Comparison between a New Optical Biometry Device and an Anterior Segment Optical Coherence Tomographer for Measuring Central Corneal Thickness and Anterior Chamber Depth.
Authors: Huang J, Lu W, Savini G, Chen H, Wang C, Yu X, Bao F, Wang Q Abstract Purpose. To compare between a new optical biometer (AL-Scan, Nidek Co., Aichi, Japan) and an anterior segment optical coherence tomographer (Visante AS-OCT, Carl Zeiss Meditec, Dublin, USA) for measuring central corneal thickness (CCT), anterior chamber depth (ACD), and aqueous depth (AD). Methods. Sixty-three eyes of 63 normal subjects were examined with AL-Scan and Visante AS-OCT in this prospective study. One eye per subject was measured three times with both devices to record their CCT, ACD, and AD. All procedures were performed by t...
Source: Journal of Ophthalmology - July 14, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Identification of the First De Novo UBIAD1 Gene Mutation Associated with Schnyder Corneal Dystrophy.
Conclusions. We present a novel heterozygous de novo missense mutation in UBIAD1, p.(Thr103Ile), identified in a patient with classic clinical features of SCD. This highlights the value of genetic testing in clinical diagnostic settings, even in the absence of a positive family history. PMID: 27382485 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 8, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Keratorefractive Effect of High Intensity Focused Ultrasound Keratoplasty on Rabbit Eyes.
Authors: Du Z, Yan P, Luo Q, Zhang D, Zhang Y Abstract Purpose. To evaluate high intensity focused ultrasound (HIFU) as an innovation and noninvasive technique to correct presbyopia by altering corneal curvature in the rabbit eye. Methods. Eighteen enucleated rabbit eyes were treated with a prototype HIFU keratoplasty. According to the therapy power, these eyes were divided three groups: group 1 (1 W), group 2 (2 W), and group 3 (3 W). The change in corneal power was quantified by a Sirius Scheimpflug camera. Light microscopy (LM) and transmission electron microscopy (TEM) were performed to det...
Source: Journal of Ophthalmology - July 8, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

A Prospective Study of the Incidence of Retinopathy of Prematurity in China: Evaluation of Different Screening Criteria.
Authors: Li Q, Wang Z, Wang R, Tang H, Chen H, Feng Z Abstract To investigate the incidence of Retinopathy of Prematurity (ROP) in Beijing, North China, and to evaluate the effectiveness of different ROP screening criteria, we conducted a prospective cohort study in a single-neonatal intensive care unit (NICU). A total of 2997 premature infants with birth weight (BW) ≤ 2000 g and/or gestational age (GA) ≤ 34 weeks had completed ROP screening. ROP was diagnosed in 356 (11.9%) infants. The mean GA was 30.46 ± 1.98 weeks and the mean BW was 1477.35 ± 371.29 g. Of the 59 (2.0%) infants...
Source: Journal of Ophthalmology - July 8, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Differences in Central Corneal Thickness between Spectral Domain-Optical Coherence Tomography and Ultrasound Pachymetry in Patients with Dry Eye Disease.
Authors: Celebi AR, Mirza GE Abstract Purpose. To compare central corneal thickness (CCT) values via Spectral Domain-Optical Coherence Tomography (SD-OCT) and ultrasonic pachymetry in patients with severe dry eye disease (DED) to determine the level of agreement between these 2 methods. Methods. The paired samples t-test was used to compare CCT values in severe DED patients. Matching analysis between methods was performed using intraclass correlation coefficient (ICC). Intrasession reliability of the measurement methods was calculated via the concordance correlation coefficient (CCC), variation equivalent, and Pear...
Source: Journal of Ophthalmology - July 7, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Assessment of Corneal Epithelial Thickness in Asymmetric Keratoconic Eyes and Normal Eyes Using Fourier Domain Optical Coherence Tomography.
