Trends in Indications and Techniques of Corneal Transplantation from 1999 through 2015 at a Tertiary Referral Center in Athens, Greece.
Conclusion: Herein, we observed an increasing trend of endothelial pathology among keratoplasty indications as well as a major shift in preferred techniques due to a wide adoption of the new EK procedures. PMID: 30079255 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - August 7, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Customized Toric Intraocular Lens Implantation in Eyes with Cataract and Corneal Astigmatism after Deep Anterior Lamellar Keratoplasty: A Prospective Study.
Authors: Schiano Lomoriello D, Savini G, Naeser K, Colabelli-Gisoldi RM, Bono V, Pocobelli A Abstract Purpose: To investigate the effectiveness of toric intraocular lenses (IOLs) for treating corneal astigmatism in patients with cataract and previous deep anterior lamellar keratoplasty (DALK). Setting: San Giovanni-Addolorata Hospital, Rome, Italy. Design: Prospective interventional case series. Methods: Patients undergoing cataract surgery after DALK for keratoconus were enrolled. Total corneal astigmatism (TCA) was assessed by a rotating Scheimpflug camera combined with Placido-disk corneal topography...
Source: Journal of Ophthalmology - July 31, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

A Comparative Study of Vitrectomy Combined with Internal Limiting Membrane Peeling for the Treatment of Idiopathic Macular Hole with Air or C3F8 Intraocular Tamponade.
Conclusions: In idiopathic macular hole surgery, the effect of air as an intraocular tamponade material can be similar to that of C3F8 but has fewer complications. In particular, it is a better choice for patients for whom the face-down position is not suitable. PMID: 30057803 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 31, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Two-Year Outcomes of Visian Implantable Collamer Lens with a Central Hole for Correcting High Myopia.
Conclusion: Implantation of ICL V4c is a safe, effective, and predictable procedure for correcting high myopia. Reduction of anterior chamber space after surgery did not induce intraocular pressure increase during the 2-year follow-up. PMID: 30057804 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 31, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Descriptive Study of Conjunctival Cysts: A Rare Complication after Strabismus Surgery.
Conclusions: Conjunctival cyst is a rare postoperative complication of strabismus surgery, conjunctival epithelium implantation should be the primary cause, and infection might exaggerate the situation. A longer duration of the surgical procedure could increase the possibility of infection, which could be accompanied with a greater tendency to the occurrence of conjunctival cyst. PMID: 30046458 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Efficacy and Safety of Intravitreal Conbercept, Ranibizumab, and Triamcinolone on 23-Gauge Vitrectomy for Patients with Proliferative Diabetic Retinopathy.
Authors: Cui J, Chen H, Lu H, Dong F, Wei D, Jiao Y, Charles S, Gu W, Wang L Abstract Introduction: To compare the effect and safety of intravitreal conbercept (IVC), intravitreal ranibizumab (IVR), or intravitreal triamcinolone acetonide (IVTA) injection on 23-gauge (23-G) pars plana vitrectomy (PPV) for proliferative diabetic retinopathy (PDR). Methods: Fifty patients (60 eyes) of varying degrees of PDR were randomly grouped into 3 groups (1 : 1 : 1) (n = 20 in each group). The 23-G PPV was performed with intravitreal conbercept or ranibizumab injection 3-7 days before surge...
Source: Journal of Ophthalmology - July 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Clinical Features and Surgical Outcomes of Posterior Segment Intraocular Foreign Bodies in Children in East China.
Conclusions: The clinical features of pediatric posterior segment IOFBs suggest insufficient awareness of such injuries both on the playground and at school. Visual outcomes from surgical treatment were relatively favorable in this series. PMID: 30046460 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Outcomes of Corneal Tattooing by Rotring Painting Ink in Disfiguring Corneal Opacities.
