XEN Glaucoma Implant for the Management of Operated Uncontrolled Glaucoma: Results and Complications during a Long-Term Follow-Up
This study aimed to analyze the surgical and refractive outcomes of XEN glaucoma implant (Allergan, an Abbvie company, Irvine, CA, USA), a minimally invasive surgical device for the treatment of operated uncontrolled glaucoma. Eyes that received XEN Gel Stent placement from December 2014 to October 2019 were retrospectively investigated. Intraocular pressure (IOP) change, best-corrected visual acuity (BCVA), change in glaucoma medications, frequency of slit lamp revision procedures, and frequency of secondary glaucoma surgeries were the primary outcomes. Seventy-two eyes of 72 subjects were included in the study: 32 (44%) ...
Source: Journal of Ophthalmology - July 26, 2021 Category: Opthalmology Authors: Katarzyna Lewczuk Joanna Konopi ńska Joanna Jab łońska Jacek Rudowicz Patrycja Laszewicz Zofia Mariak Marek R ękas Source Type: research

New Horizons in the Treatment of Corneal Endothelial Dysfunction
J Ophthalmol. 2021 Jul 9;2021:6644114. doi: 10.1155/2021/6644114. eCollection 2021.ABSTRACTThe treatment of corneal endothelial dysfunction has experienced a revolutionary change in the past decades with the emergence of endothelial keratoplasty techniques: descemet stripping automated endothelial keratoplasty (DSAEK) and descemet membrane endothelial keratoplasty (DMEK). Recently, new treatments such as cultivated endothelial cell therapy, Rho-kinase inhibitors (ROCK inhibitors), bioengineered grafts, and gene therapy have been described. These techniques represent new lines of treatment for endothelial dysfunction. Their...
Source: Journal of Ophthalmology - July 26, 2021 Category: Opthalmology Authors: Carlos Rocha-de-Lossada Rahul Rachwani-Anil Davide Borroni Jos é-María Sánchez-González Raquel Esteves-Marques Fernando-Luis Soler-Ferr ández Jose-Antonio Geg úndez-Fernández Vito Romano Eitan Livny Marina Rodr íguez Calvo-de-Mora Source Type: research

Efficacy and Safety of Combined Surgeries including Intraocular Direct Cyclophotocoagulation with a 532  nm Laser to Treat Advanced Neovascular Glaucoma
J Ophthalmol. 2021 Jul 7;2021:9938928. doi: 10.1155/2021/9938928. eCollection 2021.ABSTRACTPURPOSE: The purpose of this study was to assess the efficacy and safety of intraocular direct cyclophotocoagulation (IDCP) using a 532 nm laser with combination treatment in reducing intraocular pressure (IOP) for patients with advanced neovascular glaucoma (NVG) with angle closure. In addition, we sought to determine the success rate and frequency of complications and explore an optimized solution to reduce the number of topical medications and the pain of patients.METHODS: A retrospective case note review of all patients undergoin...
Source: Journal of Ophthalmology - July 26, 2021 Category: Opthalmology Authors: Xiaomin Chen Tian Zheng Wen Zeng Xia Fu Shun Wang Weijuan Zeng Min Ke Source Type: research

XEN Glaucoma Implant for the Management of Operated Uncontrolled Glaucoma: Results and Complications during a Long-Term Follow-Up
This study aimed to analyze the surgical and refractive outcomes of XEN glaucoma implant (Allergan, an Abbvie company, Irvine, CA, USA), a minimally invasive surgical device for the treatment of operated uncontrolled glaucoma. Eyes that received XEN Gel Stent placement from December 2014 to October 2019 were retrospectively investigated. Intraocular pressure (IOP) change, best-corrected visual acuity (BCVA), change in glaucoma medications, frequency of slit lamp revision procedures, and frequency of secondary glaucoma surgeries were the primary outcomes. Seventy-two eyes of 72 subjects were included in the study: 32 (44%) ...
Source: Journal of Ophthalmology - July 26, 2021 Category: Opthalmology Authors: Katarzyna Lewczuk Joanna Konopi ńska Joanna Jab łońska Jacek Rudowicz Patrycja Laszewicz Zofia Mariak Marek R ękas Source Type: research

