Log in to search using one of your social media accounts:

 

Primary Outcomes of Accelerated Epithelium-Off Corneal Cross-Linking in Progressive Keratoconus in Children: A 1-Year Prospective Study.
This study included 47 eyes (25 patients), aged 9-14 years, with documented progressive keratoconus. After applying 0.1% riboflavin drops, ACXL was performed. Assessment included corrected distance visual acuity (CDVA), uncorrected visual acuity (UCVA), corneal haze, and corneal densitometry in grayscale units (GSU). Result: The mean baseline and corneal densitometry peaked at 3 months post-ACXL while central and posterior densitometry showed a statistically significant increase (P
Source: Journal of Ophthalmology - February 24, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Ocular Biometry in Primary Angle-Closure Glaucoma Associated with Retinitis Pigmentosa.
Authors: Xu J, Ouyang Z, Yang Y, Cai X, Wang Z, Lin M, Zhang X, Liu X, Yu M Abstract Background: Retinitis pigmentosa (RP) comprises a group of inherited disorders in which patients typically lose night vision in adolescence and then lose peripheral vision in young adulthood before eventually losing central vision later in life. A retrospective case-control study was performed to evaluate differences in ocular biometric parameters in primary angle-closure glaucoma (PACG) patients with and without concomitant RP to determine whether a relationship exists between PACG and RP. Methods: We used ultrasound biomicros...
Source: Journal of Ophthalmology - February 24, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Nonsurgical Procedures for Keratoconus Management.
Conclusions: In the context of nonsurgical procedures, the use of contact lenses for the management of keratoconic patients represents a good alternative to restore vision and improve the quality of live in this population. PMID: 29430305 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - February 14, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Pattern of Contrast Sensitivity Changes in Acute Central Serous Chorioretinopathy.
Conclusion: The impaired CS gradually improved as the SRF reduced at all spatial frequencies. CS at 3 and 12 cpd continued to improve after complete fluid resolution. Despite an excellent final VA, the CS at 6 months did not regain its normal value. PMID: 29423320 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - February 11, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Evaluation of Predictive Factors for Successful Intravitreal Dexamethasone in Pseudophakic Cystoid Macular Edema.
Authors: Kakkassery V, Schultz T, Wunderlich MI, Schargus M, Dick HB, Rehrmann J Abstract Purpose: To determine the efficacy, safety, and predictive outcome factors for intravitreal dexamethasone implant (DEX) in pseudophakic cystoid macular edema (PCME). Methods: Retrospective, interventional, controlled study. Patients included had to have clinically significant PCME and have been treated with the DEX between 2012 and 2015. Charts and one-year data were selected consecutively, and efficacy and safety were abstracted. Visual acuity (VA) and central foveal thickness (CFT) were analysed. Results: Nineteen pa...
Source: Journal of Ophthalmology - February 9, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Distribution of the Photoreceptor Outer Segment Length in a Healthy Population.
Authors: Maden G, Cakir A, Icar D, Erden B, Bolukbasi S, Elcioglu M Abstract Purpose: To evaluate the effects of age and sex on the photoreceptor outer segment (PROS) length in healthy eyes, using spectral-domain optical coherence tomography (SD-OCT). Methods: A total of 97 eyes of 97 healthy participants (spherical equivalent 
Source: Journal of Ophthalmology - February 9, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Surgical Options for the Refractive Correction of Keratoconus: Myth or Reality.
Authors: Fernández-Vega-Cueto L, Romano V, Zaldivar R, Gordillo CH, Aiello F, Madrid-Costa D, Alfonso JF Abstract Keratoconus provides a decrease of quality of life to the patients who suffer from it. The treatment used as well as the method to correct the refractive error of these patients may influence on the impact of the disease on their quality of life. The purpose of this review is to describe the evidence about the conservative surgical treatment for keratoconus aiming to therapeutic and refractive effect. The visual rehabilitation for keratoconic corneas requires addressing three concerns: halting th...
