Early Changes in Visual Quality and Corneal Structure after DMEK: Does DMEK Approach Optical Quality of a Healthy Cornea?
Authors: Satue M, Idoipe M, Gavin A, Romero-Sanz M, Liarakos VS, Mateo A, Garcia-Martin E, Blasco-Martinez A, Sanchez-Perez A Abstract Purpose: To evaluate early changes in visual function and visual quality parameters after Descemet membrane endothelial keratoplasty (DMEK) and to compare the outcomes with healthy controls. Methods: Thirteen patients who underwent DMEK and 14 controls were evaluated. All subjects underwent visual function evaluation, including visual acuity under photopic and mesopic lighting conditions and contrast sensitivity (CSV) tests CSV 1000 and Pelli-Robson. Corneal parameters were asse...
Source: Journal of Ophthalmology - October 23, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Challenges and Complication Management in Novel Artificial Iris Implantation.
Authors: Mayer CS, Laubichler AE, Khoramnia R, Tandogan T, Prahs P, Zapp D, Reznicek L Abstract Purpose: Evaluation of postoperative artificial iris prosthesis-related complications. Design: Retrospective cohort study. Methods: Fifty-one consecutive patients underwent pupillary reconstruction using an artificial iris implant made from silicone between 2011 and 2015. Quantity and quality of complications were subclassified into three groups including mild, moderate, and severe complications. Their management and the learning curve were evaluated. Results: In total, 13 (25.5%) of 51 included artificial ir...
Source: Journal of Ophthalmology - October 23, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Anterior Chamber Flare as an Objective and Quantitative Noninvasive Method for Oculopathy in Transthyretin V30M Amyloidosis Patients.
Conclusions: In this study, aqueous humor flare values in the scalloped iris eyes may be a valid marker for controlling the stage of the oculopathy in ATTRV30M patients. PMID: 30327725 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 19, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Long-Term Follow-Up after Intravenous Immunoglobulin Therapy in Patients with Severe Ocular Mucous Membrane Pemphigoid Unresponsive to Conventional Therapy.
In conclusion, the IVIg has to be considered as a safe and successful alternative therapy in patients with severe ocular mucous membrane pemphigoid; furthermore, this kind of therapy seems to be effective in maintaining the clinical remission by the time. PMID: 30327726 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 19, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Analysis of Foveal Microvascular Abnormalities in Diabetic Retinopathy Using Optical Coherence Tomography Angiography with Projection Artifact Removal.
Authors: Liu L, Jian Gao, Bao W, Hu C, Xu Y, Zhao B, Zheng J, Fan L, Sun Y Abstract Purpose: To analyze foveal microvascular abnormalities in different stages of diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA) with projection artifact removal (PAR). Methods: We analyzed 93 eyes of 59 patients with diabetes-31 with no DR (no DR), 34 with mild to moderate nonproliferative DR (mild DR), and 28 with severe nonproliferative DR to proliferative DR (severe DR)-and 31 age-matched healthy controls. Sections measuring 3 × 3 mm2 centered on the fovea were obtained...
Source: Journal of Ophthalmology - October 16, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Retinal Vessel Diameter Changes in Relation to Dark Adaptation and Acute Hyperglycemia.
Authors: Kappelgaard P, Holfort SK, Klefter ON, Larsen M Abstract The purpose of this experimental clinical study was to assess the effects of dark adaptation and acute changes in glycemia on retinal vessel diameters in men. The study included 14 patients (mean age 63 years, range 48-74 years) with type 2 diabetes mellitus and minimal or no diabetic retinopathy. Retinal vessel diameters were assessed using infrared photography before and after dark adaptation, first while fasting and then at peak hyperglycemia during an oral glucose tolerance test (OGTT). Dark adaptation was accompanied by retinal vasodilatation, b...
Source: Journal of Ophthalmology - October 16, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Vascular Endothelial Growth Factor (VEGF) Serological and Lacrimal Signaling in Patients Affected by Vernal Keratoconjunctivitis (VKC).
