Changes of Subfoveal Choroidal Thickness after Cataract Surgery: A Meta-Analysis.
Authors: Zeng S, Liang C, He Y, Chen Y, Zhao Q, Dai S, Cheng F, Zhang J, Jiang X Abstract Purpose: To investigate the effect of cataract surgery on subfoveal choroid thickness (SFCT) using enhanced-depth imaging optical coherence tomography (EDI-OCT). Materials and Methods: Relevant publications were searched systematically through various databases from inception to March 2018. The unit of choroidal thickness measurements is micrometers. Studies comparing SFCT before and after cataract surgery were retrieved. All qualified articles were analyzed using RevMan 5.3. Results: A total of 13 studies with 802 eye...
Source: Journal of Ophthalmology - January 5, 2019 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Long-Term Anatomic and Functional Outcomes after Macular Hole Surgery.
Authors: Kaźmierczak K, Stafiej J, Stachura J, Żuchowski P, Malukiewicz G Abstract Aim: To evaluate the structural and functional outcomes in patients who underwent macular hole (MH) surgery in the long-term follow-up. Materials and Methods: Forty-four eyes of 40 patients (28 females and 12 males) were examined. The examination included visual acuity, optical coherence tomography, and colour vision testing. The same evaluation was performed in 30 fellow eyes. Results: MH closure was obtained in 42 eyes (95.45%). There was no reopening of the initially closed MHs. In long-term postoperative examination, we...
Source: Journal of Ophthalmology - January 2, 2019 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Navigation-Guided Endoscopy Combined with Deep Lateral Orbitotomy for Removal of Small Tumors at the Lateral Orbital Apex.
Conclusions: Navigation-guided endoscopy combined with deep lateral orbitotomy seems to be a feasible, efficient, and safe approach for removing small tumors at the lateral orbital apex. This trial is registered with ChiCTR1800019244. PMID: 30595911 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - January 1, 2019 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Combined Surgical Techniques for the Management of Malignant Glaucoma.
Conclusions: The combined surgical methods can completely eliminate blockade and aqueous misdirection and represent a promising treatment for malignant glaucoma. PMID: 30595912 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - January 1, 2019 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Peak Occurrence of Retinal Detachment following Cataract Surgery: A Systematic Review and Pooled Analysis with Internal Validation.
Authors: Kassem R, Greenwald Y, Achiron A, Hecht I, Man V, Ben Haim L, Bukelman A Abstract Introduction: Timing of retinal detachment (RD) following cataract surgery is of importance for both diagnostic and prognostic factors. However, results on RD onset-time following cataract surgery have been conflicting. Method: A systematic pooled analysis of the literature regarding timing of retinal detachment following cataract surgery. Outcomes were verified against an independent dataset. Results: Twenty-one studies, reporting on rates of RD in 3,352,094 eyes of 2,458,561 patients, met our inclusion criteria and ...
Source: Journal of Ophthalmology - January 1, 2019 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Risk Factors for Endothelial Decompensation after Penetrating Keratoplasty and Its Novel Therapeutic Strategies.
Conclusions: Any direct or indirect damage to the endothelium could cause the loss, morphological changes, and dysfunction of endothelial cells. Graft size, indications, and recipient glaucoma or glaucoma surgery history are risk factors for endothelial decompensation. DSAEK and DMEK are novel therapeutic strategies for failed PKP grafts and have potential superiorities compared with repeat PKP. PMID: 30581601 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - December 26, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Prechoroidal Cleft in Type 3 Neovascularization: Incidence, Timing, and Its Association with Visual Outcome.
Authors: Kim JH, Chang YS, Kim JW, Kim CG, Lee DW Abstract Purpose: To investigate the incidence and timing of prechoroidal cleft development and its association with visual prognosis in type 3 neovascularization. Methods: This retrospective study included 166 eyes that were diagnosed with type 3 neovascularization. All eyes were treated with antivascular endothelial growth factor therapy. The incidence and timing of prechoroidal cleft development were evaluated. Best-corrected visual acuity (BCVA) at diagnosis and at final follow-up was compared between eyes with (cleft group) and without (no-cleft group) prec...
Source: Journal of Ophthalmology - December 26, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Under-the-Flap Crosslinking and LASIK in Early Ectasia with Hyperopic Refractive Error.
