7-Methylxanthine Influences the Behavior of ADORA2A-DRD2 Heterodimers in Human Retinal Pigment Epithelial Cells

Conclusions: ADORA2A and DRD2 heterodimers were present in RPE cells. 7-MX may affect the behaviors of RPE cel ls through the ADORA2A-DRD2 receptor pathway. 7-MX is an inhibitor of ADORA2A receptors that can prevent inhibition of the D2 receptor pathway and increase D2 receptor pathway activity. This phenomenon may explain the mechanism of action through which 7-MX can control myopia progression.
Source: Ophthalmic Research - Category: Opthalmology Source Type: research