Conclusions: This pilot study highlights the importance of lacrimal and vascular inflammatory biomarkers that can be detected in VKC patients during the acute phase, but not in healthy children. The small group of patients warrants additional studies on a larger sample, not only to further investigate the role of VEGF but also to evaluate the angiogenic biomarkers before and after topical treatment. PMID: 30305958 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 13, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Retrospective Comparison of 27-Gauge and 25-Gauge Microincision Vitrectomy Surgery with Silicone Oil for the Treatment of Primary Rhegmatogenous Retinal Detachment.
Conclusions: This study found no significant anatomical or functional difference between 27G and 25G MIVS in the treatment of primary RRD. Therefore, 27G vitrectomy appears to be a safe and effective surgery for the treatment of primary RRD. PMID: 30305959 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 13, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Effect of Strabismus Muscle Surgery on Corneal Biomechanics.
Authors: El Gendy HA, Khalil NM, Eissa IM, Shousha SM Abstract Purpose: Studying the early effect of different extraocular muscle (EOM) surgeries on corneal biomechanics. Subjects and methods: This is a prospective, nonrandomized, interventional study, in which 42 eyes of 29 candidates for EOM surgery for strabismus correction at Cairo university hospitals, aged 14-37 years, were recruited. All participants had measuring of the visual acuity, refraction (spherical equivalent (SE)), assessment of the EOM motility and muscle balance, sensory evaluation, fundus examination, and assessing the ocular biomechanics us...
Source: Journal of Ophthalmology - October 13, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Normative Values of Peripapillary Retinal Nerve Fiber Layer Thickness in a Middle Eastern Population.
Conclusions: Our set of predicted normative data may be used to interpret measurements of pRNFL thickness in Middle Eastern patients. Our findings suggest that systemic conditions with potential ocular manifestations may require consideration in predictive models of pRNFL thickness, even in the absence of gross fundoscopic findings. Normative data from additional Middle Eastern populations are required to appraise our models, which adjust for common clinical confounders. PMID: 30310697 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 13, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Effects of Oral Supplementation with Docosahexaenoic Acid (DHA) plus Antioxidants in Pseudoexfoliative Glaucoma: A 6-Month Open-Label Randomized Trial.
Authors: Romeo Villadóniga S, Rodríguez García E, Sagastagoia Epelde O, Álvarez Díaz MD, Domingo Pedrol JC Abstract Purpose: To assess the effects of antioxidant oral supplementation based on docosahexaenoic acid (DHA) in pseudoexfoliative (PEX) glaucoma. Patients and Methods: A prospective 6-month open-label randomized controlled trial was conducted in patients with PEX glaucoma and adequate intraocular pressure (IOP) control. Patients in the DHA group received a high-rich DHA (1 g) nutraceutical formulation. Ophthalmological examination, DHA erythrocyte membrane conte...
Source: Journal of Ophthalmology - October 13, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Surgical Synechiolysis of Iridocapsular Adhesion and Sulcus Placement of a Rigid Intraocular Lens on an Oversized Residual Capsular Rim.
Conclusions: A large-optic and rigid IOL in the sulcus is a feasible alternative when a sulcus-based IOL is considered for aphakic eyes with an oversized residual capsulorhexis. A preserved capsulorhexis after sufficient synechiolysis, which can secure the IOL optic intraoperatively, may yield better stability of the IOL position. PMID: 30298104 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 10, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comparison of the Techniques of Secondary Intraocular Lens Implantation after Penetrating Keratoplasty.
Authors: Krysik K, Dobrowolski D, Wroblewska-Czajka E, Lyssek-Boron A, Wylegala E Abstract Aim: To conduct a retrospective analysis of secondary IOL implantation in patients who underwent PK with no simultaneous IOL implantation. Materials and Methods: The retrospective study of the secondary implantation of IOLs was conducted in 46 eyes that underwent a primary operation with PK and cataract/lens extraction with no IOL implantation due to capsule rupture or combining corneal or intraocular complications. The minimum period from PK was 12 months. All secondary IOL implantations were performed from January 2011 ...