Conclusion: Early results showed that under-the-flap CXL with excimer laser correction is an effective treatment for early hyperopic keratectasia, with the advantage of rapid recovery, postoperative corneal stability, and no epithelial healing complications. The procedure seems to bear a risk for postoperative epithelial growth into the flap interface. PMID: 30581603 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - December 26, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Applications of Artificial Intelligence in Ophthalmology: General Overview.
Authors: Lu W, Tong Y, Yu Y, Xing Y, Chen C, Shen Y Abstract With the emergence of unmanned plane, autonomous vehicles, face recognition, and language processing, the artificial intelligence (AI) has remarkably revolutionized our lifestyle. Recent studies indicate that AI has astounding potential to perform much better than human beings in some tasks, especially in the image recognition field. As the amount of image data in imaging center of ophthalmology is increasing dramatically, analyzing and processing these data is in urgent need. AI has been tried to apply to decipher medical data and has made extraordinary ...
Source: Journal of Ophthalmology - December 26, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Complications Associated with the Use of Expandable Gases in Vitrectomy.
Authors: Kanclerz P, Grzybowski A Abstract Intraocular gases have been used in vitreoretinal surgery for over 40 years. The aim of this study was to review the complications related to the use of expandable gases in vitrectomy and their management. A PubMed, Cochrane Library, and Embase search was conducted using the terms "intraocular gas" and "vitrectomy for retinal detachment." Of the articles retrieved by this method, all publications in English and abstracts of non-English publications were reviewed. Intraocular pressure elevation was reported in up to 58.9% patients after vitrectomy with e...
Source: Journal of Ophthalmology - December 26, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Internal Limiting Membrane Flaps for Coexistent Macular Hole and Retinal Detachment in Eyes with Proliferative Diabetic Retinopathy.
Conclusion: Various surgical approaches utilized in managing macular holes may effectively close macular holes and reattach retinas. This trial is registered with NCT 03618498. PMID: 30524755 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - December 15, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Prevalence of Myopia among Children Attending Pediatrics Ophthalmology Clinic at Ohud Hospital, Medina, Saudi Arabia.
Conclusion: The prevalence of myopia among pediatrics patients in Medina is 3.54%. We hope that the results of this study will contribute to a better understanding of this public health issue in Saudi Arabia in order to implant a strict screening program for early detection and interventions to reduce the risk of further progression of visual impairment. PMID: 30524756 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - December 15, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comparative Analysis of the Safety and Functional Outcomes of Anterior versus Retropupillary Iris-Claw IOL Fixation.
Conclusions: Anterior chamber and posterior chamber iris-claw IOL fixations proved equally effective and safe for aphakic correction in eyes with inadequate capsular support. PMID: 30524757 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - December 15, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Pentacam HR Indices Variation in Normal Corneas with Different Corneal Thickness.
Conclusions: Some Pentacam HR indices varied with different corneal thickness in normal corneas. This necessitates inclusion of pachymetric subgroups in the normative database. The use of the more robust indices (average pachymetry progression index and front elevations) is recommended in relatively thin or thick corneas. PMID: 30533219 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - December 14, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Effects of Smoking on Outcomes of Antivascular Endothelial Growth Factor Therapy in Patients with Neovascular Age-Related Macular Degeneration Smoking and Anti-VEGF Therapy in nAMD.
Conclusion: The anti-VEGF therapy was frequently required in nAMD patients with a history of heavy smoking. Heavy smoking could cause poor therapeutic response in nAMD patients. PMID: 30538852 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - December 14, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Predictive Factors for Successful Type 1 Big Bubble during Deep Anterior Lamellar Keratoplasty.
Authors: Borderie VM, Touhami S, Georgeon C, Sandali O Abstract Objective: Big bubble (BB)-deep anterior lamellar keratoplasty (DALK) has become the reference transplantation technique for corneal stromal disorders. Type 1 BB is the desired aspect but it is not constant. We aimed to determine the predictive factors of type 1 BB success. Methods: Observational cohort study including 77 consecutive eyes of 77 patients undergoing DALK by one surgeon at a single reference center without any selection. Clinical and spectral domain optical coherence tomography data were collected pre- and postoperatively. Results...
Source: Journal of Ophthalmology - December 14, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comparison between Transepithelial Photorefractive Keratectomy versus Alcohol-Assisted Photorefractive Keratectomy in Correction of Myopia and Myopic Astigmatism.
