Effect of Age on Pentacam Keratoconus Indices.
Authors: Roshdy MMS, Wahba SS, Elkitkat RS, Hakim AM, Fikry RR Abstract Purpose: To assess the effect of age on elevation and pachymetric Pentacam keratoconus (KC) detection indices, and the need to adjust normative values accordingly. Methods: In a retrospective study, 95 eyes of myopic normal subjects without KC were evaluated using the OCULUS Pentacam, with an age range of 17.4 to 46.8 years. Subjects were categorised into three groups according to their age: the first included those younger than 21 years (19 eyes), the second was for the age range of 21-40 years (65 eyes), and the third compri...
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Outcomes of Descemet Membrane Endothelial Keratoplasty for Vitrectomized Eyes with Sutured Posterior Chamber Intraocular Lens.
Authors: Yamada N, Hayashi T, Yuda K, Shimizu T, Oyakawa I, Takahashi H, Kato N Abstract Purpose: To evaluate the clinical outcomes of Descemet membrane endothelial keratoplasty (DMEK) for vitrectomized eyes that underwent pars plana vitrectomy (PPV) and transscleral-sutured intraocular lens (IOL) implantation. Methods: In this retrospective study, DMEK cases were reviewed from medical records and divided into two groups: the eyes after PPV and transscleral-sutured IOL implantation (vitrectomized group) and the eyes with in-the-bag IOL implantation (control group) prior to DMEK. The main outcome measures includ...
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comparison of Intravitreal Aflibercept and Ranibizumab following Initial Treatment with Ranibizumab in Persistent Diabetic Macular Edema.
Authors: Demircan A, Alkin Z, Yesilkaya C, Demir G, Kemer B Abstract Purpose: To compare the visual and anatomic outcomes in patients with persistent diabetic macular edema (DME) who switched from ranibizumab to aflibercept with those who continued with previous ranibizumab therapy. Methods: In this retrospective comparative study, medical records of consecutive patients with center-involved DME ≥ 350 μm who had at least three recent consecutive monthly ranibizumab injections followed by as-needed therapy with either aflibercept or ranibizumab were reviewed. Data were collected at pre...
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Clinical and Genetic Features of Tubulointerstitial Nephritis and Uveitis Syndrome with Long-Term Follow-Up.
Conclusions: TINU should be considered in the differential diagnosis in young patients with uveitis of unknown origin and renal dysfunction. Urinary β2 microglobulin level and HLA typing may help in the diagnosis of TINU. The prognosis for patients with TINU is generally good with steroid treatment. PMID: 29850203 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comparison of Visual Outcome and Morphologic Change between Different Surgical Techniques in Idiopathic Epiretinal Membrane Surgery.
Conclusion: All three techniques can achieve visual acuity improvement and macular thickness reduction. Maculorrhexis ILM peeling achieves more rapid improvement of visual function, better final visual outcome, and a higher rate of normal foveal contour than whole-piece ILM peeling. PMID: 29850204 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Treatment Efficacy and Compliance in Patients with Diabetic Macular Edema Treated with Ranibizumab in a Real-Life Setting.
Authors: Best AL, Fajnkuchen F, Nghiem-Buffet S, Grenet T, Quentel G, Delahaye-Mazza C, Cohen SY, Giocanti-Aurégan A Abstract Purpose: To assess real-life efficacy of ranibizumab and treatment compliance of patients with vision loss secondary to diabetic macular edema (DME). Methods: A retrospective study was conducted in DME patients treated with ranibizumab. Patients were monitored every 4 weeks for visual acuity (VA) and central retinal thickness (CRT) by SD-OCT. All patients received a loading dose of 3 monthly injections followed by retreatments on an as-needed basis. The primary endpoint was the ch...
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Management of Glaucoma: Structure and Function.
Authors: Hirooka K, Higashide T, Jeoung JW PMID: 29850206 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Influence of Disc Size on the Diagnostic Accuracy of Cirrus Spectral-Domain Optical Coherence Tomography in Glaucoma.