Source: Journal of Ophthalmology - February 7, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Minimally Invasive Repetitive UVA Irradiation along with Riboflavin Treatment Increased the Strength of Sclera Collagen Cross-Linking.
This study aimed to investigate the efficacy of minimally invasive repetitive UVA irradiation along with riboflavin treatment on sclera collagen cross-linking in rabbits. Method: Forty-eight healthy adult New Zealand white rabbits were randomly divided into four groups: pseudosurgery group (group I), single-irradiation group (group II), duplicate-irradiation group (group III), and triplicate-irradiation group (group IV), with 12 rabbits in each group. For the single-irradiation group, a specially made LED light source was inserted through a minimally invasive conjunctival incision to gain close contact with the sclera ...
Source: Journal of Ophthalmology - February 4, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Comparison of the Surgical Outcome for the Full-Thickness Macular Hole with/without Lamellar Hole-Associated Epiretinal Proliferation.
Conclusion: The preoperative appearance of LHEP could be one of the prognostic factor for the treatment of FTMH. PMID: 29387485 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - February 3, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Autologous Platelet-Rich Plasma Eye Drops for the Treatment of Post-LASIK Chronic Ocular Surface Syndrome.
Conclusion: Monotherapy with autologous E-PRP is a well-tolerated, safe, and effective treatment for the management of post-LASIK ocular surface syndrome. Precis: Monotherapy with autologous platelet-rich plasma eye drops has been shown to be an adequate option for the treatment of post-LASIK chronic ocular surface syndrome. This trial is registered with NCT03322917. PMID: 29379652 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - February 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Sensitivity, Specificity, and Limitations of Optical Coherence Tomography Angiography in Diagnosis of Polypoidal Choroidal Vasculopathy.
Conclusions: OCTA based on clear BVNs at the choroidal level increased sensitivity of diagnosis of PCV by 20%. However, the false-positive rate also increased in occult CNV. Several limitations for a correct diagnosis of PCV were noted. PMID: 29379653 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - February 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comparison of Repeatability and Agreement between Swept-Source Optical Biometry and Dual-Scheimpflug Topography.
Authors: Jung S, Chin HS, Kim NR, Lee KW, Jung JW Abstract Purpose: To assess the repeatability and agreement of parameters obtained with two biometers and to compare the predictability. Methods: Biometry was performed on 101 eyes with cataract using the IOLMaster 700 and the Galilei G6. Three measurements were obtained per eye with each device, and repeatability was evaluated. The axial length (AL), anterior chamber depth (ACD), keratometry (K), white-to-white (WTW) corneal diameter, central corneal thickness (CCT), and lens thickness (LT) were measured and postoperative predictability was compared. Result...
Source: Journal of Ophthalmology - January 31, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Psychological Distress in Patients with Symptomatic Vitreous Floaters.
Conclusions: Symptomatic vitreous floater patients showed substantial level of psychological distress, and the severity of floater symptoms was significantly associated with psychological distress. PMID: 29375909 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - January 31, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Optic Neuritis in the Older Chinese Population: A 5-Year Follow-Up Study.
This study aims to describe the clinical manifestations and outcomes in a cohort of older Chinese patients. Method: A retrospective study of patients aged ≥ 45 years who had a first episode of optic neuritis (ON) between May 2008 and November 2012. Clinical features at onset and last follow-up were analyzed within subgroups (age 45-65 years and age ≥ 65 years). Results: 76 patients (99 eyes) were included, of which 58% were females. The mean age at presentation was 55.53 ± 8.29 years (range: 45-83 years). Vision loss was severe at presentation, with initial bes...
Source: Journal of Ophthalmology - January 31, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Multimodality Imaging Assessment of Ocular Ischemic Syndrome.