Source: Journal of Ophthalmology - October 10, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Knockdown of Fibromodulin Inhibits Proliferation and Migration of RPE Cell via the VEGFR2-AKT Pathway.
Conclusion: Depletion of FMOD selectively downregulated the expression of VEGF and VEGFR2 and inhibited the signaling pathway of AKT phosphorylation, which consequently inhibited the proliferation and migration of RPE Cell. PMID: 30298106 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 10, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Short-Term Observation of Ultrasonic Cyclocoagulation in Chinese Patients with End-Stage Refractory Glaucoma: A Retrospective Study.
Conclusion: With high percentage of IOP reduction and a good safety profile observed in our study, HIFU-based ultrasonic cyclocoagulation might become a promising alternative to cyclodestructive methods. Long-term efficacy and safety need further assessment. The study was registered with Chinese Clinical Trial Registry (http://www.chictr.org.cn; Registration number: ChiCTR-OOC-17014028). PMID: 30271627 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 3, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Analysis of Morphologic and Functional Outcomes in Macular Edema due to Central Retinal Vein Occlusion Treated with Intravitreal Dexamethasone Implant.
Authors: Niro A, Sborgia G, Sborgia A, Sborgia L, Furino C, Recchimurzo N, Alessio G Abstract Purpose: To analyze anatomic and functional retinal changes and their correlation after intravitreal dexamethasone implant (DEX implant) in patients with central retinal vein occlusion- (CRVO-) related macular edema (ME) using optical coherence tomography and microperimetry. Methods: Fifteen treatment-naïve patients with functional impairment due to CRVO-related ME were enrolled in this prospective interventional case series. Main outcomes were best-corrected visual acuity (BCVA), retinal sensitivity (RS), and cen...
Source: Journal of Ophthalmology - October 3, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Prevalence of Keratoconus in a Refractive Surgery Population.
Conclusion: The incidence of keratoconus in Saudi Arabian refractive surgery prospects was 18.7%. Keratoconus was the most common reason for not performing refractive surgery and accounted for 24.0% of cases in which surgery was not performed. PMID: 30271629 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 3, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Risk of Ischemic Stroke, Hemorrhagic Stroke, and All-Cause Mortality in Retinal Vein Occlusion: A Nationwide Population-Based Cohort Study.
Conclusions: People with RVO are at a significantly greater risk of developing stroke, ischemic stroke, and hemorrhagic stroke. However, RVO does not significantly increase the risk of all-cause mortality. PMID: 30271630 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 3, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Combined Application of Bevacizumab and Mitomycin C or Bevacizumab and 5-Fluorouracil in Experimental Glaucoma Filtration Surgery.
Authors: Zuo L, Zhang J, Xu X Abstract The present study aimed at observing the effect of a single subconjunctival injection of bevacizumab (BVZ) combined with 5-fluorouracil (5-Fu) or mitomycin C (MMC) on the antiscarring effect of glaucoma filtration surgery (GFS). The inhibitory effect of combined BVZ and 5-Fu in retinal pigment epithelial cells on vascular endothelial growth factor (VEGF) levels was demonstrated through in vitro experiments. Combined BVZ and 5-Fu and combined BVZ and MMC inhibited cell cycle, induced apoptosis, and inhibited human umbilical vein endothelial cell migration. Also, the cytotoxicit...
Source: Journal of Ophthalmology - October 3, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Transforming Retinal Photographs to Entropy Images in Deep Learning to Improve Automated Detection for Diabetic Retinopathy.
