Quantitative Analysis of Macular Retina Using Light Reflection Indices Derived from SD-OCT for Pituitary Adenoma.
This study included 38 patients (mean age 44.66 ± 13.77 years old) with diagnosis of pituitary adenoma and 43 age-matched controls. All SD-OCT scans were light attenuation compensated by a depth-resolved model. Attenuation coefficient, the corrected intensity, and the retinal layer thickness were deduced for macular retinal nerve fiber layer (RNFL) and ganglion cell layer combined with inner plexiform layer (GCIPL), as well as comparing between patients and controls by statistical methods. Results: Attenuation coefficients of RNFL and GCIPL among patients were significantly lower compared to the co...
Source: Journal of Ophthalmology - November 20, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Digital Image Analysis of the Angle and Optic Nerve: A Simple, Fast, and Low-Cost Method for Glaucoma Assessment.
Conclusions: While OCT imaging is rapidly progressing in the area of optic disc and chamber angle assessment, rising healthcare costs and lack of availability of the technology open a demand for alternative and cost-minimizing forms of image analysis in glaucoma. Volumetric, geometric, and segmentational data obtained through digital image analysis correspond well to those obtained by OCT imaging. PMID: 33194227 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 18, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Eyes of Aniso-Axial Length Individuals Share Generally Similar Corneal Biometrics with Normal Eyes in Cataract Population.
Authors: Zhang M, Chen T, Deng M, Chen J, Jing Q, Jiang Y Abstract Aims: To determine the characteristics of corneal biometrics in eyes from aniso-axial length cataract patients compared with eyes from non-aniso-axial length individuals. Methods: This is a retrospective case series. Cataract patients with preoperative binocular measurements were recruited. A binocular axial difference of ≥1 mm was considered to indicate aniso-axial length. The anterior segmental biometrics were measured using Pentacam HR (Oculus, Wetzlar, Germany) and IOLMaster 500 (Carl Zeiss Meditec, Jena, Germany). Comparisons of b...
Source: Journal of Ophthalmology - November 14, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Choroidal Structural Changes Assessed with Swept-Source Optical Coherence Tomography after Cataract Surgery in Eyes with Diabetic Retinopathy.
Authors: Yao H, Gao S, Liu X, Zhou Y, Cheng Y, Shen X Abstract Objective: To determine the influence of phacoemulsification on choroidal vasculature in patients with diabetic retinopathy (DR) undergoing cataract surgery using swept-source optical coherence tomography (SS-OCT). Methods: The study was conducted in 23 eyes of 23 cataract patients with mild/moderate nonproliferative diabetic retinopathy (NPDR) without diabetic macular edema (DME) and 23 age-matched controls. Choroidal thickness (CT) and choroidal vascularity index (CVI) were measured at baseline and 1 week, 1 month, and 3 months after surgery. ...
Source: Journal of Ophthalmology - November 14, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Multiple Therapy Approach for Stage 3 Coats Disease: Long-Term Follow-Up.
Conclusion: The management and treatment of this rare and degenerative disease in young subjects are still a challenge. The described technique is less invasive than conventional intraocular surgery and may be preferable to halt the devastating progression of the disease. PMID: 33178453 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 14, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comparison of Corneal Biomechanical Properties between Post-LASIK Ectasia and Primary Keratoconus.
Conclusions: In our case series, KC manifested more severe than PLE in biomechanical properties. Since SSI measurements were independent of corneal thickness, it can be used for corneal biomechanical assessment. PMID: 33163228 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 11, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comparative Analysis of Visual Performance and Astigmatism Tolerance with Monofocal, Bifocal, and Extended Depth-of-Focus Intraocular Lenses Targeting Slight Myopia.
Conclusions: The EDOF IOLs targeting slight myopia offered satisfactory visual outcomes at an extended range from far to near distances. The EDOF and monofocal IOLs showed a better tolerance to astigmatism than did the bifocal IOL. PMID: 33163229 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 11, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Limited Vitrectomy versus Complete Vitrectomy for Epiretinal Membranes: A Comparative Multicenter Trial.
