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Use of OCT Angiography in Choroidal Melanocytic Tumors.
Conclusion: OCTA is a promising new technology that can be used to study in vivo the differential characteristics of microcirculations between posterior segment melanocytic lesions. Today, larger studies are needed to corroborate these findings and to correlate it with malignancy. PMID: 29201456 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - December 6, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Effect of CM082, an Oral Tyrosine Kinase Inhibitor, on Experimental Choroidal Neovascularization in Rats.
Authors: Ren C, Shi H, Jiang J, Liu Q, Du Y, He M, Cai W, Wei Q, Yu J Abstract The aims of this study were to evaluate the effects of CM082 on the development of choroidal neovascularization (CNV) in a laser-induced CNV rat model and to determine the drug concentration in the ocular tissues. After the laser-induced CNV model was established in rats, CM082 was orally administered. The effects of CM082 on the CNV lesions were assessed using fundus fluorescein angiography (FFA), CNV histology, and retinal pigment epithelium- (RPE-) choroid-sclera eyecup analysis. The concentrations of CM082 in the plasma and eye tissu...
Source: Journal of Ophthalmology - December 6, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Switch to Aflibercept in the Treatment of Neovascular AMD: Long-Term Results.
Authors: Neves Cardoso P, Pinheiro AF, Meira J, Pedrosa AC, Falcão MS, Pinheiro-Costa J, Falcão-Reis F, Carneiro ÂM Abstract Purpose: To report the long-term clinical outcomes after switching from intravitreal bevacizumab or ranibizumab to aflibercept therapy in eyes with AMD. Methods: Retrospective analysis of changes in BCVA, SD-OCT image, and frequency of injections after 1, 2, and 3 years of follow-up. Results: 164 eyes were analyzed, 101 eyes switched from bevacizumab (group 1) and 63 from ranibizumab (group 2). One year after the switch, there was an overall nonsignificant mean dec...
Source: Journal of Ophthalmology - December 6, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Algorithm for Correcting the Keratometric Error in the Estimation of the Corneal Power in Keratoconus Eyes after Accelerated Corneal Collagen Crosslinking.
Authors: Piñero DP, Camps VJ, Caravaca-Arens E, de Fez D, Blanes-Mompó FJ Abstract Purpose: To analyze the errors associated to corneal power calculation using the keratometric approach in keratoconus eyes after accelerated corneal collagen crosslinking (CXL) surgery and to obtain a model for the estimation of an adjusted corneal refractive index (nkadj ) minimizing such errors. Methods: Potential differences (ΔPc) among keratometric (Pk ) and Gaussian corneal power (PcGauss) were simulated. Three algorithms based on the use of nkadj for the estimation of an adjusted keratometric corneal pow...
Source: Journal of Ophthalmology - December 6, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Involvement of β-Catenin/COX-2/VEGF Axis in NMDA-Caused Retinopathy.
The Involvement of β-Catenin/COX-2/VEGF Axis in NMDA-Caused Retinopathy. J Ophthalmol. 2017;2017:9760501 Authors: Ning D, Zhang WK, Tian H, Li XJ, Liu M, Li YS, Tang HB Abstract NMDA, a molecule that is capable of producing the loss of retinal ganglia cells (RGCs), has been widely studied; however, the detailed mechanism is not yet clarified. Previously, Wnt/β-catenin signaling has been suggested to be involved in the NMDA-induced retinopathy. In addition, previous investigations in our group demonstrated the presence of a Wnt/β-catenin/COX-2 axis in dorsal root ganglions (DRGs). Therefo...
Source: Journal of Ophthalmology - November 23, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Effect of MT3 on Retinal and Choroidal TGF- β2 and HAS2 Expressions in Form Deprivation Myopia of Guinea Pig.
Conclusion: MT3 can inhibit form deprivation myopia, and MT3 treatment can result in changes of retinal and choroidal TGF-β2 and HAS2 mRNA and protein expressions. PMID: 29163988 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 23, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Axial Length and Ocular Development of Premature Infants without ROP.