Authors: Lin GM, Chen MJ, Yeh CH, Lin YY, Kuo HY, Lin MH, Chen MC, Lin SD, Gao Y, Ran A, Cheung CY Abstract Entropy images, representing the complexity of original fundus photographs, may strengthen the contrast between diabetic retinopathy (DR) lesions and unaffected areas. The aim of this study is to compare the detection performance for severe DR between original fundus photographs and entropy images by deep learning. A sample of 21,123 interpretable fundus photographs obtained from a publicly available data set was expanded to 33,000 images by rotating and flipping. All photographs were transformed into entropy...
Source: Journal of Ophthalmology - October 3, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Ologen Implantation versus Conjunctival Autograft Transplantation for Treatment of Pterygium.
Conclusions: Ologen transplantation was technically easier, provided short operative time compared with conjunctival autograft transplantation, and preserved healthy conjunctiva with less complication and less recurrence; it may be a new, safe, and effective alternative for improving the short-term success rate of primary surgery. PMID: 30254754 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - September 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Efficacy and Safety of Bevacizumab in the Treatment of Pterygium: An Updated Meta-Analysis of Randomized Controlled Trials.
Conclusions: Application of bevacizumab showed a statistically significant decrease in recurrence rate following removal of primary pterygia, or in cases with conjunctival autograft, or with follow-up longer than 12 months, while complications were not increased. PMID: 30254755 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - September 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Effect of Proparacaine 0.375%-Sodium Fluorescein 0.25% Eye Drop Mixture and Fluorescein Strip on Anterior Segment Parameters.
Authors: Do─čan M, Sabaner MC, Erol MA Abstract Purpose: To determine the effect of proparacaine 0.375%-sodium fluorescein 0.25% eye drop mixture and fluorescein strip on anterior segment parameters commonly used in routine ophthalmology practice. Methods: 115 healthy volunteers without any systemic or ocular disease were divided into two groups. 57 volunteers were in the proparacaine 0.375%-sodium fluorescein 0.25% eye drop mixture group, and 58 volunteers were in the fluorescein strip group. Measurements (CCT (central corneal thickness), topographic pupil diameter, AD (aqueous depth), ACV (anterior chamber vo...
Source: Journal of Ophthalmology - September 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Prospective Randomized Multicenter Comparison of the Clinical Outcomes of V4c and V5 Implantable Collamer Lenses: A Contralateral Eye Study.
Conclusion: The V4c and V5 ICL models achieved similar visual and refractive outcomes, whereas the V5 model showed a possible advantage in reducing night vision disturbances. PMID: 30254757 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - September 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

HLA-C Alleles and Cytomegalovirus Retinitis in Brazilian Patients with AIDS.
Conclusion: The HLA-C∗07 allele group conferred protection against the development of CR in Brazilian AIDS patients, whereas the HLA-C∗05 and HLA-C∗16 allele groups were associated with AIDS susceptibility or protection, respectively. PMID: 30245869 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - September 26, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Development of Corneal Astigmatism (CA) according to Axial Length/Corneal Radius (AL/CR) Ratio in a One-Year Follow-Up of Children in Beijing, China.
Authors: Wang F, Xiao L, Meng X, Wang L, Wang D Abstract Purpose: The correlations between the axial length-to-corneal radius (AL/CR) ratio and corneal astigmatism (CA) were studied by prospectively analyzing and comparing survey data from school children in the Beijing urban area from 2014 to 2015. Methods: In this longitudinal study, a total of 2,970 students were enrolled in 2014, and 2,179 students were enrolled in 2015. The students were in grades 1 and 4 of primary schools located in the Yangfangdian district of Beijing. The students were examined using the standard logarithmic visual acuity chart for unc...
Source: Journal of Ophthalmology - September 26, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Genetics in Ophthalmology.
Authors: Prasov L, Armenti ST, Utz VM, Richards JE, Hufnagel RB PMID: 30245871 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - September 26, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Postexercise Recovery of Schlemm's Canal and Intraocular Pressure in Healthy Individuals: An Observational Study Using Swept-Source Optical Coherence Tomography.