Conclusions: Corneal tattooing with Rotring painting ink in blind disfigured eyes achieves favourable cosmetic results and is associated with high patient satisfaction. With better case selection, a high post-op satisfaction was achieved. Corneal tattooing acts as an alternative to more sophisticated and expensive cosmetic reconstructive surgery. This trial is registered with ISRCTN46626979. PMID: 30046461 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comparison of 25- and 27-Gauge Pars Plana Vitrectomy in Repairing Primary Rhegmatogenous Retinal Detachment.
Conclusion: The 27G TSV system is safe and useful for RRD treatment as 25G TSV. PMID: 30046462 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Myopia: Risk Factors, Disease Mechanisms, Diagnostic Modalities, and Therapeutic Options.
Authors: Mrugacz M, Gajecka M, Mrukwa-Kominek E, Witkowska KJ PMID: 30046463 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Clinical Results of Diffractive, Refractive, Hybrid Multifocal, and Monofocal Intraocular Lenses.
Authors: Dyrda A, Martínez-Palmer A, Martín-Moral D, Rey A, Morilla A, Castilla-Martí M, Aronés-Santivañez J Abstract Purpose: To present the outcomes of hybrid multifocal and monofocal intraocular lenses (IOLs) and to compare with refractive and diffractive multifocal IOLs (MFIOLs). Methods: Three hundred twenty eyes (160 patients) underwent cataract surgery with randomized IOLs bilateral implantation. Changes in uncorrected and distance-corrected logMAR distance, intermediate and near (UNVA and DCNVA) visual acuity (VA), contrast sensitivity (CS), presence of dysphotopsia, s...
Source: Journal of Ophthalmology - July 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Peripapillary Vessel Density Reversal after Trabeculectomy in Glaucoma.
Conclusions: A significant increase in the peripapillary vessel density was demonstrated after trabeculectomy using OCT angiography. The reversal of peripapillary vessel density was associated with higher preoperative IOP and greater IOP reduction. Our postoperative results suggest that the ocular perfusion impairment by high intraocular pressure can be improved by IOP reduction, and the reversal of microvasculature may contribute to the rate of glaucoma progression. PMID: 30046465 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Pediatric Traumatic Retinal Detachment: Clinical Features, Prognostic Factors, and Surgical Outcomes.
Conclusions: Visual outcomes are poorer compared to anatomical outcomes. OTS and POTS do not provide reliable prognostic information if the patient has RD. Presenting visual acuity, the presence of macula-off RD, and PVR are all important predictors of final visual acuity. PMID: 30046466 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

From Presbyopia to Cataracts: A Critical Review on Dysfunctional Lens Syndrome.
Authors: Fernández J, Rodríguez-Vallejo M, Martínez J, Tauste A, Piñero DP Abstract Dysfunctional lens syndrome (DLS) is a term coined to describe the natural aging changes in the crystalline lens. Different alterations in the refractive properties and transparency of the lens are produced during the development of presbyopia and cataract, such as changes in internal high order aberrations or an increase in ocular forward scattering, with a potentially significant impact on clinical measures, including visual acuity and contrast sensitivity. Objective technologies have emerged to solve t...
Source: Journal of Ophthalmology - July 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Corneal Cap Thickness and Its Effect on Visual Acuity and Corneal Biomechanics in Eyes Undergoing Small Incision Lenticule Extraction.
Authors: Liu T, Yu T, Liu L, Chen K, Bai J Abstract Purpose: To evaluate the effect of corneal cap thickness on visual acuity and corneal biomechanics in small incision lenticule extraction (SMILE) for the treatment of myopia. Methods: Forty eyes of 20 patients undergoing SMILE for the treatment of myopia were enrolled in this prospective controlled study. The patients with 510 μm-560 μm central corneal thickness (CCT) and a refractive spherical equivalent of -3.00 D to -8.00 D were included. It was designed randomly to undergo SMILE with a 110 μm cap thickness in one...
Source: Journal of Ophthalmology - July 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Emerging Therapeutic Strategies for Limbal Stem Cell Deficiency.