New Horizons in the Treatment of Corneal Endothelial Dysfunction
J Ophthalmol. 2021 Jul 9;2021:6644114. doi: 10.1155/2021/6644114. eCollection 2021.ABSTRACTThe treatment of corneal endothelial dysfunction has experienced a revolutionary change in the past decades with the emergence of endothelial keratoplasty techniques: descemet stripping automated endothelial keratoplasty (DSAEK) and descemet membrane endothelial keratoplasty (DMEK). Recently, new treatments such as cultivated endothelial cell therapy, Rho-kinase inhibitors (ROCK inhibitors), bioengineered grafts, and gene therapy have been described. These techniques represent new lines of treatment for endothelial dysfunction. Their...
Source: Journal of Ophthalmology - July 26, 2021 Category: Opthalmology Authors: Carlos Rocha-de-Lossada Rahul Rachwani-Anil Davide Borroni Jos é-María Sánchez-González Raquel Esteves-Marques Fernando-Luis Soler-Ferr ández Jose-Antonio Geg úndez-Fernández Vito Romano Eitan Livny Marina Rodr íguez Calvo-de-Mora Source Type: research

Efficacy and Safety of Combined Surgeries including Intraocular Direct Cyclophotocoagulation with a 532  nm Laser to Treat Advanced Neovascular Glaucoma
J Ophthalmol. 2021 Jul 7;2021:9938928. doi: 10.1155/2021/9938928. eCollection 2021.ABSTRACTPURPOSE: The purpose of this study was to assess the efficacy and safety of intraocular direct cyclophotocoagulation (IDCP) using a 532 nm laser with combination treatment in reducing intraocular pressure (IOP) for patients with advanced neovascular glaucoma (NVG) with angle closure. In addition, we sought to determine the success rate and frequency of complications and explore an optimized solution to reduce the number of topical medications and the pain of patients.METHODS: A retrospective case note review of all patients undergoin...
Source: Journal of Ophthalmology - July 26, 2021 Category: Opthalmology Authors: Xiaomin Chen Tian Zheng Wen Zeng Xia Fu Shun Wang Weijuan Zeng Min Ke Source Type: research

Metamorphopsia and Morphological Changes in the Macula after Scleral Buckling Surgery for Macula-Off Rhegmatogenous Retinal Detachment
CONCLUSIONS: The continuation of the ELM may be a critical factor in determining the severity of metamorphopsia after SB surgery for macula-off RRD.PMID:34258046 | PMC:PMC8253631 | DOI:10.1155/2021/5525049 (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Sisi Xu Ling Wang Kangjie Kong Gang Li Yingqin Ni Source Type: research

Incorporating Differential Gene Expression Analysis with Predictive Biomarkers to Identify Novel Therapeutic Drugs for Fuchs Endothelial Corneal Dystrophy
CONCLUSIONS: Based on differential gene expression signatures, several candidate drugs have been identified to reverse the disease phenotypes in FECD. Gene expression signature with LINCS small molecule prediction software can discover novel preclinical drug candidates for FECD.PMID:34258047 | PMC:PMC8260298 | DOI:10.1155/2021/5580595 (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Huaming Wen Ryan A Gallo Xiaosheng Huang Jiamin Cai Shaoyi Mei Ammad Ahmad Farooqi Jun Zhao Wensi Tao Source Type: research

Early Age of the First Myopic Spectacle Prescription, as an Indicator of Early Onset of Myopia, Is a Risk Factor for High Myopia in Adulthood
J Ophthalmol. 2021 Jun 22;2021:6612116. doi: 10.1155/2021/6612116. eCollection 2021.ABSTRACTPURPOSE: The present study investigated the risk factors for high myopia in adulthood, with a focus on the age at which children wore their first spectacles.METHODS: Adults aged between 20 and 45 years were invited to complete a questionnaire about age, sex, current refractive error, high myopia in parents, early onset of myopia presented by the age of the first myopic spectacle prescription, refractive power of the first spectacles, and life habits at different educational stages. The associations between these factors and high myo...
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Wei-Yu Chiang Yun-Wen Chen Yu-Peng Liu Yung-Hsun Liu Pei-Chang Wu Source Type: research

A Real-World Single-Centre Study of Patients with Diabetic Macular Oedema Who Wore a Home-Use Sleep Mask (Noctura 400) for One Year
J Ophthalmol. 2021 Jun 15;2021:6612126. doi: 10.1155/2021/6612126. eCollection 2021.ABSTRACTA "Real-World" single-centre observational study was carried out to analyse the effects of enhanced patient interaction with the use of the Noctura 400 sleep mask on a group of 26 diabetics displaying diabetic retinopathy (DR) and diabetic macular oedema (DMO), of which 24 completed the study. We hoped to find if patient compliance could be maintained and to determine the anatomical and functional consequences of consistent mask wear. While this study was ongoing, COVID-19 impacted on normal eye clinic practice, allowing a...
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Ulrich Meyer-Bothling Oliver Meyer-Bothling Marika Pinney Source Type: research

