Poor Sleep Quality Is the Risk Factor for Central Serous Chorioretinopathy.
This study is designed to investigate sleep status in CSC using definite and well-established methods. Methods: A total of 134 CSC patients and 134 age- and sex-matched normal controls were recruited in the study. Demographic data were collected through a questionnaire. Body mass index (BMI) was calculated by weight divided by height squared. The Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) were administered to all subjects to assess the sleep quality and daytime sleepiness, respectively. Depression Anxiety Stress Scales 21-item version (DASS-21) was also used to evaluate the emotion status ...
Source: Journal of Ophthalmology - August 30, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Vector Analysis of the Effects of FS-LASIK and Toric ICL for Moderate to High Astigmatism Correction.
Conclusion: Both FS-LASIK and Toric ICL were effective for correcting moderate and high astigmatism, although Toric ICL might produce a larger error of angle than FS-LASIK when an off-axis correction occurs. PMID: 30147948 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - August 29, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Refractive Correction Treatment in Ectatic Corneal Disorders.
Authors: Romano V, Cueto LF, Zaldivar R PMID: 30147949 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - August 29, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Medial Rectus Tendon Elongation with Bovine Pericard (Tutopatch ®) in Thyroid-Associated Orbitopathy: A Long-Term Follow-Up including Oculodynamic MRI.
Discussion: In the Tutopatch group, preoperative angles ranged from 14 to 120∆ (prism diopters) at distance and 12-120∆ at near. Mean dose effect was 3.63∆/mm for the distance and 3.43∆/mm for the near angle. All patients were orthotropic at final FU (ranging from 1 to 10 years). OD-MRI showed the elasticity of Tutopatch. In the conventional recession group, preoperative angles ranged between 18 and 35∆ at distance and 12-33∆ at near. At final FU, 2 patients had reverted to their underlying microesotropia 
Source: Journal of Ophthalmology - August 26, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Corrigendum to "Five-Year Incidence and Progression of Diabetic Retinopathy in Patients with Type II Diabetes in a Tertiary Care Center in Lebanon".
Corrigendum to "Five-Year Incidence and Progression of Diabetic Retinopathy in Patients with Type II Diabetes in a Tertiary Care Center in Lebanon". J Ophthalmol. 2018;2018:2424757 Authors: Mehanna CJ, Fattah MA, Tamim H, Nasrallah MP, Zreik R, Haddad SS, El-Annan J, Raad S, Haddad RS, Salti HIS Abstract [This corrects the article DOI: 10.1155/2017/9805145.]. PMID: 30140451 [PubMed - in process] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - August 26, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Mineralocorticoid Receptor Antagonist Treatment for Steroid-Induced Central Serous Chorioretinopathy Patients with Continuous Systemic Steroid Treatment.
Authors: Kim JY, Chae JB, Kim J, Kim DY Abstract Purpose: To investigate the effectiveness of mineralocorticoid receptor (MR) antagonist in patients with steroid-induced central serous chorioretinopathy (CSC). Methods: A retrospective review was conducted of steroid-induced CSC patients who were treated with the MR antagonist spironolactone 50 mg once per day for at least 1 month. The primary outcome measure was complete resolution rate of subretinal fluid (SRF) after spironolactone treatment. Secondary outcomes included central subfield thickness (CST), subfoveal choroidal thickness (SFCT), and best-cor...
Source: Journal of Ophthalmology - August 26, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Erratum to "Prevalence of Selected Eye Diseases Using Data Harvested from Ophthalmic Checkup Examination of a Cohort of Two Thousand Middle Eastern and North African Subjects".
Erratum to "Prevalence of Selected Eye Diseases Using Data Harvested from Ophthalmic Checkup Examination of a Cohort of Two Thousand Middle Eastern and North African Subjects". J Ophthalmol. 2018;2018:6168597 Authors: Samy El Gendy NM, Abdel-Kader AA Abstract [This corrects the article DOI: 10.1155/2018/8049475.]. PMID: 30140453 [PubMed - in process] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - August 26, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Choroid and Retinal Nerve Fiber Layer Thickness in Patients with Chronic Obstructive Pulmonary Disease Exacerbation.