Authors: Wang H, Wang Y, Li H Abstract Objectives: To assess the underlying mechanisms of OIS and confirm the haemodynamic and retinal structure changes of early OIS. Methods: An observational cross-sectional study was conducted of 60 internal carotid artery (ICA) stenosis patients, and they were divided into OIS and control group. Colour doppler imaging, optical coherence tomography, and fundus fluorescein angiography were performed. Results: The middle cerebral artery (MCA) stenosis differs significantly between the two groups. More OIS patients had new collateral patency of posterior communicating artery...
Source: Journal of Ophthalmology - January 31, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Regulation of Reentrainment Function Is Dependent on a Certain Minimal Number of Intact Functional ipRGCs in rd Mice.
Conclusion: Our study indicates that the regulation of some NIF visual functions is dependent on a certain minimal number of intact functional ipRGCs. PMID: 29359039 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - January 25, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Glaucomatocyclitic Crises May Occur in Patients with Narrow or Closed Angles.
Conclusions: The coexistence of narrow or closed angles and a glaucomatocyclitic crisis is possible, especially in patients of Asian descent. In patients with shallow anterior chambers, a glaucomatocyclitic crisis may be a cause of acute glaucoma episodes. PMID: 29348928 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - January 21, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Influence of Environmental Factors on the Prevalence of Myopia in Poland.
Conclusions: The results of our study point to insufficiency of accommodation contributing to the pathogenesis of myopia. PMID: 29348929 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - January 21, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Analysis of Genetic Mutations in a Cohort of Hereditary Optic Neuropathy in Shanghai, China.
Conclusion: Leber hereditary optic neuropathy is the most common detected type of hereditary optic neuropathy in Shanghai, China. The detection of other autosomal mutations in hereditary optic neuropathy is limited by the currently available technique. PMID: 29348930 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - January 21, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Detection of Silent Type I Choroidal Neovascular Membrane in Chronic Central Serous Chorioretinopathy Using En Face Swept-Source Optical Coherence Tomography Angiography.
Conclusion: Silent type 1 CNV is an established complication of chronic CSCR. SS-OCTA is indispensable in excluding CNV especially in high-risk patients and whenever FFA and SS-OCT are inconclusive. PMID: 29348931 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - January 21, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Long-Term Follow-Up in Children with Anisocoria: Cocaine Test Results and Patient Outcome.
We describe cocaine test results, outcome of systemic investigation, and long-term follow-up in children with anisocoria. Methods: Retrospective review of medical records and phone interview of consecutive pediatric patients (
Source: Journal of Ophthalmology - January 21, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Clinical Characteristics and Surgical Procedures for Children with Congenital Membranous Cataract.
Conclusion: Ultrasound biomicroscopy was used successfully to classify congenital membranous cataracts prior to surgery. Anterior and posterior capsulorhexis was performed using Klöti RF capsulotomy tips, and capsulectomy was performed using a vitrectomy cutter. These were effective techniques and should be considered for congenital membranous cataract removal surgery. This trial is registered with registration number chiCTR-OOC-17010913. PMID: 29333290 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - January 17, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Effect of Perioperative Topical Ketorolac 0.5% on Macular Thickness after Uneventful Phacoemulsification.
Authors: Dal D, Sarac O, Toklu Y, Kocak Altintas AG, Cakmak HB, Damar Gungor E, Simsek S Abstract Background: To evaluate the effects of topical 0.5% ketorolac treatment combined with topical steroids on macular thickness in cases who had uneventful phacoemulsification surgery. Methods: 58 eyes of 58 consecutive cases were included. The mean foveal thickness (MFT), parafoveal thickness (ParaFT), and perifoveal thickness (PeriFT) measurements were performed with optical coherence tomography (RTVue-100, Optovue, Fremont, CA, USA) preoperatively and at postoperative 1 week, 1 month, and 2 months. All cases receive...
Source: Journal of Ophthalmology - January 17, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Applying Sutureless Encircling Number 41 Band and Transscleral Chandelier-Assisted Laser Retinopexy for Scleral Buckling Procedure.