Authors: Catalan S, Cadarso L, Esteves F, Salgado-Borges J, Lopez M, Cadarso C Abstract Purpose. To compare the characteristics of asymmetric keratoconic eyes and normal eyes by Fourier domain optical coherence tomography (OCT) corneal mapping. Methods. Retrospective corneal and epithelial thickness OCT data for 74 patients were compared in three groups of eyes: keratoconic (n = 22) and normal fellow eyes (n = 22) in patients with asymmetric keratoconus and normal eyes (n = 104) in healthy subjects. Areas under the curve (AUC) of receiver operator characteristic (ROC) curves for each variable were compared across g...
Source: Journal of Ophthalmology - July 7, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Is Floppy Eyelid Syndrome More Prevalent in Obstructive Sleep Apnea Syndrome Patients?
Authors: Wang P, Yu DJ, Feng G, Long ZH, Liu CJ, Li H, Zhao TL Abstract Controversial findings are reported about the relationship between floppy eyelid syndrome (FES) and obstructive sleep apnea syndrome (OSAS). The main goal of this study was to evaluate whether FES is more prevalent in OSAS patients by performing a meta-analysis. A comprehensive literature search of Pubmed, Embase, and Cochrane databases was performed. Only studies related to the prevalence of FES in OSAS were included in the meta-analysis. We estimated a pooled odds ratio (OR) for the prevalence of FES in OSAS. In total, 6 studies with 767 part...
Source: Journal of Ophthalmology - July 2, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Fascicular Visual Field Defects in Open-Angle Glaucoma: Evaluation with Microperimetry.
Conclusions. Topographic visualization of the perimetric alteration by microperimetry allows retesting areas with reduced sensitivity which are topographically visualized and displayable on the ocular fundus examination, avoiding worsening of the functional defect by better modulation of the antiglaucoma therapy and therefore it allows better monitoring of the pathologic functional damage. PMID: 27366329 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 2, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Evaluation of Different Power of Near Addition in Two Different Multifocal Intraocular Lenses.
Conclusion. The +2.5 diopters near addition could be a better choice in younger patients with more distance and intermediate visual requirements (driving, outdoor activities), whereas the + 3.0 diopters should be considered for patients with more near vision correction (reading). PMID: 27340560 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 26, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Central Corneal Thickness in Spectral-Domain OCT and Associations with Ocular and Systemic Parameters.
Authors: Schuster AK, Fischer JE, Vossmerbaeumer U Abstract Background. Optical coherence tomography (OCT) allows quantitative analysis of the anterior segment of the eye with a noncontact examination. The aim of this study is to analyze associations of central corneal thickness (CCT) as measured by OCT with ocular and systemic cardiovascular parameters. Methods. A cross-sectional study of 734 persons was performed in a working age population. Only healthy eyes were included. A comprehensive ophthalmological examination including refraction, noncontact tonometry, and imaging of the anterior segment by SD-OCT was pe...
Source: Journal of Ophthalmology - June 26, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Inhibition of Zymosan-Induced Inflammatory Factors Expression by ATRA Nanostructured Lipid Carriers.
Conclusions. ATRA may be a potent anti-inflammatory agent for the therapy of fungal keratitis (FK). PMID: 27340562 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 26, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Lecithin-Bound Iodine Prevents Disruption of Tight Junctions of Retinal Pigment Epithelial Cells under Hypoxic Stress.
Conclusions. LBI results in a protective action from hypoxia. PMID: 27340563 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 26, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Cationic Thiolated Poly(aspartamide) Polymer as a Potential Excipient for Artificial Tear Formulations.
Authors: Budai-Szűcs M, Horvát G, Szilágyi BÁ, Gyarmati B, Szilágyi A, Berkó S, Szabó-Révész P, Sandri G, Bonferoni MC, Caramella C, Soós J, Facskó A, Csányi E Abstract Dry eye disease is a relatively common ocular problem, which causes eye discomfort and visual disorders leading to a decrease in the quality of life. The aim of this study was to find a possible excipient for eye drop formulations, which is able to stabilize the tear film. A cationic thiolated polyaspartamide polymer, poly[(N-mercaptoethylaspartamide)-co-(N-(N',N'-dimethyl...