Immunogenetics of the Ocular Anterior Segment: Lessons from Inherited Disorders
J Ophthalmol. 2021 Jun 28;2021:6691291. doi: 10.1155/2021/6691291. eCollection 2021.ABSTRACTAutoimmune and autoinflammatory diseases cause morbidity in multiple organ systems including the ocular anterior segment. Genetic disorders of the innate and adaptive immune system present an avenue to study more common inflammatory disorders and host-pathogen interactions. Many of these Mendelian disorders have ophthalmic manifestations. In this review, we highlight the ophthalmic and molecular features of disorders of the innate immune system. A comprehensive literature review was performed using PubMed and the Online Mendelian In...
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Jasmine Y Serpen Stephen T Armenti Lev Prasov Source Type: research

One-Year Visual and Refractive Outcomes following LASIK for Myopia and Myopic Astigmatism with MEL 90 versus Schwind Amaris 750S Excimer Laser: A Comparative Study
CONCLUSION: At 12 months, both Schwind Amaris 750S and MEL 90 lasers demonstrated comparable clinical outcomes for myopic LASIK in a single surgeon setting.PMID:34258051 | PMC:PMC8257363 | DOI:10.1155/2021/9929181 (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Sheetal Brar Dishitha P Rathod C R Roopashree Sri Ganesh Source Type: research

Short-Term Outcomes of Cataract Surgery in Patients with a History of Central Serous Chorioretinopathy
This study aimed to evaluate the short-term outcomes of cataract surgery in patients with a history of idiopathic central serous chorioretinopathy (CSC).METHODS: This retrospective study included 26 patients with a history of CSC who underwent uncomplicated phacoemulsification and intraocular lens implantation. The best-corrected visual acuity (BCVA) and central foveal thickness (CFT) measured before the surgery were compared with those obtained at mean 3.6 months after the surgery. BCVA outcome was also analyzed in eyes with and without subretinal fluid (SRF).RESULTS: The mean logarithm of the minimal angle of resolution ...
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Jeon Young Joon Jae Hui Kim Jong Woo Kim Chul Gu Kim Source Type: research

Manifestations and Virus Detection in the Ocular Surface of Adult COVID-19 Patients: A Meta-Analysis
CONCLUSION: As per our findings, it was determined that ocular transmission of SARS-CoV-2 might be possible, highlighting the importance of eye protective equipment among healthcare personnel.PMID:34258053 | PMC:PMC8225454 | DOI:10.1155/2021/9997631 (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Yu-Yen Chen Yung-Feng Yen Li-Ying Huang Pesus Chou Source Type: research

Metamorphopsia and Morphological Changes in the Macula after Scleral Buckling Surgery for Macula-Off Rhegmatogenous Retinal Detachment
CONCLUSIONS: The continuation of the ELM may be a critical factor in determining the severity of metamorphopsia after SB surgery for macula-off RRD.PMID:34258046 | PMC:PMC8253631 | DOI:10.1155/2021/5525049 (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Sisi Xu Ling Wang Kangjie Kong Gang Li Yingqin Ni Source Type: research

Incorporating Differential Gene Expression Analysis with Predictive Biomarkers to Identify Novel Therapeutic Drugs for Fuchs Endothelial Corneal Dystrophy
CONCLUSIONS: Based on differential gene expression signatures, several candidate drugs have been identified to reverse the disease phenotypes in FECD. Gene expression signature with LINCS small molecule prediction software can discover novel preclinical drug candidates for FECD.PMID:34258047 | PMC:PMC8260298 | DOI:10.1155/2021/5580595 (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Huaming Wen Ryan A Gallo Xiaosheng Huang Jiamin Cai Shaoyi Mei Ammad Ahmad Farooqi Jun Zhao Wensi Tao Source Type: research

Early Age of the First Myopic Spectacle Prescription, as an Indicator of Early Onset of Myopia, Is a Risk Factor for High Myopia in Adulthood
J Ophthalmol. 2021 Jun 22;2021:6612116. doi: 10.1155/2021/6612116. eCollection 2021.ABSTRACTPURPOSE: The present study investigated the risk factors for high myopia in adulthood, with a focus on the age at which children wore their first spectacles.METHODS: Adults aged between 20 and 45 years were invited to complete a questionnaire about age, sex, current refractive error, high myopia in parents, early onset of myopia presented by the age of the first myopic spectacle prescription, refractive power of the first spectacles, and life habits at different educational stages. The associations between these factors and high myo...
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Wei-Yu Chiang Yun-Wen Chen Yu-Peng Liu Yung-Hsun Liu Pei-Chang Wu Source Type: research