Conclusions: The high diagnostic accuracy of the rim area demonstrated by Cirrus HD-OCT for the quantitative assessment of the ONH was not significantly affected by disc size in this study. PMID: 29850207 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Phenotypic Variation in a Four-Generation Family with Aniridia Carrying a Novel PAX6 Mutation.
Authors: Wang GM, Prasov L, Al-Hasani H, Marrs CER, Tolia S, Wiinikka-Buesser L, Richards JE, Bohnsack BL Abstract Aniridia is a congenital disease that affects almost all eye structures and is primarily caused by loss-of-function mutations in the PAX6 gene. The degree of vision loss in aniridia varies and is dependent on the extent of foveal, iris, and optic nerve hypoplasia and the presence of glaucoma, cataracts, and corneal opacification. Here, we describe a 4-generation family in which 7 individuals across 2 generations carry a novel disease-causing frameshift mutation (NM_000280.4(PAX6):c.565TC>T) in PAX6....
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Effect of Reformation of the Anterior Chamber by Air or by a Balanced Salt Solution (BSS) on Corneal Endothelium after Phacoemulsification: A Comparative Study.
Conclusion: There is no difference between the effect of reformation of the anterior chamber after phacoemulsification, using air or using a BSS injection, on the corneal endothelial count and morphology. PMID: 29850209 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Group Analysis of Q Values Calculated with Tangential Radius of Curvature from Human Anterior Corneal Surface.
Conclusion: The method using the tangential radius of curvature combined with linear regression to obtain anterior surface Q values for both adults and children was stable and reliable. When we analyzed the anterior corneal Q value, area division was necessary. PMID: 29850210 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

A Review of Surgical Outcomes and Advances for Macular Holes.
Authors: Zhao PP, Wang S, Liu N, Shu ZM, Zhao JS Abstract The surgical outcomes of macular holes (MHs) have improved greatly in recent years. The closure rate is as high as 90-100%, but the outcomes of some special types of MHs remain unsatisfactory. Internal limiting membrane (ILM) peeling dramatically improves the anatomic success rate, but recent studies have found that it could also cause mechanical and subclinical traumatic changes to the retina. Dyes are widely used, and apart from indocyanine green (ICG), the toxicities of other dyes require further research. Face-down posturing is necessary for MHs larger t...
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Difference in the Vitreal Protein Profiles of Patients with Proliferative Diabetic Retinopathy with and without Intravitreal Conbercept Injection.
Authors: Zou C, Zhao M, Yu J, Zhu D, Wang Y, She X, Hu Y, Zheng Z Abstract Purpose: To examine the difference in the vitreal protein profiles of patients with proliferative diabetic retinopathy (PDR) with and without preoperative intravitreal conbercept (IVC) treatment. Methods: Liquid chromatography-tandem mass spectrometry- (LC-MS/MS-) based proteomic methods were used to determine the protein profiles of the vitreous humor in patients with PDR treated with (IVC group; n = 9) and without (PDR group; n = 8) preoperative IVC. Gene ontology (GO) annotation and REACTOME pathway analysis were obtained to overview ...
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Effect of Exogenous Alpha-B Crystallin on the Structures and Functions of Trabecular Meshwork Cells.
This study, for the first time, focused on the role of CRYAB in undesired changes of the structures and functions in trabecular meshwork (TM) cells. Methods: Cell proliferation and migration were assessed using a cell counting kit-8 (CCK8) and transwell assay analysis, respectively. Immunofluorescence (IF), quantitative real-time PCR (Rt-qPCR), and Western blot were performed to determine the effect of CRYAB on F-actin, tight junctions, and the expression of epithelial to mesenchymal transition- (EMT-) associated proteins in TM cells. Results: CRYAB promoted proliferation (p
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Vascular Endothelial Growth Factor, Basic Fibroblast Growth Factor, and Pigment Epithelium-Derived Factor Expression in the Neovascular Iris in Retinal Diseases.