Authors: Gomaa AR, Elbaha SM Abstract Purpose: To assess the outcome of sutureless encirlcing number 41 band and transscleral laser retinopexy in uncomplicated rhegmatogenous retinal detachment (RRD), using a wide-angle viewing system (WAVS) and chandelier endoillumination. Methods: Prospective intervention study included 30 eyes of 30 patients presenting with RRD of recent onset indicated for SB. All cases were treated by sutureless encircling number 41 band and transscleral laser retinopexy. Visualization was provided by the Resight WAVS and a single 27-gauge chandelier endoillumination. Anatomical and visual...
Source: Journal of Ophthalmology - January 17, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Corrigendum to "Genotype-Phenotype Characterization of Novel Variants in Six Italian Patients with Familial Exudative Vitreoretinopathy".
Corrigendum to "Genotype-Phenotype Characterization of Novel Variants in Six Italian Patients with Familial Exudative Vitreoretinopathy". J Ophthalmol. 2017;2017:7969364 Authors: Iarossi G, Bertelli M, Maltese PE, Gusson E, Marchini G, Bruson A, Benedetti S, Volpetti S, Catena G, Buzzonetti L, Ziccardi L Abstract [This corrects the article DOI: 10.1155/2017/3080245.]. PMID: 29333293 [PubMed - in process] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - January 17, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Quantification of Macular Vascular Density Using Optical Coherence Tomography Angiography and Its Relationship with Retinal Thickness in Myopic Eyes of Young Adults.
Conclusions: Varying degrees of myopia did not affect macular vascular density in young healthy adults. In addition, superficial macular vascular density, as an independent factor, was positively correlated with mGCC thickness. PMID: 29318037 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - January 11, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Vision Improvement with Refractive Correction Does Not Completely Exclude Major Eye Diseases: Analyses of Visually Impaired South Korean Population in the Korea National Health and Nutrition Examination Survey 2009-2011.
Authors: Suh YW, Lee JS, Heo H, Park SH, Kim SH, Lim KH, Moon NJ, Lee SJ, Park SH, Baek SH Abstract Purpose: To investigate the association between vision improvement with refractive correction in the visually impaired eyes and the prevalence of ocular comorbidities in the South Korean population. Materials and Methods: The data of 24,620 individuals in the Korea National Health and Nutrition Examination Survey (KNHANES 2009-2011) were reviewed. Visual impairment was defined as a presenting visual acuity 
Source: Journal of Ophthalmology - January 11, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Surgical Outcomes of 27-Gauge Pars PLana Vitrectomy for Symptomatic Vitreous Floaters.
Authors: Lin Z, Zhang R, Liang QH, Lin K, Xiao YS, Moonasar N, Wu RH Abstract Purpose: To report the surgical outcomes of 27-gauge pars plana vitrectomy (PPV) for symptomatic vitreous floaters. Methods: 47 eyes of 47 patients (39 males, 83.0%) with symptomatic vitreous floaters who underwent 27-gauge PPV and followed up for more than 6 months were included. The mean age was 34.7 ± 13.5 years. Results: No operative complication occurred. At first day postoperatively, the intraocular pressure (IOP) was significantly lower than that at other time points (8.6 ± 2.7 mmHg, p
Source: Journal of Ophthalmology - January 11, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

In Vitro Aberrometric Assessment of a Multifocal Intraocular Lens and Two Extended Depth of Focus IOLs.
Conclusions: In an optical bench, the MW induces negative primary and positive secondary SA for all pupils. The SYM aberrations seem to be pupil dependent; it does not produce negative primary SA for 3 mm but increases for higher pupils. Meanwhile, the HOAs for the MW and SYM were not significant. The MP showed in all cases the highest HOAs. PMID: 29318040 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - January 11, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Seroprevalence against Rickettsia and Borrelia Species in Patients with Uveitis: A Prospective Survey.
