Macular Thickness Assessed with Optical Coherence Tomography in Young Chinese Myopic Patients.
Conclusions. The retina was thinner in women than in men. Associated with myopic progression and AL extension, the central foveal thickness increased, while the retinal thickness of the inner and outer regions decreased. PMID: 26609427 [PubMed - as supplied by publisher] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 29, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Usefulness of Implantation of Diffractive Multifocal Intraocular Lens in Eyes with Long Axial Lengths.
This study retrospectively analyzed the postoperative visual functions of myopic eyes implanted with multifocal intraocular lens (IOL) to evaluate the efficacy of multifocal IOL in highly myopic eyes. Methods. We studied 61 patients (96 eyes) who were implanted with multifocal IOL ZMA00 or ZMB00 (Abbott Medical Optics). The patients were stratified into two groups by axial length: 26 mm or above (AL ≥ 26 group) and below 26 mm (AL
Source: Journal of Ophthalmology - November 29, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Role of the Endothelin System in the Vascular Dysregulation Involved in Retinitis Pigmentosa.
Authors: Sorrentino FS, Bonifazzi C, Perri P Abstract Retinitis pigmentosa is a clinical and genetic group of inherited retinal disorders characterized by alterations of photoreceptors and retinal pigment epithelium leading to a progressive concentric visual field restriction, which may bring about severe central vision impairment. Haemodynamic studies in patients with retinitis pigmentosa have demonstrated ocular blood flow abnormalities both in retina-choroidal and in retroocular vascular system. Moreover, several investigations have studied the augmentation of endothelin-1 plasma levels systemically in the body ...
Source: Journal of Ophthalmology - November 29, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma: A Review of the Literature with Updates on Surgical Management.
Authors: Plateroti P, Plateroti AM, Abdolrahimzadeh S, Scuderi G Abstract Pseudoexfoliation syndrome (PES) is a systemic disorder caused by progressive accumulation of extracellular material over various tissues. PES usually determines increased intraocular pressure, changes in the anatomical aspects of the optic nerve, and visual field alterations leading to the diagnosis of pseudoexfoliation glaucoma (PEG). Use of topical medical treatment usually leads to poor results in terms of long-term follow-up but many surgical techniques, such as Argon Laser or Selective Laser Trabeculoplasty, have been proposed for the m...
Source: Journal of Ophthalmology - November 27, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Acute Effect of Hemodialysis on Choroidal Thickness.
Authors: Çelikay O, Çalışkan S, Biçer T, Kabataş N, Gürdal C Abstract Objective. To determine the effect of hemodialysis (HD) on choroidal thickness (CT). Methods. The right eyes of 41 patients with end-stage renal disease (ESRD) undergoing HD were included. All patients underwent an ophthalmic examination, including CT measurement via optical coherence tomography, intraocular pressure (IOP), blood pressure, and body weight measurement immediately before and after a HD session. Results. Mean subfoveal choroidal thickness (SFCT) after HD decreased significantly from 254.59 ± 84.66...
Source: Journal of Ophthalmology - November 27, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Iris from Iridectomy Used as Spacer underneath the Scleral Flap: The Iridenflip Trabeculectomy Technique.
Conclusion. By using the iris from the iridectomy as spacer under the scleral flap, fibrosis of the scleral flap is no longer possible. This iridenflip trabeculectomy technique gives an excellent complete success rate (IOP ≤ 16 mmHg) of 90%. A larger study is currently being done. PMID: 26579233 [PubMed - as supplied by publisher] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 22, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Photoreceptor Inner and Outer Segment Junction Reflectivity after Vitrectomy for Macula-Off Rhegmatogenous Retinal Detachment.
Conclusions. A gradual increase of the IS/OS reflectivity was observed in eyes after PPV-mOFF. The process is not random and starts independently in the peripheral and central part of the macula which may be attributed to the variable regenerative potential of cones and rods. PMID: 26579234 [PubMed - as supplied by publisher] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 22, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Clear Corneal Phacovitrectomy with Posterior Capsulorhexis and IOL Implantation in Management of Selective Vitreoretinal Cases.