Source: Journal of Ophthalmology - June 19, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

The Effect of Air Pollution on the Occurrence of Nonspecific Conjunctivitis.
Conclusions. The air quality index within two days before presentation affected the probability of attending the outpatient clinic for nonspecific conjunctivitis. High number of cases can be expected in colder season. PMID: 27313867 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 19, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Shallow Inferior Conjunctival Fornix in Contracted Socket and Anophthalmic Socket Syndrome: A Novel Technique to Deepen the Fornix Using Fascia Lata Strips.
Conclusion. Fascia lata technique is a new alternative and effective procedure to deepen the shallow inferior fornix that can be used in moderate to severe contracted sockets or anophthalmic socket syndrome with minimal lower eyelid or socket complications. PMID: 27313868 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 19, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Refractive Results: Safety and Efficacy of Secondary Piggyback Sensar™ AR40 Intraocular Lens Implantation to Correct Pseudophakic Refractive Error.
Conclusions. Implantation of the second sulcus SensarAR40 IOL was found to be safe, easy, and simple technique for management of ametropia following uncomplicated phacoemulsification. PMID: 27313869 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 19, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Morphometric Optic Nerve Head Analysis in Glaucoma Patients: A Comparison between the Simultaneous Nonmydriatic Stereoscopic Fundus Camera (Kowa Nonmyd WX3D) and the Heidelberg Scanning Laser Ophthalmoscope (HRT III).
Authors: Mariacher S, Hipp S, Wirthky R, Blumenstock G, Bartz-Schmidt KU, Ziemssen F, Schiefer U, Voykov B, Januschowski K Abstract Purpose. To investigate the agreement between morphometric optic nerve head parameters assessed with the confocal laser ophthalmoscope HRT III and the stereoscopic fundus camera Kowa nonmyd WX3D retrospectively. Methods. Morphometric optic nerve head parameters of 40 eyes of 40 patients with primary open angle glaucoma were analyzed regarding their vertical cup-to-disc-ratio (CDR). Vertical CDR, disc area, cup volume, rim volume, and maximum cup depth were assessed with both devices by...
Source: Journal of Ophthalmology - June 19, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

In Vivo Near-Infrared Fluorescence Imaging of Aqueous Humor Outflow Structures.
Authors: Zeppa L, Ambrosone L, Guerra G, Fortunato M, Costagliola C Abstract The aim of this study has been to visualize the aqueous outflow system in patients affected by primary open angle glaucoma. A solution of indocyanine green (ICG) plus high viscosity viscoelastic solution was injected into the Schlemm canal during surgery in 10 glaucomatous patients undergoing canaloplasty. Soon after injection of the dye the borders of the scleral flap were completely stained due to partial reflux caused by the intrachannel resistance; progression of the dye along the Schlemm canal starting from the site of injection was t...
Source: Journal of Ophthalmology - June 19, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comparison between Limbal and Pars Plana Approaches Using Microincision Vitrectomy for Removal of Congenital Cataracts with Primary Intraocular Lens Implantation.
Conclusions. The visual results were encouraging in both approaches. We recommend the pars plana approach for lower incidence of complications. The limbal approach should be reserved for children older than 3 years of age and caution should be exercised to minimize iris disturbance. PMID: 27313872 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 19, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Peripapillary Choroidal Thickness and Open-Angle Glaucoma: A Meta-Analysis.
Conclusions. This meta-analysis suggests that open-angle glaucoma patients have significantly decreased peripapillary choroidal thickness compared to healthy individuals. Peripapillary choroidal thickness measured by optical coherence tomography may be an important parameter to consider in open-angle glaucoma. PMID: 27298732 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 16, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Assessment of Anterior Segment Changes in Pseudophakic Eyes, Using Ultrasonic Biomicroscopic Imaging, after Pars Plana Vitrectomy with Silicone Oil or Gas Tamponade.