Authors: Madsen KB, Wallménius K, Fridman Å, Påhlson C, Nilsson K Abstract Vector-borne diseases such as Lyme borreliosis and rickettsioses have been associated with ocular inflammation. Our aim was to study patients with diagnosed uveitis to evaluate serological signs of infection or exposure to these tick-borne agents. Forty-eight patients were prospectively examined with serology together with medical records and a questionnaire concerning previous exposure, diseases, and treatments. Seven patients (14.6%) showed seroconversion to Rickettsia spp. between acute and convalescent phase sera, whic...
Source: Journal of Ophthalmology - January 11, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Effect of Cap-Lenticule Diameter Difference on the Visual Outcome and Higher-Order Aberrations in SMILE: 0.4  mm versus 1.0 mm.
Effect of Cap-Lenticule Diameter Difference on the Visual Outcome and Higher-Order Aberrations in SMILE: 0.4 mm versus 1.0 mm. J Ophthalmol. 2017;2017:8259546 Authors: Torun Acar B, Acar S Abstract Purpose: To evaluate the effect of cap-lenticule diameter difference (CLDD) on the visual outcome and higher-order aberrations (HOAs) of small-incision lenticule extraction (SMILE). Methods: A total of 132 patients who had bilateral SMILE for myopia or myopic astigmatism were included. The CLDD was 0.4 mm in 54 patients (group 1) and 1.0 mm in 78 patients (group 2). The refrac...
Source: Journal of Ophthalmology - December 23, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Corrigendum to "Relationship between the Direction of Ophthalmic Artery Blood Flow and Ocular Microcirculation before and after Carotid Artery Stenting".
Corrigendum to "Relationship between the Direction of Ophthalmic Artery Blood Flow and Ocular Microcirculation before and after Carotid Artery Stenting". J Ophthalmol. 2017;2017:7861491 Authors: Ishii M, Hayashi M, Yagi F, Sato K, Tomita G, Iwabuchi S Abstract [This corrects the article DOI: 10.1155/2016/2530914.]. PMID: 29259825 [PubMed - in process] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - December 22, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Estimation of the Corneal Young's Modulus In Vivo Based on a Fluid-Filled Spherical-Shell Model with Scheimpflug Imaging.
This study proposes a practical approach to correctly measure IOP in vivo. By embedding a new model-based correction to the Corvis® ST, we can extract the corneal Young's modulus from the patient data. This Young's modulus can be used to correct the IOP readings. The tests were applied to 536 right eyes of 536 healthy subjects (228 male and 308 female) between March of 2012 and April of 2016. The tests were applied to patients at the Department of Ophthalmology, National Taiwan University Hospital and the Hung-Chuo Eye Clinics. The statistical analysis showed that the value for the Young's modulus was independent of al...
Source: Journal of Ophthalmology - December 19, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Applying a New Automated Perimetry Pattern Based on the Stimulus Distribution of the Multifocal ERG to Improve Structure-Function Investigation in Glaucoma.
Authors: Brandão LM, Monhart M, Schötzau A, Ledolter AA, Palmowski-Wolfe AM Abstract Purpose: To validate a new automated perimetry pattern (mf103 pattern) for the investigation of retinal structure-function relationships in glaucoma in comparison to the standard G2 pattern and to relate either field's performance to optical coherence tomography (OCT). Methods: Automated perimetry data from the mfERG103 pattern were compared with the standard G2 pattern in glaucoma patients (18) and controls (15). The results of both (mean defect (MD) and mean sensitivity (MS)) were compared with optical coherence t...
Source: Journal of Ophthalmology - December 16, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Influence of Juvenile Graves' Ophthalmopathy on Graves' Disease Course.
Authors: Jankauskiene J, Jarusaitiene D Abstract Purpose: To investigate juvenile Graves' ophthalmopathy (GO) signs and compare Graves' disease (GD) course in patients with or without GO. Patients and Methods: There were analyzed data (visual acuity, proptosis, palpebral fissure measurements, clinical activity score (CAS), and the course of GD) of 67 children who have been newly diagnosed with GD. 26.9% of patients with GD had signs of ophthalmopathy (GO+), and 73.1% were without ophthalmopathy (GO-). Results: Upper eyelid retraction (72.3%), proptosis (66.7%), and soft tissue changes (27.8-38.9%) were in G...