Conclusion. Selected vitreoretinal IOFB, PDLF, and PDR cases can be successfully managed by a combined surgical approach involving clear corneal phacovitrectomy with posterior capsulorhexis and implantation of an IOL, with good visual outcome and a low complication rate. PMID: 26587281 [PubMed - as supplied by publisher] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 22, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Micro-Bypass Implantation for Primary Open-Angle Glaucoma Combined with Phacoemulsification: 4-Year Follow-Up.
Conclusion. Patients in the combined group maintained low IOP levels after long-term follow-up. Cataract surgery alone showed a loss of efficacy in controlling IOP over time. Both treatments reduced the number of ocular hypotensive medications prescribed. This trial is registered with: NCT00847158. PMID: 26587282 [PubMed - as supplied by publisher] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 22, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Corneal Biomechanical Properties in Myopic Eyes Measured by a Dynamic Scheimpflug Analyzer.
Authors: Wang J, Li Y, Jin Y, Yang X, Zhao C, Long Q Abstract Purpose. To evaluate the corneal biomechanical parameters in myopic and emmetropic eyes using Corneal Visualization Scheimpflug Technology (CorVis ST). Methods. 103 myopic and emmetropic eyes of 103 patients were examined. Corneal biomechanical parameters, axial length, and mean keratometry were measured using CorVis ST, IOL Master, and topography, respectively. Corneal biomechanical properties were compared within four groups. Bivariate correlation analysis was used to assess the relationship between corneal biomechanical parameters and ocular character...
Source: Journal of Ophthalmology - November 19, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Success of Cataract Surgery and the Preoperative Measurement of Retinal Function by Electrophysiological Techniques.
Conclusions. The amplitude of central point mfERG in cataract patients was the most relevant parameter to the preoperative VA compared with PVEP and ERG. The 95% CI of the amplitude of central point mfERG for each level of VA could help to evaluate preoperative macular function which is used to predict the outcome of cataract surgery. PMID: 26576292 [PubMed - as supplied by publisher] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 19, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comparison of ExPress Mini-Device Implantation Alone or Combined with Phacoemulsification for the Treatment of Open-Angle Glaucoma.
Authors: Stawowski Ł, Konopińska J, Deniziak M, Saeed E, Zalewska R, Mariak Z Abstract We propose comparative assessment of the effectiveness of two surgical methods for the treatment of open-angle glaucoma: (1) ExPress mini-device implantation combined with phacoemulsification and (2) ExPress mini-device implantation alone. In this prospective study, 81 patients (88 phakic eyes) with uncontrolled open-angle glaucoma enrolled for surgery. They were assigned two groups, those with coexisting cataracts (46 eyes; P-ExPress group) and those with glaucoma alone (42 eyes; ExPress group). The follow-up period was 12.9 &...
Source: Journal of Ophthalmology - November 19, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Bacterial Spectrum and Antibiotic Resistance Patterns of Ocular Infection: Differences between External and Intraocular Diseases.
This study aimed to compare the differences of microbial spectrum and antibiotic resistance patterns between external and intraocular bacterial infections in an eye hospital in South China. A total of 737 bacteria isolates from suspected ocular infections were included in this retrospective study covering the period 2010-2013. The organisms cultured from the ocular surface (cornea, conjunctiva) accounted for the majority of the isolates (82.77%, n = 610), followed by the intraocular (aqueous humor, vitreous fluid), which accounted for 17.23% (n = 127). The top three species accounting for the external ocular infections wer...
Source: Journal of Ophthalmology - November 19, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Ocular Blood Flow Autoregulation Mechanisms and Methods.
Authors: Luo X, Shen YM, Jiang MN, Lou XF, Shen Y Abstract The main function of ocular blood flow is to supply sufficient oxygen and nutrients to the eye. Local blood vessels resistance regulates overall blood distribution to the eye and can vary rapidly over time depending on ocular need. Under normal conditions, the relation between blood flow and perfusion pressure in the eye is autoregulated. Basically, autoregulation is a capacity to maintain a relatively constant level of blood flow in the presence of changes in ocular perfusion pressure and varied metabolic demand. In addition, ocular blood flow dysregulatio...
Source: Journal of Ophthalmology - November 19, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Identification of Iron Homeostasis Genes Dysregulation Potentially Involved in Retinopathy of Prematurity Pathogenicity by Microarray Analysis.