Conclusions: The protein level of bFGF increased in the irises of the NVG patients was not expressed by the iris itself, whereas PEDF may be expressed by the iris tissue in these patients. PMID: 29850214 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Evaluation of TGF-Beta 2 and VEGF α Gene Expression Levels in Epiretinal Membranes and Internal Limiting Membranes in the Course of Retinal Detachments, Proliferative Diabetic Retinopathy, Macular Holes, and Idiopathic Epiretinal Membranes.
Conclusions: Our results revealed that factors associated with angiogenesis and wound healing processes in eyes with RRD, PDR, iERM, and MH were more upregulated in ERMs than in ILMs. This may indicate that ILM is not responsible for reproliferation and its peeling should be avoided in routine PPV. PMID: 29850215 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Clinical Outcomes of Sequential Intrastromal Corneal Ring Segments and an Extended Range of Vision Intraocular Lens Implantation in Patients with Keratoconus and Cataract.
This study comprised patients with keratoconus and cataract that had ICRS implantation followed 6 months later by extended range of vision IOL implantation. The uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), and residual refractive errors, analysed using vector analysis, were recorded preoperatively, 6 months after ICRS implantation, and 6 months after IOL implantation, respectively. Results: The study enrolled 17 eyes (11 patients). The mean UDVA (logMAR scale) was 1.15 ± 0.67 preoperatively, 0.88 ± 0.69 six months after ICRS implantation (...
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Screening of Primary School Children for Amblyopia and Amblyogenic Factors in Central Cairo, Egypt.
Authors: Rashad MA, Abd Elaziz KM, Fawzy SM, Abdel Latif AAM, Abdel Latif MAM Abstract Objective: To measure the prevalence of amblyopia and amblyogenic factors among primary school children and to evaluate distance visual acuity (VA) as a screening test to detect amblyopia and define its cutoff value. Subjects and Methods: A cross-sectional study was conducted on primary school children in two schools in Central Cairo. Children underwent assessment of visual acuity using Landolt broken ring. Comprehensive ophthalmologic examination was performed for amblyopia suspects at the Ophthalmology Department of Ain Sha...
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Outcome of Primary Nonpenetrating Deep Sclerectomy in Patients with Steroid-Induced Glaucoma.
Conclusion: Primary nonpenetrating deep sclerectomy is a safe and an effective method of treating eyes with steroid-induced glaucoma. No major complications were encountered. After 4 years of follow-up, complete success rate was 56.7% and qualified success rate was 70%. PMID: 29850218 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Less Expansion of Short-Pulse Laser Scars in Panretinal Photocoagulation for Diabetic Retinopathy.
Authors: Higaki M, Nozaki M, Yoshida M, Ogura Y Abstract Purpose: To compare the expansion rates of laser photocoagulation scars between the conventional laser and short-pulse laser using fundus autofluorescence (FAF). Methods: Retrospective chart review. Conventional laser was performed on 6 eyes of 6 patients, and short-pulse laser was performed on 11 eyes of 8 patients with diabetic retinopathy. FAF images were obtained by Optos® 200Tx (Optos, Dunfermline, Scotland, UK) at 1, 3, 6, and 12 months after treatment. The average area of 20 photocoagulation scars was measured by using ImageJ software. The expa...
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Total Penetrating Keratoplasty: Indications, Therapeutic Approach, and Long-Term Follow-Up.
Conclusion: TPK should be considered as a last line treatment in huge corneal destruction to restore integrity of the eye globe. PMID: 29850220 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 1, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Generation of Femtosecond Laser-Cut Decellularized Corneal Lenticule Using Hypotonic Trypsin-EDTA Solution for Corneal Tissue Engineering.
Conclusion: We generated an ideal protocol for DCLs using a novel method. Furthermore, it is possible to create a scaffold using a bioengineered corneal substitute. PMID: 29805794 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - May 31, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Corneal Stability following Hyperopic LASIK with Advanced Laser Ablation Profiles Analyzed by a Light Propagation Study.
