siRNA Silencing of the Mutant Keratin 12 Allele in Corneal Limbal Epithelial Cells Grown From Patients With Meesmann's Epithelial Corneal Dystrophy [Cornea]

Conclusions.
Combined with an effective delivery vehicle this siRNA approach represents a viable treatment option for prevention of the MECD pathology observed in K12-Leu132Pro heterozygous individuals.

Source: Investigative Ophthalmology - May 29, 2014 Category: Opthalmology Authors: Courtney, D. G., Atkinson, S. D., Allen, E. H. A., Moore, J. E., Walsh, C. P., Pedrioli, D. M. L., MacEwen, C. J., Pellegrini, G., Maurizi, E., Serafini, C., Fantacci, M., Liao, H., Irvine, A. D., McLean, W. H. I., Moore, C. B. T. Tags: Cornea Source Type: research