Nanophthalmos: A Review of the Clinical Spectrum and Genetics.
Authors: Carricondo PC, Andrade T, Prasov L, Ayres BM, Moroi SE Abstract Nanophthalmos is a clinical spectrum of disorders with a phenotypically small but structurally normal eye. These disorders present significant clinical challenges to ophthalmologists due to a high rate of secondary angle-closure glaucoma, spontaneous choroidal effusions, and perioperative complications with cataract and retinal surgeries. Nanophthalmos may present as a sporadic or familial disorder, with autosomal-dominant or recessive inheritance. To date, five genes (i.e., MFRP, TMEM98, PRSS56, BEST1, and CRB1) and two loci have been implica...
Source: Journal of Ophthalmology - June 5, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Characterization of Soft Contact Lens Edge Fitting during Daily Wear Using Ultrahigh-Resolution Optical Coherence Tomography.
Authors: Cui L, Chen S, Zhou W, Sheng K, Zhang L, Shen M, Li M Abstract Purpose: To determine conjunctival overlap over the edge of soft contact lens and to visualize the peripheral postlens tear film (PoLTF) underneath soft contact lenses using ultrahigh-resolution optical coherence tomography (UHR-OCT). Methods: Twenty participants (4 males and 16 females, 23.0 ± 3.7 years) were fitted with two different types of soft contact lenses randomly. The limbus with lens was imaged with the UHR-OCT at the horizontal meridian every two hours up to 6 hours during lens wear. The conjunctival overlap...
Source: Journal of Ophthalmology - June 5, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Effects of Ageing on the Anterior Segment of the Eye Structure and Function.
Authors: Cerviño A, Radhakrishnan H, Alfonso JF, Brautaset R, González-Meijome JM PMID: 29862065 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 5, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Continuation of Aspirin Therapy before Cataract Surgery with Different Incisions: Safe or Not?
Conclusions: The outcomes indicated that phacoemulsification cataract surgery under topical anesthesia could be safely performed without ceasing systemic aspirin therapy. Clear corneal incision could be a better choice in patients treated with aspirin. PMID: 29862066 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 5, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comparison of SNP Genotypes Related to Proliferative Vitreoretinopathy (PVR) across Slovenian and European Subpopulations.
Authors: Lumi X, Jelen MM, Jevšinek Skok D, Boštjančič E, Ravnik-Glavač M, Hawlina M, Glavač D Abstract The present study investigated the distribution of genotypes within single nucleotide polymorphisms (SNPs) in genes, related to PVR pathogenesis across European subpopulations. Genotype distributions of 42 SNPs among 96 Slovenian healthy controls were investigated and compared to genotype frequencies in 503 European individuals (Ensembl database) and their subpopulations. Furthermore, a case-control status was simulated to evaluate effects of allele frequency changes on statistically significant...
Source: Journal of Ophthalmology - June 5, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Ahmed Glaucoma Valve Implantation in Vitrectomized Eyes.
Conclusions: Despite complications necessitating medical and surgical interventions, vitrectomized eyes were effectively managed with AGV implantation. PMID: 29862068 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 5, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Application of Novel Drugs for Corneal Cell Regeneration.
Authors: Han SB, Liu YC, Mohamed-Noriega K, Mehta JS Abstract Corneal transplantation has been the only treatment method for corneal blindness, which is the major cause of reversible blindness. However, despite the advancement of surgical techniques for corneal transplantation, demand for the surgery can never be met due to a global shortage of donor cornea. The development of bioengineering and pharmaceutical technology provided us with novel drugs and biomaterials that can be used for innovative treatment methods for corneal diseases. In this review, the authors will discuss the efficacy and safety of pharmacolog...
Source: Journal of Ophthalmology - June 3, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Age Differences in Axial Length, Corneal Curvature, and Corneal Astigmatism in Marfan Syndrome with Ectopia Lentis.