Conclusion: Decreased subfoveal choroid thickness was found in the COPD patients both during an exacerbation and in the stable period, when compared to the control group. The mean RNFL thickness was similar in the exacerbation and stable period of the stable COPD patients when compared to the control group. This suggests that ocular findings might be important in terms of COPD morbidity. This trial is registered with www.chictr.org.cn/enIndex.aspx. PMID: 30116623 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - August 19, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus.
Authors: He F, Zhao Z, Liu Y, Lu L, Fu Y Abstract Purpose: To investigate the impact of disease duration on the ocular surface during the course of type 2 diabetes mellitus compared with nondiabetic controls. Methods: One hundred twenty diabetic patients were divided into three groups according to disease duration: less than 5 years, 5-10 years, and over 10 years. All eyes were imaged using a corneal topographer (Oculus Keratograph 5M). Tear film measurements and meibography were also recorded. Meibomian gland changes were scored from 0 to 6 (meiboscore). Results: The noninvasive breakup time first (NIKBUT-...
Source: Journal of Ophthalmology - August 19, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Outcomes of Wound Dehiscence after Penetrating Keratoplasty and Lamellar Keratoplasty.
Authors: Wang X, Liu T, Zhang S, Qi X, Li S, Shi W, Gao H Abstract Objective: To investigate the incidence, causes, occurrence time, and range of wound and outcomes of wound dehiscence in patients treated by penetrating keratoplasty (PK) or lamellar keratoplasty (LK). Methods: We retrospectively reviewed medical records of keratoplasty in Shandong Eye Hospital from January 2006 to June 2017. Thirty-one eyes of 30 patients had sustained wound dehiscence (WD) after surgical treatment. The surgical type, causes, occurrence time, extent of the wound, treatment, and outcomes were recorded. Results: The study pop...
Source: Journal of Ophthalmology - August 19, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Effect of NSAID Pretreatment on Aqueous Humor Prostaglandin E2 Concentration in Eyes Undergoing Femtosecond Laser-Assisted Capsulotomy.
Authors: Diakonis VF, Anagnostopoulos AG, Moutsiopoulou A, Yesilirmak N, Cabot F, Waren DP, O'Brien TP, Yoo SH, Weinstock RJ, Donaldson KE Abstract Purpose: To assess aqueous humor concentration of prostaglandin E2 (PGE2) after capsulotomy creation using a femtosecond laser (FLAC) in patients pretreated with short-term topical ketorolac versus patients without pretreatment. Methods: This prospective study comprised consecutive patients scheduled to undergo cataract surgery using a femtosecond laser platform to perform only capsulotomies. An identical protocol for preoperative mydriasis was used for all the eyes...
Source: Journal of Ophthalmology - August 19, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Transpalpebral Electrical Stimulation as a Novel Therapeutic Approach to Decrease Intraocular Pressure for Open-Angle Glaucoma: A Pilot Study.
Authors: Gil-Carrasco F, Ochoa-Contreras D, Torres MA, Santiago-Amaya J, Pérez-Tovar FW, Gonzalez-Salinas R, Nino-de-Rivera L Abstract Purpose: To determine the effect on intraocular pressure of transpalpebral specific exogenous voltages in a cohort of open-angle glaucoma patients. Methods: This is a prospective, comparative, and experimental pilot study. The electrical stimuli applied consisted of 10 Hz, biphasic, nonrectangular current pulses (100 μA) delivered from an isolated constant current stimulator. At intake, baseline IOP measurements were obtained from each eye. The measuremen...
Source: Journal of Ophthalmology - August 19, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Peripheral Cone Dystrophy: Expanded Clinical Spectrum, Multimodal and Ultrawide-Field Imaging, and Genomic Analysis.
Conclusions: In contrast to the original description, the funduscopic and fluorescein angiographic appearance of PCD is abnormal, although the defects are subtle. Peripheral lesions may be observed in some patients. Bilateral, symmetric, macular hyperautofluorescence associated with outer retinal atrophy that spares the fovea is a characteristic of PCD. Pathogenic variants in the same gene were not shared across the cohort, suggesting genetic heterogeneity. Further evaluation is warranted. PMID: 30116628 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - August 19, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Role of Dll4/Notch Signaling in Normal and Pathological Ocular Angiogenesis: Dll4 Controls Blood Vessel Sprouting and Vessel Remodeling in Normal and Pathological Conditions.