Conclusions: Preterm infants had shorter AL, shallow ACD, thicker LT, and thinner VD compared to term infants. Refractive error in preterm infants at GA between 28 to 37 weeks was not related to axial length. Among all the growth parameters of preterm infants, GA, BW, and HC had effect on axial length. PMID: 29163989 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 23, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Molecular Age-Related Changes in the Anterior Segment of the Eye.
Conclusions: In this review, we summarize the current knowledge regarding some of the molecular mechanisms related to aging in the anterior segment of the eye. We also introduce and propose potential roles of autophagy, an important mechanism responsible for maintaining homeostasis and proteostasis under stress conditions in the anterior segment during aging. PMID: 29147580 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 19, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Impact of Topically Administered Steroids, Antibiotics, and Sodium Hyaluronate on Bleb-Related Infection Onset: The Japan Glaucoma Society Survey of Bleb-Related Infection Report 4.
Conclusions: Topical steroid administration beyond the immediate postoperative period may affect severe and earlier onset bleb-related infections. Conversely, topical antibiotic administration may be effective in suppressing earlier onset bleb-related infections. PMID: 29138694 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 16, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Risk Factors of Malignant Glaucoma Occurrence after Glaucoma Surgery.
Conclusions: The risk of malignant glaucoma development is associated with penetrating characteristic of glaucoma surgery, after which this complication appears and its occurrence is higher in eyes with shallow iridocorneal angle. The risk of malignant glaucoma after trabeculectomy compared to iridencleisis as well as after phacotrabeculectomy compared to phacoiridencleisis is equivalent. PMID: 29138695 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 16, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Changes in Retinal and Choroidal Vascular Blood Flow after Oral Sildenafil: An Optical Coherence Tomography Angiography Study.
Authors: Berrones D, Salcedo-Villanueva G, Morales-Cantón V, Velez-Montoya R Abstract Purpose: To describe changes in the retina and choroidal flow by optical coherence tomography angiography (OCT-A) after a single dose of oral sildenafil. Method: A case-control study. Patients in the study group received 50 mg of oral sildenafil. Patients in the control group received a sham pill. Retinal and choroidal images were obtained at baseline (before pill ingestion) and 1 hour after ingestion. Central macular and choroidal thickness, choroidal and outer retina flow, and the retinal and choroidal vascular...
Source: Journal of Ophthalmology - November 15, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comparison between the Correlations of Retinal Nerve Fiber Layer Thickness Measured by Spectral Domain Optical Coherence Tomography and Visual Field Defects in Standard Automated White-on-White Perimetry versus Pulsar Perimetry.
Conclusions: In the control group, the correlation between structure and function based on the PP data was significantly stronger than that based on SAP. PMID: 29119021 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 11, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Bruch's Membrane Opening Minimum Rim Width Measurement with SD-OCT: A Method to Correct for the Opening Size of Bruch's Membrane.
Authors: Kromer R, Spitzer MS Abstract A precise evaluation of the retinal nerve fiber layer thickness (RNFLT) is key for diagnosing and monitoring glaucoma. The Bruch's membrane opening minimum rim width (BMO-MRW) has been proposed as a reproducible assessment of the optic nerve. The BMO-MRW measures the minimum distance from the BMO to the internal limiting membrane. We propose an approach to correct the BMO-MRW using the BMO size for increased accuracy in interindividual comparisons in future studies. Eighty-one healthy patients received SPECTRALIS spectral domain optical coherence tomography measurements for th...
Source: Journal of Ophthalmology - November 11, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

OM-101 Decreases the Fibrotic Response Associated with Proliferative Vitreoretinopathy.
Conclusions: OM-101 was found effective in reducing the incidence of RD and PVR maintaining the normal architecture of the retina. This study suggests that OM-101 is a potentially effective and safe drug for the treatment of PVR patients. PMID: 29109865 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 9, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Correlation between Choroidal Neovascularization Shown by OCT Angiography and Choroidal Thickness in Patients with Chronic Central Serous Chorioretinopathy.