Authors: Luo XQ, Zhang CY, Zhang JW, Jiang JB, Yin AH, Guo L, Nie C, Lu XZ, Deng H, Zhang L Abstract Retinopathy of prematurity (ROP) is a serious disease of preterm neonates and there are limited systematic studies of the molecular mechanisms underlying ROP. Therefore, here we performed global gene expression profiling in human fetal retinal microvascular endothelial cells (RMECs) under hypoxic conditions in vitro. Aborted fetuses were enrolled and primary RMECs were isolated from eyeballs. Cultivated cells were treated with CoCl2 to induce hypoxia. The dual-color microarray approach was adopted to compare gene ex...
Source: Journal of Ophthalmology - November 14, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comment on "Extraction of Iron from the Rabbit Anterior Chamber with Reverse Iontophoresis".
Comment on "Extraction of Iron from the Rabbit Anterior Chamber with Reverse Iontophoresis". J Ophthalmol. 2015;2015:212095 Authors: Ozge G, Ayyildiz O, Ozgonul C, Kucukevcilioglu M, Mumcuoglu T PMID: 26550486 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 11, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

A Comparative Study between Vitrectomy with Internal Tamponade and a New Modified Fiber Optic Illuminated Ando Plombe for Cases of Macular Hole Retinal Detachment in Myopic Eyes.
Authors: Bedda AM, Abdel Hadi AM, Abd Al Shafy MS Abstract Aim. To compare pars plana vitrectomy (PPV) with silicone tamponade or gas (Groups Ia and Ib) and a new modified Ando plombe equipped with a fiber optic light (Group II) for cases with macular hole retinal detachment (MHRD) in high myopic eyes (axial length> 26 mm). Methods. A prospective interventional randomized case series included 60 eyes (20 in each group). Successful outcome was considered if the retina was completely attached at the end of the follow-up period. Complications were identified for each group. Results. Visual acuity improved by...
Source: Journal of Ophthalmology - November 11, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Vision Health-Related Quality of Life in Chinese Glaucoma Patients.
This study showed that visual acuity correlated linearly with VRQOL, and VF loss might reach a certain level, correlating with abnormal VRQOL scores. Stroke was significantly associated with abnormal VRQOL. PMID: 26523231 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 4, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Erratum to "Size of the Optic Nerve Head and Its Relationship with the Thickness of the Macular Ganglion Cell Complex and Peripapillary Retinal Nerve Fiber Layer in Patients with Primary Open Angle Glaucoma".
Erratum to "Size of the Optic Nerve Head and Its Relationship with the Thickness of the Macular Ganglion Cell Complex and Peripapillary Retinal Nerve Fiber Layer in Patients with Primary Open Angle Glaucoma". J Ophthalmol. 2015;2015:747302 Authors: Enomoto N, Anraku A, Ishida K, Takeyama A, Yagi F, Tomita G Abstract [This corrects the article DOI: 10.1155/2015/186249.]. PMID: 26523232 [PubMed - as supplied by publisher] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - November 4, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Small-Gauge Pars Plana Vitrectomy for the Management of Symptomatic Posterior Vitreous Detachment after Phacoemulsification and Multifocal Intraocular Lens Implantation: A Pilot Study from the Pan-American Collaborative Retina Study Group.
Conclusion. PPV may increase UCVA and quality of vision in patients with bilateral multifocal IOLs and symptomatic PVD. Larger studies are advised. PMID: 26504590 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 31, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Responses of Multipotent Retinal Stem Cells to IL-1β, IL-18, or IL-17.
Conclusions. IL-1β, IL-18, and IL-17A induce retinal cell death via pyroptosis/necroptosis and apoptosis. They also provoke proinflammatory responses in RSCs. Though IL-1β and IL-18 could not induce Il-17a expression in RSCs, they both increase Il-17rc expression, which may mediate the effect of Il-17a. PMID: 26504591 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 31, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Human Serum Eye Drops in Eye Alterations: An Insight and a Critical Analysis.