A Real-World Single-Centre Study of Patients with Diabetic Macular Oedema Who Wore a Home-Use Sleep Mask (Noctura 400) for One Year
J Ophthalmol. 2021 Jun 15;2021:6612126. doi: 10.1155/2021/6612126. eCollection 2021.ABSTRACTA "Real-World" single-centre observational study was carried out to analyse the effects of enhanced patient interaction with the use of the Noctura 400 sleep mask on a group of 26 diabetics displaying diabetic retinopathy (DR) and diabetic macular oedema (DMO), of which 24 completed the study. We hoped to find if patient compliance could be maintained and to determine the anatomical and functional consequences of consistent mask wear. While this study was ongoing, COVID-19 impacted on normal eye clinic practice, allowing a...
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Ulrich Meyer-Bothling Oliver Meyer-Bothling Marika Pinney Source Type: research

Immunogenetics of the Ocular Anterior Segment: Lessons from Inherited Disorders
J Ophthalmol. 2021 Jun 28;2021:6691291. doi: 10.1155/2021/6691291. eCollection 2021.ABSTRACTAutoimmune and autoinflammatory diseases cause morbidity in multiple organ systems including the ocular anterior segment. Genetic disorders of the innate and adaptive immune system present an avenue to study more common inflammatory disorders and host-pathogen interactions. Many of these Mendelian disorders have ophthalmic manifestations. In this review, we highlight the ophthalmic and molecular features of disorders of the innate immune system. A comprehensive literature review was performed using PubMed and the Online Mendelian In...
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Jasmine Y Serpen Stephen T Armenti Lev Prasov Source Type: research

One-Year Visual and Refractive Outcomes following LASIK for Myopia and Myopic Astigmatism with MEL 90 versus Schwind Amaris 750S Excimer Laser: A Comparative Study
CONCLUSION: At 12 months, both Schwind Amaris 750S and MEL 90 lasers demonstrated comparable clinical outcomes for myopic LASIK in a single surgeon setting.PMID:34258051 | PMC:PMC8257363 | DOI:10.1155/2021/9929181 (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Sheetal Brar Dishitha P Rathod C R Roopashree Sri Ganesh Source Type: research

Short-Term Outcomes of Cataract Surgery in Patients with a History of Central Serous Chorioretinopathy
This study aimed to evaluate the short-term outcomes of cataract surgery in patients with a history of idiopathic central serous chorioretinopathy (CSC).METHODS: This retrospective study included 26 patients with a history of CSC who underwent uncomplicated phacoemulsification and intraocular lens implantation. The best-corrected visual acuity (BCVA) and central foveal thickness (CFT) measured before the surgery were compared with those obtained at mean 3.6 months after the surgery. BCVA outcome was also analyzed in eyes with and without subretinal fluid (SRF).RESULTS: The mean logarithm of the minimal angle of resolution ...
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Jeon Young Joon Jae Hui Kim Jong Woo Kim Chul Gu Kim Source Type: research

Manifestations and Virus Detection in the Ocular Surface of Adult COVID-19 Patients: A Meta-Analysis
CONCLUSION: As per our findings, it was determined that ocular transmission of SARS-CoV-2 might be possible, highlighting the importance of eye protective equipment among healthcare personnel.PMID:34258053 | PMC:PMC8225454 | DOI:10.1155/2021/9997631 (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Yu-Yen Chen Yung-Feng Yen Li-Ying Huang Pesus Chou Source Type: research

Metamorphopsia and Morphological Changes in the Macula after Scleral Buckling Surgery for Macula-Off Rhegmatogenous Retinal Detachment
CONCLUSIONS: The continuation of the ELM may be a critical factor in determining the severity of metamorphopsia after SB surgery for macula-off RRD.PMID:34258046 | PMC:PMC8253631 | DOI:10.1155/2021/5525049 (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Sisi Xu Ling Wang Kangjie Kong Gang Li Yingqin Ni Source Type: research

Incorporating Differential Gene Expression Analysis with Predictive Biomarkers to Identify Novel Therapeutic Drugs for Fuchs Endothelial Corneal Dystrophy
CONCLUSIONS: Based on differential gene expression signatures, several candidate drugs have been identified to reverse the disease phenotypes in FECD. Gene expression signature with LINCS small molecule prediction software can discover novel preclinical drug candidates for FECD.PMID:34258047 | PMC:PMC8260298 | DOI:10.1155/2021/5580595 (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Huaming Wen Ryan A Gallo Xiaosheng Huang Jiamin Cai Shaoyi Mei Ammad Ahmad Farooqi Jun Zhao Wensi Tao Source Type: research