Conclusions: TPRK and AAPRK produce similar results 6 months postoperatively. However, in the early postoperative period, there were significant differences in UDVA, pain score, level of haze, and complete epithelial healing time. The pain scores were lower, level of haze was less, and healing time was shorter in the TPRK group which provided patient better felling and comfort in this period. Both of procedures are effective and safe for correction of myopia and compound myopic astigmatism. This trial is registered with NCT03569423. PMID: 30538854 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - December 14, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Effect of D-Panthenol on Corneal Epithelial Healing after Surface Laser Ablation.
Conclusion: D-Panthenol effect on corneal epithelial regeneration is of minimal clinical relevance. A different dosage and a larger sample of patients might reveal a statistical relevance. This trial is registered with https://doi.org/10.1186/ISRCTN81441126. PMID: 30538855 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - December 14, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Analysis of Correlative Factors of Visual Acuity with Intravitreal Conbercept Injection in Macular Edema Associated with Branch Retinal Vein Occlusion.
Authors: Luo W, Jia F, Liu M, Wang Y, Zhang T Abstract Purpose: To evaluate the correlative factors of best-corrected visual acuity (BCVA) with intravitreal conbercept injection in macular edema secondary to branch retinal vein occlusion (BRVO). Methods: This is a self-controlled retrospective study. 35 eyes of 35 patients with macular edema secondary to BRVO were enrolled. After an initial intravitreal injection of conbercept (0.5 mg/0.05 ml) monthly up to 3 months, a pro re nata (PRN) strategy was adopted based on the increase in central foveal thickness (CFT). Data collected at various time poi...
Source: Journal of Ophthalmology - December 14, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Ability of Swept-Source Optical Coherence Tomography to Detect Retinal and Choroidal Changes in Patients with Multiple Sclerosis.
Authors: Garcia-Martin E, Jarauta L, Vilades E, Ara JR, Martin J, Polo V, Larrosa JM, Pablo LE, Satue M Abstract Purpose: To evaluate the ability of new swept-source (SS) optical coherence tomography (OCT) technology to detect changes in retinal and choroidal thickness in patients with multiple sclerosis (MS). Methods: A total of 101 healthy and 97 MS eyes underwent retinal and choroidal assessment using SS Triton OCT (Topcon). Macular thickness and peripapillary data (retinal, ganglion cell layer (GCL+, GCL++) and retinal nerve fiber layer (RNFL) thickness) were analyzed, including choroidal thickness evaluati...
Source: Journal of Ophthalmology - December 14, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Scanning Electron Microscopy Analysis of the Anterior Capsulotomy Edge: A Comparative Study between Femtosecond Laser-Assisted Capsulotomy and Manual Capsulorhexis.
Authors: Tognetto D, De Giacinto C, Perrotta AA, Candian T, Bova A, Rinaldi S, Turco G Abstract Purpose: To compare the capsule edges ultrastructure obtained by two femtosecond laser-assisted cataract surgery (FLACS) platforms and manual continuous curvilinear capsulorhexis (CCC) using scanning electron microscopy (SEM). Setting: Eye Clinic, University of Trieste, Italy. Design: Experimental comparative study. Methods: 150 anterior capsules were collected and divided into three groups as follows: Group 1 (50 capsules) obtained with manual CCC, Groups 2 and 3 (each with 50 capsules) obtained with the Cat...
Source: Journal of Ophthalmology - December 14, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Factors Affecting the Outcome of Scleral Buckling Surgery for Primary Rhegmatogenous Retinal Detachment.
Conclusion: Scleral buckle surgery is a highly effective surgery in uncomplicated retinal detachment cases, and single surgery success rates are better in cases with good preoperative visual acuity, partial detachment, and clear crystalline lens. PMID: 30538859 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - December 14, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Deep Neural Network-Based Method for Detecting Central Retinal Vein Occlusion Using Ultrawide-Field Fundus Ophthalmoscopy.
Authors: Nagasato D, Tabuchi H, Ohsugi H, Masumoto H, Enno H, Ishitobi N, Sonobe T, Kameoka M, Niki M, Hayashi K, Mitamura Y Abstract The aim of this study is to assess the performance of two machine-learning technologies, namely, deep learning (DL) and support vector machine (SVM) algorithms, for detecting central retinal vein occlusion (CRVO) in ultrawide-field fundus images. Images from 125 CRVO patients (n=125 images) and 202 non-CRVO normal subjects (n=238 images) were included in this study. Training to construct the DL model using deep convolutional neural network algorithms was provided using ultrawide-fiel...