Authors: Dong Y, Peng H, Lavker RM Abstract Identification and characterization of the limbal epithelial stem cells (LESCs) has proven to be a major accomplishment in anterior ocular surface biology. These cells have been shown to be a subpopulation of limbal epithelial basal cells, which serve as the progenitor population of the corneal epithelium. LESCs have been demonstrated to play an important role in maintaining corneal epithelium homeostasis. Many ocular surface diseases, including intrinsic (e.g., Sjogren's syndrome) or extrinsic (e.g., alkali or thermal burns) insults, which impair LESCs, can lead to limba...
Source: Journal of Ophthalmology - July 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Reduction in Ocular Hypotensive Eyedrops by Ab Interno Trabeculotomy Improves Not Only Ocular Surface Condition But Also Quality of Vision.
Authors: Kashiwagi K, Matsubara M Abstract Purpose: To investigate the effect of ab interno trabeculotomy using the Trabectome surgical system on tear film stability and functional visual acuity (FVA). Patients and Methods: Adult glaucoma patients who underwent Trabectome surgery alone or Trabectome surgery combined with phacoemulsification with intraocular lens insertion were included in this study. Corneal epithelial defects, tear film breakup time (TBUT), tear meniscus height, tear film spreading grade, tear interferometry grade, and FVA were assessed before and after surgery in addition to routine ophthalmi...
Source: Journal of Ophthalmology - July 25, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Prevalence and Associations of Peripheral Retinopathy: Baseline Study of Guangzhou Office Computer Workers.
Authors: Zhang T, Zuo Y, Wei Y, Huang W, Zhou X, Liu R, Zhong L, Peng M, Zhang S Abstract Purpose: To determine the prevalence of peripheral retinopathy and its associated risk factors among a sample of Guangzhou office computer workers. Methods: A cross-sectional study of Guangzhou Chinese computer workstations and operators in different departments and units of the Guangzhou Power Supply Bureau, China, in 2016. Peripheral retinopathy was recorded and analyzed using a scanning laser ophthalmoscope (SLO; Optos, Daytona, United Kingdom) and slit-lamp microscopy combined with a three-mirror contact lens. Resu...
Source: Journal of Ophthalmology - July 22, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Association between Female Reproductive Factors and Open-Angle Glaucoma in Korean Women: The Korean National Health and Nutrition Examination Survey V.
Conclusions: Only early menopause was associated with an increased risk of OAG in our study, in contrast to previous Western studies reporting both early menopause and late menarche as associated factors. PMID: 30026984 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 22, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Clinical Efficacy of Platelet-Rich Plasma in the Treatment of Neurotrophic Corneal Ulcer.
Authors: Wróbel-Dudzińska D, Alio J, Rodriguez A, Suchodoła-Ratajewicz E, Kosior-Jarecka E, Rymgayłło-Jankowska B, Ćwiklińska-Haszcz A, Żarnowski T Abstract Purpose: Platelet-rich plasma (PRP) is an autologous blood product without preservatives and rich in proteins and growth factors which make it possible for cells to differentiate, proliferate, and migrate, thus stimulating healing and regeneration of tissues. The aim of this study was to evaluate the efficiency of autologous platelet-rich plasma in the treatment of neurotrophic keratopathy. Methods: The study group consists of 25 patients with...
Source: Journal of Ophthalmology - July 22, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Ahmed Glaucoma Valves versus EX-PRESS Devices in Glaucoma Secondary to Silicone Oil Emulsification.
Authors: Qian Z, Xu K, Kong X, Xu H Abstract Objective: To evaluate and compare the clinical effects of Ahmed glaucoma valves (AGVs) and EX-PRESS implants on glaucoma secondary to silicone oil (SO) emulsification. Methods: A retrospective case-series study was designed. A total of 23 eyes with late intraocular pressure (IOP) elevation secondary to SO emulsification were included in the study. Antiglaucoma surgery with implantation of AGVs or EX-PRESS devices was performed. Pre- and postoperative ocular parameters were recorded at each visit during a 1-year follow-up period. The rates of complete success (IOP 
Source: Journal of Ophthalmology - July 22, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Early Results with a New Posterior Chamber Phakic Intraocular Lens in Patients with High Myopia.