Conclusions: All current studies demonstrated that Dll4 controls blood vessel sprouting, growth, and remodeling in normal and pathological conditions as well as arterial-venous differentiation. Genetic and therapeutic Dll4 modulation studies show that Dll4 inhibition can promote blood vessel sprouting and might be useful to stimulate vessel growth in the ischemic retina and Dll4 is the key modulator of the postangiogenic vascular remodeling that ultimately defines vascular patterning. PMID: 30116629 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - August 19, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Lanosterol Synthase Pathway Alleviates Lens Opacity in Age-Related Cortical Cataract.
Conclusions: This study indicated that LSS and lanosterol were localized in the lens of human ARC, including ARCC, ARNC, and ARPSC. LSS and lanosterol level are only correlated with opaque degree of ARCC. Furthermore, activated LSS pathway in lens is protective for lens transparency in cortical cataract. PMID: 30116630 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - August 19, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Inhibition of Proteasome Activity Upregulates IL-6 Expression in RPE Cells through the Activation of P38 MAPKs.
Conclusions: We concluded that the proteasome inhibitor, MG132, upregulates IL-6 production in RPE cells through the activation of P38 MAPKs. PMID: 30116631 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - August 19, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Analysis of Anthocyanins Extracted from the Acai Fruit (Euterpe oleracea): A Potential Novel Vital Dye for Chromovitrectomy.
Conclusions: Lyophilization and the correction of pH and osmolarity (7.00 and 300 mOsm, resp.) were performed successfully. Five anthocyanins are present in the dye from the acai fruit. The major anthocyanin is cyanidin-3-O-glucoside. Independent of the dye concentration tested, the anthocyanin concentration was similar. Standardized chemical characteristics of this new dye may allow its use during chromovitrectomy in humans. PMID: 30116632 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - August 19, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Decorin, Tenascin C, Total Antioxidant, and Total Oxidant Level Changes in Patients with Pseudoexfoliation Syndrome.
Conclusions: We suggest that parameters such as DEC, TN-C, TAS, and TOS play a role in the etiopathology of pseudoexfoliation syndrome. Thus, bringing these increased levels of extracellular proteins and TOS and decreased levels of TAS back to within physiological limits can mediate the reorganization of the blood-aqueous fluid barrier and slow the progression of pseudoexfoliation syndrome. PMID: 30116633 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - August 19, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

High Concentration of Glucose Increases Reactive Oxygen Species Generation and Apoptosis Induced by Endoplasmic Reticulum Stress Pathway in Rabbit Corneal Epithelial Cells.
Authors: Lu J, Sheng M, Yao P, Ran C, Liu H, Chen L, Liu R, Li B Abstract Objective: To investigate the effect of high concentration of glucose on reactive oxygen species (ROS) production in rabbit corneal epithelial cells (RECEs) and explore whether the increased ROS initiates the apoptosis process of RECEs through oxidative stress and endoplasmic reticulum (ER) stress pathway. Methods: RECEs were treated by different concentrations of glucose for a while, and then the production of ROS was detected by flow cytometry. The expressions of PERK, p-PERK, Akt, p-Akt, and CHOP were determined by western blot, and th...
Source: Journal of Ophthalmology - August 19, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Extended Injection Intervals after Switching from Ranibizumab to Aflibercept in Macular Edema due to Central Retinal Vein Occlusion.
Conclusion: In case of insufficient response or frequent recurrences of ME due to CRVO in patients treated with ranibizumab on a TAE basis, switching to aflibercept could allow extending treatment intervals, which could reduce the injection burden for these patients. PMID: 30116635 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - August 19, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Corrigendum to "Two-Year Outcome of Aflibercept in Patients with Pigment Epithelial Detachment due to Neovascular Age-Related Macular Degeneration (nAMD) Refractory to Ranibizumab".
Corrigendum to "Two-Year Outcome of Aflibercept in Patients with Pigment Epithelial Detachment due to Neovascular Age-Related Macular Degeneration (nAMD) Refractory to Ranibizumab". J Ophthalmol. 2018;2018:9171269 Authors: Tran THC, Dumas S, Coscas F Abstract [This corrects the article DOI: 10.1155/2017/8984313.]. PMID: 30116636 [PubMed - in process] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - August 19, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Trends in Indications and Techniques of Corneal Transplantation from 1999 through 2015 at a Tertiary Referral Center in Athens, Greece.