Early Age of the First Myopic Spectacle Prescription, as an Indicator of Early Onset of Myopia, Is a Risk Factor for High Myopia in Adulthood
J Ophthalmol. 2021 Jun 22;2021:6612116. doi: 10.1155/2021/6612116. eCollection 2021.ABSTRACTPURPOSE: The present study investigated the risk factors for high myopia in adulthood, with a focus on the age at which children wore their first spectacles.METHODS: Adults aged between 20 and 45 years were invited to complete a questionnaire about age, sex, current refractive error, high myopia in parents, early onset of myopia presented by the age of the first myopic spectacle prescription, refractive power of the first spectacles, and life habits at different educational stages. The associations between these factors and high myo...
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Wei-Yu Chiang Yun-Wen Chen Yu-Peng Liu Yung-Hsun Liu Pei-Chang Wu Source Type: research

A Real-World Single-Centre Study of Patients with Diabetic Macular Oedema Who Wore a Home-Use Sleep Mask (Noctura 400) for One Year
J Ophthalmol. 2021 Jun 15;2021:6612126. doi: 10.1155/2021/6612126. eCollection 2021.ABSTRACTA "Real-World" single-centre observational study was carried out to analyse the effects of enhanced patient interaction with the use of the Noctura 400 sleep mask on a group of 26 diabetics displaying diabetic retinopathy (DR) and diabetic macular oedema (DMO), of which 24 completed the study. We hoped to find if patient compliance could be maintained and to determine the anatomical and functional consequences of consistent mask wear. While this study was ongoing, COVID-19 impacted on normal eye clinic practice, allowing a...
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Ulrich Meyer-Bothling Oliver Meyer-Bothling Marika Pinney Source Type: research

Immunogenetics of the Ocular Anterior Segment: Lessons from Inherited Disorders
J Ophthalmol. 2021 Jun 28;2021:6691291. doi: 10.1155/2021/6691291. eCollection 2021.ABSTRACTAutoimmune and autoinflammatory diseases cause morbidity in multiple organ systems including the ocular anterior segment. Genetic disorders of the innate and adaptive immune system present an avenue to study more common inflammatory disorders and host-pathogen interactions. Many of these Mendelian disorders have ophthalmic manifestations. In this review, we highlight the ophthalmic and molecular features of disorders of the innate immune system. A comprehensive literature review was performed using PubMed and the Online Mendelian In...
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Jasmine Y Serpen Stephen T Armenti Lev Prasov Source Type: research

One-Year Visual and Refractive Outcomes following LASIK for Myopia and Myopic Astigmatism with MEL 90 versus Schwind Amaris 750S Excimer Laser: A Comparative Study
CONCLUSION: At 12 months, both Schwind Amaris 750S and MEL 90 lasers demonstrated comparable clinical outcomes for myopic LASIK in a single surgeon setting.PMID:34258051 | PMC:PMC8257363 | DOI:10.1155/2021/9929181 (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Sheetal Brar Dishitha P Rathod C R Roopashree Sri Ganesh Source Type: research

Short-Term Outcomes of Cataract Surgery in Patients with a History of Central Serous Chorioretinopathy
This study aimed to evaluate the short-term outcomes of cataract surgery in patients with a history of idiopathic central serous chorioretinopathy (CSC).METHODS: This retrospective study included 26 patients with a history of CSC who underwent uncomplicated phacoemulsification and intraocular lens implantation. The best-corrected visual acuity (BCVA) and central foveal thickness (CFT) measured before the surgery were compared with those obtained at mean 3.6 months after the surgery. BCVA outcome was also analyzed in eyes with and without subretinal fluid (SRF).RESULTS: The mean logarithm of the minimal angle of resolution ...
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Jeon Young Joon Jae Hui Kim Jong Woo Kim Chul Gu Kim Source Type: research

Manifestations and Virus Detection in the Ocular Surface of Adult COVID-19 Patients: A Meta-Analysis
CONCLUSION: As per our findings, it was determined that ocular transmission of SARS-CoV-2 might be possible, highlighting the importance of eye protective equipment among healthcare personnel.PMID:34258053 | PMC:PMC8225454 | DOI:10.1155/2021/9997631 (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Yu-Yen Chen Yung-Feng Yen Li-Ying Huang Pesus Chou Source Type: research