This study included 114 MFS patients (215 eyes) with a mean age of 19.0 ± 13.9 years. Axial length differed significantly across age groups in MFS patients (P
Source: Journal of Ophthalmology - June 3, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Flt3 Regulation in the Mononuclear Phagocyte System Promotes Ocular Neovascularization.
Authors: Gao Y, Zhong Y, Zhu Y, Demetriades AM, Cai Y, Shen J, Lu Q, Shen X, Xie B Abstract Fms-like tyrosine kinase 3 (Flt3), a tyrosine kinase receptor expressed in CD34+ hematopoietic stem/progenitor cells, is important for both normal myeloid and lymphoid differentiation. It has been implicated in mice and humans for potential multilineage differentiation. We found that mice deficient in Flt3 or mice that received an Flt3 inhibitor (AC220) showed significantly reduced areas of ischemia-induced retinal neovascularization (RNV) and laser-induced choroidal NV (CNV) (P
Source: Journal of Ophthalmology - June 3, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Evaluation of Navigated Laser Photocoagulation (Navilas 577+) for the Treatment of Refractory Diabetic Macular Edema.
Authors: Kato F, Nozaki M, Kato A, Hasegawa N, Morita H, Yoshida M, Ogura Y Abstract Purpose: To evaluate navigated laser photocoagulation for the treatment of refractory diabetic macular edema (DME). Methods: Retrospective study of 25 eyes (21 patients) treated with Navilas 577+ focal laser system. Best-corrected visual acuity (BCVA) and spectral-domain optical coherence tomography (OCT) parameters were measured at baseline, 1, 3, and 6 months, and final visit. Results: The mean follow-up period was 12.8 ± 2.4 (7-16 months). All subjects had history of previous treatment which was inje...
Source: Journal of Ophthalmology - June 3, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Role of the Epipapillary Membrane in Maculopathy Associated with Cavitary Optic Disc Anomalies: Morphology, Surgical Outcomes, and Histopathology.
Conclusions: These results suggest that epipapillary membrane is involved in the pathogenesis of some patients with cavitary optic disc anomaly-associated maculopathy as well as posterior hyaloid membrane. PPV with epipapillary membrane removal may be a useful treatment option for this maculopathy. This trial is registered with UMIN000011123. PMID: 29854427 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 3, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Mutation Spectrum of the ABCA4 Gene in a Greek Cohort with Stargardt Disease: Identification of Novel Mutations and Evidence of Three Prevalent Mutated Alleles.
Conclusions: By using a combination of methods, we completely molecularly diagnosed 48 of the 59 patients studied. In addition, we identified six previously unreported, potentially pathogenic ABCA4 mutations. PMID: 29854428 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 3, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Evaluation of Vitrectomy with Planned Foveal Detachment as Surgical Treatment for Refractory Diabetic Macular Edema with or without Vitreomacular Interface Abnormality.
Conclusion: Vitrectomy with a planned foveal detachment technique was shown to be a promising solution for refractory DME cases with rapid edema resolution. CMT was shown to improve more in eyes where conventional vitrectomy was not attempted. Moreover, cases with VMA resistant to pharmacotherapy was shown to respond well to this technique. The study has been registered in Contact ClinicalTrials.gov PRS Identifier: NCT03345056. PMID: 29854429 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 3, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Vision-Threatening Behcet's Disease: Severity of Ocular Involvement Predictors.
Conclusion: Certain findings in Behcet's disease may act as predictors for the severity of ocular affection. Directing our attention to these factors by the internist and ophthalmologist can help plan the frequency of follow-up as well as the aggressiveness of treatment in patients with Behcet's disease. PMID: 29854430 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 3, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Mapping the Structure-Function Relationship in Glaucoma and Healthy Patients Measured with Spectralis OCT and Humphrey Perimetry.