Conclusion: Herein, we observed an increasing trend of endothelial pathology among keratoplasty indications as well as a major shift in preferred techniques due to a wide adoption of the new EK procedures. PMID: 30079255 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - August 7, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Customized Toric Intraocular Lens Implantation in Eyes with Cataract and Corneal Astigmatism after Deep Anterior Lamellar Keratoplasty: A Prospective Study.
Authors: Schiano Lomoriello D, Savini G, Naeser K, Colabelli-Gisoldi RM, Bono V, Pocobelli A Abstract Purpose: To investigate the effectiveness of toric intraocular lenses (IOLs) for treating corneal astigmatism in patients with cataract and previous deep anterior lamellar keratoplasty (DALK). Setting: San Giovanni-Addolorata Hospital, Rome, Italy. Design: Prospective interventional case series. Methods: Patients undergoing cataract surgery after DALK for keratoconus were enrolled. Total corneal astigmatism (TCA) was assessed by a rotating Scheimpflug camera combined with Placido-disk corneal topography...
Source: Journal of Ophthalmology - July 31, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

A Comparative Study of Vitrectomy Combined with Internal Limiting Membrane Peeling for the Treatment of Idiopathic Macular Hole with Air or C3F8 Intraocular Tamponade.
Conclusions: In idiopathic macular hole surgery, the effect of air as an intraocular tamponade material can be similar to that of C3F8 but has fewer complications. In particular, it is a better choice for patients for whom the face-down position is not suitable. PMID: 30057803 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 31, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Two-Year Outcomes of Visian Implantable Collamer Lens with a Central Hole for Correcting High Myopia.
Conclusion: Implantation of ICL V4c is a safe, effective, and predictable procedure for correcting high myopia. Reduction of anterior chamber space after surgery did not induce intraocular pressure increase during the 2-year follow-up. PMID: 30057804 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 31, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Descriptive Study of Conjunctival Cysts: A Rare Complication after Strabismus Surgery.
Conclusions: Conjunctival cyst is a rare postoperative complication of strabismus surgery, conjunctival epithelium implantation should be the primary cause, and infection might exaggerate the situation. A longer duration of the surgical procedure could increase the possibility of infection, which could be accompanied with a greater tendency to the occurrence of conjunctival cyst. PMID: 30046458 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Efficacy and Safety of Intravitreal Conbercept, Ranibizumab, and Triamcinolone on 23-Gauge Vitrectomy for Patients with Proliferative Diabetic Retinopathy.
Authors: Cui J, Chen H, Lu H, Dong F, Wei D, Jiao Y, Charles S, Gu W, Wang L Abstract Introduction: To compare the effect and safety of intravitreal conbercept (IVC), intravitreal ranibizumab (IVR), or intravitreal triamcinolone acetonide (IVTA) injection on 23-gauge (23-G) pars plana vitrectomy (PPV) for proliferative diabetic retinopathy (PDR). Methods: Fifty patients (60 eyes) of varying degrees of PDR were randomly grouped into 3 groups (1 : 1 : 1) (n = 20 in each group). The 23-G PPV was performed with intravitreal conbercept or ranibizumab injection 3-7 days before surge...
Source: Journal of Ophthalmology - July 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Clinical Features and Surgical Outcomes of Posterior Segment Intraocular Foreign Bodies in Children in East China.
Conclusions: The clinical features of pediatric posterior segment IOFBs suggest insufficient awareness of such injuries both on the playground and at school. Visual outcomes from surgical treatment were relatively favorable in this series. PMID: 30046460 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Outcomes of Corneal Tattooing by Rotring Painting Ink in Disfiguring Corneal Opacities.
Conclusions: Corneal tattooing with Rotring painting ink in blind disfigured eyes achieves favourable cosmetic results and is associated with high patient satisfaction. With better case selection, a high post-op satisfaction was achieved. Corneal tattooing acts as an alternative to more sophisticated and expensive cosmetic reconstructive surgery. This trial is registered with ISRCTN46626979. PMID: 30046461 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comparison of 25- and 27-Gauge Pars Plana Vitrectomy in Repairing Primary Rhegmatogenous Retinal Detachment.