Conclusions: OCTA detected CNV more frequently than other imaging modalities. CNV coexisted with irregular PED in all cases. CT was increased in eyes with chronic CSCR, but without any correlation with CNV occurrence; therefore, CT cannot be considered as a predictor of CNV occurrence. Further studies with a larger number of patients are needed to confirm these findings. PMID: 29109866 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 9, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Clinical Profile of Unilateral Proptosis in a Tertiary Care Centre.
Authors: Dsouza S, Kandula P, Kamath G, Kamath M Abstract Proptosis, the forward protrusion of the eyeball, is a common manifestation of a wide variety of diseases inside the orbit and its spaces. Its diagnosis is usually a combined effort of the ophthalmologist, otolaryngologist, neurosurgeon, and radiologist. A clinical study of twenty-five cases with unilateral proptosis were studied in different age groups over a period of about 3 years under different headings like distribution, clinical features, radiological features, histopathological aspects, management, and outcomes of diseases. Proptosis measurement was ...
Source: Journal of Ophthalmology - November 9, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Visual Quality Assessment of Posterior Capsule Opacification Using Optical Quality Analysis System (OQAS).
Authors: Zhang H, Wang J Abstract Objective: To evaluate intraocular scattering in eyes with posterior capsule opacification by means of an objective scatter index (OSI) obtained from double-pass images of optical quality assessment system (OQAS TM II) and to determine the indication for laser capsulotomy when patients report visual disturbances without decreased visual acuity. Methods: In this prospective, observational, and nonconsecutive case series study, a total of 32 eyes of 29 patients are diagnosed with posterior capsule opacification after age-associated cataract were analyzed. Patient examination incl...
Source: Journal of Ophthalmology - November 9, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Impact of Adherence and Instillation Proficiency of Topical Glaucoma Medications on Intraocular Pressure.
Authors: Atey TM, Shibeshi W, T Giorgis A, Asgedom SW Abstract Background: The possible sequel of poorly controlled intraocular pressure (IOP) includes treatment failure, unnecessary medication use, and economic burden on patients with glaucoma. Objective: To assess the impact of adherence and instillation technique on IOP control. Methods: A cross-sectional study was conducted on 359 glaucoma patients in Menelik II Hospital from June 1 to July 31, 2015. After conducting a Q-Q analysis, multiple binary logistic analyses, linear regression analyses, and two-tailed paired t-test were conducted to compare IOP ...
Source: Journal of Ophthalmology - November 8, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

New Objective Refraction Metric Based on Sphere Fitting to the Wavefront.
Authors: Jaskulski M, Martínez-Finkelshtein A, López-Gil N Abstract Purpose: To develop an objective refraction formula based on the ocular wavefront error (WFE) expressed in terms of Zernike coefficients and pupil radius, which would be an accurate predictor of subjective spherical equivalent (SE) for different pupil sizes. Methods: A sphere is fitted to the ocular wavefront at the center and at a variable distance, t. The optimal fitting distance, topt, is obtained empirically from a dataset of 308 eyes as a function of objective refraction pupil radius, r0, and used to define the formula of a n...
Source: Journal of Ophthalmology - November 8, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Reduced Expression of VAMP8 in Lacrimal Gland Affected by Chronic Graft-versus-Host Disease.
Conclusions: Our results suggested that expression of VAMP8 in the cGVHD-affected LG was decreased and accordingly tear secretion in cGVHD was reduced. Collectively, the reduction of VAMP8 expression in the cGVHD-affected LG can be involved in the pathogenic processes of cGVHD-induced dry eye disease. PMID: 29098081 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 5, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Inherited Retinal Degeneration: Genetics, Disease Characterization, and Outcome Measures.
Authors: Khan NW, Falsini B, Kondo M, Robson AG PMID: 29098082 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 5, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

An Analysis of 3-Year Outcomes Following Canaloplasty for the Treatment of Open-Angle Glaucoma.