Conclusions. Gases cause more morphological changes in the anterior segment structures. It is thought that complications such as increased intraocular pressure can be seen more frequently for this reason. PMID: 27298733 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 16, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Therapeutic Effect of Intrastromal Voriconazole, Topical Voriconazole, and Topical Natamycin on Fusarium Keratitis in Rabbit.
Conclusion. Intrastromal injection of voriconazole seems to be effective in treatment of Fusarium keratitis as much as topical natamycin and these are more effective than topical voriconazole. PMID: 27298734 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 16, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Optical Quality and Related Factors in Ocular Hypertension: Preliminary Study.
Authors: Wang YJ, Yang YN, Huang LY, Wang B, Han YC, Yan JB Abstract Background. To evaluate the optical quality and related factors in patients with ocular hypertension (OHT). Methods. This was a prospective case-control study. A total of 12 eyes with OHT and 20 control eyes underwent testing with Optical Quality Analysis System II (OQAS II) to evaluate the modulation transfer function cut off frequency (MTF cutoff), the Strehl 2D ratio (SR), objective scatter index (OSI), tear-film mean OSI (TFOSI), and the OQAS values (OV100%,OV20%, and OV9%). Results. The optical quality of patients with OHT declined, with lowe...
Source: Journal of Ophthalmology - June 14, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Intravitreal Ranibizumab Injection as an Adjuvant in the Treatment of Neovascular Glaucoma Accompanied by Vitreous Hemorrhage after Diabetic Vitrectomy.
Conclusions. The findings suggest that intravitreal ranibizumab injection as adjuvant therapy for treatment of NVG accompanied by PDVH may be safe and potentially effective. This clinical trial is registered with NCT02647515. PMID: 27293875 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 14, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Diagnostic Performance of McMonnies Questionnaire as a Screening Survey for Dry Eye: A Multicenter Analysis.
Authors: Guo Y, Peng R, Feng K, Hong J Abstract Purpose. To evaluate the diagnostic performance of the McMonnies questionnaire as a screening survey for dry eye in Chinese outpatients. Methods. The questionnaire was self-administered by 27,999 patients with dry eye symptoms. A thorough ophthalmic examination including tear break-up time (TBUT), fluorescein staining, and Schirmer I test was completed to make a clinical diagnosis of dry eye. Reliability, validity, and accuracy of the McMonnies questionnaire were assessed. Results. The McMonnies questionnaire showed poor internal consistency (Cronbach α = 0.37),...
Source: Journal of Ophthalmology - June 14, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Use of Mechanical Turk as a MapReduce Framework for Macular OCT Segmentation.
Authors: Lee AY, Lee CS, Keane PA, Tufail A Abstract Purpose. To evaluate the feasibility of using Mechanical Turk as a massively parallel platform to perform manual segmentations of macular spectral domain optical coherence tomography (SD-OCT) images using a MapReduce framework. Methods. A macular SD-OCT volume of 61 slice images was map-distributed to Amazon Mechanical Turk. Each Human Intelligence Task was set to $0.01 and required the user to draw five lines to outline the sublayers of the retinal OCT image after being shown example images. Each image was submitted twice for segmentation, and interrater reliabi...
Source: Journal of Ophthalmology - June 14, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Ultrasound Biomicroscopy Comparison of Ab Interno and Ab Externo Intraocular Lens Scleral Fixation.
Conclusions. Ab externo and ab interno scleral fixation techniques presented similar results in haptic placement. Ab externo technique presented higher vertical tilt when compared to the ab interno. PMID: 27293878 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 14, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Efficacy and Safety of a Dexamethasone Implant in Patients with Diabetic Macular Edema at Tertiary Centers in Korea.