Source: Journal of Ophthalmology - December 6, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Corneal Epithelial Damage and Impaired Tear Functions in Patients with Inflamed Pinguecula.
In this study, we evaluated corneal epithelial integrity and tear film parameters in patients with inflamed pinguecula and compared these findings with their fellow eyes and with healthy controls. Methods: We evaluated the fluorescein staining properties and performed the tear break-up time (TBUT) test and Schirmer 2 test (ST2) measurements of 32 patients who had symptomatic unilateral inflamed pinguecula and compared the results with their fellow eyes and also with an age- and sex-matched control group. Results: Twenty-three eyes (72%) in the inflamed pinguecula group and 1 eye (3.1%) in the fellow eyes group had ...
Source: Journal of Ophthalmology - December 6, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Visual Outcomes of Ultrathin-Descemet Stripping Endothelial Keratoplasty versus Descemet Stripping Endothelial Keratoplasty.
Conclusion: DSAEK grafts with a thickness under 100 μm offered better visual outcomes during the early postoperative period. PMID: 30515318 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - December 6, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Autoimmune Diseases and the Anterior Segment of the Eye.
Authors: Sacchetti M, Mantelli F, Lambiase A PMID: 30515319 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - December 6, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Cyanin Chloride Inhibits Hyperbaric Pressure-Induced Decrease of Intracellular Glutamate-Aspartate Transporter in Rat Retinal M üller Cells.
Cyanin Chloride Inhibits Hyperbaric Pressure-Induced Decrease of Intracellular Glutamate-Aspartate Transporter in Rat Retinal Müller Cells. J Ophthalmol. 2018;2018:6128470 Authors: Chen X, Wang Y, Han F, Ke M Abstract Purpose: Glaucoma is the leading cause of irreversible blindness throughout the world. The pathogenesis of glaucoma is complex, and neuroprotection is a crucial aspect of therapy. High concentrations of extracellular glutamate are toxic to the optic nerve. The glutamate-aspartate transporter (GLAST) in retinal Müller cells is involved in the development of glaucoma. Anthocyanin ...
Source: Journal of Ophthalmology - December 6, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Impact of Unilateral Orbital Radiotherapy on the Structure and Function of Bilateral Human Meibomian Gland.
Conclusion: Orbital radiotherapy could cause significant damage to the meibomian gland structure and function, not only the diseased eyes but also the contralateral eyes. PMID: 30498598 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - December 2, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

HMBG1 as a Driver of Inflammatory and Immune Processes in the Pathogenesis of Ocular Diseases.
Authors: Liu Y, Zhuang GB, Zhou XZ Abstract High-mobility group box 1 (HMGB1) is a nuclear protein that can also act as an extracellular trigger of inflammation, proliferation, and migration in eye diseases. It induces signaling pathways by binding to the receptor for advanced glycation end products (RAGE) and Toll-like receptors (TLRs) 2, 4, and 9. This proinflammatory activity is considered to be important in the pathogenesis of a wide range of ocular diseases resulting from hemodynamic changes, presence of neovascular endothelial cells, secretion of intraocular immune factors or inflammation, and apoptosis of re...
Source: Journal of Ophthalmology - November 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comparison of Individual Retinal Layer Thicknesses after Epiretinal Membrane Surgery with or without Internal Limiting Membrane Peeling.
Conclusions: This study demonstrates that ILM peeling for ERM surgery may result in better preservation of GCL compared to no ILM peeling. PMID: 30420914 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 15, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

A Comparative Study of Characteristics and Outcomes of Patients with Proved and Suggested Sarcoid Uveitis Occurring after Ophthalmic Procedure.
Conclusions: Sarcoid uveitis has similar characteristics in patients with new onset sarcoid uveitis after or without ophthalmic procedure. As a consequence, ophthalmic intervention should be seen as a potential trigger of latent sarcoidosis. PMID: 30420915 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 15, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Visual and Refractive Outcomes of Small-Incision Lenticule Extraction in High Myopia: 5-Year Results.
Conclusion: SMILE with an intended correction of up to a spherical equivalent of 10 D is safe and effective. However, there is regression of the refractive effect over extended follow-up. PMID: 30420916 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 15, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Efficacy Comparison of Intravitreal Anti-VEGF Therapy for Three Subtypes of Neovascular Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis.
