with ILM removal or transplantation.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - May 29, 2018 Category: Opthalmology Source Type: research

Peripheral Microvascular Abnormalities Detected by Wide-Field Fluorescein Angiography in Eyes with Branch Retinal Vein Occlusion
Conclusion: The presence of peripheral abnormalities or scatter PC for NPAs did not affect the visual outcome in eyes with BRVO.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - May 29, 2018 Category: Opthalmology Source Type: research

Optical Coherence Tomography Angiography in Glaucoma: A Review
Conclusion: OCTA shows potential to become a part of everyday glaucoma management.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - May 29, 2018 Category: Opthalmology Source Type: research

Comparing Cytokine Kinetics between Ranibizumab and Aflibercept in Central Retinal Vein Occlusion with Macular Edema
Conclusions: In CRVO patients, both ranibizumab and aflibercept achieved similar improvement in clinical parameters and similar reductions in aqueous VEGF, PlGF, MCP-1, and IL-6 levels.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - May 29, 2018 Category: Opthalmology Source Type: research

Optimizing Genipin Concentration for Corneal Collagen Cross-Linking: An ex vivo Study
Conclusions: Genipin 0.5%, in a 140- µL drop applied hourly for 2 h, showed better potential to enhance corneal stiffness and stability through inducing CXL.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - May 29, 2018 Category: Opthalmology Source Type: research

Ultrasound Cyclo-Plasty in Patients with Glaucoma: 1-Year Results from a Multicentre Prospective Study
Conclusions: UCP is safe and effective for reducing IOP. The procedure determines a greater IOP reduction in patients with higher preoperative IOP. Second-generation probes improve outcomes without detrimental effects on safety.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - May 16, 2018 Category: Opthalmology Source Type: research

Animal Models of Proliferative Vitreoretinopathy and Their Use in Pharmaceutical Investigations
Animal models are indispensable for pharmaceutical investigations. However, investigators often have difficulty choosing the appropriate modal for their research. To provide a comprehensive and convenient source of information about animal models of proliferative vitreoretinopathy (PVR), the current review sorted and analyzed representative animal models for pharmacotherapy of PVR since 1976.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - May 3, 2018 Category: Opthalmology Source Type: research

Autophagy: A Role in the Apoptosis, Survival, Inflammation, and Development of the Retina
Autophagy is a lysosomal degradation process that maintains cellular homeostasis by removing dysfunctional organelles and unfolded proteins. Increasing evidence has shown that autophagy proteins are involved in retinal physiology and pathology and that defective autophagy contributes to retinal degeneration. In retinal diseases, autophagy plays a dual role: promoting retinal cell survival and death. Autophagy at a normal level helps retinal cells defend themselves against harmful stress; however, excessive autophagy results in retinal deterioration. Both synergistic and antagonistic roles of autophagy and apoptosis in the ...
Source: Ophthalmic Research - April 25, 2018 Category: Opthalmology Source Type: research

Findings of Optical Coherence Tomography Angiography in Best Vitelliform Macular Dystrophy
Conclusions: Vascular changes in BVMD were apparent in the choriocapillary layer. The changes became more striking in late stages of the disease. OCTA provides useful quantitative measurements for staging and monitoring the progression of BVMD.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - April 13, 2018 Category: Opthalmology Source Type: research

Visual Field Variability after Gene Therapy for Leber ’s Hereditary Optic Neuropathy
Conclusion: There was a statistically significant VF improvement after gene therapy. This suggests that monocular intravitreal injection of AAV2-ND4 can improve binocular VF values. This study also suggests that gene therapy can be effective in patients with a disease duration of #x3e; 2 years.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - April 12, 2018 Category: Opthalmology Source Type: research

A Pathogenetic Classification of Diabetic Macular Edema
Conclusion: The study offers a new pathogenetic classification able to detect significant differences among DME subtypes. A tailored therapeutic approach could take into consideration specific changes associated with the different DME subtypes.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - April 11, 2018 Category: Opthalmology Source Type: research

Cyclophosphamide or Rituximab Treatment of Scleritis and Uveitis for Patients with Granulomatosis with Polyangiitis
Conclusions: Cyclophosphamide and rituximab are safe and effective agents for controlling scleritis and uveitis associated with GPA, with eventual progression towards steroid-sparing remission.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - April 10, 2018 Category: Opthalmology Source Type: research

Meibomian Gland Dysfunction in Primary and Secondary Sj ögren Syndrome
Conclusions: Our findings support our hypothesis and show that individuals with pSS, sSS + SLE, and sSS + RA have MGD. In addition, our study indicates that patients with pSS and sSS have both aqueous-deficient and evaporative DED.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - April 6, 2018 Category: Opthalmology Source Type: research

Assessment of Corneal Changes Associated with Topical Antiglaucoma Therapy Using in vivo Confocal Microscopy
Purpose: Ocular surface disease (OSD) is highly prevalent in eyes treated with chronic, topical antiglaucoma (A/G) therapy. The purpose of this study was to utilize in vivo confocal microscopy (IVCM) to evaluate the corneal morphology, including characteristics of corneal epithelial cells, presence of epithelial dendritic cells (DCs), and characteristics of subbasal nerve plexus, of eyes under topical A/G therapy versus normal eyes.Methods: Central corneal images were prospectively captured from 30 eyes of 16 patients under topical A/G therapy (>6 months) and 20 normal control eyes, using IVCM (HRT 3 RCM, Heidelberg, Ge...
Source: Ophthalmic Research - April 6, 2018 Category: Opthalmology Source Type: research

Peripheral Retinal Imaging Biomarkers for Alzheimer ’s Disease: A Pilot Study
Conclusions: UWF retinal imaging revealed a significant association between AD and peripheral hard drusen formation and changes to the vasculature beyond the posterior pole, at BL and after clinical progression over 2 years, suggesting that monitoring pathological changes in the peripheral retina might become a valuable tool in AD monitoring.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - April 5, 2018 Category: Opthalmology Source Type: research

Curcumin Alleviates Diabetic Retinopathy in Experimental Diabetic Rats
Conclusions: Taken together, these results suggest that curcumin may have great therapeutic potential in the treatment of diabetic retinopathy which could be attributed to the hypoglycemic, antioxidant, VEGF-downregulating and neuroprotection properties of curcumin.Ophthalmic Res (Source: Ophthalmic Research)
Source: Ophthalmic Research - March 29, 2018 Category: Opthalmology Source Type: research