Authors: Khaimi MA, Dvorak JD, Ding K Abstract Purpose: To report 3-year results investigating the safety and efficacy of canaloplasty for open-angle glaucoma. Setting: University of Oklahoma, Dean McGee Eye Institute, Oklahoma, United States of America. Design: Nonrandomized single-center retrospective chart review. Methods: Adult open-angle glaucoma eyes underwent canaloplasty or combined cataract-canaloplasty surgery. A tensioning suture was placed into Schlemm's canal in all eyes. Primary endpoints included the mean IOP and mean number of glaucoma medications at each follow-up visit. Secondary endpo...
Source: Journal of Ophthalmology - November 5, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Influence of Overnight Orthokeratology on Corneal Surface Shape and Optical Quality.
Authors: Sun Y, Wang L, Gao J, Yang M, Zhao Q Abstract Purpose: To investigate the changes of corneal surface shape and optical quality during orthokeratology. Methods: 49 eyes of 26 patients (10.63 ± 2.02 years old) who underwent overnight orthokeratology for myopia were prospectively examined. The corneal surface shape parameters, including surface regularity index (SRI) and surface asymmetry index (SAI), were attained with an OPD-III SCAN. The higher-order aberrations and higher-order Strehl ratios were calculated under a 3 mm pupil diameter before orthokeratology, 1 month, 3 mont...
Source: Journal of Ophthalmology - November 5, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Protective Effects of αB-Crystallin on Ischemia-Reperfusion Injury in the Rat Retina.
The Protective Effects of αB-Crystallin on Ischemia-Reperfusion Injury in the Rat Retina. J Ophthalmol. 2017;2017:7205408 Authors: Yan H, Peng Y, Huang W, Gong L, Li L Abstract To investigate whether αB-crystallin protects against acute retinal ischemic reperfusion injury (I/R) and elucidate the potential antioxidant mechanisms. Retinal I/R injury was made by elevating the intraocular pressure (IOP) 110 mmHg for 60 min, and αB-crystallin (1 × 10(-5) g/L) or vehicle solution was administered intravitreously immediately after I/R injury. The anim...
Source: Journal of Ophthalmology - November 5, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Two-Year Outcome of Aflibercept in Patients with Pigment Epithelial Detachment due to Neovascular Age-Related Macular Degeneration (nAMD) Refractory to Ranibizumab.
Conclusions: Aflibercept intravitreal injection in patients with fibrovascular DEP due to nAMD who respond poorly to monthly ranibizumab led to short-term functional and anatomical improvement. Reduction of intravitreal injection frequency was obtained until 2 years of follow-up. PMID: 29093970 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 3, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Steeper Iris Conicity Is Related to a Shallower Anterior Chamber: The Gutenberg Health Study.
CONCLUSIONS: Associations indicate a correlation between iris conicity with risk factors for angle-closure, namely, shallower anterior chamber depth and thicker human lens. In pseudophakic eyes, iris conicity is significantly lower, indicating that cataract surgery flattens the iris. PMID: 29085672 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 2, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Analysis of Factors Associated with the Ocular Features of Congenital Cataract Children in the Shanghai Pediatric Cataract Study.
Authors: He W, Sun T, Yang J, Qin G, Wu Z, Zhu X, Lu Y Abstract PURPOSE: To investigate the ocular features of children with congenital cataract in a tertiary referral eye center in East China. METHODS: We retrospectively reviewed the clinical data of congenital cataract children who underwent cataract surgery between April 2009 and April 2014 at the Eye and ENT Hospital of Fudan University and identified factors associated with the axial length (AXL) and corneal curvature (K value). RESULTS: We included 493 children, 210 with unilateral and 283 with bilateral cataract. The mean AXL was 22.03 ±...
Source: Journal of Ophthalmology - November 2, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Phenotypic Description of the Spanish Multicentre Genetic Glaucoma Group Cohort.
CONCLUSIONS: The strength of the hereditary component of glaucoma seems to worsen the clinical course, causing more structural and functional damage and requiring more intense glaucoma treatment. The family history of glaucoma should be carefully investigated and taken into consideration when making treatment decisions or intensifying previous treatment. PMID: 29082038 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 1, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Laser Peripheral Iridotomy versus Trabeculectomy as an Initial Treatment for Primary Angle-Closure Glaucoma.