Conclusions: The reactivity to VEGF inhibitors varied among different subtypes of nAMD. The efficacy of intravitreal anti-VEGF therapy in type 3 nAMD was statistically better than type 1 when considering vision improvement at 3 and 12 months. Thus, the lesion subtype is a predictor for the treatment outcome which can help guide prognosis. PMID: 30425852 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 15, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Characteristics of New Onset Herpes Simplex Keratitis after Keratoplasty.
Conclusion: New onset HSK after keratoplasty primarily resulted in epithelial and stromal lesion, involving both the graft and recipient. Effective treatments included antiviral medications and amniotic membrane transplantation. Delayed treatment may lead to aggravated graft opacification. PMID: 30425853 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 15, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Modified Vitrectomy Technique for Phakic Rhegmatogenous Retinal Detachment with Intermediate Break.
Conclusions: "Localized vitrectomy" has a high anatomical success rate in phakic eyes with primary uncomplicated macula-on RRD with intermediate retinal break(s) and marked vitreous traction, without causing progression of cataract. PMID: 30425854 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 15, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Increased Corneal Toricity after Long-Term Orthokeratology Lens Wear.
This study investigated 136 subjects aged between 6 and 14 (9.1 ± 1.5) years old at the commencement of ortho-k treatment, who had been undergoing overnight ortho-k treatment for 24 to 72 (37.4 ± 11.9) months. Corneal refractive power and manifest refraction were measured and compared before ortho-k and 1 month after discontinuation of ortho-k lens wear. Changes in corneal curvature were analyzed. Corneal curvature data from a historical longitudinal study were used as control. Results: Compared to pre-ortho-k values, the corneal curvature became significantly flatter in the flatter meridian (-0.22 ± 0.27 D, P
Source: Journal of Ophthalmology - November 15, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Effect of Anterior Capsule Polishing on Capsular Contraction and Lens Stability in Cataract Patients with High Myopia.
Conclusion: 360° anterior capsule polishing can effectively reduce the extent of the anterior capsule contraction and increase the stability of IOL. The study was registered at http://www.clinicaltrials.gov, and the clinical trial accession number is NCT 03142269. PMID: 30425856 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 15, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Role of 25  MHz Ultrasound Biomicroscopy in the Detection of Subluxated Lenses.
Conclusions: The results indicated that 25 MHz UBM has a greater diagnostic value than 50 MHz UBM in verifying the status of the lens subluxation and can provide reliable and quantitative imaging evidence for clinical use. This trial is registered with ChiCTR-DOD -15007603. PMID: 30416825 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 14, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Preliminary Investigation of the Mechanical Anisotropy of the Normal Human Corneal Stroma.
Conclusions: The biomechanical behavior in normal human corneal stroma tissue is slightly stiffer in the vertical direction than in the horizontal direction. This information may aid our understanding of the biomechanical properties of the cornea and related diseases. PMID: 30416826 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 14, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Ocular Biometric Characteristics of Chinese with History of Acute Angle Closure.
This study included 1500 healthy subjects (2624 eyes, mean age of 66.54 ± 15.82 years) and 107 subjects with AAC (202 eyes, mean age of 70.01 ± 11.05 years). Eyes with AAC had thicker lens (P ≤ 0.001), shallower anterior chamber depth (P ≤ 0.001), and shorter axial length (P ≤ 0.001) than healthy eyes. Logistic regression analysis and ROC curve analysis indicated that a crowding value above 0.13 was a significant (P
Source: Journal of Ophthalmology - November 14, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Changes and Diurnal Variation of Visual Quality after Orthokeratology in Myopic Children.
Authors: Guo HC, Jin WQ, Pan AP, Wang QM, Qu J, Yu AY Abstract Purpose: To assess the changes and the diurnal variation of visual quality after orthokeratology in myopic children. Methods: Forty-four eyes of 22 subjects with a mean age of 10.55 ± 1.53 years (8 to 14 years) were enrolled in this prospective study. Their spherical equivalent ranged from -1.25 to -4.25 diopters (D) and astigmatism was less than 1.00 D. Parameters including corneal curvature, ocular objective scatter index (OSI), the modulation transfer function (MTF), root mean square of ocular and corneal wavefr...
Source: Journal of Ophthalmology - November 11, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Association between Visual Acuity and Retinal Layer Metrics in Diabetics with and without Macular Edema.
Conclusions: Alterations in retinal layer thickness and reflectance metrics derived from enface OCT images were associated with reduced VA with and without presence of DME, suggestive of their potential for monitoring development, progression, and treatment of DME. PMID: 30402277 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 9, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Spectral Domain Optical Coherence Tomography Assessment of Macular and Optic Nerve Alterations in Patients with Glaucoma and Correlation with Visual Field Index.