Conclusions: The exercise-induced SC expansion and IOP reduction could recover to preexercise values after exercise, and SC recovered to preexercise values ahead of IOP. Moreover, SC might be regulated by the sympathetic nerves and could be an important causative factor of changes in IOP during and after exercise. PMID: 30245872 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - September 26, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Evaluation of Sutureless, Glueless, Flapless, Intrascleral Fixated Posterior Chamber Intraocular Lens in Children with Ectopia Lentis.
Authors: Nb K, Kohli P, Pangtey BPS, Ramasamy K Abstract Aim: This paper aims at evaluating refractive outcome and complication profile of sutureless, glueless, flapless, intrascleral fixation of intraocular lens (SFIOL) in pediatric population. Methods: This retrospective study included patients ≤18 years of age who underwent SFIOL for ectopia lentis. Details obtained included preoperative uncorrected visual acuity (UCVA), cycloplegic refraction, and best-corrected visual acuity (BCVA); intraoperative complications; and postoperative UCVA, cycloplegic refraction, and BCVA and complications. Results: Med...
Source: Journal of Ophthalmology - September 20, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Increment of Choroidal Thickness in Euthyroid Graves' Ophthalmopathy: Is It an Early Sign of Venous Congestion?
Conclusions: This elevation is because of the intraorbital inflammation even in this nonsevere GO group. Choroidal thickness might be affected from the venous obstruction and congestion in patients with GO. The elevation of the choroidal thickness might be an early sign of venous congestion that occurs before the elevation of intraocular pressure. PMID: 30228914 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - September 20, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Evaluation of Reliability and Validity of Three Common Dry Eye Questionnaires in Chinese.
Authors: Lu F, Tao A, Hu Y, Tao W, Lu P Abstract Purpose: To investigate the psychometric properties of three commonly used dry eye questionnaires including McMonnies Questionnaire (MQ), the Ocular Surface Disease Index (OSDI), and the Salisbury Eye Evaluation Questionnaire (SEEQ) in Chinese. Methods: This prospective cross-sectional study was conducted at the Eye Hospital of Wenzhou Medical University. Ninety-eight participants completed three questionnaires in a random order. Ophthalmic examinations including tear break-up time, corneal fluorescein staining score, and Schirmer I test were performed. Reliabili...
Source: Journal of Ophthalmology - September 19, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

New Strategies for Treatment of Diabetic Macular Edema.
Authors: Takamura Y, Ohkoshi K, Murata T PMID: 30210868 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - September 15, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Ocular Surface Disease: Advances in Diagnostics and Therapeutics.
Authors: Gatzioufas Z, Hamada S, Palioura S PMID: 30210869 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - September 15, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Effects of Residual Anterior Lens Epithelial Cell Removal on Axial Position of Intraocular Lens after Cataract Surgery.
Conclusion: Our findings suggest that residual anterior LEC polishing enhances the axial position stability of IOLs, without any complications, after cataract surgery. PMID: 30210870 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - September 15, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Fluorescein Leakage within Recent Subretinal Hemorrhage in Pathologic Myopia: Suggestive of CNV?
Conclusions: Dye leakage within recent subretinal hemorrhage on FA could be caused by new-onset lacquer cracks in pathologic myopia. Multimodal imaging including OCTA is helpful to differentiate lacquer cracks from myopic CNV. PMID: 30186627 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - September 8, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Graft Survival after Penetrating Keratoplasty in Cases of Trabeculectomy versus Ahmed Valve Implant.
Conclusion: Managing postpenetrating keratoplasty glaucoma could be bothersome especially in complex cases. Ahmed glaucoma valve implant controls the intraocular pressure more effectively than trabeculectomy with mitomycin C. However, Ahmed glaucoma valve can result in higher rates of corneal graft failure in a shorter duration of time. This trial is registered with PACTR201712002861391 on 21 Dec 2017. PMID: 30186628 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - September 8, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Current Evidence for the Prevention of Endophthalmitis in Anti-VEGF Intravitreal Injections.