Authors: Forlini M, Date P, D'Eliseo D, Rossini P, Bratu A, Volinia A, Neri G, Verdina T, Carbotti MR, Cavallini GM, Sborgia L, Galeone A, Imburgia A, Mularoni A, Meduri A Abstract Purpose: To evaluate whether limited vitrectomy is as effective as complete vitrectomy in eyes with epiretinal membrane (ERM) and to compare the surgical times and rates of complications. Methods: In this multicentre European study, data of eyes with ERM that underwent vitrectomy from January 2017 to July 2018 were analyzed retrospectively. In the limited vitrectomy group, a posterior vitreous detachment (PVD) was induced up till the...
Source: Journal of Ophthalmology - November 7, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Bleb Morphology Using Anterior-Segment Optical Coherence Tomography after Ahmed Glaucoma Valve Surgery with Tenon Capsule Resection.
Conclusion: AS-OCT was beneficial in the analysis of bleb morphology after AGV surgery where there were more diffuse functioning multicystic blebs and less thinning in the bleb wall thickness during the hypertensive phase after resection of the Tenon capsule, which might be related to the less incidence of fibrosis around the surgical site. PMID: 33149944 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 7, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Endogenous Endophthalmitis: A Review of Case Series Published between 2011 and 2020.
Authors: Danielescu C, Anton N, Stanca HT, Munteanu M Abstract This is a literature review of 31 case series of endogenous endophthalmitis (EE) published in the last ten years, identified from a literature search of several databases (PubMed, EMBASE, and the Cochrane Library). While diabetes mellitus and malignancies remain the most frequently associated medical conditions, intravenous drug use is a significant risk factor (especially in the last years, in studies from Western countries). Ophthalmologic screening is recommended for candidaemia, but not in patients with sepsis of other aetiologies (however, the phys...
Source: Journal of Ophthalmology - November 7, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Evaluation of Anxiety Levels in Patients Undergoing Intravitreal Injections and Associated Risk Factors Related to the Disease.
Conclusions: Sex and age may have an influence on anxiety levels. BCVA and the number ofinjections received did not seem to have an influence on our patients anxiety levels. PMID: 33145102 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 6, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Effectiveness and Safety of Trabeculectomy along with Amniotic Membrane Transplantation on Glaucoma: A Systematic Review.
Authors: Shen TY, Hu WN, Cai WT, Jin HZ, Yu DH, Sun JH, Yu J Abstract Purpose: To determine the effectiveness and safety of trabeculectomy along with amniotic membrane transplantation (AMT) for glaucoma. Methods: This systematic review was performed using RevMan 5.3. We searched PubMed, EMBASE, and the Cochrane Library and included studies published until September 2019. The treatment group included patients with AMT and trabeculectomy (group A), and the control group had only trabeculectomy (group B). We only included randomized controlled trials. The outcomes were intraocular pressure (IOP), complete success ...
Source: Journal of Ophthalmology - November 4, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Traumatic Macular Hole: Clinical Management and Optical Coherence Tomography Features.
Authors: Lei C, Chen L Abstract The complex and uncertain prognosis of traumatic macular hole (TMH) makes it a difficult and challenging problem in clinical management. The features of spontaneously closed TMH and the time of vitrectomy remain unclear. This retrospective study aimed to demonstrate the optical coherence tomography (OCT) features of TMH, explore the relationship between OCT parameters and visual outcomes, and further evaluate the therapeutic effect of surgical management. Seventeen TMH patients were included in this study. 13 eyes of TMH received vitrectomy surgery and 4 eyes of TMH were closed spont...
Source: Journal of Ophthalmology - November 4, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Impact of Ophthalmic Viscosurgical Devices in Cataract Surgery.
Conclusion: Improvement in IOP was shown with Viscoat + Provisc. Additionally, IOP nonsignificant upsurge was observed with Healon GV, Healon5, 2% HPMC, and OcuCoat compared to significant upsurge with Healon, Viscoat, and Soft Shell. PMID: 33133677 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 4, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Effect of Selective Laser Trabeculoplasty on Intraocular Pressure in Patients with Dexamethasone Intravitreal Implant-Induced Elevated Intraocular Pressure.