Conclusions: Both maps and point-to-point functions obtained linking structure and function damage contribute to a better understanding of this relationship and may help in the future to improve glaucoma diagnosis. PMID: 29850196 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Evaluating Eye Drop Instillation Technique and Its Determinants in Glaucoma Patients.
Conclusions: Eye drop instillation technique in glaucoma patients deserves great attention from eye care practitioners during their lifelong follow-up, especially those aged older and have worse visual acuity. PMID: 29850197 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Internal Astigmatism and Its Role in the Growth of Axial Length in School-Age Children.
Authors: Wu L, Weng C, Xia F, Wang X, Zhou X Abstract Objectives: To explore the role of internal astigmatism (IA) in the growth of axial length (AL) in school-age children. Methods: Total astigmatism (TA), corneal astigmatism (CA), and AL of all children in Jing'an District 2nd Centre Primary School in Shanghai were measured. In IA, the difference between TA and CA was also calculated using vector analysis. The association of axial length with IA, genders, and age was analyzed using linear regression. The difference of IA between both eyes was also calculated. The AL between both eyes was compared using paired...
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comparison of the Effect of Intravitreal Dexamethasone Implant in Vitrectomized and Nonvitrectomized Eyes for the Treatment of Diabetic Macular Edema.
Authors: Çevik SG, Yılmaz S, Çevik MT, Akalp FD, Avcı R Abstract Purpose: To compare the effectiveness of sustained-release dexamethasone (DEX) intravitreal implant in nonvitrectomized eyes and vitrectomized eyes with diabetic macular edema (DME). Methods: A retrospective review of the medical records of 40 eyes of 30 consecutive patients with diabetic macular edema who underwent intravitreal DEX implant injection. Patients were divided into 2 subgroups: 31 eyes that were nonvitrectomized (group 1) and 9 eyes that had previously undergone standard pars plana vitrectomy (group 2). The main outcom...
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Effect of Age on Pentacam Keratoconus Indices.
Authors: Roshdy MMS, Wahba SS, Elkitkat RS, Hakim AM, Fikry RR Abstract Purpose: To assess the effect of age on elevation and pachymetric Pentacam keratoconus (KC) detection indices, and the need to adjust normative values accordingly. Methods: In a retrospective study, 95 eyes of myopic normal subjects without KC were evaluated using the OCULUS Pentacam, with an age range of 17.4 to 46.8 years. Subjects were categorised into three groups according to their age: the first included those younger than 21 years (19 eyes), the second was for the age range of 21-40 years (65 eyes), and the third compri...
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Outcomes of Descemet Membrane Endothelial Keratoplasty for Vitrectomized Eyes with Sutured Posterior Chamber Intraocular Lens.
Authors: Yamada N, Hayashi T, Yuda K, Shimizu T, Oyakawa I, Takahashi H, Kato N Abstract Purpose: To evaluate the clinical outcomes of Descemet membrane endothelial keratoplasty (DMEK) for vitrectomized eyes that underwent pars plana vitrectomy (PPV) and transscleral-sutured intraocular lens (IOL) implantation. Methods: In this retrospective study, DMEK cases were reviewed from medical records and divided into two groups: the eyes after PPV and transscleral-sutured IOL implantation (vitrectomized group) and the eyes with in-the-bag IOL implantation (control group) prior to DMEK. The main outcome measures includ...
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comparison of Intravitreal Aflibercept and Ranibizumab following Initial Treatment with Ranibizumab in Persistent Diabetic Macular Edema.
Authors: Demircan A, Alkin Z, Yesilkaya C, Demir G, Kemer B Abstract Purpose: To compare the visual and anatomic outcomes in patients with persistent diabetic macular edema (DME) who switched from ranibizumab to aflibercept with those who continued with previous ranibizumab therapy. Methods: In this retrospective comparative study, medical records of consecutive patients with center-involved DME ≥ 350 μm who had at least three recent consecutive monthly ranibizumab injections followed by as-needed therapy with either aflibercept or ranibizumab were reviewed. Data were collected at pre...