Source: Journal of Ophthalmology - December 13, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Chosen Vascular Risk Markers in Pseudoexfoliation Syndrome: An Age-Related Disorder.
Conclusions: Our results cast doubt on the opinion on the possible PEX and vascular diseases relation. Further studies on this subject are mandatory. PMID: 29225964 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - December 13, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Anti-VEGF and Beyond.
Authors: Bertelmann T, Kaymak H, Kretz FTA, Koss MJ PMID: 29225965 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - December 13, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Changes in Glaucoma Medication during the Past Eight Years and Future Directions in Japan Based on an Insurance Medical Claim Database.
Conclusions: The prevalence of glaucoma patients has significantly increased during the past eight years. The number of antiglaucoma medications continuously increased during the treatment period. PMID: 29225966 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - December 13, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Management of Retinal Detachment: Techniques and Perspectives.
Authors: Moisseiev E, Loewenstein A, Moshiri A, Yiu G PMID: 29230321 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - December 13, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Macular Retinal Vessel Oxygen Saturation Elevation in Chinese Central Serous Chorioretinopathy.
Conclusions: AS increased in the TI, and VS decreased in the NI in the eyes with CSC. In addition, AS also increased around the macular region, suggesting that these are contributors to CSC pathophysiology. PMID: 29230322 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - December 13, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Assessment of Ocriplasmin Effects on the Vitreoretinal Compartment in Porcine and Human Model Systems.
In conclusion, transient hyperreflective spots and fluid in a porcine ocriplasmin-induced PVD model did not correlate with retinal ECM rearrangement nor inflammation. Reversible in vitro effects on blood-retinal barrier permeability provide grounds for a hypothesis on the mechanisms behind transient subretinal fluid observed in ocriplasmin-treated patients. PMID: 29214073 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - December 9, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Tilt, Decentration, and Internal Higher-Order Aberrations of Sutured Posterior-Chamber Intraocular Lenses in Patients with Open Globe Injuries.
Authors: Zhu X, Zhang Y, He W, Ye H, Jiang C, Lu Y Abstract Purpose: To evaluate the tilt, decentration, and internal higher-order aberrations (HOAs) of sutured posterior-chamber intraocular lenses (IOLs) in patients with open globe injuries. Methods: 46 consecutive patients (47 eyes) who underwent transsclerally sutured IOL implantation were enrolled in this prospective cohort study. Nineteen eyes had a history of open globe injury. The tilt and decentration of the IOLs and the visual quality were measured 1 month after surgery. Results: The horizontal tilt and decentration of the IOLs in the open-globe-in...
Source: Journal of Ophthalmology - December 9, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Air Bubble Technique for Fundus Visualization during Vitrectomy in Aphakia.
This study included 53 eyes of 53 patients who are phakic and indicated for phacovitrectomy (7 eyes, group 1), aphakic and indicated for vitrectomy (22 eyes, group 2), or underwent unplanned vitrectomy for immediate management of a phacoemulsification surgery complicated by rupture posterior capsule with dropped nucleus, fragments, or IOL (24 eyes, group 3). Cases with complicated vitreoretinal pathology were not included in this study. All vitrectomy surgeries were conducted by the air bubble technique in the anterior chamber. Main outcomes included anatomical success, visual acuity, and intraoperative and postoperative c...
Source: Journal of Ophthalmology - December 9, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Posterior Segment Ocular Trauma: Timing and Indications for Vitrectomy.
Authors: Rejdak R, Juenemann AG, Natarajan S PMID: 29214076 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - December 9, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Use of OCT Angiography in Choroidal Melanocytic Tumors.
