Inhibition of Polo-Like Kinase 1 Promotes Hyperthermia Sensitivity via Inactivation of Heat Shock Transcription Factor 1 in Human Retinoblastoma Cells [New Developments]

Conclusions.
Polo-like kinase 1 inhibition may attenuate the thermoresistance of HT through the inactivation of HSF1 concomitant with reductions in HSPs and BAG3. The combination of PLK1 inhibition and HT may become an option for HT therapy in patients with retinoblastoma.

Source: Investigative Ophthalmology - December 23, 2013 Category: Opthalmology Authors: Yunoki, T., Tabuchi, Y., Hayashi, A., Kondo, T. Tags: New Developments Source Type: research