Authors: Moon BG, Lee JY, Yu HG, Song JH, Park YH, Kim HW, Ji YS, Chang W, Lee JE, Oh J, Chung I Abstract Purpose. To evaluate the real-world efficacy and safety of the dexamethasone implant (DEX implant) in patients with diabetic macular edema (DME). Methods. Retrospective, multicenter, and noncomparative study of DME patients who were treated with at least one DEX implant. A total of 186 eyes from 165 patients were included. Best-corrected visual acuity (BCVA), central retinal thickness (CRT), complications, and number of retreatments were collected. Data at baseline and monthly for 6 months were analyzed. Result...
Source: Journal of Ophthalmology - June 14, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Retinal Ganglion Cell Atrophy in Homonymous Hemianopia due to Acquired Occipital Lesions Observed Using Cirrus High-Definition-OCT.
Conclusion. Our findings confirmed our previous observations that the degeneration of retinal ganglion cells can occur after PCA stroke. GCL+IPL thinning was demonstrated in the hemiretinae corresponding to the affected hemifields. Also, it is suggested that the retinal changes observed are progressive. PMID: 27274865 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 10, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Daily Optical Coherence Tomography Examinations after First Antivascular Endothelial Growth Factor Injections: An Interventional Case Series.
Conclusion. The CRT decreased early after the first injection. We observed a tendency for reductions in the speed with which the CRT decreased by day 17 after the first injection, which may affect retreatment regime. PMID: 27274866 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 10, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Association of Common Variants in eNOS Gene with Primary Open Angle Glaucoma: A Meta-Analysis.
Authors: Xiang Y, Dong Y, Li X, Tang X Abstract Purpose. To clarify the association of endothelial nitric oxide synthase (eNOS) polymorphisms and primary open angle glaucoma (POAG). Methods. After a systematic literature search in the MEDLINE, EMBASE, and ISI Web of Science databases, all relevant studies evaluating the association between the polymorphisms (rs2070744 and rs1799983) of eNOS gene and POAG were screened and included. The pooled odds ratios (ORs) and the 95% confidence interval (CI) of each single-nucleotide polymorphism (SNP) in five genetic models were estimated using fixed-effect model if I (2)
Source: Journal of Ophthalmology - June 2, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Propolis, a Constituent of Honey, Inhibits the Development of Sugar Cataracts and High-Glucose-Induced Reactive Oxygen Species in Rat Lenses.
Conclusion. Propolis significantly inhibited the onset and progression of sugar cataract in rats and mitigated high-glucose-induced ROS production and cell death. These effects may be associated with the ability of propolis to inhibit hyperglycemia-evoked oxidative or osmotic stress-induced cellular insults. PMID: 27242920 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 2, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

In Vivo and Cadaver Studies of the Canalicular/Lacrimal Sac Mucosal Folds.
Conclusion. Common canaliculus is the most common type that the canaliculus opens to lacrimal sac. CLS-MFs exist in a certain ratio that can be opened/closed with the movement of the orifices. They may be involved in the drainage of tears or the pathogenesis of acute dacryocystitis or lacrimal sac mucocele. PMID: 27242921 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 2, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Estimated Prevalence of Glaucoma in South Korea Using the National Claims Database.
Conclusion. The estimated prevalence and socioeconomic burden of glaucoma have steadily increased each year in South Korea. Nevertheless, many glaucoma patients remain undiagnosed in the present study using national claims database. PMID: 27247797 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 2, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Expression of Wnt/β-Catenin Signaling Pathway and Its Regulatory Role in Type I Collagen with TGF-β1 in Scleral Fibroblasts from an Experimentally Induced Myopia Guinea Pig Model.
Conclusions. The activation of Wnt3/β-catenin signaling pathway was demonstrated in primary scleral fibroblasts in FDM. This pathway further reduced the expression of type I collagen by TGF-β1, which ultimately played a role in scleral remodeling during myopia development. PMID: 27247798 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 2, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

An Important Cause of Blindness in Children: Open Globe Injuries.
Conclusion. Presence of hyphema and zone 2 and zone 3 injuries and retinal detachment may end up with visual impairment and/or blindness in children. PMID: 27247799 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 2, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

A Meta-Analysis for Association of Maternal Smoking with Childhood Refractive Error and Amblyopia.