This article provides an up to date assessment of various aspects of the procedure such as the setting, ventilation, type of anaesthetic, and control of sterility during the procedure; including discussions on performing bilateral eye same-day injections and the use of antibiotics. PMID: 30174946 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - September 5, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Retrospective Analyses of Potential Risk Factors for Posterior Capsule Opacification after Cataract Surgery.
Authors: Wu S, Tong N, Pan L, Jiang X, Li Y, Guo M, Li H Abstract Purpose: To evaluate the potential risk factors of posterior capsule opacification (PCO) after cataract surgery. Methods: Data on PCO patients diagnosed from September 2015 to May 2017 were obtained from the Department of Ophthalmology at Qingdao Municipal Hospital, Qingdao, China. The factors associated with PCO were assessed using Pearson's χ2 test for univariate analyses and logistic regression for multivariate analyses. Results: Eyes (652) from 550 patients were enrolled in this study. All patients were diagnosed with PCO/non-PCO and had
Source: Journal of Ophthalmology - September 5, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Macular Thickness, Foveal Volume, and Choroidal Thickness in Amblyopic Eyes and Their Relationships to the Treatment Outcome.
This study enrolled eyes with amblyopia resulting from strabismus, anisometropia, or ametropia. All patients underwent detailed eye examinations, including spectral domain optical coherence tomography (SD-OCT) scan. All of the subjects received amblyopic treatment and were divided into 2 groups after 6 months of follow-up: the recovered amblyopic group with a best-corrected visual acuity (BCVA) ≥0.8 and the persistent amblyopic group with a BCVA
Source: Journal of Ophthalmology - August 31, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Application of Optical Coherence Tomography Angiography to Retinal Disease.
Authors: de Carlo TE, Waheed NK, Sridhar J, Ferrara D PMID: 30159165 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - August 31, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Manifestation of Clinical Categories of Ocular Graft-versus-Host Disease.
This study aims at improving the understanding of the subjective symptoms and signs of two different clinical categories of ocular graft-versus-host disease. After reviewing and screening 193 posthematopoietic stem cell transplantation (HSCT) patients of Peking University Third Hospital, we enrolled 148 (21 acute ocular GVHD, 127 chronic ocular GVHD). Patients' subjective symptoms, ocular parameters, and typical ocular signs were collected and evaluated at the same visit. Classic acute ocular GVHD patients had variable levels of conjunctival involvement but few had keratopathy; increased mucus secretion (21 of 21, 100.0%),...
Source: Journal of Ophthalmology - August 31, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Estimation of Eyelid Pressure Using a Blepharo-Tensiometer in Patients with Functional Nasolacrimal Duct Obstruction.
Authors: Kim J, Lee SM, Choi YJ, Lee MJ Abstract Purpose: To compare the eyelid pressure between patients with functional nasolacrimal duct obstruction (FNLDO) and normal controls using blepharo-tensiometer, and to evaluate the relationship between eyelid pressure and the outcomes of silicone intubation (SI) in patients with FNLDO. Study design: Prospective case-control study. Methods: We enrolled 36 eyes of 36 patients with suspected FNLDO who underwent SI and 36 healthy eyes of age-matched controls. One eye of each patient with FNLDO was randomly selected for analysis. The eyelid pressure was estimated us...
Source: Journal of Ophthalmology - August 31, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Evolution of Central Retinal and Choroidal Thickness in Acute Anterior Uveitic Patients with Spondyloarthropathy.
Authors: Szepessy Z, Barsi Á, Kránitz K, Nagy ZZ Abstract Purpose: To describe and correlate the degree of anterior segment inflammation with central retinal and choroidal thickness throughout the treatment period (in the course of follow-up) in the eyes affected with acute anterior uveitis in the patients with seronegative spondyloarthropathy (subgroup: ankylosing spondylitis). Methods: Thirty eyes of 30 consecutive Caucasian patients with HLA-B27-associated acute anterior uveitis were included in this study. The flare, AC cell number, and central retinal/choroidal thickness were determined at ea...