Authors: De Pascale MR, Lanza M, Sommese L, Napoli C Abstract Human serum contains a physiological plethora of bioactive elements naturally released by activated platelets which might have a significant effect on the regeneration of corneal layers by stimulating the cell growth. This mechanism supported the use of human serum eye drops in some ocular diseases associated with dystrophic changes and alterations of the tear film, such as persistent corneal epithelial defects and dry eye syndrome. We focused our effort on potential benefits and limitations of the use of human serum eye drops when conventional therapies...
Source: Journal of Ophthalmology - October 31, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Acute-Onset Vitreous Hemorrhage of Unknown Origin before Vitrectomy: Causes and Prognosis.
Conclusions. RVO, retinal break, and AMD are the most common causes of acute-onset preoperatively unknown origin VH and the most common causes of VH change with age. The visual prognosis of unknown origin VH is relatively good, except among AMD patients. Older patients with poor preoperative BCVA in both eyes and patients with AMD in the fellow eye are at a higher risk of poor visual prognosis following vitrectomy. PMID: 26504593 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 31, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Lutein Leads to a Decrease of Factor D Secretion by Cultured Mature Human Adipocytes.
Conclusions. Our earlier observations showing that a daily lutein supplement in individuals with early signs of AMD lowered the level of circulating FD might be caused by blocking adipocyte FD production. PMID: 26504594 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 31, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Wavefront-Guided Photorefractive Keratectomy with the Use of a New Hartmann-Shack Aberrometer in Patients with Myopia and Compound Myopic Astigmatism.
Conclusion. The use of a new Hartmann-Shack aberrometer for wavefront-guided photorefractive keratectomy resulted in high predictability, efficacy, and patient satisfaction. PMID: 26504595 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 31, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Choroidal Thickness in Eyes with Unilateral Ocular Ischemic Syndrome.
Authors: Kim DY, Joe SG, Lee JY, Kim JG, Yang SJ Abstract Aim. To analyze the subfoveal choroid thickness and choroidal volume in unilateral ocular ischemic syndrome (OIS). Methods. A retrospective review was conducted for all patients with unilateral OIS from October 2010 through June 2014. The subfoveal choroidal thickness (SFChT) and choroidal volume of both eyes were compared. Results. 19 unilateral OIS patients were included in this study. The mean SFChT of OIS eyes was significantly lower than that of fellow eyes (OIS eyes: 208.89 ± 82.62 μm and fellow eyes: 265.31 ± 82.77 μm, P
Source: Journal of Ophthalmology - October 31, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Determination of a New Parameter, Elevated Epiretinal Membrane, by En Face OCT as a Prognostic Factor for Pars Plana Vitrectomy and Safer Epiretinal Membrane Peeling.
Conclusion. The detection of elevated EM via en face OCT could assist safer grasping of the EM and indicate the potential for visual outcome improvement after PPV and EM peeling. PMID: 26504597 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 31, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Clinical Outcome of Hypertensive Uveitis.
Conclusion. Patients with VU were older and had more unilateral hypertensive uveitis. Glaucoma frequently complicates hypertensive uveitis. Half of the patients had an elevated IOP before topical corticosteroid treatment. PMID: 26504598 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 31, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Ocular Biometry of Adult Cataract Patients on Lifeline Express Hospital Eye-Train in Rural China.
Authors: Cao X, Hou X, Bao Y Abstract Aims. To describe and explore the distribution of ocular biometric parameters of adult cataract patients in rural China. Methods. Three Lifeline Express Hospital Eye-Train missions of Peking University People's Hospital in China were chosen. 3828 adult cataract patients aged 29 to 88 years with axial length (AL) less than 27.0 mm were enrolled. The ocular biometry including visual acuity (VA), intraocular pressure, AL, corneal power (K1 and K2), and corneal endothelial counting (CEC) were collected and analysis. Corneal radius (CR) was calculated from the corneal power. ...
Source: Journal of Ophthalmology - October 31, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Effect of Glyceraldehyde Cross-Linking on a Rabbit Bullous Keratopathy Model.