Discussion: All subjects were grouped according to stage as follows: Controls (CTRL); Early Stage Group (EG) (Stage 1 + Stage 2); Advanced Stage Group (AG) (Stage 3 + Stage 4 + Stage 5). mGCL TI, mGCL TO, mIPL TO, mean mGCL, cpRNFLt NS, and cpRNFLt TI showed the best results in terms of AUC according classification proposed by Swets (0.9 
Source: Journal of Ophthalmology - November 9, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Effect of Collagen Cross-Linking on Alkali Burn-Induced Corneal Neovascularization in Rabbits.
Conclusions: Our results indicate that riboflavin-ultraviolet-A-induced cross-linking (corneal collagen cross-linking, CXL) significantly inhibits alkali burn-induced CNV in rabbits, possibly through downregulating VEGF, MMP-2, MMP-9, and TIMP-1 expression. PMID: 30402279 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 9, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Tear Ferning Test and Pathological Effects on Ocular Surface before and after Topical Cyclosporine in Vernal Keratoconjunctivitis Patients.
Conclusions: The results obtained demonstrated for the first time a significant alteration of the lacrimal mucin component evaluated in the VKC group, and an improvement of the latter after CY therapy. PMID: 30405906 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 9, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Efficacy and Safety of an Aflibercept Treat-and-Extend Regimen in Treatment-Na ïve Patients with Macular Oedema Secondary to Central Retinal Vein Occlusion (CRVO): A Prospective 12-Month, Single-Arm, Multicentre Trial.
Efficacy and Safety of an Aflibercept Treat-and-Extend Regimen in Treatment-Naïve Patients with Macular Oedema Secondary to Central Retinal Vein Occlusion (CRVO): A Prospective 12-Month, Single-Arm, Multicentre Trial. J Ophthalmol. 2018;2018:8310350 Authors: Garcia-Arumi J, Gómez-Ulla F, Amparo N, Cervera E, Fonollosa A, Arias L, Araiz J, Donate J, de Figueroa MS, Manzanas L, Crespí J, Gallego R Abstract Objectives: To evaluate efficacy and safety of an aflibercept treat-and-extend (TAE) regimen in patients with macular oedema (MO) secondary to central retinal vein occlusion (CRVO). ...
Source: Journal of Ophthalmology - November 9, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Klebsiella pneumoniae Orbital Cellulitis: Clinical Manifestations and Outcomes in a Tertiary Medical Center in Taiwan.
Conclusion: Diabetes may be a risk factor of Klebsiella pneumoniae orbital cellulitis, especially for those of nonsinus origin. PMID: 30370149 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 30, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Topographic Asymmetry Indices: Correlation between Inferior Minus Superior Value and Index of Height Decentration.
Authors: Wahba SS, Roshdy MM, Fikry RR, Abdellatif MK, Abodarahim AM Abstract Purpose: To investigate the correlation between decentration index (index of height decentration, IHD) automatically calculated by the Pentacam HR software and the manually calculated inferior minus superior (I-S) value. Setting: Al Watany Eye Hospital, Cairo, Egypt. Methods: In a retrospective study, history taking, clinical examination, and rotating Scheimpflug camera scanning (by Oculyzer II equivalent to Pentacam HR) were done to 128 eyes: 82 normal, 24 forme fruste keratoconus FFKC (apparently normal cornea with evident kerat...
Source: Journal of Ophthalmology - October 30, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comment on "An Analysis of 3-Year Outcomes following Canaloplasty for the Treatment of Open-Angle Glaucoma".
Comment on "An Analysis of 3-Year Outcomes following Canaloplasty for the Treatment of Open-Angle Glaucoma". J Ophthalmol. 2018;2018:4257512 Authors: Bin Khathlan AA PMID: 30363638 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 27, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Washout Duration of Prostaglandin Analogues: A Systematic Review and Meta-analysis.
Conclusion: A significant IOP-lowering effect of latanoprost was not observed beyond 4 weeks, suggesting this may be an appropriate washout period for latanoprost. We could not identify appropriate washout periods for either travoprost or bimatoprost, although a majority of articles had 4-week washout durations for the two drugs. Despite the widespread use of this class of medication, there is a paucity of literature on the effects of PGA washout in patients that are treatment naïve to other topical medications. PMID: 30363694 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 27, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research