Source: Journal of Ophthalmology - August 31, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Epi-Off versus Epi-On Corneal Collagen Cross-Linking in Keratoconus Patients: A Comparative Study through 2-Year Follow-Up.
Conclusion: Our findings demonstrate that both procedures are able to slow keratoconus progression. Both treatment modalities are equivalent in terms of results and related complications. CXL epi-on technique is preferable to CXL epi-off since it preserves the corneal thickness and improves visual acuity, also reducing the postoperative ocular discomfort during the study period. PMID: 30151277 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - August 30, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Intravitreal Dexamethasone in Patients with Wet Age-Related Macular Degeneration Resistant to Anti-VEGF: A Prospective Pilot Study.
Conclusion: In patients showing an incomplete response to anti-VEGF therapy, DXI combined with intravitreal anti-VEGF seems to improve retinal fluid resorption without functional advantage. This trial is registered with ACTRN12618001102268. PMID: 30151278 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - August 30, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Ocular Manifestations of Alzheimer's and Other Neurodegenerative Diseases: The Prospect of the Eye as a Tool for the Early Diagnosis of Alzheimer's Disease.
Authors: Colligris P, Perez de Lara MJ, Colligris B, Pintor J Abstract Dementia, including Alzheimer's disease (AD), is a major disorder, leading to several ocular manifestations amongst the elderly population. These visual disorders may be due to retinal nerve degenerative changes, including nerve fibre layer thinning, degeneration of retinal ganglion cells, and changes to vascular parameters. There is no cure for Alzheimer's, but medicines can slow down the development of many of the classic symptoms, such as loss of memory and communication skills, mood swings, and depression. The disease diagnosis is difficult,...
Source: Journal of Ophthalmology - August 30, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Stereoacuity of Black-White and Red-Green Patterns in Individuals with and without Color Deficiency.
Conclusion: Chromatic contrast is an influential factor for stereopsis measurement in individuals with color deficiency. PMID: 30155280 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - August 30, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comparative Study of Y-Split Recession versus Faden Technique for Management of Infantile Esotropia in Egyptians.
Conclusion: The results of this study suggest that both techniques show comparable results for the correction of IET. PMID: 30155281 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - August 30, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Effect of Hyaluronic Acid/Trehalose in Two Different Formulations on Signs and Symptoms in Patients with Moderate to Severe Dry Eye Disease.
Authors: Fondi K, Wozniak PA, Schmidl D, Bata AM, Witkowska KJ, Popa-Cherecheanu A, Schmetterer L, Garhöfer G Abstract Purpose: This randomized, observer-masked, crossover study investigated the effect of two hyaluronic acid/trehalose-based containing formulations, with different physical properties, on the signs and symptoms in patients with moderate to severe dry eye disease (DED). Methods: In one group, patients received a mixture of sodium hyaluronate and trehalose (HT, Thealoz Duo®) for use during the day. In the other group, patients received a more viscous formulation consisting of hyaluronic ac...
Source: Journal of Ophthalmology - August 30, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

From DMEK to Corneal Endothelial Cell Therapy: Technical and Biological Aspects.
Authors: Nuzzi R, Marolo P, Tridico F Abstract The main treatment available for restoration of the corneal endothelium is keratoplasty and DMEK provides faster visual recovery and better postoperative visual acuity when compared to DSAEK. However, the technical challenges related to this technique and the steep technical learning curve seem to prevent the overcoming of DSAEK in favor of DMEK. Furthermore, the outcome of lamellar keratoplasty techniques is influenced by problems related to corneal grafting tissue availability, management, and quality. On the other hand, improvements in the field of cell engineering ...
Source: Journal of Ophthalmology - August 30, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research