CONCLUSIONS: Primary trabeculectomy for PACG (PAS ≥ 6 clock hours) is more effective than LPI in lowering IOP. PMID: 29082039 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 1, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Accommodative Stimulus-Response Curve with Emoji Symbols.
Authors: Montés-Micó R, Esteve Taboada JJ, Bernal-Molina P, Ferrer-Blasco T Abstract PURPOSE: To evaluate the static measurement of the accommodative stimulus-response curve with emoji symbols. METHODS: The accommodative stimulus-response curve was measured in 18 subjects using a Hartmann-Shack sensor to obtain the objective accommodative response from the Zernike defocus term. Measurements were acquired at different accommodative demands, from 0 to 3 D with a step of 0.5 D. Detailed and nondetailed emoji targets were used with two different sizes, corresponding to the two most commo...
Source: Journal of Ophthalmology - November 1, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

A Masked, Randomized, Phase 3 Comparison of Triple Fixed-Combination Bimatoprost/Brimonidine/Timolol versus Fixed-Combination Brimonidine/Timolol for Lowering Intraocular Pressure.
CONCLUSIONS: TFC demonstrated IOP-lowering benefits that outweigh the risk of predominantly mild ocular side effects, which may be particularly relevant in patients who require greater IOP lowering to prevent/delay disease progression. This trial is registered with ClinicalTrials.gov registry number: NCT01241240. PMID: 29057117 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 24, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Long-Term Follow-Up of Intrastromal Corneal Ring Segments in Paracentral Keratoconus with Coincident Corneal Keratometric, Comatic, and Refractive Axes: Stability of the Procedure.
CONCLUSION: Ferrara-type ICRS implantation in keratoconus that meets the characteristics of the sample under study reduces the refractive error at the same time as it improves postoperative UDVA and CDVA six months after surgery and that these results remain stable over five years of follow-up. PMID: 28948045 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - September 29, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Prospective 3D Investigation of Bleb Wall after Trabeculectomy Using Anterior-Segment OCT.
Authors: Watanabe-Kitamura F, Inoue T, Kojima S, Nakashima KI, Fukushima A, Tanihara H Abstract PURPOSE: We used three-dimensional anterior-segment optical coherence tomography (3D AS-OCT) to evaluate time-dependent posttrabeculectomy changes in bleb wall volume and intensity. METHODS: This prospective observational study included patients with open-angle glaucoma who underwent fornix-based trabeculectomy between January 2012 and October 2012. Twenty-nine eyes met inclusion criteria, and the bleb walls of 22 were amenable to three-dimensional analysis by 3D AS-OCT for 1 year after surgery. The high-intensity vo...
Source: Journal of Ophthalmology - September 29, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Predictive Factors of the Standard Cross-linking Outcomes in Adult Keratoconus: One-Year Follow-Up.
CONCLUSIONS: The multivariate analysis disclosed a significant negative association between the baseline BCVA and postoperative BCVA and a positive relationship between the cone eccentricity and postoperative K max. PMID: 28951783 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - September 29, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Intrastromal Corneal Ring Segments for Astigmatism Correction after Deep Anterior Lamellar Keratoplasty.
Authors: Arantes JCD, Coscarelli S, Ferrara P, Araújo LPN, Ávila M, Torquetti L Abstract Background. To evaluate the change in corneal astigmatism after intrastromal corneal ring segment (ICRS) implantation in keratoconus patients with previous deep anterior lamellar keratoplasty (DALK). Design was a longitudinal, retrospective, interventional study. The study included 25 eyes of 24 patients with keratoconus who had DALK performed at least two years prior to ICRS implantation. All patients had a clear corneal graft with up to 8.00 D of corneal astigmatism and intolerance to contact lenses. The ...
Source: Journal of Ophthalmology - September 29, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Association of Neovascular Glaucoma with Risk of Stroke: A Population-Based Cohort Study.