Authors: Yaşa D, Ürdem U, Ağca A, Yildirim Y, Kepez Yildiz B, Kandemir Beşek N, Yiğit U, Demirok A Abstract Purpose: To report clinical results of a foldable, hydrophilic acrylic, single-piece, injectable, posterior chamber phakic intraocular lens (pIOL). Material and Methods: Medical records of patients who underwent posterior chamber phakic IOL (Eyecryl Phakic IOL, Biotech Vision Care, Ahmedabad, India) implantation for surgical correction of myopia were retrospectively reviewed. Only patients with at least a one-year follow-up were included. Manifest refraction, uncorrected distance visual acuity (U...
Source: Journal of Ophthalmology - July 20, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Effect of Steep Trendelenburg Positioning on Retinal Structure and Function during Robotic-Assisted Laparoscopic Procedures.
Conclusions: Although IOP significantly increased during RALP, there were no significant changes in the retinal structure and function between the pre- and postoperation observations. PMID: 30009047 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 18, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Psychological Aspects and Depression in Patients with Symptomatic Keratoconus.
Authors: Moschos MM, Gouliopoulos NS, Kalogeropoulos C, Androudi S, Kitsos G, Ladas D, Tsatsos M, Chatziralli I Abstract Purpose: To assess the psychological status of keratoconus sufferers and to determine the relationship between depression and visual impairment in this group of patients. Methods: Fifty-six patients with keratoconus and forty-seven age- and gender-matched healthy control subjects were retroprospectively analyzed. Every participant underwent a complete ophthalmological examination. Keratoconus diagnosis was confirmed with corneal topography and tomography. Zung Depression Inventory Questionnai...
Source: Journal of Ophthalmology - July 15, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Association of Genes in the High-Density Lipoprotein Metabolic Pathway with Polypoidal Choroidal Vasculopathy in Asian Population: A Systematic Review and Meta-Analysis.
Authors: Yuan MZ, Han RA, Zhang CX, Chen YX Abstract Purpose: To assess the association of genes in the high-density lipoprotein metabolic pathway (HDLMP) with polypoidal choroidal vasculopathy (PCV) and the genetic difference in the HDLMP between PCV and age-related macular degeneration (AMD). Methods: We performed a literature search in EMBASE, PubMed, and Web of Science for genetic studies on 7 single nucleotide polymorphisms (SNPs) from 5 genes in the HDLMP including cholesteryl ester transfer protein (CETP), hepatic lipase (LIPC), lipoprotein lipase (LPL), ATP-binding cassette transporter A1 (ABCA1), and A...
Source: Journal of Ophthalmology - July 8, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Protection of Corneal Limbus from Riboflavin Prevents Epithelial Stem Cell Loss after Collagen Cross-Linking.
Conclusions: Protection of limbus from riboflavin during CXL was effective in preserving LESCs. However, inflammation was increased in the cornea treated with riboflavin using a ring. PMID: 29967694 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 4, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Effects of Uncomplicated Cataract Surgery on Retinal Layer Thickness.
Authors: Kurt A, Kılıç R Abstract Purpose: Our aim was to assess changes in the total retinal thickness (TRT), total retinal volume (TRV), and retinal layer thickness after uncomplicated cataract surgery. Methods: A total of 32 eyes of 32 patients who had undergone uncomplicated phacoemulsification surgery and intraocular lens implantation in one eye were enrolled. Effective phacoemulsification time (EPT) and total energy (TE) were recorded. Thickness and TRV were measured using optical coherence tomography. Data were collected preoperatively and at postoperative day 1, 7, 30, 90, and 180. Results:...
Source: Journal of Ophthalmology - July 4, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Choroidal Thickness in Chinese Children Aged 8 to 11 Years with Mild and Moderate Myopia.