Authors: Li L, Qi Y, Shi W, Wang Y, Liu W, Hu M Abstract Background. We aimed to evaluate the association between maternal smoking and the occurrence of childhood refractive error and amblyopia. Methods. Relevant articles were identified from PubMed and EMBASE up to May 2015. Combined odds ratio (OR) corresponding with its 95% confidence interval (CI) was calculated to evaluate the influence of maternal smoking on childhood refractive error and amblyopia. The heterogeneity was evaluated with the Chi-square-based Q statistic and the I (2) test. Potential publication bias was finally examined by Egger's test. Results...
Source: Journal of Ophthalmology - June 2, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comparison of the Early Clinical Outcomes between Combined Small-Incision Lenticule Extraction and Collagen Cross-Linking versus SMILE for Myopia.
Authors: Ng AL, Chan TC, Cheng GP, Jhanji V, Ye C, Woo VC, Lai JS Abstract Background. To compare the early outcome of combined SMILE and collagen crosslinking (SMILE Xtra) with SMILE. Method. Prospective, comparative interventional study of 21 eyes receiving SMILE Xtra using a low energy protocol and 32 control eyes receiving SMILE only. The outcomes were compared at 1, 3, and 6 months postoperatively. Results. Both groups had myopia with spherical equivalent refraction (SEQ)> 4.00 D. The SMILE Xtra group had thinner preoperative central corneal thickness and residual stromal bed thickness (p
Source: Journal of Ophthalmology - June 1, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Retinal Electrophysiology Is a Viable Preclinical Biomarker for Drug Penetrance into the Central Nervous System.
Conclusions. Retinal electrophysiology, when recorded in conscious animals, shows promise as a viable biomarker of drug penetration into the CNS. In contrast, when conducted under anaesthetised conditions confounds can be induced in both cortical and retinal electrophysiological recordings. PMID: 27239335 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 1, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Comparison between Subjective Sensations during First and Second Phacoemulsification Eye Surgeries in Patients with Bilateral Cataract.
Conclusions. Our research confirms the common observation that patients with bilateral cataracts often report more ocular discomfort during the second surgery. There are, therefore, additional factors that should be considered upon treating patients with bilateral cataracts, and the provision of preoperative counseling could play an important role in providing adequate patient care. PMID: 27239336 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - June 1, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Canaloplasty: Current Value in the Management of Glaucoma.
Authors: Cagini C, Peruzzi C, Fiore T, Spadea L, Lippera M, Lippera S Abstract Canaloplasty is a nonpenetrating blebless surgical technique for open-angle glaucoma, in which a flexible microcatheter is inserted within Schlemm's canal for the entire 360 degrees. When the microcatheter exits the opposite end, a 10-0 prolene suture is tied and it is then withdrawn, by pulling microcatheter back through the canal in the opposite direction. Ligation of prolene suture provides tension on the canal and facilitates aqueous outflow. The main advantage of canaloplasty is that this technique avoids the major complications of ...
Source: Journal of Ophthalmology - June 1, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Loop Myopexy Surgery for Strabismus Associated with High Myopia.
Authors: Su Y, Shen Q, Fan X Abstract Strabismus associated with high myopia is a rare abnormality of ocular motility, leading to the impairment of abduction and supraduction. Loop myopexy of the superior rectus (SR) and lateral rectus (LR) muscles is now the most preferred surgery for restoring the dislocated eye globe back into the muscle cone. Various procedural modifications have been made based on this concept, and satisfactory outcomes have been reached in most cases. In this paper, we review various surgical modifications published in the literature that are based on the loop myopexy surgery in patients with...
Source: Journal of Ophthalmology - June 1, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Usefulness of Discarded Vitreous Samples from Routine Vitrectomy.