Authors: Bennedjai A, Theillac V, Akesbi J, Adam R, Rodallec T, Keilani C, Blumen-Ohana E, Labbé A, Nordmann JP Abstract Introduction: To assess the safety and efficacy of selective laser trabeculoplasty (SLT) for ocular hypertension (OHT) induced by a dexamethasone (DEX) intravitreal implant. Materials and Methods: We performed a retrospective study of patients who underwent an SLT procedure for ocular hypertension induced by injection of a DEX intravitreal implant. Patients had, at least, one injection of the DEX-implant for symptomatic macular edema. SLT was delivered to 360° of the trabecular mes...
Source: Journal of Ophthalmology - October 29, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Assessment of Spontaneous Retinal Arterial Pulsations in Acute Central Retinal Vein Occlusions.
This study demonstrates that SRAPs are a frequent finding, easily detected by infrared fundus video recording, and associated with a younger age and lesser macular edema. PMID: 33101730 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 28, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Intracorneal Stromal Ring Can Affect the Biomechanics of Ectatic Cornea.
Conclusion: Both MyoRing and KeraRings have positive effects on the biomechanics of cornea at least during the first year after implantation. Comparison of these two types of ICR did not show significant differences in Corvis and ORA parameters. PMID: 33083047 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 22, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Clinical Features of Optic Disc Drusen in an Ophthalmic Genetics Cohort.
Authors: Serpen JY, Prasov L, Zein WM, Cukras CA, Cunningham D, Murphy EC, Turriff A, Brooks BP, Huryn LA Abstract Materials and Methods: Electronic medical records of patients evaluated in the Ophthalmic Genetics clinic at the National Eye Institute (NEI) between 2008 and 2018 were searched for a superficial ODD diagnosis. Color fundus and autofluorescence images were reviewed to confirm ODD, supplemented with optical coherence tomography (OCT) in uncertain cases when available. Demographic information, examination, and genetic testing were reviewed. Disc areas and disc-to-macula distance to disc diameter ratios (...
Source: Journal of Ophthalmology - October 22, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Ocular Emergencies in Children: Demographics, Origin, Symptoms, and Most Frequent Diagnoses.
Conclusions: Infectious conjunctivitis was the most frequent pathology. It is necessary to increase public awareness about the symptoms, the way of transmission, and treatment. Ocular trauma was also a common cause of presentation and the majority were contusional and mild. There is also a need for education of parents, teachers, and coaches regarding the potential for eye injuries. Ophthalmologists and paediatricians must take an active role in educating people about the prophylactic measures to prevent eye injuries in children. PMID: 33083049 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 22, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Double Retinal Tamponade for Treatment of Rhegmatogenous Retinal Detachment with Proliferative Vitreoretinopathy and Inferior Breaks.
Conclusions: The results of this study indicated that primary vitrectomy with simultaneous use of both C3F8 and short-term PFO as retinal tamponades was effective and safe in the management of complex cases of RRD with PVR grade C and inferior breaks. This trial is registered with NCT04168255. PMID: 33083050 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 22, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Anatomical and Visual Outcomes after LASIK Performed in Myopic Eyes with the WaveLight ® Refractive Suite (Alcon® Laboratories Inc., USA).
We examined 60 myopic eyes (average SE -4.5 D, from -9.3 to -0.75 D) of 30 patients from 21.3 to 38.7 years old. Pachymetry, keratometry, Q factor, corneal aberrations, visual acuity (VA), contrast sensitivity, dry eye assessment, and quality of vision were measured preoperatively, one day (D1), and 1, 3, and 6 months postoperatively. Results: 6 months postoperatively, keratometry became flatter, and the Q factor became more oblate (from -0.18 ± 0.08 to +0.19 ± 0.06). Pachymetry decreased by 117.9 ± 62.2 µm at D1 and increased by ...
Source: Journal of Ophthalmology - October 22, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Reporting of Safety Events during Anti-VEGF Treatment: Pharmacovigilance in a Noninterventional Trial.