Conclusion: The 27G TSV system is safe and useful for RRD treatment as 25G TSV. PMID: 30046462 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Myopia: Risk Factors, Disease Mechanisms, Diagnostic Modalities, and Therapeutic Options.
Authors: Mrugacz M, Gajecka M, Mrukwa-Kominek E, Witkowska KJ PMID: 30046463 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Clinical Results of Diffractive, Refractive, Hybrid Multifocal, and Monofocal Intraocular Lenses.
Authors: Dyrda A, Martínez-Palmer A, Martín-Moral D, Rey A, Morilla A, Castilla-Martí M, Aronés-Santivañez J Abstract Purpose: To present the outcomes of hybrid multifocal and monofocal intraocular lenses (IOLs) and to compare with refractive and diffractive multifocal IOLs (MFIOLs). Methods: Three hundred twenty eyes (160 patients) underwent cataract surgery with randomized IOLs bilateral implantation. Changes in uncorrected and distance-corrected logMAR distance, intermediate and near (UNVA and DCNVA) visual acuity (VA), contrast sensitivity (CS), presence of dysphotopsia, s...
Source: Journal of Ophthalmology - July 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Peripapillary Vessel Density Reversal after Trabeculectomy in Glaucoma.
Conclusions: A significant increase in the peripapillary vessel density was demonstrated after trabeculectomy using OCT angiography. The reversal of peripapillary vessel density was associated with higher preoperative IOP and greater IOP reduction. Our postoperative results suggest that the ocular perfusion impairment by high intraocular pressure can be improved by IOP reduction, and the reversal of microvasculature may contribute to the rate of glaucoma progression. PMID: 30046465 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Pediatric Traumatic Retinal Detachment: Clinical Features, Prognostic Factors, and Surgical Outcomes.
Conclusions: Visual outcomes are poorer compared to anatomical outcomes. OTS and POTS do not provide reliable prognostic information if the patient has RD. Presenting visual acuity, the presence of macula-off RD, and PVR are all important predictors of final visual acuity. PMID: 30046466 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

From Presbyopia to Cataracts: A Critical Review on Dysfunctional Lens Syndrome.
Authors: Fernández J, Rodríguez-Vallejo M, Martínez J, Tauste A, Piñero DP Abstract Dysfunctional lens syndrome (DLS) is a term coined to describe the natural aging changes in the crystalline lens. Different alterations in the refractive properties and transparency of the lens are produced during the development of presbyopia and cataract, such as changes in internal high order aberrations or an increase in ocular forward scattering, with a potentially significant impact on clinical measures, including visual acuity and contrast sensitivity. Objective technologies have emerged to solve t...
Source: Journal of Ophthalmology - July 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Corneal Cap Thickness and Its Effect on Visual Acuity and Corneal Biomechanics in Eyes Undergoing Small Incision Lenticule Extraction.
Authors: Liu T, Yu T, Liu L, Chen K, Bai J Abstract Purpose: To evaluate the effect of corneal cap thickness on visual acuity and corneal biomechanics in small incision lenticule extraction (SMILE) for the treatment of myopia. Methods: Forty eyes of 20 patients undergoing SMILE for the treatment of myopia were enrolled in this prospective controlled study. The patients with 510 μm-560 μm central corneal thickness (CCT) and a refractive spherical equivalent of -3.00 D to -8.00 D were included. It was designed randomly to undergo SMILE with a 110 μm cap thickness in one...
Source: Journal of Ophthalmology - July 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Emerging Therapeutic Strategies for Limbal Stem Cell Deficiency.
Authors: Dong Y, Peng H, Lavker RM Abstract Identification and characterization of the limbal epithelial stem cells (LESCs) has proven to be a major accomplishment in anterior ocular surface biology. These cells have been shown to be a subpopulation of limbal epithelial basal cells, which serve as the progenitor population of the corneal epithelium. LESCs have been demonstrated to play an important role in maintaining corneal epithelium homeostasis. Many ocular surface diseases, including intrinsic (e.g., Sjogren's syndrome) or extrinsic (e.g., alkali or thermal burns) insults, which impair LESCs, can lead to limba...