Metamorphopsia and Morphological Changes in the Macula after Scleral Buckling Surgery for Macula-Off Rhegmatogenous Retinal Detachment
CONCLUSIONS: The continuation of the ELM may be a critical factor in determining the severity of metamorphopsia after SB surgery for macula-off RRD.PMID:34258046 | PMC:PMC8253631 | DOI:10.1155/2021/5525049 (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Sisi Xu Ling Wang Kangjie Kong Gang Li Yingqin Ni Source Type: research

Incorporating Differential Gene Expression Analysis with Predictive Biomarkers to Identify Novel Therapeutic Drugs for Fuchs Endothelial Corneal Dystrophy
CONCLUSIONS: Based on differential gene expression signatures, several candidate drugs have been identified to reverse the disease phenotypes in FECD. Gene expression signature with LINCS small molecule prediction software can discover novel preclinical drug candidates for FECD.PMID:34258047 | PMC:PMC8260298 | DOI:10.1155/2021/5580595 (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Huaming Wen Ryan A Gallo Xiaosheng Huang Jiamin Cai Shaoyi Mei Ammad Ahmad Farooqi Jun Zhao Wensi Tao Source Type: research

Early Age of the First Myopic Spectacle Prescription, as an Indicator of Early Onset of Myopia, Is a Risk Factor for High Myopia in Adulthood
J Ophthalmol. 2021 Jun 22;2021:6612116. doi: 10.1155/2021/6612116. eCollection 2021.ABSTRACTPURPOSE: The present study investigated the risk factors for high myopia in adulthood, with a focus on the age at which children wore their first spectacles.METHODS: Adults aged between 20 and 45 years were invited to complete a questionnaire about age, sex, current refractive error, high myopia in parents, early onset of myopia presented by the age of the first myopic spectacle prescription, refractive power of the first spectacles, and life habits at different educational stages. The associations between these factors and high myo...
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Wei-Yu Chiang Yun-Wen Chen Yu-Peng Liu Yung-Hsun Liu Pei-Chang Wu Source Type: research

A Real-World Single-Centre Study of Patients with Diabetic Macular Oedema Who Wore a Home-Use Sleep Mask (Noctura 400) for One Year
J Ophthalmol. 2021 Jun 15;2021:6612126. doi: 10.1155/2021/6612126. eCollection 2021.ABSTRACTA "Real-World" single-centre observational study was carried out to analyse the effects of enhanced patient interaction with the use of the Noctura 400 sleep mask on a group of 26 diabetics displaying diabetic retinopathy (DR) and diabetic macular oedema (DMO), of which 24 completed the study. We hoped to find if patient compliance could be maintained and to determine the anatomical and functional consequences of consistent mask wear. While this study was ongoing, COVID-19 impacted on normal eye clinic practice, allowing a...
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Ulrich Meyer-Bothling Oliver Meyer-Bothling Marika Pinney Source Type: research

Immunogenetics of the Ocular Anterior Segment: Lessons from Inherited Disorders
J Ophthalmol. 2021 Jun 28;2021:6691291. doi: 10.1155/2021/6691291. eCollection 2021.ABSTRACTAutoimmune and autoinflammatory diseases cause morbidity in multiple organ systems including the ocular anterior segment. Genetic disorders of the innate and adaptive immune system present an avenue to study more common inflammatory disorders and host-pathogen interactions. Many of these Mendelian disorders have ophthalmic manifestations. In this review, we highlight the ophthalmic and molecular features of disorders of the innate immune system. A comprehensive literature review was performed using PubMed and the Online Mendelian In...
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Jasmine Y Serpen Stephen T Armenti Lev Prasov Source Type: research

One-Year Visual and Refractive Outcomes following LASIK for Myopia and Myopic Astigmatism with MEL 90 versus Schwind Amaris 750S Excimer Laser: A Comparative Study
CONCLUSION: At 12 months, both Schwind Amaris 750S and MEL 90 lasers demonstrated comparable clinical outcomes for myopic LASIK in a single surgeon setting.PMID:34258051 | PMC:PMC8257363 | DOI:10.1155/2021/9929181 (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Sheetal Brar Dishitha P Rathod C R Roopashree Sri Ganesh Source Type: research

Short-Term Outcomes of Cataract Surgery in Patients with a History of Central Serous Chorioretinopathy
This study aimed to evaluate the short-term outcomes of cataract surgery in patients with a history of idiopathic central serous chorioretinopathy (CSC).METHODS: This retrospective study included 26 patients with a history of CSC who underwent uncomplicated phacoemulsification and intraocular lens implantation. The best-corrected visual acuity (BCVA) and central foveal thickness (CFT) measured before the surgery were compared with those obtained at mean 3.6 months after the surgery. BCVA outcome was also analyzed in eyes with and without subretinal fluid (SRF).RESULTS: The mean logarithm of the minimal angle of resolution ...
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Jeon Young Joon Jae Hui Kim Jong Woo Kim Chul Gu Kim Source Type: research