Authors: Qi Y, Li L, Zhang F Abstract Purpose: To investigate macular choroidal thickness (CT), topographical variation, and associations between subfoveal choroidal thickness (SFCT) and age, gender, spherical equivalent (SE), and axial length (AL) in Chinese healthy mild and moderate myopia children aged 8 to 11 years. Methods: One hundred twenty eyes from 120 healthy children were studied. Children were divided into mild and moderate myopia groups. AL and CT were evaluated. CTs were measured at the fovea, and 1 mm, 2 mm, and 3 mm nasal, temporal, superior, and inferior to the fovea. R...
Source: Journal of Ophthalmology - July 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Bandage Lenses in the Postoperative Care for Cataract Surgery Patients: A Substitute for Eye Patch?
Conclusion: Bandage lenses can be used as a safe and effective substitute for eye patch in the postoperative care for cataract surgery patients. The Clinical Study registration number is ChiCTR-IOC-17012167. PMID: 29887990 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 13, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Modern Corneal Eye-Banking Using a Software-Based IT Management Solution.
Conclusion: The new software for corneal eye banking supports the whole process chain by taking over both most of the required documentation and the management of the transplant waiting list. It may provide a standardized IT-based solution for German eye banks working within the same HIS. PMID: 29887991 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 13, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Patient and Surgeon Satisfaction Levels after Using an Acrylic, Hydrophobic, Monofocal IOL and the Malyugin Ring in Pseudoexfoliation Syndrome Patients.
Conclusion: Our results show that the implantation of the fully preloaded CT LUCIA 601P (Zeiss, Germany) is safe and enhances OR workflow in complicated cases as pseudoexfoliation. In these cases, an adapted approach (special preoperative, intraoperative, and postoperative regime) with considering possible complications is necessary to achieve best outcomes. PMID: 29887992 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 13, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Nanophthalmos: A Review of the Clinical Spectrum and Genetics.
Authors: Carricondo PC, Andrade T, Prasov L, Ayres BM, Moroi SE Abstract Nanophthalmos is a clinical spectrum of disorders with a phenotypically small but structurally normal eye. These disorders present significant clinical challenges to ophthalmologists due to a high rate of secondary angle-closure glaucoma, spontaneous choroidal effusions, and perioperative complications with cataract and retinal surgeries. Nanophthalmos may present as a sporadic or familial disorder, with autosomal-dominant or recessive inheritance. To date, five genes (i.e., MFRP, TMEM98, PRSS56, BEST1, and CRB1) and two loci have been implica...
Source: Journal of Ophthalmology - June 5, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Characterization of Soft Contact Lens Edge Fitting during Daily Wear Using Ultrahigh-Resolution Optical Coherence Tomography.
Authors: Cui L, Chen S, Zhou W, Sheng K, Zhang L, Shen M, Li M Abstract Purpose: To determine conjunctival overlap over the edge of soft contact lens and to visualize the peripheral postlens tear film (PoLTF) underneath soft contact lenses using ultrahigh-resolution optical coherence tomography (UHR-OCT). Methods: Twenty participants (4 males and 16 females, 23.0 ± 3.7 years) were fitted with two different types of soft contact lenses randomly. The limbus with lens was imaged with the UHR-OCT at the horizontal meridian every two hours up to 6 hours during lens wear. The conjunctival overlap...
Source: Journal of Ophthalmology - June 5, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Effects of Ageing on the Anterior Segment of the Eye Structure and Function.
Authors: Cerviño A, Radhakrishnan H, Alfonso JF, Brautaset R, González-Meijome JM PMID: 29862065 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 5, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Continuation of Aspirin Therapy before Cataract Surgery with Different Incisions: Safe or Not?
Conclusions: The outcomes indicated that phacoemulsification cataract surgery under topical anesthesia could be safely performed without ceasing systemic aspirin therapy. Clear corneal incision could be a better choice in patients treated with aspirin. PMID: 29862066 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 5, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comparison of SNP Genotypes Related to Proliferative Vitreoretinopathy (PVR) across Slovenian and European Subpopulations.