Conclusions: The results did not raise any new safety concerns for ranibizumab. The findings allow conclusions to be drawn on how pharmacovigilance data can be collected even more effectively in real-world studies to facilitate discussion on benefit-risk ratio. PMID: 33083052 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 22, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Correlation Analysis of Refractive and Visual Quality after Wavefront-Optimized Laser In Situ Keratomileusis for 50% and 100% Angle Kappa Compensation.
Conclusion: The postoperative visual acuity and spherical equivalent were not affected in the two groups. However, when P-Dist>0.220 mm, the residual astigmatism and coma were lower in the 50% group. Individualized operations for those with moderate myopia and large-angle kappa in which 100% adjustment is chosen may not result in a better visual quality effect than 50%. PMID: 33083053 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 22, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Effect of Adding Losartan to Bevacizumab for Treating Diabetic Macular Edema.
Conclusion: Short-term adjuvant treatment with Losartan in patients with diabetic macular edema and nonproliferative diabetic retinopathy has no greater effect than the standard treatment. PMID: 33062311 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 21, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comparative Study of the Effects of 1% Atropine on the Anterior Segment.
Authors: Zhou Y, Huang XB, Cai Q, Li JJ, Xiong YJ, Gong YX, Lin LW, Zhu Y, Sun ZM Abstract Purpose: To investigate the influences of atropine on changes in anterior segment geometry, as measured by ultrasound biomicroscopy in children. Methods: A prospective observational study was performed. Anterior segment parameters were obtained by UBM before and after the instillation of 1% atropine. Univariate linear regression was performed to identify the variables contributing to the changes in the trabecular meshwork-iris angle (TIA). Results: The study included 21 boys and 37 girls with a mean age of 10.79&thins...
Source: Journal of Ophthalmology - October 21, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Optical Coherence Tomography Parameters Related to Vision Impairment in Patients with Diabetic Macular Edema: A Quantitative Correlation Analysis.
This study was a retrospective observational case series. One-hundred eyes from 66 patients with DME were retrospectively included. OCT parameters, including central macular thickness (CMT), height of intraretinal cystoid, subretinal fluid and sponge-like retinal swelling, density of hyperreflective foci (HRF), and integrity of the ellipsoidal zone (EZ), were assessed. Correlation analyses and multiple linear regression analysis were performed to quantitatively explore the relationship between best-corrected visual acuity (BCVA) and OCT parameters. Results: Among all OCT parameters, CMT, height of intraretinal cystoid,...
Source: Journal of Ophthalmology - October 21, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Prevalence and Age-Related Changes of Corneal Astigmatism in Patients Undergoing Cataract Surgery in Northern China.
Authors: Wu Z, Liu C, Chen Z Abstract Purpose: To examine the magnitude, orientation, and age-related changes of corneal astigmatism of the eyes before cataract surgery. Setting. Hebei Eye Hospital, Hebei, China. Design: A clinical-based retrospective study. Results: The study consisted of 5662 eyes of 5662 consecutive cataract surgery patients with a mean age of 68.26 ± 10.39 (mean ± standard deviation (SD)) years (range 40 to 97 years), and 59.86% of the patients were women. Mean corneal astigmatism was 0.98 ± 0.76 diopter (D) (range 0.00-9.61...
Source: Journal of Ophthalmology - October 21, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

First Experience in Small Incision Lenticule Extraction with the Femto LDV Z8 and Lenticule Evaluation Using Scanning Electron Microscopy.
Conclusions: Femto LDV Z8 showed promising performances as a novel SMILE equipment for the correction of myopia. It has special and unique features for SMILE procedures, which need more learning and researching processes. With its low-energy high-frequency nJ-level laser system, the Femto LDV Z8 provided smoother lenticule surface than VisuMax. PMID: 33062315 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 21, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Does Cataract Surgery Improve the Progression of Age-Related Macular Degeneration? A Meta-Analysis.