Conclusions: Light propagation analysis confirms corneal surface stability following modern hyperopic LASIK with a 6th-generation excimer laser technology over a 12-month period. PMID: 29785300 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - May 24, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Impact of Baseline Central Retinal Thickness on Outcomes in the VIVID-DME and VISTA-DME Studies.
Authors: Midena E, Gillies M, Katz TA, Metzig C, Lu C, Ogura Y Abstract Purpose: To report the impact of baseline central retinal thickness (CRT) on outcomes in patients with diabetic macular edema (DME) in VIVID-DME and VISTA-DME. Methods: Post hoc analyses of two randomized controlled trials in which 862 DME patients were randomized 1 : 1 : 1 to treatment with intravitreal aflibercept 2.0 mg every 4 weeks (2q4), intravitreal aflibercept 2.0 mg every 8 weeks after five initial monthly doses (2q8), or macular laser photocoagulation at baseline and as needed. We compared...
Source: Journal of Ophthalmology - May 24, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comparisons of Visual and Surgical Outcomes after Reuse or Replacement of Dislocated in-the-Bag Intraocular Lens.
Conclusions: Half of the cases with reused in-the-bag dislocated IOL had a breakage or a tilting of the IOL. The replacement of the in-the-bag dislocated IOL is better than the reuse of the IOL with intrascleral haptics fixation. PMID: 29785302 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - May 24, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Ocular Manifestations of Biopsy-Proven Pulmonary Sarcoidosis in Korea.
Conclusions: In patients with biopsy-proven pulmonary sarcoidosis, the presence of ocular involvement and uveitis as a first sign could be significant factors associated with higher systemic treatment rate, especially with immunosuppressive agents. Biopsy site determined by location and size had no influence on clinical features. PMID: 29785303 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - May 24, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Application of 25  MHz B-Scan Ultrasonography to Determine the Integrity of the Posterior Capsule in Posterior Polar Cataract.
Conclusion: This is the first report to show that 25 MHzB can be used to clearly visualize the status of the PC in PPC. These results, in turn, could be used to select the appropriate treatment and to thereby avoid further complications during PPC surgery. PMID: 29785304 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - May 24, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Molecular Genetics of Pigment Dispersion Syndrome and Pigmentary Glaucoma: New Insights into Mechanisms.
Authors: Lahola-Chomiak AA, Walter MA Abstract We explore the ideas and advances surrounding the genetic basis of pigment dispersion syndrome (PDS) and pigmentary glaucoma (PG). As PG is the leading cause of nontraumatic blindness in young adults and current tailored interventions have proven ineffective, a better understanding of the underlying causes of PDS, PG, and their relationship is essential. Despite PDS being a subclinical disease, a large proportion of patients progress to PG with associated vision loss. Decades of research have supported a genetic component both for PDS and conversion to PG. We review th...
Source: Journal of Ophthalmology - May 22, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Effect of Timing of Initial Cataract Surgery, Compliance to Amblyopia Therapy on Outcomes of Secondary Intraocular Lens Implantation in Chinese Children: A Retrospective Case Series.
Authors: Li L, Wang Y, Xue C Abstract Purpose: As a secondary analysis, we reassess the association of initial congenital cataract surgery times, compliance to amblyopia therapy, and visual outcomes for a long-term follow-up in a secondary IOL implantation. Methods: Retrospective review of records of all infants with congenital cataracts who underwent secondary IOL implantation in the Eye and ENT Hospital of Fudan University from January 1, 2001, to December 31, 2007, and the minimum follow-up period was 5 years. Multiple regression analysis was used and the possible confounding factors were also analyzed to as...
Source: Journal of Ophthalmology - May 18, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Outcomes and Complications of Scleral-Fixated Intraocular Lens Combined with Ahmed Tube Surgery.