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Clinical and Genetic Features of Tubulointerstitial Nephritis and Uveitis Syndrome with Long-Term Follow-Up.
Conclusions: TINU should be considered in the differential diagnosis in young patients with uveitis of unknown origin and renal dysfunction. Urinary β2 microglobulin level and HLA typing may help in the diagnosis of TINU. The prognosis for patients with TINU is generally good with steroid treatment. PMID: 29850203 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comparison of Visual Outcome and Morphologic Change between Different Surgical Techniques in Idiopathic Epiretinal Membrane Surgery.
Conclusion: All three techniques can achieve visual acuity improvement and macular thickness reduction. Maculorrhexis ILM peeling achieves more rapid improvement of visual function, better final visual outcome, and a higher rate of normal foveal contour than whole-piece ILM peeling. PMID: 29850204 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Treatment Efficacy and Compliance in Patients with Diabetic Macular Edema Treated with Ranibizumab in a Real-Life Setting.
Authors: Best AL, Fajnkuchen F, Nghiem-Buffet S, Grenet T, Quentel G, Delahaye-Mazza C, Cohen SY, Giocanti-Aurégan A Abstract Purpose: To assess real-life efficacy of ranibizumab and treatment compliance of patients with vision loss secondary to diabetic macular edema (DME). Methods: A retrospective study was conducted in DME patients treated with ranibizumab. Patients were monitored every 4 weeks for visual acuity (VA) and central retinal thickness (CRT) by SD-OCT. All patients received a loading dose of 3 monthly injections followed by retreatments on an as-needed basis. The primary endpoint was the ch...
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Management of Glaucoma: Structure and Function.
Authors: Hirooka K, Higashide T, Jeoung JW PMID: 29850206 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Influence of Disc Size on the Diagnostic Accuracy of Cirrus Spectral-Domain Optical Coherence Tomography in Glaucoma.
Conclusions: The high diagnostic accuracy of the rim area demonstrated by Cirrus HD-OCT for the quantitative assessment of the ONH was not significantly affected by disc size in this study. PMID: 29850207 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Phenotypic Variation in a Four-Generation Family with Aniridia Carrying a Novel PAX6 Mutation.
Authors: Wang GM, Prasov L, Al-Hasani H, Marrs CER, Tolia S, Wiinikka-Buesser L, Richards JE, Bohnsack BL Abstract Aniridia is a congenital disease that affects almost all eye structures and is primarily caused by loss-of-function mutations in the PAX6 gene. The degree of vision loss in aniridia varies and is dependent on the extent of foveal, iris, and optic nerve hypoplasia and the presence of glaucoma, cataracts, and corneal opacification. Here, we describe a 4-generation family in which 7 individuals across 2 generations carry a novel disease-causing frameshift mutation (NM_000280.4(PAX6):c.565TC>T) in PAX6....
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Effect of Reformation of the Anterior Chamber by Air or by a Balanced Salt Solution (BSS) on Corneal Endothelium after Phacoemulsification: A Comparative Study.
Conclusion: There is no difference between the effect of reformation of the anterior chamber after phacoemulsification, using air or using a BSS injection, on the corneal endothelial count and morphology. PMID: 29850209 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Group Analysis of Q Values Calculated with Tangential Radius of Curvature from Human Anterior Corneal Surface.
Conclusion: The method using the tangential radius of curvature combined with linear regression to obtain anterior surface Q values for both adults and children was stable and reliable. When we analyzed the anterior corneal Q value, area division was necessary. PMID: 29850210 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

A Review of Surgical Outcomes and Advances for Macular Holes.