Conclusion: We could draw out such a conclusion that there is still a positive correlation between cataract surgery and the progression of AMD, especially for the Asians. However, based on the current results, it is not possible to draw conclusions from existing studies on the impact of cataract surgery on early AMD development. PMID: 33062316 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 21, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Efficacy and Safety Outcomes of Intravitreal Dexamethasone Implant Therapy for the Treatment of Adult Coats' Disease.
Conclusion: Intravitreal dexamethasone implant therapy is effective for adult Stage 3A Coats' disease, which provides a new treatment option for ophthalmologists. PMID: 33062317 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 21, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Secondary Vitrectomy with Internal Limiting Membrane Plug due to Persistent Full-Thickness Macular Hole OCT-Angiography and Microperimetry Features: Case Series.
Conclusion: Although the anatomical results of repeated surgeries of FTMH with ILM plug are favorable, visual function results may be limited. Secondary closure of FTMH with ILM plug may lead to atrophy, changes in the macular vasculature, and eccentric fixation. The trial is registered with NCT03701542. PMID: 33029387 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 9, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Long-Term Evaluation of Capsulotomy Shape and Posterior Capsule Opacification after Low-Energy Bimanual Femtosecond Laser-Assisted Cataract Surgery.
Authors: Verdina T, Peppoloni C, Barbieri L, Carbotti MR, Battaglia B, Mastropasqua R, Cavallini GM Abstract Purpose: To evaluate capsulotomy shape and posterior capsule opacification (PCO) during an 18-month follow-up for bimanual femtosecond laser-assisted cataract surgery (FLACS). Methods: 74 eyes operated by a well-trained surgeon with bimanual FLACS technique using low-energy LDV Z8 (Ziemer Ophthalmic Systems AG, Port, Switzerland) were included in the study. The follow-up period was 18 ± 2 months. Another 91 eyes, which underwent standard bimanual microincision cataract surgery (B-MIC...
Source: Journal of Ophthalmology - October 9, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Clinical Characteristics of Visual Dysfunction in Carbon Monoxide Poisoning Patients.
Conclusion: The incidence of visual dysfunction in patients with CO poisoning was high, the clinical symptoms were rich and diverse, the duration of disease was long, and the prognosis was poor. Thus, the relevant ophthalmological examination and intervention treatment should be perfected as soon as possible. PMID: 33029389 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 9, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Assessment of Scleral and Conjunctival Thickness of the Eye after Ultrasound Ciliary Plasty.
This study aims to assess scleral and conjunctival thickness using optical coherence tomography after ultrasound ciliary plasty (UCP) procedure with reference to scleral marks appearing in the area where the ultrasound energy was applied. Materials and Methods: Seventy-eight patients with primary and secondary refractory glaucoma participated in this study. Complete ophthalmic examinations including measurements of scleral and conjunctival thickness were performed preoperatively and at 1 week, and 1, 3, 6, 12, 18, and 24 months postoperatively. The parameters were determined using the Swept Source OCT with anterior att...
Source: Journal of Ophthalmology - October 9, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Clinical Features of Acute Anterior Uveitis with Complicated Course in a Slovenian Patient Population.
Authors: Vergot K, Pockar S, Umek L, Vidovic Valentincic N Abstract Purpose: To report on patients who needed hospitalization due to acute anterior uveitis (AAU) and within this group to compare clinical features and outcomes of treatment of HLA-B27+ and HLA-B27- AAU in the population of Slovenian patients. Methods: Retrospective study of hospitalized patients with AAU in the last 39 months at the Eye Hospital in Ljubljana. The data of AAU patients were retroactively studied and compared on the basis of HLA-B27 antigen presence: visual acuity upon admission, visual outcome, the presence of hypopyon, fibrinous r...
Source: Journal of Ophthalmology - October 6, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Measurement and Analysis of Central Corneal Thickness at Different Postnatal Stages in Chinese Premature Infants.