Authors: Sachdev N, Aquino MC, Loon SC, Chan YH, Chew P, Koh V Abstract Background: To evaluate the outcome and complications of transscleral suture-fixated posterior chamber intraocular lens (PCIOL) implantation combined with Ahmed glaucoma valve (AGV) surgery in Asian eyes. Design: This was a retrospective study that included 22 eyes from 22 participants. The surgeries were performed at Singapore's National University Hospital. Participants underwent an Ahmed tube surgery, together with transscleral suture-fixated posterior chamber intraocular lens. Main Outcome Measures: Complete success was defined as 6...
Source: Journal of Ophthalmology - May 18, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Changing Trends in Eye-Related Complaints Presenting to the Emergency Department in Beirut, Lebanon, over 15 Years.
Authors: Salti HI, Mehanna CJ, Abiad B, Ghazi N, Raad S, Barikian A, Haddad R, Ashkar A, Harmouche E, Zaghrini E, Mufarrij A Abstract Objective: To report the 15-year trend in ophthalmic presentations to the emergency department (ED) at the only medical center in Lebanon that provides 24-hour ophthalmologic care. Methods: Retrospective review of 1967 patients presenting to the ED with eye-related complaints between September 1997 and August 1998 and between September 2012 and August 2013. Diagnoses were classified into 4 categories according to the International Society of Ocular Trauma and include penetrating ...
Source: Journal of Ophthalmology - May 12, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

In Vivo Confocal Microscopic Observations of Vortex Keratopathy in Patients with Amiodarone-Induced Keratopathy and Fabry Disease.
Conclusion: These findings suggest that the corneal epithelial cells most likely endocytose amiodarone from the tear film in the amiodarone-induced keratopathy. In Fabry disease, globotriaosylceramide deposits are taken up by the lysosomes of the limbal epithelial stem cells, and they differentiate and migrate to the center of the cornea to form the whorl pattern. PMID: 29750121 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - May 12, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Analysis of Visual Field Defects Obtained with Semiautomated Kinetic Perimetry in Patients with Leber Hereditary Optic Neuropathy.
Conclusions: SKP provides additional clinical information in regard to the visual function of LHON patients. SKP enables the quantification of the area of central scotoma, preserved peripheral VF, and residual central island of vision. Using V4 stimulus is especially useful in LHON patients with poor visual acuity, when SAP is difficult to obtain. PMID: 29750122 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - May 12, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Visual Subfield Progression in Glaucoma Subtypes.
Conclusion: The rate of visual field progression was correlated with the peak posttreatment IOP and the long-term IOP fluctuation but with subfield differences. PMID: 29750123 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - May 12, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

A Small Disc Area Is a Risk Factor for Visual Field Loss Progression in Primary Open-Angle Glaucoma: The Glaucoma Stereo Analysis Study.
Authors: Kitaoka Y, Tanito M, Yokoyama Y, Nitta K, Katai M, Omodaka K, Nakazawa T Abstract Purpose: The Glaucoma Stereo Analysis Study, a cross-sectional multicenter collaborative study, used a stereo fundus camera (nonmyd WX) to assess various morphological parameters of the optic nerve head (ONH) in glaucoma patients. We compared the associations of each parameter between the visual field loss progression group and no-progression group. Methods: The study included 187 eyes of 187 patients with primary open-angle glaucoma or normal-tension glaucoma. We divided the mean deviation (MD) slope values of all patien...
Source: Journal of Ophthalmology - May 12, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Phenotypic Progression of Stargardt Disease in a Large Consanguineous Tunisian Family Harboring New ABCA4 Mutations.
Authors: Falfoul Y, Habibi I, Turki A, Chebil A, Hassairi A, Schorderet DF, El Matri L Abstract To assess the progression of Stargardt (STGD) disease over nine years in two branches of a large consanguineous Tunisian family. Initially, different phenotypes were observed with clinical intra- and interfamilial variations. At presentation, four different retinal phenotypes were observed. In phenotype 1, bull's eye maculopathy and slight alteration of photopic responses in full-field electroretinography were observed in the youngest child. In phenotype 2, macular atrophy and yellow white were observed in two brothers. ...