Authors: Wang M Abstract Background. To evaluate the effects of corneal glyceraldehyde CXL on the rabbit bullous keratopathy models established by descemetorhexis. Methods. Fifteen rabbits were randomly divided into five groups. Group A (n = 3) is the control group. The right eyes of animals in Groups B,C, D, and E (n = 3, resp.) were suffered with descemetorhexis procedures. From the 8th day to the 14th day postoperatively, the right eyes in Groups C and D were instilled with hyperosmolar drops and glyceraldehyde drops, respectively; the right eyes in Group E were instilled with both hyperosmolar drops and glycera...
Source: Journal of Ophthalmology - October 31, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Continuous Curvilinear Capsulorhexis in Cataract Surgery Using a Modified 3-Bend Cystotome.
Authors: Zeng Y, Gao JH Abstract We modified a 2-bend cystotome for continuous curvilinear capsulorhexis (CCC) in manual or phacoemulsification cataract surgery to improve the safety and ease of performance. A 26G needle was converted into a cystotome with 3 bends. In this retrospective study, the performance of modified 3-bend cystotome was compared with conventional 2-bend cystotome. During cataract surgery, in the 3-bend cystotome group, mean completion time of CCC was shorter, mean times of viscoelastic agent supplement were less, and CCC success rate was higher than that in 2-bend group. Complication incidence...
Source: Journal of Ophthalmology - October 31, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Epigenetic Regulation of Werner Syndrome Gene in Age-Related Cataract.
Conclusions. A hypermethylation in WRN promoter and altered histone modification in anterior lens capsules might contribute to the ARC mechanism. The data suggest an association of altered DNA repair capability in lens with ARC pathogenesis. PMID: 26509079 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 31, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

An Evaluation of Effects of Different Mydriatics on Choroidal Thickness by Examining Anterior Chamber Parameters: The Scheimpflug Imaging and Enhanced Depth Imaging-OCT Study.
Authors: Yuvacı İ, Pangal E, Yuvacı S, Bayram N, Ataş M, Başkan B, Demircan S, Akal A Abstract Aim. To assess the effects of mydriatics commonly used in clinical practice on choroidal thickness and anterior chamber change. Methods. This was a prospective, randomized, controlled, double-blinded study including a single eye of the participants. The subjects were assigned into 4 groups to receive tropicamide 1%, phenylephrine 2.5%, cyclopentolate 1%, and artificial tears. At the baseline, anterior chamber parameters were assessed using a Pentacam Scheimpflug camera system, and choroidal thickness (CT) was measure...
Source: Journal of Ophthalmology - October 31, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Safety and Efficacy of Adding Fixed-Combination Brinzolamide/Timolol Maleate to Prostaglandin Therapy for Treatment of Ocular Hypertension or Glaucoma.
Authors: Hommer A, Hubatsch DA, Cano-Parra J Abstract Purpose. To evaluate the safety and efficacy of adding brinzolamide 1%/timolol maleate 0.5% fixed combination (BTFC) to a prostaglandin analog (PGA). Methods. This was a 12-week, open-label, single-arm study of patients with open-angle glaucoma or ocular hypertension with intraocular pressure (IOP) not sufficiently controlled after ≥4 weeks of PGA monotherapy. The primary outcome was mean IOP change from baseline at week 12. Other outcomes included IOP change from baseline at week 4, percentage of patients achieving IOP ≤18 mmHg at week 12, and pati...
Source: Journal of Ophthalmology - October 25, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Canaloplasty: A Minimally Invasive and Maximally Effective Glaucoma Treatment.
Authors: Khaimi MA Abstract Canaloplasty is a highly effective, minimally invasive, surgical technique indicated for the treatment of open-angle glaucoma that works by restoring the function of the eye's natural outflow system. The procedure's excellent safety profile and long-term efficacy make it a viable option for the majority of glaucoma patient types. It can be used in conjunction with existing drug based glaucoma treatments, after laser or other types of incisional surgery, and does not preclude or affect the outcome of future surgery. Numerous scientific studies have shown Canaloplasty to be safe and effect...
Source: Journal of Ophthalmology - October 25, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Blood Pressure and Heart Rate Variability to Detect Vascular Dysregulation in Glaucoma.
Conclusions. Nonlinear uni- and bivariate indices of continuous recordings of blood pressure and heart rate are altered in glaucoma. Abnormal blood pressure variability suggests disturbed autonomic regulation in patients with glaucoma. PMID: 26495136 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 25, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Outcomes of Late-Onset Bleb-Related Endophthalmitis Treated with Pars Plana Vitrectomy.