Authors: Lumi X, Jelen MM, Jevšinek Skok D, Boštjančič E, Ravnik-Glavač M, Hawlina M, Glavač D Abstract The present study investigated the distribution of genotypes within single nucleotide polymorphisms (SNPs) in genes, related to PVR pathogenesis across European subpopulations. Genotype distributions of 42 SNPs among 96 Slovenian healthy controls were investigated and compared to genotype frequencies in 503 European individuals (Ensembl database) and their subpopulations. Furthermore, a case-control status was simulated to evaluate effects of allele frequency changes on statistically significant...
Source: Journal of Ophthalmology - June 5, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Ahmed Glaucoma Valve Implantation in Vitrectomized Eyes.
Conclusions: Despite complications necessitating medical and surgical interventions, vitrectomized eyes were effectively managed with AGV implantation. PMID: 29862068 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 5, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Application of Novel Drugs for Corneal Cell Regeneration.
Authors: Han SB, Liu YC, Mohamed-Noriega K, Mehta JS Abstract Corneal transplantation has been the only treatment method for corneal blindness, which is the major cause of reversible blindness. However, despite the advancement of surgical techniques for corneal transplantation, demand for the surgery can never be met due to a global shortage of donor cornea. The development of bioengineering and pharmaceutical technology provided us with novel drugs and biomaterials that can be used for innovative treatment methods for corneal diseases. In this review, the authors will discuss the efficacy and safety of pharmacolog...
Source: Journal of Ophthalmology - June 3, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Age Differences in Axial Length, Corneal Curvature, and Corneal Astigmatism in Marfan Syndrome with Ectopia Lentis.
This study included 114 MFS patients (215 eyes) with a mean age of 19.0 ± 13.9 years. Axial length differed significantly across age groups in MFS patients (P
Source: Journal of Ophthalmology - June 3, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Flt3 Regulation in the Mononuclear Phagocyte System Promotes Ocular Neovascularization.
Authors: Gao Y, Zhong Y, Zhu Y, Demetriades AM, Cai Y, Shen J, Lu Q, Shen X, Xie B Abstract Fms-like tyrosine kinase 3 (Flt3), a tyrosine kinase receptor expressed in CD34+ hematopoietic stem/progenitor cells, is important for both normal myeloid and lymphoid differentiation. It has been implicated in mice and humans for potential multilineage differentiation. We found that mice deficient in Flt3 or mice that received an Flt3 inhibitor (AC220) showed significantly reduced areas of ischemia-induced retinal neovascularization (RNV) and laser-induced choroidal NV (CNV) (P
Source: Journal of Ophthalmology - June 3, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Evaluation of Navigated Laser Photocoagulation (Navilas 577+) for the Treatment of Refractory Diabetic Macular Edema.
Authors: Kato F, Nozaki M, Kato A, Hasegawa N, Morita H, Yoshida M, Ogura Y Abstract Purpose: To evaluate navigated laser photocoagulation for the treatment of refractory diabetic macular edema (DME). Methods: Retrospective study of 25 eyes (21 patients) treated with Navilas 577+ focal laser system. Best-corrected visual acuity (BCVA) and spectral-domain optical coherence tomography (OCT) parameters were measured at baseline, 1, 3, and 6 months, and final visit. Results: The mean follow-up period was 12.8 ± 2.4 (7-16 months). All subjects had history of previous treatment which was inje...
Source: Journal of Ophthalmology - June 3, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Role of the Epipapillary Membrane in Maculopathy Associated with Cavitary Optic Disc Anomalies: Morphology, Surgical Outcomes, and Histopathology.
Conclusions: These results suggest that epipapillary membrane is involved in the pathogenesis of some patients with cavitary optic disc anomaly-associated maculopathy as well as posterior hyaloid membrane. PPV with epipapillary membrane removal may be a useful treatment option for this maculopathy. This trial is registered with UMIN000011123. PMID: 29854427 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 3, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Mutation Spectrum of the ABCA4 Gene in a Greek Cohort with Stargardt Disease: Identification of Novel Mutations and Evidence of Three Prevalent Mutated Alleles.