Authors: Zhao PP, Wang S, Liu N, Shu ZM, Zhao JS Abstract The surgical outcomes of macular holes (MHs) have improved greatly in recent years. The closure rate is as high as 90-100%, but the outcomes of some special types of MHs remain unsatisfactory. Internal limiting membrane (ILM) peeling dramatically improves the anatomic success rate, but recent studies have found that it could also cause mechanical and subclinical traumatic changes to the retina. Dyes are widely used, and apart from indocyanine green (ICG), the toxicities of other dyes require further research. Face-down posturing is necessary for MHs larger t...
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Difference in the Vitreal Protein Profiles of Patients with Proliferative Diabetic Retinopathy with and without Intravitreal Conbercept Injection.
Authors: Zou C, Zhao M, Yu J, Zhu D, Wang Y, She X, Hu Y, Zheng Z Abstract Purpose: To examine the difference in the vitreal protein profiles of patients with proliferative diabetic retinopathy (PDR) with and without preoperative intravitreal conbercept (IVC) treatment. Methods: Liquid chromatography-tandem mass spectrometry- (LC-MS/MS-) based proteomic methods were used to determine the protein profiles of the vitreous humor in patients with PDR treated with (IVC group; n = 9) and without (PDR group; n = 8) preoperative IVC. Gene ontology (GO) annotation and REACTOME pathway analysis were obtained to overview ...
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Effect of Exogenous Alpha-B Crystallin on the Structures and Functions of Trabecular Meshwork Cells.
This study, for the first time, focused on the role of CRYAB in undesired changes of the structures and functions in trabecular meshwork (TM) cells. Methods: Cell proliferation and migration were assessed using a cell counting kit-8 (CCK8) and transwell assay analysis, respectively. Immunofluorescence (IF), quantitative real-time PCR (Rt-qPCR), and Western blot were performed to determine the effect of CRYAB on F-actin, tight junctions, and the expression of epithelial to mesenchymal transition- (EMT-) associated proteins in TM cells. Results: CRYAB promoted proliferation (p
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Vascular Endothelial Growth Factor, Basic Fibroblast Growth Factor, and Pigment Epithelium-Derived Factor Expression in the Neovascular Iris in Retinal Diseases.
Conclusions: The protein level of bFGF increased in the irises of the NVG patients was not expressed by the iris itself, whereas PEDF may be expressed by the iris tissue in these patients. PMID: 29850214 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Evaluation of TGF-Beta 2 and VEGF α Gene Expression Levels in Epiretinal Membranes and Internal Limiting Membranes in the Course of Retinal Detachments, Proliferative Diabetic Retinopathy, Macular Holes, and Idiopathic Epiretinal Membranes.
Conclusions: Our results revealed that factors associated with angiogenesis and wound healing processes in eyes with RRD, PDR, iERM, and MH were more upregulated in ERMs than in ILMs. This may indicate that ILM is not responsible for reproliferation and its peeling should be avoided in routine PPV. PMID: 29850215 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Clinical Outcomes of Sequential Intrastromal Corneal Ring Segments and an Extended Range of Vision Intraocular Lens Implantation in Patients with Keratoconus and Cataract.
This study comprised patients with keratoconus and cataract that had ICRS implantation followed 6 months later by extended range of vision IOL implantation. The uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), and residual refractive errors, analysed using vector analysis, were recorded preoperatively, 6 months after ICRS implantation, and 6 months after IOL implantation, respectively. Results: The study enrolled 17 eyes (11 patients). The mean UDVA (logMAR scale) was 1.15 ± 0.67 preoperatively, 0.88 ± 0.69 six months after ICRS implantation (...
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Screening of Primary School Children for Amblyopia and Amblyogenic Factors in Central Cairo, Egypt.
Authors: Rashad MA, Abd Elaziz KM, Fawzy SM, Abdel Latif AAM, Abdel Latif MAM Abstract Objective: To measure the prevalence of amblyopia and amblyogenic factors among primary school children and to evaluate distance visual acuity (VA) as a screening test to detect amblyopia and define its cutoff value. Subjects and Methods: A cross-sectional study was conducted on primary school children in two schools in Central Cairo. Children underwent assessment of visual acuity using Landolt broken ring. Comprehensive ophthalmologic examination was performed for amblyopia suspects at the Ophthalmology Department of Ain Sha...