Manifestations and Virus Detection in the Ocular Surface of Adult COVID-19 Patients: A Meta-Analysis
CONCLUSION: As per our findings, it was determined that ocular transmission of SARS-CoV-2 might be possible, highlighting the importance of eye protective equipment among healthcare personnel.PMID:34258053 | PMC:PMC8225454 | DOI:10.1155/2021/9997631 (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Yu-Yen Chen Yung-Feng Yen Li-Ying Huang Pesus Chou Source Type: research

Metamorphopsia and Morphological Changes in the Macula after Scleral Buckling Surgery for Macula-Off Rhegmatogenous Retinal Detachment
CONCLUSIONS: The continuation of the ELM may be a critical factor in determining the severity of metamorphopsia after SB surgery for macula-off RRD.PMID:34258046 | PMC:PMC8253631 | DOI:10.1155/2021/5525049 (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Sisi Xu Ling Wang Kangjie Kong Gang Li Yingqin Ni Source Type: research

Incorporating Differential Gene Expression Analysis with Predictive Biomarkers to Identify Novel Therapeutic Drugs for Fuchs Endothelial Corneal Dystrophy
CONCLUSIONS: Based on differential gene expression signatures, several candidate drugs have been identified to reverse the disease phenotypes in FECD. Gene expression signature with LINCS small molecule prediction software can discover novel preclinical drug candidates for FECD.PMID:34258047 | PMC:PMC8260298 | DOI:10.1155/2021/5580595 (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Huaming Wen Ryan A Gallo Xiaosheng Huang Jiamin Cai Shaoyi Mei Ammad Ahmad Farooqi Jun Zhao Wensi Tao Source Type: research

Early Age of the First Myopic Spectacle Prescription, as an Indicator of Early Onset of Myopia, Is a Risk Factor for High Myopia in Adulthood
J Ophthalmol. 2021 Jun 22;2021:6612116. doi: 10.1155/2021/6612116. eCollection 2021.ABSTRACTPURPOSE: The present study investigated the risk factors for high myopia in adulthood, with a focus on the age at which children wore their first spectacles.METHODS: Adults aged between 20 and 45 years were invited to complete a questionnaire about age, sex, current refractive error, high myopia in parents, early onset of myopia presented by the age of the first myopic spectacle prescription, refractive power of the first spectacles, and life habits at different educational stages. The associations between these factors and high myo...
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Wei-Yu Chiang Yun-Wen Chen Yu-Peng Liu Yung-Hsun Liu Pei-Chang Wu Source Type: research

A Real-World Single-Centre Study of Patients with Diabetic Macular Oedema Who Wore a Home-Use Sleep Mask (Noctura 400) for One Year
J Ophthalmol. 2021 Jun 15;2021:6612126. doi: 10.1155/2021/6612126. eCollection 2021.ABSTRACTA "Real-World" single-centre observational study was carried out to analyse the effects of enhanced patient interaction with the use of the Noctura 400 sleep mask on a group of 26 diabetics displaying diabetic retinopathy (DR) and diabetic macular oedema (DMO), of which 24 completed the study. We hoped to find if patient compliance could be maintained and to determine the anatomical and functional consequences of consistent mask wear. While this study was ongoing, COVID-19 impacted on normal eye clinic practice, allowing a...
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Ulrich Meyer-Bothling Oliver Meyer-Bothling Marika Pinney Source Type: research

Immunogenetics of the Ocular Anterior Segment: Lessons from Inherited Disorders
J Ophthalmol. 2021 Jun 28;2021:6691291. doi: 10.1155/2021/6691291. eCollection 2021.ABSTRACTAutoimmune and autoinflammatory diseases cause morbidity in multiple organ systems including the ocular anterior segment. Genetic disorders of the innate and adaptive immune system present an avenue to study more common inflammatory disorders and host-pathogen interactions. Many of these Mendelian disorders have ophthalmic manifestations. In this review, we highlight the ophthalmic and molecular features of disorders of the innate immune system. A comprehensive literature review was performed using PubMed and the Online Mendelian In...
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Jasmine Y Serpen Stephen T Armenti Lev Prasov Source Type: research