Conclusions: By using a combination of methods, we completely molecularly diagnosed 48 of the 59 patients studied. In addition, we identified six previously unreported, potentially pathogenic ABCA4 mutations. PMID: 29854428 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 3, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Evaluation of Vitrectomy with Planned Foveal Detachment as Surgical Treatment for Refractory Diabetic Macular Edema with or without Vitreomacular Interface Abnormality.
Conclusion: Vitrectomy with a planned foveal detachment technique was shown to be a promising solution for refractory DME cases with rapid edema resolution. CMT was shown to improve more in eyes where conventional vitrectomy was not attempted. Moreover, cases with VMA resistant to pharmacotherapy was shown to respond well to this technique. The study has been registered in Contact ClinicalTrials.gov PRS Identifier: NCT03345056. PMID: 29854429 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 3, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Vision-Threatening Behcet's Disease: Severity of Ocular Involvement Predictors.
Conclusion: Certain findings in Behcet's disease may act as predictors for the severity of ocular affection. Directing our attention to these factors by the internist and ophthalmologist can help plan the frequency of follow-up as well as the aggressiveness of treatment in patients with Behcet's disease. PMID: 29854430 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 3, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Mapping the Structure-Function Relationship in Glaucoma and Healthy Patients Measured with Spectralis OCT and Humphrey Perimetry.
Conclusions: Both maps and point-to-point functions obtained linking structure and function damage contribute to a better understanding of this relationship and may help in the future to improve glaucoma diagnosis. PMID: 29850196 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Evaluating Eye Drop Instillation Technique and Its Determinants in Glaucoma Patients.
Conclusions: Eye drop instillation technique in glaucoma patients deserves great attention from eye care practitioners during their lifelong follow-up, especially those aged older and have worse visual acuity. PMID: 29850197 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Internal Astigmatism and Its Role in the Growth of Axial Length in School-Age Children.
Authors: Wu L, Weng C, Xia F, Wang X, Zhou X Abstract Objectives: To explore the role of internal astigmatism (IA) in the growth of axial length (AL) in school-age children. Methods: Total astigmatism (TA), corneal astigmatism (CA), and AL of all children in Jing'an District 2nd Centre Primary School in Shanghai were measured. In IA, the difference between TA and CA was also calculated using vector analysis. The association of axial length with IA, genders, and age was analyzed using linear regression. The difference of IA between both eyes was also calculated. The AL between both eyes was compared using paired...
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comparison of the Effect of Intravitreal Dexamethasone Implant in Vitrectomized and Nonvitrectomized Eyes for the Treatment of Diabetic Macular Edema.
Authors: Çevik SG, Yılmaz S, Çevik MT, Akalp FD, Avcı R Abstract Purpose: To compare the effectiveness of sustained-release dexamethasone (DEX) intravitreal implant in nonvitrectomized eyes and vitrectomized eyes with diabetic macular edema (DME). Methods: A retrospective review of the medical records of 40 eyes of 30 consecutive patients with diabetic macular edema who underwent intravitreal DEX implant injection. Patients were divided into 2 subgroups: 31 eyes that were nonvitrectomized (group 1) and 9 eyes that had previously undergone standard pars plana vitrectomy (group 2). The main outcom...
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Effect of Age on Pentacam Keratoconus Indices.
Authors: Roshdy MMS, Wahba SS, Elkitkat RS, Hakim AM, Fikry RR Abstract Purpose: To assess the effect of age on elevation and pachymetric Pentacam keratoconus (KC) detection indices, and the need to adjust normative values accordingly. Methods: In a retrospective study, 95 eyes of myopic normal subjects without KC were evaluated using the OCULUS Pentacam, with an age range of 17.4 to 46.8 years. Subjects were categorised into three groups according to their age: the first included those younger than 21 years (19 eyes), the second was for the age range of 21-40 years (65 eyes), and the third compri...
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research