This study included 416 NVG patients and 4160 controls. Medical comorbidities were also evaluated. The cumulative incidence of ischemic stroke was 15.6% higher in the NVG cohort than in the control cohort (p
Source: Journal of Ophthalmology - September 22, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Corneal Spherical Aberration and Corneal Asphericity after Small Incision Lenticule Extraction and Femtosecond Laser-Assisted LASIK.
This study enrolled 70 patients having SMILE and 64 subjects receiving FS-LASIK. The preoperative spherical equivalent (SE) was -5.83 ± 1.23 diopters (D) and -6.20 ± 1.52 D, respectively. The uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), SE, corneal spherical aberration, and asphericity over the 6.0 mm cornea were evaluated preoperatively and postoperatively. RESULTS: At 6 months, the UDVA, CDVA, and SE were -0.12 ± 0.11, -0.05 ± 0.05, and -0.16 ± 0.19 D in ...
Source: Journal of Ophthalmology - September 22, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Influences of 27-Gauge Vitrectomy on Corneal Topographic Conditions.
CONCLUSION: 27-gauge vitrectomy did not induce substantial changes in the corneal topographic conditions. PMID: 28928983 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - September 22, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Rho Kinase in Eye Disease.
Authors: Okumura N, Nakao S, Inoue T, Pattabiraman P PMID: 28928984 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - September 22, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

ABCC6 Gene Analysis in 20 Japanese Patients with Angioid Streaks Revealing Four Frequent and Two Novel Variants and Pseudodominant Inheritance.
CONCLUSIONS: We identified disease-causing ABCC6 variants that were in homozygous or compound heterozygous states in 13 of 18 families (72.2%). Our results indicated that ABCC6 variants play a significant role in patients with AS in the Japanese population. PMID: 28912966 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - September 16, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Correlation of Macular Focal Electroretinogram with Ellipsoid Zone Extension in Stargardt Disease.
Authors: Abed E, Placidi G, Calandriello L, Piccardi M, Campagna F, Bertelli M, Minnella AM, Savastano MC, Falsini B Abstract Stargardt disease (STGD1) is the most common cause of inherited juvenile macular degeneration. This disease is characterized by a progressive accumulation of lipofuscin in the outer retina and subsequent loss of photoreceptors and retinal pigment epithelium. The aim of this study was to evaluate the relationship between cone photoreceptor function and structure in STGD1. Macular function was assessed by visual acuity measurement and focal electroretinogram (FERG) recording while spectral dom...
Source: Journal of Ophthalmology - September 16, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Bimanual Microincision Cataract Surgery versus Coaxial Microincision Cataract Surgery: A Meta-Analysis of Randomized Controlled Trials and Cohort Studies.
Authors: Fu C, Chu N, Yu X, Yao K Abstract PURPOSE: This meta-analysis was conducted to compare the intraoperative and postoperative outcomes of bimanual microincision cataract surgery (B-MICS) and coaxial microincision cataract surgery (C-MICS). METHODS: Three databases were searched for papers that compared B-MICS and C-MICS from inception to June 2016. The following intraoperative and postoperative outcomes were included in the final meta-analysis: ultrasound time (UST), effective phacoemulsification time (EPT), balanced salt solution use (BSS use), mean surgery time, best-corrected visual acuity (BCVA), cen...
Source: Journal of Ophthalmology - September 16, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Switching to Aflibercept in Diabetic Macular Edema Not Responding to Ranibizumab and/or Intravitreal Dexamethasone Implant.
CONCLUSION: Switching to aflibercept in refractory DME results in significant functional and anatomical improvement. The study was approved by the France Macula Federation ethical committee (FMF 2017-138). PMID: 28900543 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - September 14, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Effect of Spherical Aberration on the Optical Quality after Implantation of Two Different Aspherical Intraocular Lenses.
CONCLUSIONS: Optical quality was better in eyes with the aberration-correcting Tecnis IOL when pupils were large. In contrast, this could not be shown in eyes with pupils under 4 mm or larger. This trial is registered with Clinicaltrials.gov NCT03224728. PMID: 28900544 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - September 14, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Corneal Nerve Regeneration after Self-Retained Cryopreserved Amniotic Membrane in Dry Eye Disease.