Conclusion. Visual prognosis of BRE treated by PPV is significantly better when the pathogenic bacteria are not HPB. Severe visual loss occurred with HPB infection even though patients had appropriate treatments. Physicians need to have careful consideration to prevent bleb infection after trabeculectomy with MMC. PMID: 26495137 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 25, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Posterior Corneal Surface Stability after Femtosecond Laser-Assisted Keratomileusis.
Authors: Cagini C, Messina M, Lupidi M, Piccinelli F, Fiore T, Fruttini D, Spadea L Abstract The purpose of this study was to evaluate posterior corneal surface variation after femtosecond laser-assisted keratomileusis in patients with myopia and myopic astigmatism. Patients were evaluated by corneal tomography preoperatively and at 1, 6, and 12 months. We analyzed changes in the posterior corneal curvature, posterior corneal elevation, and anterior chamber depth. Moreover, we explored correlation between corneal ablation depth, residual corneal thickness, percentage of ablated corneal tissue, and preoperative corn...
Source: Journal of Ophthalmology - October 23, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

A Comparison of Different Operating Systems for Femtosecond Lasers in Cataract Surgery.
Authors: Wu BM, Williams GP, Tan A, Mehta JS Abstract The introduction of femtosecond lasers is potentially a major shift in the way we approach cataract surgery. The development of increasingly sophisticated intraocular lenses (IOLs), coupled with heightened patient expectation of high quality postsurgical visual outcomes, has generated the need for a more precise, highly reproducible and standardized method to carry out cataract operations. As femtosecond laser-assisted cataract surgery (FLACS) becomes more commonplace in surgical centers, further evaluation of the potential risks and benefits needs to be establi...
Source: Journal of Ophthalmology - October 23, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Excimer versus Femtosecond Laser Assisted Penetrating Keratoplasty in Keratoconus and Fuchs Dystrophy: Intraoperative Pitfalls.
Conclusions. Intraoperative decentration, misalignment of the donor in the recipient bed, and need for additional interrupted sutures as well as high percentage of severe intraocular positive pressure were predominantly present in the femtosecond laser in keratoconus eyes. PMID: 26483974 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 23, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Correlation Analysis between Corneal Biomechanical Properties and the Surgically Induced Corneal High-Order Aberrations after Small Incision Lenticule Extraction and Femtosecond Laser In Situ Keratomileusis.
Authors: Wu W, Wang Y Abstract Background. To investigate the correlation between corneal biomechanics and the surgically induced corneal high-order aberrations (HOAs) after small incision lenticule extraction (SMILE) and femtosecond laser in situ keratomileusis (FS-LASIK). Methods. A total of 150 right myopic eyes that underwent SMILE or FS-LASIK surgery were included in this retrospective study, 75 eyes in each group. The corneal hysteresis (CH) and the corneal resistance factor (CRF) with the corneal HOAs of the anterior, posterior, and total cornea were assessed preoperatively and three months postoperatively. ...
Source: Journal of Ophthalmology - October 23, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Outcomes and Prognostic Factors of Intravitreal Bevacizumab Monotherapy in Zone I Stage 3+ and Aggressive Posterior Retinopathy of Prematurity.
Conclusion. ROP regression rate after one intravitreal bevacizumab injection was 85.13%. This trial is registered with trial registration number IRCT2014101618966N2. PMID: 26491545 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 23, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Inhibition of Corneal Neovascularization by Subconjunctival Injection of Fc-Endostatin, a Novel Inhibitor of Angiogenesis.
Authors: Yoshida J, Wicks RT, Zambrano AI, Tyler BM, Javaherian K, Grossman R, Daoud YJ, Gehlbach P, Brem H, Stark WJ Abstract We assessed the antiangiogenic effects of subconjunctival injection of Fc-endostatin (FcE) using a human vascular endothelial growth factor-induced rabbit corneal neovascularization model. Angiogenesis was induced in rabbit corneas through intrastromal implantations of VEGF polymer implanted 2 mm from the limbus. NZW rabbits were separated into groups receiving twice weekly subconjunctival injections of either saline; 25 mg/mL bevacizumab; 2 mg/mL FcE; or 20 mg/m...