The objective of this study was to evaluate central corneal thickness (CCT) in Chinese premature infants at different postnatal stages to study the peak point and analyze influential factors on CCT development. Methods: This was a cross-sectional study of premature infants. Initial CCT measurement was taken at 34 weeks of gestational age (GA) and at intervals until 88 weeks of postmenstrual age (PMA) was reached. The comparison and correlation analysis were carried out to access the association of CCT with gender, birth weight (BW), GA, and retinopathy of prematurity (ROP) for each PMA. The premature infants were divid...
Source: Journal of Ophthalmology - October 6, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Efficacy and Safety of Selective Laser Trabeculoplasty among Ethiopian Glaucoma Patients.
Conclusion: SLT is an effective and safe treatment modality for OHT, POAG, and PXG among Ethiopian patients either as a first-line treatment or as an adjunct to topical glaucoma treatment. PMID: 33014442 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 6, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Therapeutic HL-Contact Lens versus Standard Bandage Contact Lens for Corneal Edema: A Prospective, Multicenter, Randomized, Crossover Study.
Conclusions: The Therapeutic Hyper-CL™ lens was associated with a higher chance for significant visual acuity improvement when compared to a standard bandage contact lens combined with 5% sodium chloride. This trial is registered with NCT02660151. PMID: 33014443 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 6, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Corrigendum to "Retrospective Observational Study on Rebamipide Ophthalmic Suspension on Quality of Life of Dry Eye Disease Patients".
Corrigendum to "Retrospective Observational Study on Rebamipide Ophthalmic Suspension on Quality of Life of Dry Eye Disease Patients". J Ophthalmol. 2020;2020:8486704 Authors: Sakane Y, Yamaguchi M, Shiraishi A Abstract [This corrects the article DOI: 10.1155/2019/8145731.]. PMID: 33014444 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 6, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Long-Term Visual Quality after Microincision Cataract Surgery.
This study aimed to evaluate the long-term visual quality after microincision cataract surgery (MICS). Methods: 96 patients (144 eyes) diagnosed with age-related cataracts were enrolled in this one-year study. The patients underwent MICS and received aspheric monofocal intraocular lens implants. Uncorrected distance visual acuity (UDVA) was evaluated together with best-corrected distance visual acuity (BCDVA), best-corrected near visual acuity (BCNVA), contrast sensitivity, and surgically induced astigmatism (SIA). Results: Compared to preoperative measurements, UDVA, BCDVA, and BCNVA were significantly better after surgery (P
Source: Journal of Ophthalmology - October 6, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Innovative IOP-Independent Neuroprotection and Neuroregeneration Strategies in the Pipeline for Glaucoma.
Authors: Tsai JC Abstract While sustained reduction of intraocular pressure (IOP) has been shown to halt and/or delay the progressive death of retinal ganglion cells (RGCs) in glaucoma, there exists great interest in the development and validation of IOP-independent therapeutic strategies for neuroprotection and/or neuroregeneration. Multiple etiologies for RGC death have been implicated in glaucoma including defective axonal transport, ischemia, excitotoxicity, reactive oxygen species, trophic factor withdrawal, and loss of RGC electrical activity. However, IOP lowering with medical, laser, and surgical therapies ...
Source: Journal of Ophthalmology - October 6, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Early Detection of Incipient Retinal Pigment Epithelium Atrophy Overlying Drusen with Fundus Autofluorescence vs. Spectral Domain Optical Coherence Tomography.
This study aims to find out which tool, fundus autofluorescence (FAF) or spectral domain optical coherence tomography (SD-OCT), is more sensitive in detecting retinal pigment epithelium (RPE) demise overlying drusen and can, therefore, help predict geographic atrophy (GA) appearance in Age-Related Macular Degeneration (AMD). Methods: A single-site, retrospective, observational, longitudinal study was conducted. Patients with intermediate AMD (iAMD) (large (>125 μm) or intermediate (63-125 μm) drusen with hyper/hypopigmentation) with a minimum follow-up of 18 months were included. Drusen wi...
Source: Journal of Ophthalmology - October 6, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Cytoprotective Effect of Astaxanthin in a Model of Normal Intraocular Pressure Glaucoma.