Source: Journal of Ophthalmology - July 28, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Reduction in Ocular Hypotensive Eyedrops by Ab Interno Trabeculotomy Improves Not Only Ocular Surface Condition But Also Quality of Vision.
Authors: Kashiwagi K, Matsubara M Abstract Purpose: To investigate the effect of ab interno trabeculotomy using the Trabectome surgical system on tear film stability and functional visual acuity (FVA). Patients and Methods: Adult glaucoma patients who underwent Trabectome surgery alone or Trabectome surgery combined with phacoemulsification with intraocular lens insertion were included in this study. Corneal epithelial defects, tear film breakup time (TBUT), tear meniscus height, tear film spreading grade, tear interferometry grade, and FVA were assessed before and after surgery in addition to routine ophthalmi...
Source: Journal of Ophthalmology - July 25, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Prevalence and Associations of Peripheral Retinopathy: Baseline Study of Guangzhou Office Computer Workers.
Authors: Zhang T, Zuo Y, Wei Y, Huang W, Zhou X, Liu R, Zhong L, Peng M, Zhang S Abstract Purpose: To determine the prevalence of peripheral retinopathy and its associated risk factors among a sample of Guangzhou office computer workers. Methods: A cross-sectional study of Guangzhou Chinese computer workstations and operators in different departments and units of the Guangzhou Power Supply Bureau, China, in 2016. Peripheral retinopathy was recorded and analyzed using a scanning laser ophthalmoscope (SLO; Optos, Daytona, United Kingdom) and slit-lamp microscopy combined with a three-mirror contact lens. Resu...
Source: Journal of Ophthalmology - July 22, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Association between Female Reproductive Factors and Open-Angle Glaucoma in Korean Women: The Korean National Health and Nutrition Examination Survey V.
Conclusions: Only early menopause was associated with an increased risk of OAG in our study, in contrast to previous Western studies reporting both early menopause and late menarche as associated factors. PMID: 30026984 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 22, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Clinical Efficacy of Platelet-Rich Plasma in the Treatment of Neurotrophic Corneal Ulcer.
Authors: Wróbel-Dudzińska D, Alio J, Rodriguez A, Suchodoła-Ratajewicz E, Kosior-Jarecka E, Rymgayłło-Jankowska B, Ćwiklińska-Haszcz A, Żarnowski T Abstract Purpose: Platelet-rich plasma (PRP) is an autologous blood product without preservatives and rich in proteins and growth factors which make it possible for cells to differentiate, proliferate, and migrate, thus stimulating healing and regeneration of tissues. The aim of this study was to evaluate the efficiency of autologous platelet-rich plasma in the treatment of neurotrophic keratopathy. Methods: The study group consists of 25 patients with...
Source: Journal of Ophthalmology - July 22, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Ahmed Glaucoma Valves versus EX-PRESS Devices in Glaucoma Secondary to Silicone Oil Emulsification.
Authors: Qian Z, Xu K, Kong X, Xu H Abstract Objective: To evaluate and compare the clinical effects of Ahmed glaucoma valves (AGVs) and EX-PRESS implants on glaucoma secondary to silicone oil (SO) emulsification. Methods: A retrospective case-series study was designed. A total of 23 eyes with late intraocular pressure (IOP) elevation secondary to SO emulsification were included in the study. Antiglaucoma surgery with implantation of AGVs or EX-PRESS devices was performed. Pre- and postoperative ocular parameters were recorded at each visit during a 1-year follow-up period. The rates of complete success (IOP 
Source: Journal of Ophthalmology - July 22, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Early Results with a New Posterior Chamber Phakic Intraocular Lens in Patients with High Myopia.
Authors: Yaşa D, Ürdem U, Ağca A, Yildirim Y, Kepez Yildiz B, Kandemir Beşek N, Yiğit U, Demirok A Abstract Purpose: To report clinical results of a foldable, hydrophilic acrylic, single-piece, injectable, posterior chamber phakic intraocular lens (pIOL). Material and Methods: Medical records of patients who underwent posterior chamber phakic IOL (Eyecryl Phakic IOL, Biotech Vision Care, Ahmedabad, India) implantation for surgical correction of myopia were retrospectively reviewed. Only patients with at least a one-year follow-up were included. Manifest refraction, uncorrected distance visual acuity (U...