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Outcome of Primary Nonpenetrating Deep Sclerectomy in Patients with Steroid-Induced Glaucoma.
Conclusion: Primary nonpenetrating deep sclerectomy is a safe and an effective method of treating eyes with steroid-induced glaucoma. No major complications were encountered. After 4 years of follow-up, complete success rate was 56.7% and qualified success rate was 70%. PMID: 29850218 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Less Expansion of Short-Pulse Laser Scars in Panretinal Photocoagulation for Diabetic Retinopathy.
Authors: Higaki M, Nozaki M, Yoshida M, Ogura Y Abstract Purpose: To compare the expansion rates of laser photocoagulation scars between the conventional laser and short-pulse laser using fundus autofluorescence (FAF). Methods: Retrospective chart review. Conventional laser was performed on 6 eyes of 6 patients, and short-pulse laser was performed on 11 eyes of 8 patients with diabetic retinopathy. FAF images were obtained by Optos® 200Tx (Optos, Dunfermline, Scotland, UK) at 1, 3, 6, and 12 months after treatment. The average area of 20 photocoagulation scars was measured by using ImageJ software. The expa...
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Total Penetrating Keratoplasty: Indications, Therapeutic Approach, and Long-Term Follow-Up.
Conclusion: TPK should be considered as a last line treatment in huge corneal destruction to restore integrity of the eye globe. PMID: 29850220 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Generation of Femtosecond Laser-Cut Decellularized Corneal Lenticule Using Hypotonic Trypsin-EDTA Solution for Corneal Tissue Engineering.
Conclusion: We generated an ideal protocol for DCLs using a novel method. Furthermore, it is possible to create a scaffold using a bioengineered corneal substitute. PMID: 29805794 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - May 31, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Corneal Stability following Hyperopic LASIK with Advanced Laser Ablation Profiles Analyzed by a Light Propagation Study.
Conclusions: Light propagation analysis confirms corneal surface stability following modern hyperopic LASIK with a 6th-generation excimer laser technology over a 12-month period. PMID: 29785300 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - May 24, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Impact of Baseline Central Retinal Thickness on Outcomes in the VIVID-DME and VISTA-DME Studies.
Authors: Midena E, Gillies M, Katz TA, Metzig C, Lu C, Ogura Y Abstract Purpose: To report the impact of baseline central retinal thickness (CRT) on outcomes in patients with diabetic macular edema (DME) in VIVID-DME and VISTA-DME. Methods: Post hoc analyses of two randomized controlled trials in which 862 DME patients were randomized 1 : 1 : 1 to treatment with intravitreal aflibercept 2.0 mg every 4 weeks (2q4), intravitreal aflibercept 2.0 mg every 8 weeks after five initial monthly doses (2q8), or macular laser photocoagulation at baseline and as needed. We compared...
Source: Journal of Ophthalmology - May 24, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comparisons of Visual and Surgical Outcomes after Reuse or Replacement of Dislocated in-the-Bag Intraocular Lens.
Conclusions: Half of the cases with reused in-the-bag dislocated IOL had a breakage or a tilting of the IOL. The replacement of the in-the-bag dislocated IOL is better than the reuse of the IOL with intrascleral haptics fixation. PMID: 29785302 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - May 24, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Ocular Manifestations of Biopsy-Proven Pulmonary Sarcoidosis in Korea.
Conclusions: In patients with biopsy-proven pulmonary sarcoidosis, the presence of ocular involvement and uveitis as a first sign could be significant factors associated with higher systemic treatment rate, especially with immunosuppressive agents. Biopsy site determined by location and size had no influence on clinical features. PMID: 29785303 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - May 24, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Application of 25  MHz B-Scan Ultrasonography to Determine the Integrity of the Posterior Capsule in Posterior Polar Cataract.