Source: Journal of Ophthalmology - May 9, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Effect of Perioperative Fluid Management on Intraocular Pressure during Gynecologic Laparoscopic Pelvic Surgery.
Conclusion: IOP was elevated during laparoscopic pelvic surgery and particularly at the steep Trendelenburg position. No differences were found in any of the parameters examined according to a liberal or restrictive fluid management protocol. PMID: 29736280 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - May 9, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Association of Optic Neuritis with CYP4F2 Gene Single Nucleotide Polymorphism and IL-17A Concentration.
Authors: Banevicius M, Vilkeviciute A, Glebauskiene B, Kriauciuniene L, Liutkeviciene R Abstract Background: The aetiology and pathophysiology of optic neuritis (ON) is not absolutely clear but genetic and inflammatory factors may be also involved in its development. The aim of the present study was to determine the influence of single nucleotide polymorphism (SNP) of CYP4F2 (rs1558139) and serum levels of IL-17A on ON development. Materials and Methods: Forty patients with ON and 164 control subjects were evaluated. Patients were divided by gender, also ON patients were divided into two subgroups: ON with and ...
Source: Journal of Ophthalmology - May 9, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Biomaterial Influence on Intraocular Lens Performance: An Overview.
Authors: Pérez-Vives C Abstract There is strong evidence that the IOL material is the factor having the greatest impact on posterior capsule opacification (PCO), anterior capsule opacification (ACO) development, and glistening formation after cataract surgery, even though there are other IOL features-such as haptic material and design and edge and optic design-that also have some influence. We reviewed the published literature describing the adverse events that are mainly related to the intraocular lens (IOL) material, such as PCO, ACO, and the subsequent capsule contraction, as well as glistening formation....
Source: Journal of Ophthalmology - May 9, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Macular Integrity Assessment and Fixation Analysis in Chronic Central Serous Chorioretinopathy.
Conclusion: New microperimetry technology may provide valuable information regarding the visual status of chronic CSC cases. Our findings suggest that retinal sensitivity and fixation stability in chronic CSC eyes may serve as useful indicators for assessing the effectiveness of clinical treatments. PMID: 29725542 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - May 8, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comparison of Efficacy and Ocular Surface Disease Index Score between Bimatoprost, Latanoprost, Travoprost, and Tafluprost in Glaucoma Patients.
Authors: El Hajj Moussa WG, Farhat RG, Nehme JC, Sahyoun MA, Schakal AR, Jalkh AE, Abi Karam MP, Azar GG Abstract Aim: The purpose of this study is to evaluate and compare the efficacy of 4 prostaglandin analogues (PGAs) and to determine the incidence of ocular surface disease in newly diagnosed, primary open-angle glaucoma (POAG) patients started on one of those 4 PGAs: bimatoprost (benzalkonium chloride, BAK, 0.3 mg/mL), latanoprost (BAK 0.2 mg/mL), travoprost (polyquad), and tafluprost (BAK-free). Patients and Methods: In this single-center, open-label trial, 32 patients newly diagnosed with PO...
Source: Journal of Ophthalmology - May 2, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Effect of Patient Characteristics and Sleep Quality on Visual Field Performance Reliability.
Conclusion: In this prospective, cross-sectional study, worse MD and PSD are strongly correlated with increased FN in both eyes. Increased FN in the left eye associated with older age might be attributable to test fatigue. Worse sleep quality is associated with decreased FL in the right eye. PMID: 29707391 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - May 2, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Clinical Analysis of 42 Cases of Ocular Ischemic Syndrome.
We reported a case of corneal edema and corneal epithelium erosion in the ipsilateral eye due to internal carotid artery stenosis. As the clinical manifestations of OIS are complex, ophthalmologists must carefully examine patients to avoid a misdiagnosis or a failure to diagnose. The management of OIS requires cooperation with cardiologists and neurologists. PMID: 29713523 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - May 2, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Refractive and Biometric Outcomes in Patients with Retinopathy of Prematurity Treated with Intravitreal Injection of Ranibizumab as Compared with Bevacizumab: A Clinical Study of Correction at Three Years of Age.