Source: Journal of Ophthalmology - July 20, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Effect of Steep Trendelenburg Positioning on Retinal Structure and Function during Robotic-Assisted Laparoscopic Procedures.
Conclusions: Although IOP significantly increased during RALP, there were no significant changes in the retinal structure and function between the pre- and postoperation observations. PMID: 30009047 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 18, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Psychological Aspects and Depression in Patients with Symptomatic Keratoconus.
Authors: Moschos MM, Gouliopoulos NS, Kalogeropoulos C, Androudi S, Kitsos G, Ladas D, Tsatsos M, Chatziralli I Abstract Purpose: To assess the psychological status of keratoconus sufferers and to determine the relationship between depression and visual impairment in this group of patients. Methods: Fifty-six patients with keratoconus and forty-seven age- and gender-matched healthy control subjects were retroprospectively analyzed. Every participant underwent a complete ophthalmological examination. Keratoconus diagnosis was confirmed with corneal topography and tomography. Zung Depression Inventory Questionnai...
Source: Journal of Ophthalmology - July 15, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Association of Genes in the High-Density Lipoprotein Metabolic Pathway with Polypoidal Choroidal Vasculopathy in Asian Population: A Systematic Review and Meta-Analysis.
Authors: Yuan MZ, Han RA, Zhang CX, Chen YX Abstract Purpose: To assess the association of genes in the high-density lipoprotein metabolic pathway (HDLMP) with polypoidal choroidal vasculopathy (PCV) and the genetic difference in the HDLMP between PCV and age-related macular degeneration (AMD). Methods: We performed a literature search in EMBASE, PubMed, and Web of Science for genetic studies on 7 single nucleotide polymorphisms (SNPs) from 5 genes in the HDLMP including cholesteryl ester transfer protein (CETP), hepatic lipase (LIPC), lipoprotein lipase (LPL), ATP-binding cassette transporter A1 (ABCA1), and A...
Source: Journal of Ophthalmology - July 8, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Protection of Corneal Limbus from Riboflavin Prevents Epithelial Stem Cell Loss after Collagen Cross-Linking.
Conclusions: Protection of limbus from riboflavin during CXL was effective in preserving LESCs. However, inflammation was increased in the cornea treated with riboflavin using a ring. PMID: 29967694 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 4, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Effects of Uncomplicated Cataract Surgery on Retinal Layer Thickness.
Authors: Kurt A, Kılıç R Abstract Purpose: Our aim was to assess changes in the total retinal thickness (TRT), total retinal volume (TRV), and retinal layer thickness after uncomplicated cataract surgery. Methods: A total of 32 eyes of 32 patients who had undergone uncomplicated phacoemulsification surgery and intraocular lens implantation in one eye were enrolled. Effective phacoemulsification time (EPT) and total energy (TE) were recorded. Thickness and TRV were measured using optical coherence tomography. Data were collected preoperatively and at postoperative day 1, 7, 30, 90, and 180. Results:...
Source: Journal of Ophthalmology - July 4, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Choroidal Thickness in Chinese Children Aged 8 to 11 Years with Mild and Moderate Myopia.
Authors: Qi Y, Li L, Zhang F Abstract Purpose: To investigate macular choroidal thickness (CT), topographical variation, and associations between subfoveal choroidal thickness (SFCT) and age, gender, spherical equivalent (SE), and axial length (AL) in Chinese healthy mild and moderate myopia children aged 8 to 11 years. Methods: One hundred twenty eyes from 120 healthy children were studied. Children were divided into mild and moderate myopia groups. AL and CT were evaluated. CTs were measured at the fovea, and 1 mm, 2 mm, and 3 mm nasal, temporal, superior, and inferior to the fovea. R...
Source: Journal of Ophthalmology - July 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Bandage Lenses in the Postoperative Care for Cataract Surgery Patients: A Substitute for Eye Patch?
Conclusion: Bandage lenses can be used as a safe and effective substitute for eye patch in the postoperative care for cataract surgery patients. The Clinical Study registration number is ChiCTR-IOC-17012167. PMID: 29887990 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 13, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research