Authors: Kikuchi K, Dong Z, Shinmei Y, Murata M, Kanda A, Noda K, Harada T, Ishida S Abstract Glaucoma is characterized by axonal degeneration of retinal ganglion cells (RGCs) and apoptotic death of their cell bodies. Lowering intraocular pressure is currently the only way to treat glaucoma, but it is often insufficient to inhibit the progression of the disease. Glaucoma is a multifactorial disease, and the involvement of oxidative stress has recently received much attention. In the present study, we investigated the cytoprotective effect of astaxanthin (AST) on RGC degeneration using a normal-tension glaucoma (NTG...
Source: Journal of Ophthalmology - October 6, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Persistent Retinal Detachment in Retinoblastoma: The Challenges.
Conclusion: Persistent RD occurs in eyes with advanced RB stages with complex RD with more than one component. The dilemma is performing a vitrectomy in eyes with cancer and poor visual outcome. PMID: 33005444 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 3, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Vitrectomy with Air Endotamponade for Traumatic Cyclodialysis.
Conclusions: This study revealed that vitrectomy with air endotamponade is an effective and minimally invasive alternative surgical approach for small traumatic cyclodialysis clefts. PMID: 33005445 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 3, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Clinical Presentations and Outcomes of Retinoblastoma Patients in relation to the Advent of New Multimodal Treatments: A 12-Year Report from Single Tertiary Referral Institute in Thailand.
Conclusions: Recent advanced treatment modalities have improved the probability of globe salvage. However, enucleation remains an important life-saving intervention in many advanced cases. PMID: 33005446 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 3, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Intraoperative Optical Coherence Tomography Analysis of Clear Corneal Incision: Effect of the Lateral Stromal Hydration.
Conclusion: Lateral stromal hydration seldom affects the condition of the corneal incision. Still, it can cause both deterioration and improvement of the corneal incision architecture. Intraoperative OCT provides real-time monitoring of corneal incision morphology during hydration procedure. PMID: 33005447 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 3, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Short-Term Results of Switch from Conbercept to Bevacizumab or Ranibizumab in Eyes with Persistent Neovascular Age-Related Macular Degeneration.
Authors: Wang Z, Li M, Yao Y, Hu J, Tang J, Tang R, Piao Z, Qu J Abstract Purpose: To study the short-term anatomical and functional outcomes in patients with neovascular age-related macular degeneration (nAMD) who were previously treated with conbercept and switched to ranibizumab or bevacizumab due to persistent activity. Methods: This retrospective single-arm study included nAMD patients who were followed up for at least three months after switching from at least 3 monthly intravitreal conbercept injections to bevacizumab or ranibizumab for persistent choroidal neovascularization (CNV) activity. The demograp...
Source: Journal of Ophthalmology - October 3, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Effects of Oral Vitamin B1 and Mecobalamin on Dry Eye Disease.
Authors: Ren X, Chou Y, Jiang X, Hao R, Wang Y, Chen Y, Li X Abstract Purpose: To assess the effects of oral vitamin B1 and mecobalamin on dry eye disease (DED) and patient satisfaction with treatment. Methods: In this randomized controlled study, DED patients were divided into 4 groups based on treatment: group 1, only artificial tears; group 2, corticosteroid eye drops and artificial tears; group 3, oral vitamin B1, mecobalamin, and artificial tears; and group 4, oral vitamin B1, mecobalamin, corticosteroid eye drops, and artificial tears. DED symptoms, signs, and patient satisfaction with treatment were asse...
Source: Journal of Ophthalmology - October 3, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Ocular Findings in COVID-19 Patients: A Review of Direct Manifestations and Indirect Effects on the Eye.
Authors: Bertoli F, Veritti D, Danese C, Samassa F, Sarao V, Rassu N, Gambato T, Lanzetta P Abstract The novel pandemic coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has challenged the medical community. While diagnostic and therapeutic efforts have been focused on respiratory complications of the disease, several ocular implications have also emerged. SARS-CoV-2 RNA has been found in tears of the infected patients, and reports suggest that the ocular surface could serve as a portal of entry and a reservoir for viral transmission. Clinically, COVID-...
Source: Journal of Ophthalmology - September 25, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research