Authors: Chen YC, Chen SN, Yang BC, Lee KH, Chuang CC, Cheng CY Abstract Purpose: To compare refractive and biometric outcomes in patients with type 1 retinopathy of prematurity (ROP) treated with intravitreal injection of ranibizumab (IVR) versus bevacizumab (IVB), at a corrected age of 3 years. Methods: A retrospective case series compared cycloplegic refractive statuses and biometric statuses in patients who received either IVR or IVB for type 1 ROP, from April 2011 to April 2014. Results: A total of 62 eyes (33 patients) with type 1 ROP were evaluated (26 eyes in 13 IVR patients and 36 eyes in 20 IVB pa...
Source: Journal of Ophthalmology - May 2, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Efficacy of Osthole in Management of Hypoperfused Retina.
Conclusions: Osthole protects the retina from ischemia injury secondary to CCH induced by BCCAO, mainly through anti-inflammatory, antioxidant, and antiapoptotic effects. PMID: 29713525 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - May 2, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Long-Term Functional and Anatomical Outcome after Descemet Stripping Automated Endothelial Keratoplasty: A Prospective Single-Center Study.
Conclusions: We observed a low graft failure rate and a normalization of graft thickness. Postoperative straylight remained elevated relative to the normal population. The sharp initial and the subsequent more gradual ECD decline are consistent with other studies. A significant and prolonged functional gain can be achieved by posterior lamellar grafting for endothelial dysfunction. PMID: 29713526 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - May 2, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Prevalence of Selected Eye Diseases Using Data Harvested from Ophthalmic Checkup Examination of a Cohort of Two Thousand Middle Eastern and North African Subjects.
Conclusion: Different ophthalmic conditions were discovered for the first time at the general checkup clinic. Certain conditions were more common than others in certain countries. The lack of regular checkups and the unavailability of medical services due to low to moderate socioeconomic status as well as political turbulence may account for the delay in initial diagnosis of many treatable conditions. PMID: 29686888 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - April 26, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Myopia Progression Risk: Seasonal and Lifestyle Variations in Axial Length Growth in Czech Children.
Authors: Rusnak S, Salcman V, Hecova L, Kasl Z Abstract The growth in the prevalence of myopia leads to the growth of socioeconomic stress in society. It is important to detect any potential risk factors leading to myopia onset and progression. Among the potential risk factors, the lack of natural daylight exposure and the lack of the physical activity together with excess of near-work activities in children are the most prevalent. In the study, the axial length growth depending on the season and the type of behaviour was measured. The assessment was performed in 12-year-old children, 398 eyes of whom were included...
Source: Journal of Ophthalmology - April 26, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Refraction and Ocular Biometry of Preschool Children in Shanghai, China.
Authors: Zhang L, He X, Qu X, You X, Wang B, Shi H, Tan H, Zou H, Zhu J Abstract Purpose: To investigate the refraction and ocular biometry characteristics and to examine the prevalence of refractive errors in preschool children aged 3 to 6 years in Shanghai, China. Methods: A school-based cross-sectional study was conducted in Jiading and Xuhui District, Shanghai, in 2013. We randomly selected 7 kindergartens in Jiading District and 10 kindergartens in Xuhui District, with a probability proportionate to size. The children underwent comprehensive eye examinations, including cycloplegic refraction and biometric ...
Source: Journal of Ophthalmology - April 26, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Canaloplasty versus Nonpenetrating Deep Sclerectomy: 2-Year Results and Quality of Life Assessment.
Conclusions: PC leads to a more effective decrease in IOP than PDS in midterm observation with similar safety profiles. PDS patients required a vast number of additional procedures in contrast to PC patients, but this fact did not influence QoL. PMID: 29682338 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - April 25, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research