Authors: John T, Tighe S, Sheha H, Hamrah P, Salem ZM, Cheng AMS, Wang MX, Rock ND Abstract PURPOSE: To evaluate the efficacy of self-retained cryopreserved amniotic membrane (CAM) in promoting corneal nerve regeneration and improving corneal sensitivity in dry eye disease (DED). METHODS: In this prospective randomized clinical trial, subjects with DED were randomized to receive CAM (study group) or conventional maximum treatment (control). Changes in signs and symptoms, corneal sensitivity, topography, and in vivo confocal microscopy (IVCM) were evaluated at baseline, 1 month, and 3 months. RESULTS: Twenty...
Source: Journal of Ophthalmology - September 13, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Evaluation of Cholinergic Deficiency in Preclinical Alzheimer's Disease Using Pupillometry.
Authors: Frost S, Robinson L, Rowe CC, Ames D, Masters CL, Taddei K, Rainey-Smith SR, Martins RN, Kanagasingam Y Abstract Cortical cholinergic deficiency is prominent in Alzheimer's disease (AD), and published findings of diminished pupil flash response in AD suggest that this deficiency may extend to the visual cortical areas and anterior eye. Pupillometry is a low-cost, noninvasive technique that may be useful for monitoring cholinergic deficits which generally lead to memory and cognitive disorders. The aim of the study was to evaluate pupillometry for early detection of AD by comparing the pupil flash response ...
Source: Journal of Ophthalmology - September 13, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Clinical Features and Visual Acuity Outcomes in Culture-Positive Endogenous Fungal Endophthalmitis in Southern China.
CONCLUSION: Molds were a common cause of culture-proven fungal endophthalmitis. Endogenous fungal endophthalmitis is generally associated with poor VA outcomes, especially if caused by molds and if the patient's initial VA is too low to permit finger counting. PMID: 28884023 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - September 10, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Combined Phacoemulsification and Intravitreal Dexamethasone Implant (Ozurdex ®) in Diabetic Patients with Coexisting Cataract and Diabetic Macular Edema.
CONCLUSION: Intravitreal slow-release dexamethasone implant combined with cataract surgery may be an effective approach on morphologic and functional outcomes for patients with cataract and diabetic macular edema for at least three months after surgery. PMID: 28884024 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - September 10, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Pattern of Retinal Nerve Fiber Layer and Macular Ganglion Cell-Inner Plexiform Layer Thickness Changes in Glaucoma.
Authors: Choi JA, Shin HY, Park HL, Park CK Abstract BACKGROUND/AIMS: To investigate the patterns of retinal ganglion cell damage at different stages of glaucoma, using the circumpapillary retinal nerve fiber layer (RNFL) and macula ganglion cell-inner plexiform layer (GCIPL) thicknesses. METHODS: In 296 eyes of 296 glaucoma patients and 55 eyes of 55 healthy controls, the correlations of mean deviation (MD) with the superior and inferior quadrant RNFL/GCIPL thickness (defined as the average of three superior and inferior sectors, resp.) were analyzed. RESULTS: In early to moderate glaucoma, most of the RNF...
Source: Journal of Ophthalmology - September 10, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

A Critical Analysis of the Available In Vitro and Ex Vivo Methods to Study Retinal Angiogenesis.
Authors: Moleiro AF, Conceição G, Leite-Moreira AF, Rocha-Sousa A Abstract Angiogenesis is a biological process with a central role in retinal diseases. The choice of the ideal method to study angiogenesis, particularly in the retina, remains a problem. Angiogenesis can be assessed through in vitro and in vivo studies. In spite of inherent limitations, in vitro studies are faster, easier to perform and quantify, and typically less expensive and allow the study of isolated angiogenesis steps. We performed a systematic review of PubMed searching for original articles that applied in vitro or ex vivo ang...
Source: Journal of Ophthalmology - August 31, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research