One-Year Visual and Refractive Outcomes following LASIK for Myopia and Myopic Astigmatism with MEL 90 versus Schwind Amaris 750S Excimer Laser: A Comparative Study
CONCLUSION: At 12 months, both Schwind Amaris 750S and MEL 90 lasers demonstrated comparable clinical outcomes for myopic LASIK in a single surgeon setting.PMID:34258051 | PMC:PMC8257363 | DOI:10.1155/2021/9929181 (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Sheetal Brar Dishitha P Rathod C R Roopashree Sri Ganesh Source Type: research

Short-Term Outcomes of Cataract Surgery in Patients with a History of Central Serous Chorioretinopathy
This study aimed to evaluate the short-term outcomes of cataract surgery in patients with a history of idiopathic central serous chorioretinopathy (CSC).METHODS: This retrospective study included 26 patients with a history of CSC who underwent uncomplicated phacoemulsification and intraocular lens implantation. The best-corrected visual acuity (BCVA) and central foveal thickness (CFT) measured before the surgery were compared with those obtained at mean 3.6 months after the surgery. BCVA outcome was also analyzed in eyes with and without subretinal fluid (SRF).RESULTS: The mean logarithm of the minimal angle of resolution ...
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Jeon Young Joon Jae Hui Kim Jong Woo Kim Chul Gu Kim Source Type: research

Manifestations and Virus Detection in the Ocular Surface of Adult COVID-19 Patients: A Meta-Analysis
CONCLUSION: As per our findings, it was determined that ocular transmission of SARS-CoV-2 might be possible, highlighting the importance of eye protective equipment among healthcare personnel.PMID:34258053 | PMC:PMC8225454 | DOI:10.1155/2021/9997631 (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Yu-Yen Chen Yung-Feng Yen Li-Ying Huang Pesus Chou Source Type: research

Metamorphopsia and Morphological Changes in the Macula after Scleral Buckling Surgery for Macula-Off Rhegmatogenous Retinal Detachment
CONCLUSIONS: The continuation of the ELM may be a critical factor in determining the severity of metamorphopsia after SB surgery for macula-off RRD.PMID:34258046 | PMC:PMC8253631 | DOI:10.1155/2021/5525049 (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Sisi Xu Ling Wang Kangjie Kong Gang Li Yingqin Ni Source Type: research

Incorporating Differential Gene Expression Analysis with Predictive Biomarkers to Identify Novel Therapeutic Drugs for Fuchs Endothelial Corneal Dystrophy
CONCLUSIONS: Based on differential gene expression signatures, several candidate drugs have been identified to reverse the disease phenotypes in FECD. Gene expression signature with LINCS small molecule prediction software can discover novel preclinical drug candidates for FECD.PMID:34258047 | PMC:PMC8260298 | DOI:10.1155/2021/5580595 (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Huaming Wen Ryan A Gallo Xiaosheng Huang Jiamin Cai Shaoyi Mei Ammad Ahmad Farooqi Jun Zhao Wensi Tao Source Type: research

Early Age of the First Myopic Spectacle Prescription, as an Indicator of Early Onset of Myopia, Is a Risk Factor for High Myopia in Adulthood
J Ophthalmol. 2021 Jun 22;2021:6612116. doi: 10.1155/2021/6612116. eCollection 2021.ABSTRACTPURPOSE: The present study investigated the risk factors for high myopia in adulthood, with a focus on the age at which children wore their first spectacles.METHODS: Adults aged between 20 and 45 years were invited to complete a questionnaire about age, sex, current refractive error, high myopia in parents, early onset of myopia presented by the age of the first myopic spectacle prescription, refractive power of the first spectacles, and life habits at different educational stages. The associations between these factors and high myo...
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Wei-Yu Chiang Yun-Wen Chen Yu-Peng Liu Yung-Hsun Liu Pei-Chang Wu Source Type: research

A Real-World Single-Centre Study of Patients with Diabetic Macular Oedema Who Wore a Home-Use Sleep Mask (Noctura 400) for One Year
J Ophthalmol. 2021 Jun 15;2021:6612126. doi: 10.1155/2021/6612126. eCollection 2021.ABSTRACTA "Real-World" single-centre observational study was carried out to analyse the effects of enhanced patient interaction with the use of the Noctura 400 sleep mask on a group of 26 diabetics displaying diabetic retinopathy (DR) and diabetic macular oedema (DMO), of which 24 completed the study. We hoped to find if patient compliance could be maintained and to determine the anatomical and functional consequences of consistent mask wear. While this study was ongoing, COVID-19 impacted on normal eye clinic practice, allowing a...
Source: Journal of Ophthalmology - July 14, 2021 Category: Opthalmology Authors: Ulrich Meyer-Bothling Oliver Meyer-Bothling Marika Pinney Source Type: research