Authors: Vilà N, Zoroquiain P, Bravo-Filho V, Antecka E, Dietrich H, Chen JC, Galic IJ, Kapusta MA, Burnier MN Abstract Purpose. To describe the histopathological features of vitreous samples obtained after vitrectomy surgery from diabetic and nondiabetic patients. Methods. Vitreous specimens from 137 patients who underwent vitrectomy for different clinical conditions were analysed. All samples were centrifuged and each resulting pellet was fixed and processed as part of routine paraffin section histopathology. The histopathological features were categorized in a semiquantitative fashion. The samples from di...
Source: Journal of Ophthalmology - May 24, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Spectrum and Sensitivity of Bacterial Keratitis Isolates in Auckland.
Conclusions. Despite a shift in the spectrum of bacterial keratitis isolates, antibiotic sensitivity patterns have generally remained stable and show comparability to results within the last decade from NZ centres. PMID: 27213052 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - May 24, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Dry Eye Syndrome in Patients with Diabetes Mellitus: Prevalence, Etiology, and Clinical Characteristics.
Authors: Zhang X, Zhao L, Deng S, Sun X, Wang N Abstract There has been substantial progress in our understanding of the ocular surface system/lacrimal function unit in the past 15 years. Keratoconjunctivitis sicca, more commonly referred to as dry eye syndrome (DES), is the most frequently encountered condition and diabetes mellitus (DM) has been identified as one of the leading causes of DES. Poor glycemic control affects both the anterior and the posterior segments of the eye and increasing prevalence of diabetes-associated DES (DMDES) has been reported in recent years. The pathogenesis and specific features of ...
Source: Journal of Ophthalmology - May 24, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Intrastromal Injection of China Painting Ink in Corneas of Male Rabbits: Clinical and Histological Study.
Conclusion. Corneal staining by China painting ink is effective and safe in staining of male rabbits cornea; however further study in human corneas with longer follow-up period is advisable. PMID: 27195146 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - May 21, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Properties of Retinal Precursor Cells Grown on Vertically Aligned Multiwalled Carbon Nanotubes Generated for the Modification of Retinal Implant-Embedded Microelectrode Arrays.
Conclusions. All tested MWCNT-covered slices showed good biocompatibility profiles, confirming that this nanotechnology is a promising tool to improve prostheses bearing electrodes which connect with retinal tissue. PMID: 27200182 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - May 21, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Different Strategies for the Treatment of Age-Related Macular Degeneration in China: An Economic Evaluation.
Conclusion. Bevacizumab can be a cost-effective option for the treatment of AMD in the Chinese setting. PMID: 27200183 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - May 21, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Two-Dimensional Cutting (TDC) Vitrectome: In Vitro Flow Assessment and Prospective Clinical Study Evaluating Core Vitrectomy Efficiency versus Standard Vitrectome.
Authors: Pavlidis M Abstract Purpose. To evaluate comparative aspiration flow performance and also vitrectomy operating time efficiency using a double-cutting open port vitreous cutting system incorporated in a two-dimensional cutting (TDC, DORC International) vitrectome design versus standard vitreous cutter. Methods. In vitro investigations compared aspiration flow rates in artificial vitreous humor at varying cutter speeds and vacuum levels using a TDC vitrectome and a standard vitrectome across different aspiration pump systems. A prospective single-centre clinical study evaluated duration of core vitrectomy in...
Source: Journal of Ophthalmology - May 20, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Automatic Screening and Grading of Age-Related Macular Degeneration from Texture Analysis of Fundus Images.
Authors: Phan TV, Seoud L, Chakor H, Cheriet F Abstract Age-related macular degeneration (AMD) is a disease which causes visual deficiency and irreversible blindness to the elderly. In this paper, an automatic classification method for AMD is proposed to perform robust and reproducible assessments in a telemedicine context. First, a study was carried out to highlight the most relevant features for AMD characterization based on texture, color, and visual context in fundus images. A support vector machine and a random forest were used to classify images according to the different AMD stages following the AREDS protoc...
Source: Journal of Ophthalmology - May 20, 2016 Category: Opthalmology Tags: J Ophthalmol Source Type: research