Conclusion: OCTA is a promising new technology that can be used to study in vivo the differential characteristics of microcirculations between posterior segment melanocytic lesions. Today, larger studies are needed to corroborate these findings and to correlate it with malignancy. PMID: 29201456 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - December 6, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Effect of CM082, an Oral Tyrosine Kinase Inhibitor, on Experimental Choroidal Neovascularization in Rats.
Authors: Ren C, Shi H, Jiang J, Liu Q, Du Y, He M, Cai W, Wei Q, Yu J Abstract The aims of this study were to evaluate the effects of CM082 on the development of choroidal neovascularization (CNV) in a laser-induced CNV rat model and to determine the drug concentration in the ocular tissues. After the laser-induced CNV model was established in rats, CM082 was orally administered. The effects of CM082 on the CNV lesions were assessed using fundus fluorescein angiography (FFA), CNV histology, and retinal pigment epithelium- (RPE-) choroid-sclera eyecup analysis. The concentrations of CM082 in the plasma and eye tissu...
Source: Journal of Ophthalmology - December 6, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Switch to Aflibercept in the Treatment of Neovascular AMD: Long-Term Results.
Authors: Neves Cardoso P, Pinheiro AF, Meira J, Pedrosa AC, Falcão MS, Pinheiro-Costa J, Falcão-Reis F, Carneiro ÂM Abstract Purpose: To report the long-term clinical outcomes after switching from intravitreal bevacizumab or ranibizumab to aflibercept therapy in eyes with AMD. Methods: Retrospective analysis of changes in BCVA, SD-OCT image, and frequency of injections after 1, 2, and 3 years of follow-up. Results: 164 eyes were analyzed, 101 eyes switched from bevacizumab (group 1) and 63 from ranibizumab (group 2). One year after the switch, there was an overall nonsignificant mean dec...
Source: Journal of Ophthalmology - December 6, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Algorithm for Correcting the Keratometric Error in the Estimation of the Corneal Power in Keratoconus Eyes after Accelerated Corneal Collagen Crosslinking.
Authors: Piñero DP, Camps VJ, Caravaca-Arens E, de Fez D, Blanes-Mompó FJ Abstract Purpose: To analyze the errors associated to corneal power calculation using the keratometric approach in keratoconus eyes after accelerated corneal collagen crosslinking (CXL) surgery and to obtain a model for the estimation of an adjusted corneal refractive index (nkadj ) minimizing such errors. Methods: Potential differences (ΔPc) among keratometric (Pk ) and Gaussian corneal power (PcGauss) were simulated. Three algorithms based on the use of nkadj for the estimation of an adjusted keratometric corneal pow...
Source: Journal of Ophthalmology - December 6, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Involvement of β-Catenin/COX-2/VEGF Axis in NMDA-Caused Retinopathy.
The Involvement of β-Catenin/COX-2/VEGF Axis in NMDA-Caused Retinopathy. J Ophthalmol. 2017;2017:9760501 Authors: Ning D, Zhang WK, Tian H, Li XJ, Liu M, Li YS, Tang HB Abstract NMDA, a molecule that is capable of producing the loss of retinal ganglia cells (RGCs), has been widely studied; however, the detailed mechanism is not yet clarified. Previously, Wnt/β-catenin signaling has been suggested to be involved in the NMDA-induced retinopathy. In addition, previous investigations in our group demonstrated the presence of a Wnt/β-catenin/COX-2 axis in dorsal root ganglions (DRGs). Therefo...
Source: Journal of Ophthalmology - November 23, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Effect of MT3 on Retinal and Choroidal TGF- β2 and HAS2 Expressions in Form Deprivation Myopia of Guinea Pig.
Conclusion: MT3 can inhibit form deprivation myopia, and MT3 treatment can result in changes of retinal and choroidal TGF-β2 and HAS2 mRNA and protein expressions. PMID: 29163988 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 23, 2017 Category: Opthalmology Tags: J Ophthalmol Source Type: research