Source: Journal of Ophthalmology - October 23, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Apelin Protects Primary Rat Retinal Pericytes from Chemical Hypoxia-Induced Apoptosis.
Authors: Chen L, Tao Y, Feng J, Jiang YR Abstract Pericytes are a population of cells that participate in normal vessel architecture and regulate permeability. Apelin, as the endogenous ligand of G protein-coupled receptor APJ, participates in a number of physiological and pathological processes. To date, the effect of apelin on pericyte is not clear. Our study aimed to investigate the potential protection mechanisms of apelin, with regard to primary rat retinal pericytes under hypoxia. Immunofluorescence staining revealed that pericytes colocalized with APJ in the fibrovascular membranes dissected from proliferati...
Source: Journal of Ophthalmology - October 23, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Optical Coherence Tomography Angiography in Retinal Vascular Diseases and Choroidal Neovascularization.
Conclusions. OCT-A provides detailed images of retinal vascular plexuses and quantitative data of pathologic structures. Further studies are warranted to define the role of OCT-A in the assessment of retinovascular diseases, with respect to conventional FA and ICG-A. PMID: 26491548 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 23, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Prognostic Factors for Open Globe Injuries and Correlation of Ocular Trauma Score in Tianjin, China.
Conclusion. In our study, the most important prognostic factors influencing the final VA were initial VA, RAPD, and the zone of injury. The OTS was of great importance for patients and ophthalmologists. PMID: 26491549 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 23, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Individualized Therapy with Ranibizumab in Wet Age-Related Macular Degeneration.
Authors: García-Layana A, Figueroa MS, Arias L, Araiz J, Ruiz-Moreno JM, García-Arumí J, Gómez-Ulla F, López-Gálvez MI, Cabrera-López F, García-Campos JM, Monés J, Cervera E, Armadá F, Gallego-Pinazo R Abstract Individualized treatment regimens may reduce patient burden with satisfactory patient outcomes in neovascular age-related macular degeneration. Intravitreal anti-VEGF drugs are the current gold standard. Fixed monthly injections offer the best visual outcome but this regimen is not commonly followed outside clinical trials. A PRN regimen r...
Source: Journal of Ophthalmology - October 23, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Measurement of Intraocular Biomarkers in Various Stages of Proliferative Diabetic Retinopathy Using Multiplex xMAP Technology.
Conclusions. Results of our study imply that levels of IL-6, TGFβ-1, and VEGF correlate with the severity of PDR. PMID: 26491551 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 23, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Assessment of Full-Eye Response to Osmotic Stress in Mouse Model In Vivo Using Optical Coherence Tomography.
Authors: Ni Y, Xu B, Wu L, Du C, Jiang B, Ding Z, Li P Abstract NaCl based solutions were applied as osmotic stress agents to alter the hydration state of the mouse eye. Full-eye responses to these osmotic challenges were monitored in vivo using a custom-built optical coherence tomography (OCT) with an extended imaging range of 12.38 mm. Dynamic changes in the mouse eye were quantified based on the OCT images using several parameters, including the central corneal thickness (CCT), the anterior chamber depth (ACD), the crystalline lens thickness (LT), the cornea-retina distance (CRD), the iris curvature (IC),...
Source: Journal of Ophthalmology - October 23, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Suppression of In Vivo Neovascularization by the Loss of TRPV1 in Mouse Cornea.
Authors: Tomoyose K, Okada Y, Sumioka T, Miyajima M, Flanders KC, Shirai K, Morii T, Reinach PS, Yamanaka O, Saika S Abstract To investigate the effects of loss of transient receptor potential vanilloid receptor 1 (TRPV1) on the development of neovascularization in corneal stroma in mice. Blocking TRPV1 receptor did not affect VEGF-dependent neovascularization in cell culture. Lacking TRPV1 inhibited neovascularization in corneal stroma following cauterization. Immunohistochemistry showed that immunoreactivity for active form of TGFβ1 and VEGF was detected in subepithelial stroma at the site of cauterization i...
Source: Journal of Ophthalmology - October 23, 2015 Category: Opthalmology Tags: J Ophthalmol Source Type: research