Conclusion: This is the first report to show that 25 MHzB can be used to clearly visualize the status of the PC in PPC. These results, in turn, could be used to select the appropriate treatment and to thereby avoid further complications during PPC surgery. PMID: 29785304 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - May 24, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Molecular Genetics of Pigment Dispersion Syndrome and Pigmentary Glaucoma: New Insights into Mechanisms.
Authors: Lahola-Chomiak AA, Walter MA Abstract We explore the ideas and advances surrounding the genetic basis of pigment dispersion syndrome (PDS) and pigmentary glaucoma (PG). As PG is the leading cause of nontraumatic blindness in young adults and current tailored interventions have proven ineffective, a better understanding of the underlying causes of PDS, PG, and their relationship is essential. Despite PDS being a subclinical disease, a large proportion of patients progress to PG with associated vision loss. Decades of research have supported a genetic component both for PDS and conversion to PG. We review th...
Source: Journal of Ophthalmology - May 22, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Effect of Timing of Initial Cataract Surgery, Compliance to Amblyopia Therapy on Outcomes of Secondary Intraocular Lens Implantation in Chinese Children: A Retrospective Case Series.
Authors: Li L, Wang Y, Xue C Abstract Purpose: As a secondary analysis, we reassess the association of initial congenital cataract surgery times, compliance to amblyopia therapy, and visual outcomes for a long-term follow-up in a secondary IOL implantation. Methods: Retrospective review of records of all infants with congenital cataracts who underwent secondary IOL implantation in the Eye and ENT Hospital of Fudan University from January 1, 2001, to December 31, 2007, and the minimum follow-up period was 5 years. Multiple regression analysis was used and the possible confounding factors were also analyzed to as...
Source: Journal of Ophthalmology - May 18, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Outcomes and Complications of Scleral-Fixated Intraocular Lens Combined with Ahmed Tube Surgery.
Authors: Sachdev N, Aquino MC, Loon SC, Chan YH, Chew P, Koh V Abstract Background: To evaluate the outcome and complications of transscleral suture-fixated posterior chamber intraocular lens (PCIOL) implantation combined with Ahmed glaucoma valve (AGV) surgery in Asian eyes. Design: This was a retrospective study that included 22 eyes from 22 participants. The surgeries were performed at Singapore's National University Hospital. Participants underwent an Ahmed tube surgery, together with transscleral suture-fixated posterior chamber intraocular lens. Main Outcome Measures: Complete success was defined as 6...
Source: Journal of Ophthalmology - May 18, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Changing Trends in Eye-Related Complaints Presenting to the Emergency Department in Beirut, Lebanon, over 15 Years.
Authors: Salti HI, Mehanna CJ, Abiad B, Ghazi N, Raad S, Barikian A, Haddad R, Ashkar A, Harmouche E, Zaghrini E, Mufarrij A Abstract Objective: To report the 15-year trend in ophthalmic presentations to the emergency department (ED) at the only medical center in Lebanon that provides 24-hour ophthalmologic care. Methods: Retrospective review of 1967 patients presenting to the ED with eye-related complaints between September 1997 and August 1998 and between September 2012 and August 2013. Diagnoses were classified into 4 categories according to the International Society of Ocular Trauma and include penetrating ...
Source: Journal of Ophthalmology - May 12, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

In Vivo Confocal Microscopic Observations of Vortex Keratopathy in Patients with Amiodarone-Induced Keratopathy and Fabry Disease.
Conclusion: These findings suggest that the corneal epithelial cells most likely endocytose amiodarone from the tear film in the amiodarone-induced keratopathy. In Fabry disease, globotriaosylceramide deposits are taken up by the lysosomes of the limbal epithelial stem cells, and they differentiate and migrate to the center of the cornea to form the whorl pattern. PMID: 29750121 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - May 12, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research